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TASFDPADPARFEEMYRDQRTSHGLPAATPWDIGGPQPVVRQLVALGAVKGEVLDPGTGPGHHAIYYASQ GFSATGIDGSAAAIERARANARTAGVSVNFELADATKLDGFDGRFDTVVDCAFYHVFATEPELRSSYARA LHRATKPGARLYMFEFGEHDVNGFKMMRSLSENDFRDVLPAAGWEISYLGPTTYQVNLSAETIQMMAARN PDMADEAAKLLERFRAMEPWLQAGRVHAPFWEVHATRVD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3570 | - | - | 100% (250) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. avium 104 | MAV_0119 | - | 5e-28 | 33.33% (207) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. avium 104 | MAV_0404 | - | 3e-21 | 33.70% (184) | thiopurine S-methyltransferase (tpmt) superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2694c | - | 1e-119 | 78.80% (250) | hypothetical protein Mb2694c |
| M. gilvum PYR-GCK | Mflv_4471 | - | 1e-27 | 33.18% (211) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2675c | - | 1e-119 | 78.80% (250) | hypothetical protein Rv2675c |
| M. leprae Br4923 | MLBr_00551 | - | 5e-05 | 26.32% (152) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_0868c | - | 9e-46 | 40.82% (267) | hypothetical protein MAB_0868c |
| M. marinum M | MMAR_2041 | - | 1e-110 | 73.88% (245) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_2539 | - | 3e-31 | 36.41% (206) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_3824 | - | 4e-24 | 33.85% (195) | PUTATIVE thiopurine S-methyltransferase (tpmt) superfamily |
| M. ulcerans Agy99 | MUL_3309 | - | 1e-109 | 73.47% (245) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1888 | - | 1e-30 | 39.25% (186) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2694c|M.bovis_AF2122/97 MTAQFDPADPTR---FEEMYRDDRVAHGLPAA-TPWDIGGPQPVVQQLVA
Rv2675c|M.tuberculosis_H37Rv MTAQFDPADPTR---FEEMYRDDRVAHGLPAA-TPWDIGGPQPVVQQLVA
MAV_3570|M.avium_104 MTASFDPADPAR---FEEMYRDQRTSHGLPAA-TPWDIGGPQPVVRQLVA
MMAR_2041|M.marinum_M MTAP-DPTDPTR---FEEMYRDQRVAHGLPAA-TPWDIGGPQPVVEQLVA
MUL_3309|M.ulcerans_Agy99 MTAP-DPTDPTR---FEEMYRDQRVAHGLPAA-TPWDIGGPQPVVEQLVA
MAB_0868c|M.abscessus_ATCC_199 MTASTQPPDVPSQETFEAVYNGKPMFEGAPAAGVPWDIRDAQPRIKELAA
Mflv_4471|M.gilvum_PYR-GCK -MDMDQTPTLSR---FDDFYKDE-------DKTPPWVIGEPQPAVVDIER
Mvan_1888|M.vanbaalenii_PYR-1 ---MDLTPRLSR---FDEFYKN---------QTPPWVIGEPQQAIVELEQ
MSMEG_2539|M.smegmatis_MC2_155 --------MTTPEDLFESAYRGE--APNFGGVRPPWSIGEPQPEIRKLID
TH_3824|M.thermoresistible__bu -------------MEWDDMYR--------RGVPPPWSIGAPQPELAALLD
MLBr_00551|M.leprae_Br4923 -MNLYTPIHEDQ---SLAAIHRAMWALGDYALMAEEVMAPLGPILVTATG
. : :
Mb2694c|M.bovis_AF2122/97 LG--------AIRGEVLDPGTGPGHHAIYYAAKGYAATGIDGSVAAIERA
