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AKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIRPGGQTVDLRGAGRLVIERMGLLEQMRQRSLRQ RGIAWIRADGRRRAEMPVEAFHGNGPVSELEILRGDLAAVLYRATAAGTDYRFGTRITDLAPSGDAVQAR LSDGTTVRADLVVGADGPHSGVRRLAFGPEEQFARPLGGYNAWFSAPDTVGLNGWYLMYQAPGGLNASMR PSHDPATAKAGLAFRSAPIRYDRGDLDAQRDLLAARFAGAGWQSDALIAAAREADDFYLDAIVQIHLDAW SRGRVTLVGDAGYCASPLSGMGTSLALVGAYVLAGELGPAHGDGIDEAALAAALARYETVLRPYVANCQD LPNSIDRFLPMSESEIRSNAAAMKYMQRWPFRFFAERKWFTIAESIELPRYPRLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2185 | - | - | 100% (406) | oxidoreductase |
| M. marinum M | MMAR_4180 | - | 2e-63 | 41.12% (321) | oxidoreductase |
| M. marinum M | MMAR_4675 | - | 4e-51 | 37.28% (338) | membrane-associated oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 2e-45 | 34.94% (352) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 8e-14 | 27.53% (356) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 5e-68 | 43.93% (321) | hypothetical protein Rv1260 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0649c | - | 1e-71 | 38.31% (402) | putative monooxygenase |
| M. avium 104 | MAV_1408 | - | 7e-68 | 43.27% (349) | hypothetical protein MAV_1408 |
| M. smegmatis MC2 155 | MSMEG_3039 | - | 1e-152 | 67.25% (403) | monooxygenase |
| M. thermoresistible (build 8) | TH_4641 | - | 1e-08 | 24.78% (339) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_1770 | - | 0.0 | 99.75% (406) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 1e-16 | 27.95% (322) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2621|M.gilvum_PYR-GCK ----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTGAG-SGISL
Mvan_3960|M.vanbaalenii_PYR-1 ----MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLTSG-AGISI
MMAR_2185|M.marinum_M ---MAKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIRPGGQTVDL
MUL_1770|M.ulcerans_Agy99 ---MAKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIRPGGQTVDL
MSMEG_3039|M.smegmatis_MC2_155 ---MGQPTVLISGAGVAGTSLAHWLTEYGYRAVVVETAPTLRLGGQTVDL
MAB_0649c|M.abscessus_ATCC_199 ---MSR-EILISGGGIAGPALAYWLVQEGHSVTIVERAATVRNGGQAVDF
Rv1260|M.tuberculosis_H37Rv -----MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDV
MAV_1408|M.avium_104 -----MSDVLVSGASVAGTAAAFWLGRHGHSVTVVERHRGPRPGGQAIDV
Mb0590c|M.bovis_AF2122/97 ------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMIDF
TH_4641|M.thermoresistible__bu MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPATTSRANFL
: *.. * : * * * : : .
Mflv_2621|M.gilvum_PYR-GCK WPNALAALDQIGLGDSVRDAGGRVTAGAIRWRDGTWVRRPSVRR----IV
Mvan_3960|M.vanbaalenii_PYR-1 WPNALAALDQIGLGDNVRQAGGRVTAGAIRWRDGTWLRRPSAQR----IV
MMAR_2185|M.marinum_M RGAGRLVIERMGLLEQMRQRSLRQRGIAWIRADGRRRAEMPVEA----FH
MUL_1770|M.ulcerans_Agy99 RGAGRLVIERMGLLEQMRQRSLRQRGIAWIRADGRRRAEMPVEA----FH
MSMEG_3039|M.smegmatis_MC2_155 RGAGRDVVTRMGLLDEMRARSLDQRGIAWVRGNGRRRAEMPVDA----FD
