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TAPDPTDPTRFEEMYRDQRVAHGLPAATPWDIGGPQPVVEQLVALGAVKGEVLDPGTGPGHHAIYYASKG YSATGIDGSATAIERARDNAAKAGVSVNFQVADATRLEGLDNRFDTVVDCAFYHTFGTAPELQRSYVQAL WRATKPGARLYMYEFGAHQVNGLTAIRSLPEENFREMLPLGGWEITYLGPTTYRTTVSMETLETMAARNP EVADQVGPLVERFKTIQPWLTDGIAHVPFWEVHATRPD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3309 | - | - | 100% (249) | methyltransferase |
| M. ulcerans Agy99 | MUL_0662 | - | 1e-20 | 29.83% (238) | methyltransferase |
| M. ulcerans Agy99 | MUL_3115 | - | 8e-06 | 35.96% (89) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2694c | - | 1e-114 | 77.20% (250) | hypothetical protein Mb2694c |
| M. gilvum PYR-GCK | Mflv_4471 | - | 4e-26 | 33.82% (207) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2675c | - | 1e-114 | 77.20% (250) | hypothetical protein Rv2675c |
| M. leprae Br4923 | MLBr_01723 | - | 6e-05 | 32.32% (99) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_0868c | - | 5e-42 | 38.85% (260) | hypothetical protein MAB_0868c |
| M. marinum M | MMAR_2041 | - | 1e-146 | 99.20% (249) | methyltransferase |
| M. avium 104 | MAV_3570 | - | 1e-109 | 73.47% (245) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3041 | - | 7e-30 | 40.91% (198) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_1722 | - | 2e-21 | 35.29% (153) | CONSERVED HYPOTHETICAL PROTEIN |
| M. vanbaalenii PYR-1 | Mvan_1888 | - | 8e-28 | 38.62% (189) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4471|M.gilvum_PYR-GCK ------------MDMDQTPTLSR---FDDFYKDED--------KTPPWVI
Mvan_1888|M.vanbaalenii_PYR-1 --------------MDLTPRLSR---FDEFYKN----------QTPPWVI
MUL_3309|M.ulcerans_Agy99 -----------MTAP-DPTDPTR---FEEMYRDQRVAHGLPAA--TPWDI
MMAR_2041|M.marinum_M -----------MTAP-DPTDPTR---FEEMYRDQRVAHGLPAA--TPWDI
Mb2694c|M.bovis_AF2122/97 -----------MTAQFDPADPTR---FEEMYRDDRVAHGLPAA--TPWDI
Rv2675c|M.tuberculosis_H37Rv -----------MTAQFDPADPTR---FEEMYRDDRVAHGLPAA--TPWDI
MAV_3570|M.avium_104 -----------MTASFDPADPAR---FEEMYRDQRTSHGLPAA--TPWDI
MAB_0868c|M.abscessus_ATCC_199 -----------MTASTQPPDVPSQETFEAVYNGKPMFEGAPAAG-VPWDI
MSMEG_3041|M.smegmatis_MC2_155 -----------MTGP--TGSEFD---FDALYRGESPAEGVPPITSVPWDT
TH_1722|M.thermoresistible__bu ----------MATEDPGTGDPTDTIDWDSVYRQEAPGFDGP----PPWNI
MLBr_01723|M.leprae_Br4923 MTRSTEISANAVPNPHATAEQVAAARKDSKLAQVLYHDWEAENYDEKWSI
. : *
Mflv_4471|M.gilvum_PYR-GCK GEPQ-----------PAVVDIERAGLITGRVLDVGCGTGERTILLTAAGY
Mvan_1888|M.vanbaalenii_PYR-1 GEPQ-----------QAIVELEQAGLIGGRVLDVGCGTGEHTILLARAGY
