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SREILISGGGIAGPALAYWLVQEGHSVTIVERAATVRNGGQAVDFRGPSIDVLDKMGVLDAVRAQATHMG SLVMVDADGKEIARFPSEVISGELEILWGDLARILHEAVREHVVFRFADSITGVRDDGAKVTVSFSRSAP ESYDLLIGADGVHSGVRALTFGPEHEFVTQLGQYFTFFAMDNHLGLDHQTVGFREGTRGVGIQATAPDAP ARGSLSFSDDHLEFDYRDVEGNKKLFSERFTGFGWETPAVLRALSVTAEPYFDSLCQVHLDTYSRGRVCL LGDAAWCASPRSGMGTSLAIVGAYVLAHELRSAQGDFSIAFARFHTLMAPYAARCQRLALDALKIGEADS PWATGLRRLGLWSLRLPGIRQLVARQALKVGRSFALPAYD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0649c | - | - | 100% (391) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2678 | - | 6e-66 | 36.95% (406) | hypothetical protein MAB_2678 |
| M. abscessus ATCC 19977 | MAB_1431 | - | 5e-58 | 36.96% (349) | hypothetical protein MAB_1431 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 9e-50 | 35.99% (339) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 2e-11 | 26.67% (405) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 5e-73 | 40.62% (352) | hypothetical protein Rv1260 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4180 | - | 1e-74 | 40.91% (352) | oxidoreductase |
| M. avium 104 | MAV_1408 | - | 2e-77 | 42.21% (353) | hypothetical protein MAV_1408 |
| M. smegmatis MC2 155 | MSMEG_3039 | - | 5e-66 | 37.22% (395) | monooxygenase |
| M. thermoresistible (build 8) | TH_1880 | - | 5e-11 | 26.65% (334) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_4482 | - | 1e-74 | 40.91% (352) | hypothetical protein MUL_4482 |
| M. vanbaalenii PYR-1 | Mvan_2422 | - | 3e-10 | 24.65% (357) | hypothetical protein Mvan_2422 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_0649c|M.abscessus_ATCC_199 ----------------------------------MSR-EILISGGGIAGP
MSMEG_3039|M.smegmatis_MC2_155 ----------------------------------MGQPTVLISGAGVAGT
Rv1260|M.tuberculosis_H37Rv ------------------------------------MKTVVVSGASVAGT
MAV_1408|M.avium_104 ------------------------------------MSDVLVSGASVAGT
MMAR_4180|M.marinum_M ---------------------------------MVGVQKVLISGASVAGL
MUL_4482|M.ulcerans_Agy99 ---------------------------------MVGVQKVLISGASVAGL
Mb0590c|M.bovis_AF2122/97 -------------------------------------MKVAISGAGVAGA
TH_1880|M.thermoresistible__bu ------------------------------------VYDVIVVGGGPTGM
Mvan_2422|M.vanbaalenii_PYR-1 MTTTRHKDTHKDTREDTREDTRDDSRDDGGDPNGDTDHAVVVGGGGPTGM
Mflv_2621|M.gilvum_PYR-GCK -----------------------------------MSARISVIGAGISGL
: : *.. :*