MAB_0649c|M.abscessus_ATCC_199 RGPSIDVLDKMGVLDAVRAQATHMGSLVMVDADGKEIARFPSEV----IS
Rv1260|M.tuberculosis_H37Rv RGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTES---TPTG
MAV_1408|M.avium_104 RGPALGVLERMGLLAAAAKRRTQIRGSSVVDRDGNELSRDTEAAISGPTG
Mb0590c|M.bovis_AF2122/97 WGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVDV----FR
TH_4641|M.thermoresistible__bu HARGSEVLDRLGALGGLPERSVRAMQITTHLGGEPVMRMQFGDP-----G
. . ::*
Mflv_2621|M.gilvum_PYR-GCK DALGEPLVVVRRSRLTDILRE-ALPAG-TVRTGLAATRVSVGASSVRITL
Mvan_3960|M.vanbaalenii_PYR-1 HALGEPLVVVRRSALTEILLD-ALPPD-TVQTGLSATALSIAAATARVTL
MMAR_2185|M.marinum_M GNGPVSELEILRGDLAAVLYR-ATAAGTDYRFGTRITDLAPSGDAVQARL
MUL_1770|M.ulcerans_Agy99 GNGPVSELEILRGDLAAVLYR-ATAAGTDYRFGTRITDLAPSGDAVQARL
MSMEG_3039|M.smegmatis_MC2_155 GNGMVSALEILRGDLVEVLYN-ATSARAEYRFGTRITEIDSSG----ATL
MAB_0649c|M.abscessus_ATCC_199 G-----ELEILWGDLARILHE-AVREHVVFRFADSITGVRDDGAKVTVSF
Rv1260|M.tuberculosis_H37Rv GPVNSPDIELLRDDLVELLYG-ATQPSVEYLFDDSISTLQDDGDSVRVTF
MAV_1408|M.avium_104 GPIEGPDIELLRDDLVELLYG-ASQWTAEYLFDDTITALDDRGAAVRVSF
Mb0590c|M.bovis_AF2122/97 RMVGDDFTSLPRGDLAAAIYT-TIEDQVETIFDDSIATIDEHRDGVRLTF
TH_4641|M.thermoresistible__bu MRTAAPPMVISQAEVEAALRNRLAELGGRVELDCPLTGLRQDASTVTAGI
: : : : : :
Mflv_2621|M.gilvum_PYR-GCK SDGEVRESDAVVGADGVNSVLAR---------------TLNGP---LRTR
Mvan_3960|M.vanbaalenii_PYR-1 SDGRTREADAVVGADGVNSMVAR---------------ALNGP---LPSR
MMAR_2185|M.marinum_M SDGTTVRADLVVGADGPHSGVRR---------------LAFGPEEQFARP
MUL_1770|M.ulcerans_Agy99 SDGTTVRADLVVGADGPHSGVRR---------------LAFGPEEQFARP
MSMEG_3039|M.smegmatis_MC2_155 SDGTRVDADLIVGADGPHSSVRR---------------MVFGPEEQYVTL
MAB_0649c|M.abscessus_ATCC_199 SRSAPESYDLLIGADGVHSGVRA---------------LTFGPEHEFVTQ
Rv1260|M.tuberculosis_H37Rv ERAAAREFDLVIGADGLHSNVRR---------------LVFGPEEQFVKR
MAV_1408|M.avium_104 ERAAPRDFDLVIGADGLHSNVRR---------------LVFGPEDEFIER
Mb0590c|M.bovis_AF2122/97 ERTAPRDFDLVIGADGLHSNVRR---------------LVFGPERDFEHY
TH_4641|M.thermoresistible__bu GGGGELRGRWLVGCDGTGSSTRKSVGIGYPGARLSERFLLADVYLDWRLD
::*.** * .
Mflv_2621|M.gilvum_PYR-GCK YVGYTAWRGIAAHP-LDP----ELGGETLGPGTQVGHVPLGPDHTYWFAT
Mvan_3960|M.vanbaalenii_PYR-1 YVGYTAWRGVAAYR-LDP----ALAGETMSAGTEVGHVPLGPDHTYWFAT
MMAR_2185|M.marinum_M LGGYNAWFSAPDTVGLNGWYLMYQAPGGLNASMRPSHDPATAKAGLAFRS
MUL_1770|M.ulcerans_Agy99 LGGYNAWFSAPDTVGLNGWYLMYQAPGGLNASMRPSHDPATAKAGLAFRS
MSMEG_3039|M.smegmatis_MC2_155 LGGYNAWFTAPDTAGLDGWYLMYQVPG-LNASMRPSHDPALCKAGLAFRS
MAB_0649c|M.abscessus_ATCC_199 LGQYFTFFAMDNHLGLDHQTVGFREGT-RGVGIQATAPDAPARGSLSFSD
Rv1260|M.tuberculosis_H37Rv LGTHAAIFTVPNFLELDYWQTWHYGDS-TMAGVYSARNNTEARAALAFMD
MAV_1408|M.avium_104 LGTHAAIFTVPNFLGLDYWQMWHYGDS-TMAGVYSARDNAEARAMLGFMD
Mb0590c|M.bovis_AF2122/97 LGCKVAACVVDGYRPRDERSYVLYNTVDRQLARFALRG----DRTMFLFV
TH_4641|M.thermoresistible__bu RSGTTGWIHPDGMVGAMPMPDGLWRIIAYDPGPGDLDQGALERLLYERTG
.