MUL_3309|M.ulcerans_Agy99 GGPQ-----------PVVEQLVALGAVKGEVLDPGTGPGHHAIYYASKGY
MMAR_2041|M.marinum_M GGPQ-----------PVVEQLVALGAVKGEVLDPGTGPGHHAIYYASKGY
Mb2694c|M.bovis_AF2122/97 GGPQ-----------PVVQQLVALGAIRGEVLDPGTGPGHHAIYYAAKGY
Rv2675c|M.tuberculosis_H37Rv GGPQ-----------PVVQQLVALGAIRGEVLDPGTGPGHHAIYYAAKGY
MAV_3570|M.avium_104 GGPQ-----------PVVRQLVALGAVKGEVLDPGTGPGHHAIYYASQGF
MAB_0868c|M.abscessus_ATCC_199 RDAQ-----------PRIKELAAYGALRGAILDIGCGLGENSIYLTQQGL
MSMEG_3041|M.smegmatis_MC2_155 KAPK-----------ENVVAWEQAGLVHGHVLDIGCGLGDNAIYLAQQGY
TH_1722|M.thermoresistible__bu GEPQ-----------PELAALHRAGAFRSDVLDAGCGHAEISMALAADGY
MLBr_01723|M.leprae_Br4923 SYDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLIQSGV
: : . *: * * . : *
Mflv_4471|M.gilvum_PYR-GCK DVLG--VDGAPSAVEQARHNAKTRVVDAR-FDVADALDLG-DEPAYDTII
Mvan_1888|M.vanbaalenii_PYR-1 DVLG--IDGAPTAVEQARRNAEAQGVDAR-FELADALHLG-PDPTYDTIV
MUL_3309|M.ulcerans_Agy99 SATG--IDGSATAIERARDNAAKAGVSVN-FQVADATRLEGLDNRFDTVV
MMAR_2041|M.marinum_M SATG--IDGSATAIERARDNAAKAGVSVN-FQVADATRLEGLDNRFDTVV
Mb2694c|M.bovis_AF2122/97 AATG--IDGSVAAIERARDNARKAGVSVN-FQVGDATTLDGLDGRFDTVV
Rv2675c|M.tuberculosis_H37Rv AATG--IDGSVAAIERARDNARKAGVSVN-FQVGDATTLDGLDGRFDTVV
MAV_3570|M.avium_104 SATG--IDGSAAAIERARANARTAGVSVN-FELADATKLDGFDGRFDTVV
MAB_0868c|M.abscessus_ATCC_199 SVTG--LDFSPSAIEQAKQRAAAAGVTVD-LHVADATKLDGWDAQFDTVI
MSMEG_3041|M.smegmatis_MC2_155 RVTA--LDISPTALITAERRAADAGVDVT-FAVADATRLDGYDDVFDTVV
TH_1722|M.thermoresistible__bu TVVG--IDLSPTAIAAANRTAQERGLATASFVQGDITDFGGYDGRFNTII
MLBr_01723|M.leprae_Br4923 ARRGSVTDLSPGMVKIATRNGQSLGLDIN-GRVADAEGIPYDDNTFDLVV
. * : : * . : .* : : :: ::
Mflv_4471|M.gilvum_PYR-GCK DSALFHIFDDADREK--YVRSLGRAT--------APGSVVHLLALSD---
Mvan_1888|M.vanbaalenii_PYR-1 DSALFHIFDDADRAT--YVRSLHAAT--------RPGSVVHLLALSD---
MUL_3309|M.ulcerans_Agy99 DCAFYHTFGTAPELQRSYVQALWRAT--------KPGARLYMYEFGA---
MMAR_2041|M.marinum_M DCAFYHTFGTAPELQRSYVRALWRAT--------KPGARLYMYEFGA---
Mb2694c|M.bovis_AF2122/97 DCAFYHTFSTAPELQRCYVRALRRAS--------KPGARLYMFEFGE---
Rv2675c|M.tuberculosis_H37Rv DCAFYHTFSTAPELQRCYVRALRRAS--------KPGARLYMFEFGE---
MAV_3570|M.avium_104 DCAFYHVFATEPELRSSYARALHRAT--------KPGARLYMFEFGE---
MAB_0868c|M.abscessus_ATCC_199 DSAVYHCFD--HEGHRQYASALHRAT--------RPGARWFIACFGD---
MSMEG_3041|M.smegmatis_MC2_155 DSGMFHCLS--DDAKGSYAAAVHRAT--------RAGATLLLGAFSD---
TH_1722|M.thermoresistible__bu DSTLFHSIP--VQARDGYLRSIHRAA--------APGARYFALVFAKG--
MLBr_01723|M.leprae_Br4923 GHAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTDVGNRYARVFADLTW
. . * : : . . :.