MAB_0649c|M.abscessus_ATCC_199 ALAYWLVQEGHSVTIVERAAT-VRNGGQAVDFRGPSIDVLDKMGVLDAVR
MSMEG_3039|M.smegmatis_MC2_155 SLAHWLTEYGYRAVVVETAPT-LRLGGQTVDLRGAGRDVVTRMGLLDEMR
Rv1260|M.tuberculosis_H37Rv AAAYWLGRHGYSVTMVERHPG-LRPGGQAIDVRGPALDVLERMGLLAAAQ
MAV_1408|M.avium_104 AAAFWLGRHGHSVTVVERHRG-PRPGGQAIDVRGPALGVLERMGLLAAAA
MMAR_4180|M.marinum_M TTAYWLEQQGYSVTIVERHPG-LRPGGQAIDVRGPALTVLDRMGILDAAR
MUL_4482|M.ulcerans_Agy99 TTAYWLEQQGYSVTIVERHPG-LRPGGQAIDVRGPALTVLDRMGILDAAR
Mb0590c|M.bovis_AF2122/97 ALAHWLQRTGHTPTVIERAPK-FRTGGYMIDFWGVGYQVAKRMGITDQIA
TH_1880|M.thermoresistible__bu MLAGELRLHGVRVLVVEKNSEPPAH-VRSLGLHVRSIEMLDQRGLLDRFL
Mvan_2422|M.vanbaalenii_PYR-1 MTAAELALAGVDVAVVERRTTPEITGSRAGGLLSRTLEILDQRGVVDRFL
Mflv_2621|M.gilvum_PYR-GCK AAAVALERAGHHVSVIEQRTD--TGAGSGISLWPNALAALDQIGLGDSVR
* * * ::* .. : *:
MAB_0649c|M.abscessus_ATCC_199 AQATHMGSLVMVDADGKEIARFPSE----VISG-----ELEILWGDLARI
MSMEG_3039|M.smegmatis_MC2_155 ARSLDQRGIAWVRGNGRRRAEMPVD----AFDGNGMVSALEILRGDLVEV
Rv1260|M.tuberculosis_H37Rv EHKTRIRGASFVDRDGNELFRDTES---TPTGGPVNSPDIELLRDDLVEL
MAV_1408|M.avium_104 KRRTQIRGSSVVDRDGNELSRDTEAAISGPTGGPIEGPDIELLRDDLVEL
MMAR_4180|M.marinum_M DRKTGIRGASVVDRDGNELSQDTES---TPTGGPIDSPNIELLRDDLIEL
MUL_4482|M.ulcerans_Agy99 DRKTGIRGASVVDRDGNELSRDTES---TPTGGPIDSPNIELLRDDLIEL
Mb0590c|M.bovis_AF2122/97 AAGYHMEHVRSVGPTGKVKADLGVD----VFRRMVGDDFTSLPRGDLAAA
TH_1880|M.thermoresistible__bu AHGQRHPVGGFFAAIAKPPAELDTA----------HGYVLGIRQPVTDRL
Mvan_2422|M.vanbaalenii_PYR-1 SAGETMQVHG-FAQVRLDVSDLPTR----------HPYGLALWQKHIERI
Mflv_2621|M.gilvum_PYR-GCK DAGGRVTAGAIRWRDGTWVRRPSVR----RIVDALGEPLVVVRRSRLTDI
:
MAB_0649c|M.abscessus_ATCC_199 LHEAVREHVVFRFADS-ITGVRDDGAKVTVSFSRSAPESYDLLIGADGVH
MSMEG_3039|M.smegmatis_MC2_155 LYNATSARAEYRFGTR-ITEIDSSGA----TLSDGTRVDADLIVGADGPH
Rv1260|M.tuberculosis_H37Rv LYGATQPSVEYLFDDS-ISTLQDDGDSVRVTFERAAAREFDLVIGADGLH
MAV_1408|M.avium_104 LYGASQWTAEYLFDDT-ITALDDRGAAVRVSFERAAPRDFDLVIGADGLH
MMAR_4180|M.marinum_M LYGTIQSTTEFIFDDS-IATLQDDGAAVEVTFVRSGTRTFDFLIGADGLH
MUL_4482|M.ulcerans_Agy99 LDGTIQSTTEFIFDDS-IATLQDDGAAVEVTFVRSGTRTFDFLIGADGLH
Mb0590c|M.bovis_AF2122/97 IYTTIEDQVETIFDDS-IATIDEHRDGVRLTFERTAPRDFDLVIGADGLH
TH_1880|M.thermoresistible__bu LAEWAAERGAVIRRGCAVVGLDQDAAGITVELADGSVQRARYLVGCDGGR
Mvan_2422|M.vanbaalenii_PYR-1 LAEWVDELAVPVYRGREVVGVRQDGAGVDIELSDGRVLRAGYLVGCDGGR
Mflv_2621|M.gilvum_PYR-GCK LREALPAG--TVRTGLAATRVSVGASSVRITLSDGEVRESDAVVGADGVN
: : : ::*.** .
