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VGVQKVLISGASVAGLTTAYWLEQQGYSVTIVERHPGLRPGGQAIDVRGPALTVLDRMGILDAARDRKTG IRGASVVDRDGNELSRDTESTPTGGPIDSPNIELLRDDLIELLDGTIQSTTEFIFDDSIATLQDDGAAVE VTFVRSGTRTFDFLIGADGLHSNVRRKVFGPEEQFIKRLGTYAAIFTVPNFLELDYWQKWHYGDNTMAGV YSARDNSEARAALGFMDTELQIDYRDTEAQFAELERRMIEDGWVRAQLLHYMRSAPDFYFDEMAQIVMDS WAKGRVALVGDAAYCCSPLSGQGTSVAVLGAYILAGELAAAGNDYQRGFANYHAEFSGFGERNQWLVTDN IPGGEPIPEEAFERIVNSLELEDYRQG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4482 | - | - | 100% (378) | hypothetical protein MUL_4482 |
| M. ulcerans Agy99 | MUL_1770 | - | 5e-61 | 40.19% (321) | oxidoreductase |
| M. ulcerans Agy99 | MUL_0294 | - | 9e-58 | 39.58% (336) | membrane-associated oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1290 | - | 1e-119 | 78.46% (260) | hypothetical protein Mb1290 |
| M. gilvum PYR-GCK | Mflv_2621 | - | 3e-12 | 24.34% (341) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 1e-178 | 79.57% (372) | hypothetical protein Rv1260 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0649c | - | 2e-74 | 40.91% (352) | putative monooxygenase |
| M. marinum M | MMAR_4180 | - | 0.0 | 98.94% (378) | oxidoreductase |
| M. avium 104 | MAV_1408 | - | 1e-163 | 74.46% (372) | hypothetical protein MAV_1408 |
| M. smegmatis MC2 155 | MSMEG_3039 | - | 1e-59 | 41.30% (322) | monooxygenase |
| M. thermoresistible (build 8) | TH_2800 | - | 6e-09 | 24.93% (345) | PUTATIVE putative monooxygenase, FAD-binding |
| M. vanbaalenii PYR-1 | Mvan_4906 | mhpA | 2e-13 | 25.61% (328) | 3-(3-hydroxyphenyl)propionate hydroxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4482|M.ulcerans_Agy99 --MVGVQKVLISGASVAGLTTAYWLEQQGYSVTIVERHPGLRPGGQAIDV
MMAR_4180|M.marinum_M --MVGVQKVLISGASVAGLTTAYWLEQQGYSVTIVERHPGLRPGGQAIDV
Mb1290|M.bovis_AF2122/97 -----MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDV
Rv1260|M.tuberculosis_H37Rv -----MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDV
MAV_1408|M.avium_104 -----MSDVLVSGASVAGTAAAFWLGRHGHSVTVVERHRGPRPGGQAIDV
MAB_0649c|M.abscessus_ATCC_199 ---MSR-EILISGGGIAGPALAYWLVQEGHSVTIVERAATVRNGGQAVDF
MSMEG_3039|M.smegmatis_MC2_155 ---MGQPTVLISGAGVAGTSLAHWLTEYGYRAVVVETAPTLRLGGQTVDL
Mflv_2621|M.gilvum_PYR-GCK ----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG-AGSGISL
Mvan_4906|M.vanbaalenii_PYR-1 ------MPVVVVGGGPTGVTAATLLAQYGVDTLVLDRWSQVYPQPRAVHL
TH_2800|M.thermoresistible__bu VSGPEQAPVLIVGAGPAGLATAYVLGRNGIPSVVCDQHSGIHPHPRAHVI
: : *.. :* : * * . * : : .