Mflv_2621|M.gilvum_PYR-GCK ERTAEG----------GSAPGGEHAYLTAKVADWADPIPR------LVAT
Mvan_3960|M.vanbaalenii_PYR-1 ERTREG----------SRSAGGEHAYLTAKLAGWADPIPA------LLAS
MMAR_2185|M.marinum_M APIRYD----------RGDLDAQRDLLAARFAGAGWQSDA------LIAA
MUL_1770|M.ulcerans_Agy99 APIRYD----------RGDLDAQRDLLAACFAGAGWQSDA------LIAA
MSMEG_3039|M.smegmatis_MC2_155 GPVDYD----------RRDPATQLALLNTHFAGAGWHCAD------LLAA
MAB_0649c|M.abscessus_ATCC_199 DHLEFD----------YRDVEGNKKLFSERFTGFGWETPA------VLRA
Rv1260|M.tuberculosis_H37Rv TELRID----------YRDTEAQFAELQRRMAEDGWVRAQ------LLHY
MAV_1408|M.avium_104 AELRLD----------YRDTEAQFAELERRMAGEGWVRPQ------LLEY
Mb0590c|M.bovis_AF2122/97 FRAEHD----------NPGVAPK-DELRDQFGDVGWESRD------ILAA
TH_4641|M.thermoresistible__bu HRVKVTGTVWQSEFRVHRRLADTYRRGRVFIAGDAAHAHAPFGGQGMLTG
. . ::
Mflv_2621|M.gilvum_PYR-GCK TDPGDLLRNDLYDRAR------------AARWSDGRAVLIGDAAHPMRPH
Mvan_3960|M.vanbaalenii_PYR-1 TDPADVLRNDLYDRAQ------------PRDWSRGPAVIVGDAAHPMRPH
MMAR_2185|M.marinum_M AREADDFYLDAIVQIH------------LDAWSRGRVTLVGDAGYCASPL
MUL_1770|M.ulcerans_Agy99 AREADDFYLDAIVQIH------------LDAWSRGRVTLVGDAGYCASPL
MSMEG_3039|M.smegmatis_MC2_155 AAVADDFYFDAFLQVH------------MPTLSRGPVTLVGDAGYCASPL
MAB_0649c|M.abscessus_ATCC_199 LSVTAEPYFDSLCQVH------------LDTYSRGRVCLLGDAAWCASPR
Rv1260|M.tuberculosis_H37Rv MRSAPDFYFDEMSQIL------------MDRWSRGRVALVGDAGYCCSPL
MAV_1408|M.avium_104 MRTAPDFYFDEMSQIK------------MDRWSRGRVALVGDAGYCCSPL
Mb0590c|M.bovis_AF2122/97 LDDVEDLYFDVVSQIR------------MDRWSRGRVLLIGDAAGCISLL
TH_4641|M.thermoresistible__bu LGDAENLAFKLALVIRGYAGPALLDTYEAERRPLATEVLRNTSAATKLNI
. . . : . :.
