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MDLTPRLSRFDEFYKNQTPPWVIGEPQQAIVELEQAGLIGGRVLDVGCGTGEHTILLARAGYDVLGIDGA PTAVEQARRNAEAQGVDARFELADALHLGPDPTYDTIVDSALFHIFDDADRATYVRSLHAATRPGSVVHL LALSDSGRGFGPEVSEHTIRAAFGAGWEVEALTETTYRGVVIDAHTEALNLPAGTVVDEPAWSARIRRL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1888 | - | - | 100% (209) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_5471 | - | 4e-20 | 35.20% (179) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_5517 | - | 5e-10 | 30.71% (140) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1412c | - | 3e-31 | 35.78% (218) | putative transferase |
| M. gilvum PYR-GCK | Mflv_4471 | - | 2e-87 | 74.06% (212) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1377c | - | 3e-31 | 35.78% (218) | putative transferase |
| M. leprae Br4923 | MLBr_01723 | - | 6e-06 | 31.58% (95) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_0240 | - | 2e-27 | 41.86% (172) | hypothetical protein MAB_0240 |
| M. marinum M | MMAR_2193 | - | 8e-29 | 36.61% (183) | NodS-like (sam)-dependent methyltransferase |
| M. avium 104 | MAV_3570 | - | 8e-31 | 39.25% (186) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2067 | - | 4e-81 | 69.67% (211) | methyltransferase type 12 |
| M. thermoresistible (build 8) | TH_1722 | - | 1e-23 | 38.65% (163) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3309 | - | 4e-28 | 38.62% (189) | methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1888|M.vanbaalenii_PYR-1 -----------------MDLTPRLSRFDEFYKN----------QTPPWVI
Mflv_4471|M.gilvum_PYR-GCK ---------------MDMDQTPTLSRFDDFYKDED--------KTPPWVI
MSMEG_2067|M.smegmatis_MC2_155 -----------------MDTTPTRELFDEAYES----------RTAPWVI
MAV_3570|M.avium_104 --------------MTASFDPADPARFEEMYRDQRTSHGLP--AATPWDI
MUL_3309|M.ulcerans_Agy99 --------------MTAP-DPTDPTRFEEMYRDQRVAHGLP--AATPWDI
MAB_0240|M.abscessus_ATCC_1997 ------------------MRPDGPGFFAELMYAVN---------AAPWDI
Mb1412c|M.bovis_AF2122/97 ---------------------MPGIDFDALYRGESPGEGLPPITTPPWDT
Rv1377c|M.tuberculosis_H37Rv ---------------------MPGIDFDALYRGESPGEGLPPITTPPWDT
MMAR_2193|M.marinum_M ------------------------MDFDALYRGESPRPGVAPMTTPPWDT
TH_1722|M.thermoresistible__bu ----------MATEDPGTGDPTDTIDWDSVYRQEAPGFD----GPPPWNI
MLBr_01723|M.leprae_Br4923 MTRSTEISANAVPNPHATAEQVAAARKDSKLAQVLYHDWEAENYDEKWSI
*
Mvan_1888|M.vanbaalenii_PYR-1 GEPQ-----------QAIVELEQAGLIGGRVLDVGCGTGEHTILLARAGY
Mflv_4471|M.gilvum_PYR-GCK GEPQ-----------PAVVDIERAGLITGRVLDVGCGTGERTILLTAAGY