MUL_4482|M.ulcerans_Agy99 RGPALTVLDRMGILDAAR------DRKTGIRGASVVDRDGNELSRDTES-
MMAR_4180|M.marinum_M RGPALTVLDRMGILDAAR------DRKTGIRGASVVDRDGNELSQDTES-
Mb1290|M.bovis_AF2122/97 RGPALDVLERMGLLAAAQ------EHKTRIRGASFVDRDGNELFRDTES-
Rv1260|M.tuberculosis_H37Rv RGPALDVLERMGLLAAAQ------EHKTRIRGASFVDRDGNELFRDTES-
MAV_1408|M.avium_104 RGPALGVLERMGLLAAAA------KRRTQIRGSSVVDRDGNELSRDTEAA
MAB_0649c|M.abscessus_ATCC_199 RGPSIDVLDKMGVLDAVR------AQATHMGSLVMVDADGKEIARFPSE-
MSMEG_3039|M.smegmatis_MC2_155 RGAGRDVVTRMGLLDEMR------ARSLDQRGIAWVRGNGRRRAEMPVD-
Mflv_2621|M.gilvum_PYR-GCK WPNALAALDQIGLGDSVR------DAGGRVTAGAIRWRDGTWVRRPSVR-
Mvan_4906|M.vanbaalenii_PYR-1 DDEICRILARLGVAEEFA------RISRPARGLRLVDRNLAVLAEFRRDT
TH_2800|M.thermoresistible__bu NTRSMELFRSWGIADAIARDEQAFDAGAGVRIVWKHSVSGEELGCIDLLD
. *: .
MUL_4482|M.ulcerans_Agy99 ------TPTGGPIDSPNIELLRDDLIELLDGTIQSTTEFIFDDSIATLQD
MMAR_4180|M.marinum_M ------TPTGGPIDSPNIELLRDDLIELLYGTIQSTTEFIFDDSIATLQD
Mb1290|M.bovis_AF2122/97 ------TPTGGPVNSPDIELLRDDLVELLYGATQPSVEYLFDDSISTLQD
Rv1260|M.tuberculosis_H37Rv ------TPTGGPVNSPDIELLRDDLVELLYGATQPSVEYLFDDSISTLQD
MAV_1408|M.avium_104 IS----GPTGGPIEGPDIELLRDDLVELLYGASQWTAEYLFDDTITALDD
MAB_0649c|M.abscessus_ATCC_199 -------VISG-----ELEILWGDLARILHEAVREHVVFRFADSITGVRD
MSMEG_3039|M.smegmatis_MC2_155 -------AFDGNGMVSALEILRGDLVEVLYNATSARAEYRFGTRITEIDS
Mflv_2621|M.gilvum_PYR-GCK -------RIVDALGEPLVVVRRSRLTDILREALPAG-TVRTGLAATRVSV
Mvan_4906|M.vanbaalenii_PYR-1 AVTRSGYPAANMFDQPELENLLRRNLTRFRRARFRGDVEVLDIAVDAAGV
TH_2800|M.thermoresistible__bu APVESIERRRAASPVGLISCPQDRIQRLMVDAVLRQGMSRIDYDTRVVEI
: : :
MUL_4482|M.ulcerans_Agy99 DGAAVEVTFVRS-----GTRTFDFLIGADGLHSNVRRKVFGPEEQFIKRL
MMAR_4180|M.marinum_M DGAAVEVTFVRS-----GTRTFDFLIGADGLHSNVRRKVFGPEEQFIKRL
Mb1290|M.bovis_AF2122/97 DGDSVRVTFERA-----AAREFDLVIGADGLHSNVRRLVFGPEEQFVKRL
Rv1260|M.tuberculosis_H37Rv DGDSVRVTFERA-----AAREFDLVIGADGLHSNVRRLVFGPEEQFVKRL
MAV_1408|M.avium_104 RGAAVRVSFERA-----APRDFDLVIGADGLHSNVRRLVFGPEDEFIERL