MAB_0649c|M.abscessus_ATCC_199 SGVRALTFGPEHEFVTQLGQYFTFFAMDNHLGLDHQTVGFREGTRGVGIQ
MSMEG_3039|M.smegmatis_MC2_155 SSVRRMVFGPEEQYVTLLGGYNAWFTAPDTAGLDGWYLMYQVPGLNASMR
Rv1260|M.tuberculosis_H37Rv SNVRRLVFGPEEQFVKRLGTHAAIFTVPNFLELDYWQTWHYGDSTMAGVY
MAV_1408|M.avium_104 SNVRRLVFGPEDEFIERLGTHAAIFTVPNFLGLDYWQMWHYGDSTMAGVY
MMAR_4180|M.marinum_M SNVRRKVFGPEEQFIKRLGTYAAIFTVPNFLELDYWQKWHYGDNTMAGVY
MUL_4482|M.ulcerans_Agy99 SNVRRKVFGPEEQFIKRLGTYAAIFTVPNFLELDYWQKWHYGDNTMAGVY
Mb0590c|M.bovis_AF2122/97 SNVRRLVFGPERDFEHYLGCKVAACVVDGYRPRDERSYVLYNTVDRQLAR
TH_1880|M.thermoresistible__bu STVRKLAG---IGFPGEPARSETLLGEMSLSADPATVAAVVAEVRKTQLR
Mvan_2422|M.vanbaalenii_PYR-1 SLIRKSAG---IEFPGWEPTTSYLLAEVEIAPEDG--REPEWGIRRDALG
Mflv_2621|M.gilvum_PYR-GCK SVLARTLNGP-------LRTRYVGYTAWRGIAAHPLDPELGGETLGPGTQ
* :
MAB_0649c|M.abscessus_ATCC_199 ATAPDAPARGSLSFSDDHLEFDYRDVEGNKKLFSERFTGFGWETPAVLRA
MSMEG_3039|M.smegmatis_MC2_155 PSHDPALCKAGLAFRSGPVDYDRRDPATQLALLNTHFAGAGWHCADLLAA
Rv1260|M.tuberculosis_H37Rv SARNNTEARAALAFMDTELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHY
MAV_1408|M.avium_104 SARDNAEARAMLGFMDAELRLDYRDTEAQFAELERRMAGEGWVRPQLLEY
MMAR_4180|M.marinum_M SARDNSEARAALGFMDTELQIDYRDTEAQFAELERRMIEDGWVRAQLLHY
MUL_4482|M.ulcerans_Agy99 SARDNSEARAALGFMDTELQIDYRDTEAQFAELERRMIEDGWVRAQLLHY
Mb0590c|M.bovis_AF2122/97 FALRGDRTMFLFVFRAEHDNPG----VAPKDELRDQFGDVGWESRDILAA
TH_1880|M.thermoresistible__bu FGAMPLG-DGVYRVIVPAEGVAGDRAEPTLDEFRRRLKAFAG--TDFGAH
Mvan_2422|M.vanbaalenii_PYR-1 VHALSRSDDGPVRIMVTEQDLR-RSGVPDLAELREALVTVYG--TDFGIH
Mflv_2621|M.gilvum_PYR-GCK VGHVPLGPDHTYWFATERTAEGGSAPGGEHAYLTAKVADWADPIPRLVAT
. : . .
MAB_0649c|M.abscessus_ATCC_199 LSVTAEPYFDSLCQVHLDTYSRGRVCLLGDAAWCASPRSGMGTSLAIVGA
MSMEG_3039|M.smegmatis_MC2_155 AAVADDFYFDAFLQVHMPTLSRGPVTLVGDAGYCASPLSGMGTSLALVGA
Rv1260|M.tuberculosis_H37Rv MRSAPDFYFDEMSQILMDRWSRGRVALVGDAGYCCSPLSGQGTSVALLGA
MAV_1408|M.avium_104 MRTAPDFYFDEMSQIKMDRWSRGRVALVGDAGYCCSPLSGQGTSVALLGA
MMAR_4180|M.marinum_M MRSAPDFYFDEMAQIVMDSWSKGRVALVGDAAYCCSPLSGQGTSVAVLGA
MUL_4482|M.ulcerans_Agy99 MRSAPDFYFDEMAQIVMDSWAKGRVALVGDAAYCCSPLSGQGTSVAVLGA
Mb0590c|M.bovis_AF2122/97 LDDVEDLYFDVVSQIRMDRWSRGRVLLIGDAAGCISLLGGEGTGLAITEA
TH_1880|M.thermoresistible__bu TPRWLSRFGDATR--LAERYRAGRVFLAGDAAHVHPPAGGQGLNLGIQDA
Mvan_2422|M.vanbaalenii_PYR-1 SPTSISRFTDTAR--QAVAYRSGRILLVGDAAHVHHPVGGQGLNTGMQDA
Mflv_2621|M.gilvum_PYR-GCK TDPGDLLRNDLYDRARAARWSDGRAVLIGDAAHPMRPHLGQGGCQGIEDA
* * * ***. * * .: *
MAB_0649c|M.abscessus_ATCC_199 YVLAHELR----SAQGDFSIAFARFHTLMAPYAARCQRLALDALKIGEAD
MSMEG_3039|M.smegmatis_MC2_155 YVLAGELGPADMFAHAKLGLALSRYESTMRPYIERCQDLPTGIDGYLPKS
Rv1260|M.tuberculosis_H37Rv YILAGELK----AAGDDYQLGFANYHAEFHGFVERNQWLVSDN-------