MSMEG_2067|M.smegmatis_MC2_155 GEPQ-----------PAVVELERAGLIRSRVLDVGCGAGEHTILLTRLGY
MAV_3570|M.avium_104 GGPQ-----------PVVRQLVALGAVKGEVLDPGTGPGHHAIYYASQGF
MUL_3309|M.ulcerans_Agy99 GGPQ-----------PVVEQLVALGAVKGEVLDPGTGPGHHAIYYASKGY
MAB_0240|M.abscessus_ATCC_1997 GGPQ-----------PVIRQLVALGAVRGEVLDPGCGTGWHAIEYARAGC
Mb1412c|M.bovis_AF2122/97 KAPK-----------DNVIGWHTGGWVHGDVLDIGCGLGDNAIYLARNGY
Rv1377c|M.tuberculosis_H37Rv KAPK-----------DNVIGWHTGGWVHGDVLDIGCGLGDNAIYLARNGY
MMAR_2193|M.marinum_M KAPK-----------ENVIAWQAGGWVHGDVLDIGCGLGDNAIYLAAHGH
TH_1722|M.thermoresistible__bu GEPQ-----------PELAALHRAGAFRSDVLDAGCGHAEISMALAADGY
MLBr_01723|M.leprae_Br4923 SYDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLIQSGV
: : . .*: * * . : *
Mvan_1888|M.vanbaalenii_PYR-1 DVLG--IDGAPTAVEQARRNAEAQGVDAR-FELADALHLGP--DPTYDTI
Mflv_4471|M.gilvum_PYR-GCK DVLG--VDGAPSAVEQARHNAKTRVVDAR-FDVADALDLGD--EPAYDTI
MSMEG_2067|M.smegmatis_MC2_155 DVLG--IDFSPQAIEMARENARGRGVDAR-FAVGDAMALGDLGDGAYDTI
MAV_3570|M.avium_104 SATG--IDGSAAAIERARANARTAGVSVN-FELADATKLDG-FDGRFDTV
MUL_3309|M.ulcerans_Agy99 SATG--IDGSATAIERARDNAAKAGVSVN-FQVADATRLEG-LDNRFDTV
MAB_0240|M.abscessus_ATCC_1997 SVTG--VDLAPTAIARARNNTRTAGVEAQ-FVLGDATTLD--YEARFDTV
Mb1412c|M.bovis_AF2122/97 QVTG--LDISPTALTTAKRRASDAGVDVK-FAVGDATKLTG-YTGAFDTV
Rv1377c|M.tuberculosis_H37Rv QVTG--LDISPTALTTAKRRASDAGVDVK-FAVGDATKLTG-YTGAFDTV
MMAR_2193|M.marinum_M PVTG--LDISPTALITAARRADDAGVHVT-FAVADATKLDG-YTDAFDTV
TH_1722|M.thermoresistible__bu TVVG--IDLSPTAIAAANRTAQERGLATASFVQGDITDFGG-YDGRFNTI
MLBr_01723|M.leprae_Br4923 ARRGSVTDLSPGMVKIATRNGQSLGLDIN-GRVADAEGIPY-DDNTFDLV
* * :. : * : .* : :: :
Mvan_1888|M.vanbaalenii_PYR-1 VDSALFHIFDDAD--RATYVRSLHA------ATRPGSV------------
Mflv_4471|M.gilvum_PYR-GCK IDSALFHIFDDAD--REKYVRSLGR------ATAPGSV------------
MSMEG_2067|M.smegmatis_MC2_155 LDSALFHIFDDAD--RQTYVASLHA------GCRPGGT------------
MAV_3570|M.avium_104 VDCAFYHVFATEPELRSSYARALHR------ATKPGAR------------
MUL_3309|M.ulcerans_Agy99 VDCAFYHTFGTAPELQRSYVQALWR------ATKPGAR------------
MAB_0240|M.abscessus_ATCC_1997 VDSKLLDNLDSA-EARGRYLRSLYR------AMKPQGR------------
Mb1412c|M.bovis_AF2122/97 IDCGMFHCLDDD--GKRSYAASVHR------ATRPGAT------------
Rv1377c|M.tuberculosis_H37Rv IDCGMFHCLDDD--GKRSYAASVHR------ATRPGAT------------
MMAR_2193|M.marinum_M IDSGMFHCLDDE--GKRSYAAAVHR------ATRPGAT------------
TH_1722|M.thermoresistible__bu IDSTLFHSIPVQA--RDGYLRSIHR------AAAPGAR------------