MAB_0649c|M.abscessus_ATCC_199 DGAKVTVSFSRS-----APESYDLLIGADGVHSGVRALTFGPEHEFVTQL
MSMEG_3039|M.smegmatis_MC2_155 SGA----TLSDG-----TRVDADLIVGADGPHSSVRRMVFGPEEQYVTLL
Mflv_2621|M.gilvum_PYR-GCK GASSVRITLSDG-----EVRESDAVVGADGVNSVLARTLNGPLRTRYVGY
Mvan_4906|M.vanbaalenii_PYR-1 TRVAFSDRLSGRR----SVITADYVLGCDGANSMVRNAIGATMR--NLKF
TH_2800|M.thermoresistible__bu TDAATGVEVTAESRGKPRRFRADYVVNAEGAGGRLRSALGIEMDGIPFIA
. * ::..:* . :
MUL_4482|M.ulcerans_Agy99 GTYAAIFTVPNFLELDYWQ--KWHYGDNTMAGVYSARDNSEARAALGFMD
MMAR_4180|M.marinum_M GTYAAIFTVPNFLELDYWQ--KWHYGDNTMAGVYSARDNSEARAALGFMD
Mb1290|M.bovis_AF2122/97 GTHAAIFTVPNFLELDYWQ--TWHYGDSTMAGVYSARNNTEARAALAFMD
Rv1260|M.tuberculosis_H37Rv GTHAAIFTVPNFLELDYWQ--TWHYGDSTMAGVYSARNNTEARAALAFMD
MAV_1408|M.avium_104 GTHAAIFTVPNFLGLDYWQ--MWHYGDSTMAGVYSARDNAEARAMLGFMD
MAB_0649c|M.abscessus_ATCC_199 GQYFTFFAMDNHLGLDHQT--VGFREGTRGVGIQATAPDAPARGSLSFSD
MSMEG_3039|M.smegmatis_MC2_155 GGYNAWFTAPDTAGLDGWY--LMYQVPGLNASMRPSHDPALCKAGLAFRS
Mflv_2621|M.gilvum_PYR-GCK TAWRGIAAHPLDPELG---------GETLGPGTQVGHVPLGPDHTYWFAT
Mvan_4906|M.vanbaalenii_PYR-1 DQRWLVVDVATTADLQQWEG-VHQICDPRRAGTYMRIGDTRYRWEFALSA
TH_2800|M.thermoresistible__bu DQVTSYFHADLSEWTGERPPLLQWIINTDVQGTFIAMGQNRWTFTIGFGA
. :
MUL_4482|M.ulcerans_Agy99 TELQIDYRDTEAQFAELERRMIEDGWVRAQLLHYMRSAPDFYFDEMAQIV
MMAR_4180|M.marinum_M TELQIDYRDTEAQFAELERRMIEDGWVRAQLLHYMRSAPDFYFDEMAQIV
Mb1290|M.bovis_AF2122/97 TELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYIAAH---------RIS
Rv1260|M.tuberculosis_H37Rv TELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQIL
MAV_1408|M.avium_104 AELRLDYRDTEAQFAELERRMAGEGWVRPQLLEYMRTAPDFYFDEMSQIK
MAB_0649c|M.abscessus_ATCC_199 DHLEFDYRDVEGNKKLFSERFTGFGWETPAVLRALSVTAEPYFDSLCQVH
MSMEG_3039|M.smegmatis_MC2_155 GPVDYDRRDPATQLALLNTHFAGAGWHCADLLAAAAVADDFYFDAFLQVH
Mflv_2621|M.gilvum_PYR-GCK ERTAEGGSAPGGEHAYLTAKVADWADPIPRLVATTDPGDLLRNDLYDRAR
Mvan_4906|M.vanbaalenii_PYR-1 GESADDFATLSALLPLLAPWTRHVAEADLQLVRVAEYT-------FRAQI
TH_2800|M.thermoresistible__bu TDEARRALDPQRCVELIRLAIGPAGSDVDIDFRSAGSWT------LCATT
: . .