MAV_1408|M.avium_104 YILAGELK----AAGEDHEAGFANYHREFADYVQRNQWLVVDN-------
MMAR_4180|M.marinum_M YILAGELA----AAGNDYQRGFANYHAEFSGFVERNQWLVTDN-------
MUL_4482|M.ulcerans_Agy99 YILAGELA----AAGNDYQRGFANYHAEFSGFGERNQWLVTDN-------
Mb0590c|M.bovis_AF2122/97 YVLAGELAR----AGGDHRRAFDAYEKRLRPFIEGKQASAAKFIWFFR--
TH_1880|M.thermoresistible__bu FNLGWKLAA--AVGGWAPDGLLDTYHAERHPVAADVLNNTRAQMELMSPE
Mvan_2422|M.vanbaalenii_PYR-1 VNLGWKLAQ--VVQGWSPDTLLDTYHDERQPVGARVLRNAVAQMALLRPD
Mflv_2621|M.gilvum_PYR-GCK AILARFLEL-----ADDVPTAFERFEAFRKPRVGMLVREAQTLGRIVN--
*. * : :.
MAB_0649c|M.abscessus_ATCC_199 SPWATGLRRLGLWSLRLPGIRQLVARQALKVGRSFALPAYD---------
MSMEG_3039|M.smegmatis_MC2_155 ALDITIYTQVMKWMQRWP-IRSYAARKWFTTADAIQLPSYPAAQNKR---
Rv1260|M.tuberculosis_H37Rv ----------------IPGGAPIPQEEFERIVHSITIKDY----------
MAV_1408|M.avium_104 ----------------IPGGAPIPQEVFERIVASITLKDY----------
MMAR_4180|M.marinum_M ----------------IPGGEPIPEEAFERIVNSLELEDYRQG-------
MUL_4482|M.ulcerans_Agy99 ----------------IPGGEPIPEEAFERIVNSLELEDYRQG-------
Mb0590c|M.bovis_AF2122/97 ---------------HPNPIRPVVSQRCDAHDELRPAGDAVRRQRA----
TH_1880|M.thermoresistible__bu PGPRAVRWLLAELMDFEEVNRYLTEKITAIGVRYHTMGDGHGLLGRRMRD
Mvan_2422|M.vanbaalenii_PYR-1 DRTTVLHGVVSDMLDMDEPRRRFAAMMSGLDIHYD-LGDGHPLLGLRMPD
Mflv_2621|M.gilvum_PYR-GCK VRPAVLSGLAGRATALIPERMVTAHLAWIAAGSAFVLPTAADLAR-----
MAB_0649c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3039|M.smegmatis_MC2_155 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
MMAR_4180|M.marinum_M --------------------------------------------------
MUL_4482|M.ulcerans_Agy99 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
TH_1880|M.thermoresistible__bu IPLTGG----RLYARMHAGRGVLLDR--TGTLSVSGWADRVDHIVD----
Mvan_2422|M.vanbaalenii_PYR-1 LDLETAHGPTRVSALLRQARPVLLDLGAPDAVDLTGWEARVRMVRANAAT
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0649c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3039|M.smegmatis_MC2_155 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
MMAR_4180|M.marinum_M --------------------------------------------------
MUL_4482|M.ulcerans_Agy99 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
TH_1880|M.thermoresistible__bu ------PGAALDVPAVLLRPDGHVAWVGADHPGQQDLTARLSRWFGAPA-
Mvan_2422|M.vanbaalenii_PYR-1 VWELPVIGEVPAPAAVLIRPDGHVAWVAGDSAAAP--AEAAARWFGAPTG
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0649c|M.abscessus_ATCC_199 --
MSMEG_3039|M.smegmatis_MC2_155 --
Rv1260|M.tuberculosis_H37Rv --
MAV_1408|M.avium_104 --
MMAR_4180|M.marinum_M --
MUL_4482|M.ulcerans_Agy99 --
Mb0590c|M.bovis_AF2122/97 --
TH_1880|M.thermoresistible__bu --
Mvan_2422|M.vanbaalenii_PYR-1 RR
Mflv_2621|M.gilvum_PYR-GCK --