Mflv_4471|M.gilvum_PYR-GCK ------TGRG----FGPEVSEETIRAAFADPGWDIEALTTTYYRGVITAP
Mvan_1888|M.vanbaalenii_PYR-1 ------SGRG----FGPEVSEHTIRAAFG-AGWEVEALTETTYRGVVIDA
MUL_3309|M.ulcerans_Agy99 ------HQVNGLTAIRSLPE-ENFREMLPLGGWEITYLGPTTYRTTVSME
MMAR_2041|M.marinum_M ------HQVNGLTAIRSLPE-ENFREMLPLGGWEITYLGPTTYRTTVSME
Mb2694c|M.bovis_AF2122/97 ------HNVNGFSMPRSLSE-DDFRQVLPVGGWEITYLGTTTYQVNLSVE
Rv2675c|M.tuberculosis_H37Rv ------HNVNGFSMPRSLSE-DDFRQVLPVGGWEITYLGTTTYQVNLSVE
MAV_3570|M.avium_104 ------HDVNGFKMMRSLSE-NDFRDVLPAAGWEISYLGPTTYQVNLSAE
MAB_0868c|M.abscessus_ATCC_199 ------GSVNGITMPFGVQDPDEIKSVLSEARWNIQYFGRTTYLGSRAAF
MSMEG_3041|M.smegmatis_MC2_155 ------ANLQHDNWQAAWVSEDTLRSSLDDGGWDITSLTTETIRVPG---
TH_1722|M.thermoresistible__bu -----AFPEEMEQGPGPNPVDEDELREAVSKYWEIDEIRPAFIHANMPPD
MLBr_01723|M.leprae_Br4923 KVTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLETMAT
* :
Mflv_4471|M.gilvum_PYR-GCK HADAMGLDVGT---------------------------------------
Mvan_1888|M.vanbaalenii_PYR-1 HTEALNLPAGT---------------------------------------
MUL_3309|M.ulcerans_Agy99 TLETMAARNPE------------------VADQVGPLVERFKTIQPWLTD
MMAR_2041|M.marinum_M TLETMAARNPE------------------VADQVGPLVERFKTIQPWLTD
Mb2694c|M.bovis_AF2122/97 ALELMAARNPD------------------MADQVRCVLERFRAIKPWLVG
Rv2675c|M.tuberculosis_H37Rv ALELMAARNPD------------------MADQVRCVLERFRAIKPWLVG
MAV_3570|M.avium_104 TIQMMAARNPD------------------MADEAAKLLERFRAMEPWLQA
MAB_0868c|M.abscessus_ATCC_199 VGAALAGIDPEQMPADMRE----RYQRPGVAEQAQQTFERLQQLD----D
MSMEG_3041|M.smegmatis_MC2_155 --AALAG----------------------SGDEGG--------------A
TH_1722|M.thermoresistible__bu VPGVESFDTDE--------------------------------------K
MLBr_01723|M.leprae_Br4923 NAGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTSWKTL
Mflv_4471|M.gilvum_PYR-GCK -VVDEPAWLARIRRL-------------
Mvan_1888|M.vanbaalenii_PYR-1 -VVDEPAWSARIRRL-------------
MUL_3309|M.ulcerans_Agy99 GIAHVPFWEVHATRPD------------
MMAR_2041|M.marinum_M GIAHVPFWEVHATRLD------------
Mb2694c|M.bovis_AF2122/97 GRVHAPFWEVHATRVD------------
Rv2675c|M.tuberculosis_H37Rv GRVHAPFWEVHATRVD------------
MAV_3570|M.avium_104 GRVHAPFWEVHATRVD------------
MAB_0868c|M.abscessus_ATCC_199 DMIHMPFFNIVAERG-------------
MSMEG_3041|M.smegmatis_MC2_155 DEFDAAFFLVQAQRR-------------
TH_1722|M.thermoresistible__bu GRTKLPAFLLSAHKA-------------
MLBr_01723|M.leprae_Br4923 SWVDANVWRRVIPKSWFYNIIITGVKPS
. : :