MUL_4482|M.ulcerans_Agy99 MDSWAKGRVALVGDAAYCCSPLSGQGTSVAVLGAYILAGELA----AAGN
MMAR_4180|M.marinum_M MDSWSKGRVALVGDAAYCCSPLSGQGTSVAVLGAYILAGELA----AAGN
Mb1290|M.bovis_AF2122/97 ISTKCRRS------------------------------------------
Rv1260|M.tuberculosis_H37Rv MDRWSRGRVALVGDAGYCCSPLSGQGTSVALLGAYILAGELK----AAGD
MAV_1408|M.avium_104 MDRWSRGRVALVGDAGYCCSPLSGQGTSVALLGAYILAGELK----AAGE
MAB_0649c|M.abscessus_ATCC_199 LDTYSRGRVCLLGDAAWCASPRSGMGTSLAIVGAYVLAHELR----SAQG
MSMEG_3039|M.smegmatis_MC2_155 MPTLSRGPVTLVGDAGYCASPLSGMGTSLALVGAYVLAGELGPADMFAHA
Mflv_2621|M.gilvum_PYR-GCK AARWSDGRAVLIGDAAHPMRPHLGQGGCQGIEDAAILARFLE-----LAD
Mvan_4906|M.vanbaalenii_PYR-1 ADHWRSGSIFLLGDAAHLTPPFIGQGMGAGLRDAMNLAWKLAG--VHHGS
TH_2800|M.thermoresistible__bu ARTYRAGRVFLVGDAAHQFPPTGGFGMNTGLADADNLGWKLAA--VLHGW
MUL_4482|M.ulcerans_Agy99 DYQRGFANYHAEFSGFGERNQWLVTDN-----------------------
MMAR_4180|M.marinum_M DYQRGFANYHAEFSGFVERNQWLVTDN-----------------------
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv DYQLGFANYHAEFHGFVERNQWLVSDN-----------------------
MAV_1408|M.avium_104 DHEAGFANYHREFADYVQRNQWLVVDN-----------------------
MAB_0649c|M.abscessus_ATCC_199 DFSIAFARFHTLMAPYAARCQRLALDALKIGEADSPWATGLRRLGL----
MSMEG_3039|M.smegmatis_MC2_155 KLGLALSRYESTMRPYIERCQDLPTGIDGYLPKSALDITIYTQVMK----
Mflv_2621|M.gilvum_PYR-GCK DVPTAFERFEAFRKPRVGMLVREAQTLGRIVNVRPAVLSGLAG--R----
Mvan_4906|M.vanbaalenii_PYR-1 LPPTVLDSYEQERKPHARHMISLALNMGRAMTAGGRLGAAVRRLIVP---
TH_2800|M.thermoresistible__bu ADEELLDTYESERRPVALANSEFSVTNALKMASTGIGPTGPQFAAELESD
MUL_4482|M.ulcerans_Agy99 ---------------IPGGEPIPEEAFERIVNSLELEDYRQG--------
MMAR_4180|M.marinum_M ---------------IPGGEPIPEEAFERIVNSLELEDYRQG--------
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv ---------------IPGGAPIPQEEFERIVHSITIKDY-----------
MAV_1408|M.avium_104 ---------------IPGGAPIPQEVFERIVASITLKDY-----------
MAB_0649c|M.abscessus_ATCC_199 -----------WSLRLPGIRQLVARQALKVGRSFALPAYD----------
MSMEG_3039|M.smegmatis_MC2_155 -----------WMQRWP-IRSYAARKWFTTADAIQLPSYPAAQNKR----
Mflv_2621|M.gilvum_PYR-GCK -----------ATALIPERMVTAHLAWIAAGSAFVLPTAADLAR------
Mvan_4906|M.vanbaalenii_PYR-1 -----------RLHLIPGMRGKVIDSETPALKASSLVRRTPASRRVAGR-
TH_2800|M.thermoresistible__bu DPSVAAAVRDRIRNAIPEQRPHFDHLELEIGYVYPGDASDGDPVSTPVVG
MUL_4482|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4180|M.marinum_M --------------------------------------------------
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
MAB_0649c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3039|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4906|M.vanbaalenii_PYR-1 -------LCPNPVLADGRRLDEALGSGFGVVTTGA----LTPAQQALVER
TH_2800|M.thermoresistible__bu GRLPHRWITRITPGQGTASTLDLLGDGFTLLTGPAGAAWTAGVRDVAVPV
MUL_4482|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4180|M.marinum_M --------------------------------------------------
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
MAB_0649c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3039|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4906|M.vanbaalenii_PYR-1 CGARALCVAPATELASWLRRGRVTTAMIRPDRTVMSAGRDVDALCRQFLS
TH_2800|M.thermoresistible__bu RTLTAGVDFAFTGPSDTTFLADDGAVLVRPDGHIAWIATHLPADPAAELT
MUL_4482|M.ulcerans_Agy99 -----------------------
MMAR_4180|M.marinum_M -----------------------
Mb1290|M.bovis_AF2122/97 -----------------------
Rv1260|M.tuberculosis_H37Rv -----------------------
MAV_1408|M.avium_104 -----------------------
MAB_0649c|M.abscessus_ATCC_199 -----------------------
MSMEG_3039|M.smegmatis_MC2_155 -----------------------
Mflv_2621|M.gilvum_PYR-GCK -----------------------
Mvan_4906|M.vanbaalenii_PYR-1 GNLVGVWNSVAATPD--------
TH_2800|M.thermoresistible__bu SALRGVHLSADAARSASGQGASR