MLBr_01723|M.leprae_Br4923 VGHAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTDVGNRYARVFADLT
:. . . : : . *
Mvan_1888|M.vanbaalenii_PYR-1 ----VHLLALS------DSGRGFGPEVSEHTIRAAFG-AGWEVEALTETT
Mflv_4471|M.gilvum_PYR-GCK ----VHLLALS------DTGRGFGPEVSEETIRAAFADPGWDIEALTTTY
MSMEG_2067|M.smegmatis_MC2_155 ----VHILALS------DAGRGFGPEVSEEQIRKAFG-DGWDLEALETTT
MAV_3570|M.avium_104 ----LYMFEFG---EHDVNGFKMMRSLSENDFRDVLPAAGWEISYLGPTT
MUL_3309|M.ulcerans_Agy99 ----LYMYEFG---AHQVNGLTAIRSLPEENFREMLPLGGWEITYLGPTT
MAB_0240|M.abscessus_ATCC_1997 ----LFLYGFS---DGHVNGFHN-HELDGIDYEMALTAAGFTITYLGETT
Mb1412c|M.bovis_AF2122/97 ----LLLSCFSN--AMPPDEEWPRSTVSEQTLRDVLGGAGWDIESLEPAT
Rv1377c|M.tuberculosis_H37Rv ----LLLSCFSN--AMPPDEEWPRSTVSEQTLRDVLGGAGWDIESLEPAT
MMAR_2193|M.marinum_M ----LLMSCFCD--ANPPNEQQPRPAVPEQTLRDVLGGAGWEIAALDPVT
TH_1722|M.thermoresistible__bu ----YFALVFAKGAFPEEMEQGPGPNPVDEDELREAVSKYWEIDEIRPAF
MLBr_01723|M.leprae_Br4923 WKVTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLETMA
: : :
Mvan_1888|M.vanbaalenii_PYR-1 YRGVVIDAHTEALN---------------------------------LPA
Mflv_4471|M.gilvum_PYR-GCK YRGVITAPHADAMG---------------------------------LDV
MSMEG_2067|M.smegmatis_MC2_155 YRGVVGPVHAEAIG---------------------------------LPV
MAV_3570|M.avium_104 YQVNLSAETIQMMAARNPDMADEAAKLLERFRAMEP-----------WLQ
MUL_3309|M.ulcerans_Agy99 YRTTVSMETLETMAARNPEVADQVGPLVERFKTIQP-----------WLT
MAB_0240|M.abscessus_ATCC_1997 YR--LSIPSYRRICTDCP---DQVPP------------------------
Mb1412c|M.bovis_AF2122/97 VRREL--------------------------------------------D
Rv1377c|M.tuberculosis_H37Rv VRREL--------------------------------------------D
MMAR_2193|M.marinum_M VNRQLGGS-----------------------------------------D
TH_1722|M.thermoresistible__bu IHANMPPDVPGVESFDTD-------------------------------E
MLBr_01723|M.leprae_Br4923 TNAGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTSWKT
.
Mvan_1888|M.vanbaalenii_PYR-1 GTVVDEPAWSARIRRL-------------
Mflv_4471|M.gilvum_PYR-GCK GTVVDEPAWLARIRRL-------------
MSMEG_2067|M.smegmatis_MC2_155 GTQVDEPAWLARARRL-------------
MAV_3570|M.avium_104 AGRVHAPFWEVHATRVD------------
MUL_3309|M.ulcerans_Agy99 DGIAHVPFWEVHATRPD------------
MAB_0240|M.abscessus_ATCC_1997 DGQIHIPMIEIHAVRNGLWQA--------
Mb1412c|M.bovis_AF2122/97 GTEVEMAFWNVRAQRRGS-----------
Rv1377c|M.tuberculosis_H37Rv GTEVEMAFWNVRAQRRGS-----------
MMAR_2193|M.marinum_M GQPIKLAFWYVRARRQN------------
TH_1722|M.thermoresistible__bu KGRTKLPAFLLSAHKA-------------
MLBr_01723|M.leprae_Br4923 LSWVDANVWRRVIPKSWFYNIIITGVKPS
. :