Mflv_2621|M.gilvum_PYR-GCK LGQGGCQGIEDAAILARFLELAD-------DVPTAFERFEAFRKP-----
Mvan_3960|M.vanbaalenii_PYR-1 LGQGGCQGLEDAAILARFVGLSP-------DLPAAFDRFGAFRRR-----
MMAR_2185|M.marinum_M SGMGTSLALVGAYVLAGELGPAHGDGIDEAALAAALARYETVLRP-----
MUL_1770|M.ulcerans_Agy99 SGMGTSLALVGAYVLAGELGPAHGDGIDEAALAAALARYETVLRP-----
MSMEG_3039|M.smegmatis_MC2_155 SGMGTSLALVGAYVLAGELGPA--DMFAHAKLGLALSRYESTMRP-----
MAB_0649c|M.abscessus_ATCC_199 SGMGTSLAIVGAYVLAHELRSA------QGDFSIAFARFHTLMAP-----
Rv1260|M.tuberculosis_H37Rv SGQGTSVALLGAYILAGELKAAG------DDYQLGFANYHAEFHG-----
MAV_1408|M.avium_104 SGQGTSVALLGAYILAGELKAAG------EDHEAGFANYHREFAD-----
Mb0590c|M.bovis_AF2122/97 GGEGTGLAITEAYVLAGELARAG------GDHRRAFDAYEKRLRP-----
TH_4641|M.thermoresistible__bu ADRGVGRFLRDRVVLPLLALPSVQRRLTYQTSQLWVTYRGGPLAPRTVSM
. * : :*. : .
Mflv_2621|M.gilvum_PYR-GCK -------------------RVGMLVREAQTLGRIVNVRPAVLSG----LA
Mvan_3960|M.vanbaalenii_PYR-1 -------------------RVRPLVRESAAIGRIVNLRPAFLSG----VA
MMAR_2185|M.marinum_M -------------------YVANCQDLPNSIDRFLPMSESEIRSNA--AA
MUL_1770|M.ulcerans_Agy99 -------------------YVANCQDLPNSIDRFLPMSESEIRSNA--AA
MSMEG_3039|M.smegmatis_MC2_155 -------------------YIERCQDLPTGIDGYLPKSALDITIYT--QV
MAB_0649c|M.abscessus_ATCC_199 -------------------YAARCQRLALDALKIGEADSPWATGLR--RL
Rv1260|M.tuberculosis_H37Rv -------------------FVERNQWLVSDN---IPGGAP----------
MAV_1408|M.avium_104 -------------------YVQRNQWLVVDN---IPGGAP----------
Mb0590c|M.bovis_AF2122/97 -------------------FIEGKQASAAKFIWFFRHPNP----------
TH_4641|M.thermoresistible__bu TTPRPGDRVPDQRCVRDDGHISRLYEQLGGRWAVLEPGSGRHHREGPGLL
Mflv_2621|M.gilvum_PYR-GCK GRATALIPERMVTAHLAWIAAGSAFVLPTAADLAR---------------
Mvan_3960|M.vanbaalenii_PYR-1 SRASALIPEWAVASHLASIAAGSAFILPTAGDVGG---------------
MMAR_2185|M.marinum_M MKYMQRWP-FRFFAERKWFTIAESIELPRYPRLP----------------
MUL_1770|M.ulcerans_Agy99 MKYMQRWP-FRFFAERKWFTIAESIELPRYPRLP----------------
MSMEG_3039|M.smegmatis_MC2_155 MKWMQRWP-IRSYAARKWFTTADAIQLPSYPAAQNKR-------------
MAB_0649c|M.abscessus_ATCC_199 GLWSLRLPGIRQLVARQALKVGRSFALPAYD-------------------
Rv1260|M.tuberculosis_H37Rv ------IP------QEEFERIVHSITIKDY--------------------
MAV_1408|M.avium_104 ------IP------QEVFERIVASITLKDY--------------------
Mb0590c|M.bovis_AF2122/97 ---IRPVVSQRCDAHDELRPAGDAVRRQRA--------------------
TH_4641|M.thermoresistible__bu GTAHTFLGEYVVGLRGAEMRGCDAFLVRPDGHLAWRGRDATDLADWLKSA
:.
Mflv_2621|M.gilvum_PYR-GCK -------
Mvan_3960|M.vanbaalenii_PYR-1 -------
MMAR_2185|M.marinum_M -------
MUL_1770|M.ulcerans_Agy99 -------
MSMEG_3039|M.smegmatis_MC2_155 -------
MAB_0649c|M.abscessus_ATCC_199 -------
Rv1260|M.tuberculosis_H37Rv -------
MAV_1408|M.avium_104 -------
Mb0590c|M.bovis_AF2122/97 -------
TH_4641|M.thermoresistible__bu LTVGRVR