Rv2675c|M.tuberculosis_H37Rv LG--------AIRGEVLDPGTGPGHHAIYYAAKGYAATGIDGSVAAIERA
MAV_3570|M.avium_104 LG--------AVKGEVLDPGTGPGHHAIYYASQGFSATGIDGSAAAIERA
MMAR_2041|M.marinum_M LG--------AVKGEVLDPGTGPGHHAIYYASKGYSATGIDGSATAIERA
MUL_3309|M.ulcerans_Agy99 LG--------AVKGEVLDPGTGPGHHAIYYASKGYSATGIDGSATAIERA
MAB_0868c|M.abscessus_ATCC_199 YG--------ALRGAILDIGCGLGENSIYLTQQGLSVTGLDFSPSAIEQA
Mflv_4471|M.gilvum_PYR-GCK AG--------LITGRVLDVGCGTGERTILLTAAGYDVLGVDGAPSAVEQA
Mvan_1888|M.vanbaalenii_PYR-1 AG--------LIGGRVLDVGCGTGEHTILLARAGYDVLGIDGAPTAVEQA
MSMEG_2539|M.smegmatis_MC2_155 AG--------KFHGEVLDAGCGEAATALYLAAQGFTTVGLDQSPTAIELA
TH_3824|M.thermoresistible__bu AGPAQCPVQGTVRGEVLDAGCGEAALSLELAARGHTVVGLDCSAAAVAAA
MLBr_00551|M.leprae_Br4923 IR---------PGMQVLDVAAGSGNISLPAAKTGATIVSTDLTPELLQRS
:** . * . :: : * . * : : :
Mb2694c|M.bovis_AF2122/97 RDNARKAGVS-VNFQVGDATTLDGLDGRFDTVVDCA--------------
Rv2675c|M.tuberculosis_H37Rv RDNARKAGVS-VNFQVGDATTLDGLDGRFDTVVDCA--------------
MAV_3570|M.avium_104 RANARTAGVS-VNFELADATKLDGFDGRFDTVVDCA--------------
MMAR_2041|M.marinum_M RDNAAKAGVS-VNFQVADATRLEGLDNRFDTVVDCA--------------
MUL_3309|M.ulcerans_Agy99 RDNAAKAGVS-VNFQVADATRLEGLDNRFDTVVDCA--------------
MAB_0868c|M.abscessus_ATCC_199 KQRAAAAGVT-VDLHVADATKLDGWDAQFDTVIDSA--------------
Mflv_4471|M.gilvum_PYR-GCK RHNAKTRVVD-ARFDVADALDLG-DEPAYDTIIDSA--------------
Mvan_1888|M.vanbaalenii_PYR-1 RRNAEAQGVD-ARFELADALHLG-PDPTYDTIVDSA--------------
MSMEG_2539|M.smegmatis_MC2_155 RAEAARRGLTNATFEVADISSFTGYDGRFGTIVDST--------------
TH_3824|M.thermoresistible__bu TATAAERGLTTATFAQADLTEFGGYDGRFSTIIDSG--------------
MLBr_00551|M.leprae_Br4923 QARATELGLT-LEYREADAQALPFGDGEFDVVMSAIGVMFAPDHRRAASE
* : .* : : :..::..
Mb2694c|M.bovis_AF2122/97 ---------------------FYHTFSTAPELQRCYVRALRRASKPGARL
Rv2675c|M.tuberculosis_H37Rv ---------------------FYHTFSTAPELQRCYVRALRRASKPGARL
MAV_3570|M.avium_104 ---------------------FYHVFATEPELRSSYARALHRATKPGARL
MMAR_2041|M.marinum_M ---------------------FYHTFGTAPELQRSYVRALWRATKPGARL
MUL_3309|M.ulcerans_Agy99 ---------------------FYHTFGTAPELQRSYVQALWRATKPGARL
MAB_0868c|M.abscessus_ATCC_199 ---------------------VYHCFD--HEGHRQYASALHRATRPGARW
Mflv_4471|M.gilvum_PYR-GCK ---------------------LFHIFDDADREK--YVRSLGRATAPGSVV
Mvan_1888|M.vanbaalenii_PYR-1 ---------------------LFHIFDDADRAT--YVRSLHAATRPGSVV
MSMEG_2539|M.smegmatis_MC2_155 ---------------------LFHSMP--VELRDGYQQSIVRAAAPGATY
TH_3824|M.thermoresistible__bu ---------------------LLHALP--VDRRQAYLRAIHRAAAPNARL
MLBr_00551|M.leprae_Br4923 LVRVCRPNGTIGVISWTQEGFFGRMLATIRPYRPSLSAALPPAALWGREA
. : : :: *: .
Mb2694c|M.bovis_AF2122/97 YMFEFGEHNVNGFSMPRSLSE-DDFRQVLPVGGWEITYLGTTTYQVNLSV
Rv2675c|M.tuberculosis_H37Rv YMFEFGEHNVNGFSMPRSLSE-DDFRQVLPVGGWEITYLGTTTYQVNLSV
MAV_3570|M.avium_104 YMFEFGEHDVNGFKMMRSLSE-NDFRDVLPAAGWEISYLGPTTYQVNLSA
MMAR_2041|M.marinum_M YMYEFGAHQVNGLTAIRSLPE-ENFREMLPLGGWEITYLGPTTYRTTVSM
MUL_3309|M.ulcerans_Agy99 YMYEFGAHQVNGLTAIRSLPE-ENFREMLPLGGWEITYLGPTTYRTTVSM
MAB_0868c|M.abscessus_ATCC_199 FIACFGDGSVNGITMPFGVQDPDEIKSVLSEARWNIQYFGRTTYLGSRAA
Mflv_4471|M.gilvum_PYR-GCK HLLALSD---TGRGFGPEVSE-ETIRAAFADPGWDIEALTTTYYRGVITA
Mvan_1888|M.vanbaalenii_PYR-1 HLLALSD---SGRGFGPEVSE-HTIRAAFG-AGWEVEALTETTYRGVVID
MSMEG_2539|M.smegmatis_MC2_155 VVLVFDKTTMGDTGPANPVTD-DELRDVVG-RYWVIDDISPARIHANVPA
TH_3824|M.thermoresistible__bu FILTFAERPFGDGHGPDGFTA-EELRDTVG-VLWTVDEIRPAKLYVN---
MLBr_00551|M.leprae_Br4923 YIRGLLDDTVTNVKTERRQLEVKRFNSAEGVHNYFKNHYGPTIEAYTNIG
: : . . :. : :
Mb2694c|M.bovis_AF2122/97 EALELMAARNPD--------------MADQVRCVLERFRAIKPWLVGGRV
Rv2675c|M.tuberculosis_H37Rv EALELMAARNPD--------------MADQVRCVLERFRAIKPWLVGGRV
MAV_3570|M.avium_104 ETIQMMAARNPD--------------MADEAAKLLERFRAMEPWLQAGRV
MMAR_2041|M.marinum_M ETLETMAARNPE--------------VADQVGPLVERFKTIQPWLTDGIA
MUL_3309|M.ulcerans_Agy99 ETLETMAARNPE--------------VADQVGPLVERFKTIQPWLTDGIA
MAB_0868c|M.abscessus_ATCC_199 FVGAALAGIDPEQMPADMRERYQRPGVAEQAQQTFERLQQLD----DDMI
Mflv_4471|M.gilvum_PYR-GCK PHADAMGLDVGT------------------------------------VV
Mvan_1888|M.vanbaalenii_PYR-1 AHTEALNLPAGT------------------------------------VV
MSMEG_2539|M.smegmatis_MC2_155 EFT-DFAAFAGS----------------------------DIRDEGNGRK
TH_3824|M.thermoresistible__bu DFTGDLLDGPPT----------------------------AYERAADGKL
MLBr_00551|M.leprae_Br4923 DNSVLAAELDAQLT------------------------ELAQKYLTNSTM
Mb2694c|M.bovis_AF2122/97 HAPFWEVHATRVD
Rv2675c|M.tuberculosis_H37Rv HAPFWEVHATRVD
MAV_3570|M.avium_104 HAPFWEVHATRVD
MMAR_2041|M.marinum_M HVPFWEVHATRLD
MUL_3309|M.ulcerans_Agy99 HVPFWEVHATRPD
MAB_0868c|M.abscessus_ATCC_199 HMPFFNIVAERG-
Mflv_4471|M.gilvum_PYR-GCK DEPAWLARIRRL-
Mvan_1888|M.vanbaalenii_PYR-1 DEPAWSARIRRL-
MSMEG_2539|M.smegmatis_MC2_155 SVAGWLLQAHLG-
TH_3824|M.thermoresistible__bu MFPGFLVSAHKD-
MLBr_00551|M.leprae_Br4923 GWEYLLLTAQKH-