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MTTPEDLFESAYRGEAPNFGGVRPPWSIGEPQPEIRKLIDAGKFHGEVLDAGCGEAATALYLAAQGFTTV GLDQSPTAIELARAEAARRGLTNATFEVADISSFTGYDGRFGTIVDSTLFHSMPVELRDGYQQSIVRAAA PGATYVVLVFDKTTMGDTGPANPVTDDELRDVVGRYWVIDDISPARIHANVPAEFTDFAAFAGSDIRDEG NGRKSVAGWLLQAHLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2539 | - | - | 100% (226) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6235 | - | 9e-55 | 53.18% (220) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3041 | - | 9e-26 | 37.27% (220) | thiopurine S-methyltransferase (tpmt) superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0575c | - | 8e-82 | 67.98% (228) | benzoquinone methyltransferase |
| M. gilvum PYR-GCK | Mflv_1324 | - | 1e-51 | 57.14% (189) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0560c | - | 8e-82 | 67.98% (228) | benzoquinone methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2834c | - | 7e-84 | 67.87% (221) | hypothetical protein MAB_2834c |
| M. marinum M | MMAR_0909 | - | 5e-83 | 67.24% (232) | methyltransferase |
| M. avium 104 | MAV_0119 | - | 7e-98 | 77.13% (223) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_1722 | - | 2e-58 | 52.94% (221) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0662 | - | 2e-70 | 66.50% (200) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5471 | - | 2e-55 | 55.00% (220) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2539|M.smegmatis_MC2_155 ----------------MTTP-EDLFESAYRGEAPNFG-GVRPPWSIGEPQ
MAV_0119|M.avium_104 --------------MGMSQPTHEMFEAAYRGESPEMGEGARPPWSIGEPQ
MAB_2834c|M.abscessus_ATCC_199 ----------------MTENLQDMFESSYRGEAPEQL-AARPPWSIGQPQ
Mb0575c|M.bovis_AF2122/97 MSTVLTYIRAVDIYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQ
Rv0560c|M.tuberculosis_H37Rv MSTVLTYIRAVDIYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQ
MMAR_0909|M.marinum_M ----------------MTESLDLQFETAYRGESAEFGAGIRPPWSLGEPQ
MUL_0662|M.ulcerans_Agy99 ----------------MTESLDLQFATAYRGESAEFGAGIRPPWSLGEPQ
Mflv_1324|M.gilvum_PYR-GCK ------------------MAEVMDWDSAYRGEGE-FE--GEPPWNIGEPQ
Mvan_5471|M.vanbaalenii_PYR-1 ---------------MAHMTDVMDWDSAYRGEGD-FE--GEPPWNIGEPQ
TH_1722|M.thermoresistible__bu --------MATEDPGTGDPTDTIDWDSVYRQEAPGFD--GPPPWNIGEPQ
: : ** *. ***.:*:**
MSMEG_2539|M.smegmatis_MC2_155 PEIRKLIDAGKFHGEVLDAGCGEAATALYLAAQGFTTVGLDQSPTAIELA
MAV_0119|M.avium_104 PEIAALIEAGKFHGDVLDAGCGEAAVSLYLAERGFTTVGLDQSPTAIKLA
MAB_2834c|M.abscessus_ATCC_199 PEILKLIEQGKVHGDVLDAGCGEAATALYLAERGHTAVGLDAAPTAIQLA
Mb0575c|M.bovis_AF2122/97 PELAALIVQGKFRGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELA
Rv0560c|M.tuberculosis_H37Rv PELAALIVQGKFRGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELA
MMAR_0909|M.marinum_M PELATLIEQGKVHGEVLDAGCGEAALALALAGRGHPVVGLDMSPTAVELA
MUL_0662|M.ulcerans_Agy99 PELATLIEQGKVHGEVLDAGCGEAALAMALAGRGHPVVGLDISPTAVELA
Mflv_1324|M.gilvum_PYR-GCK PELAALWRDGRFRSEVLDAGCGHAELSLALAADGYTVTGVDISPTAMAAA
Mvan_5471|M.vanbaalenii_PYR-1 PELAALWRDGKFRSEVLDAGCGHAELSLALAADGYTVTGVDLSPTAVAAA
TH_1722|M.thermoresistible__bu PELAALHRAGAFRSDVLDAGCGHAEISMALAADGYTVVGIDLSPTAIAAA
**: * * .:.:***.***.* :: ** *....*:* :*:*: *
MSMEG_2539|M.smegmatis_MC2_155 RAEAARRGLTN-ATFEVADISSFTGY----DGRFGTIVDSTLFHSMPVEL
MAV_0119|M.avium_104 REKAARRGLTS-ASFEVADISDFTGY----DGRFGTIVDSTLFHSMPVEL
MAB_2834c|M.abscessus_ATCC_199 KGYAAERGLTN-VTFDVADISNFTGY----DGRFGTIIDSTLFHSMPVEL
Mb0575c|M.bovis_AF2122/97 RHEAAKRGLAN-ASFEVADASSFTGY----DGRFDTIVDSTLFHSMPVES
Rv0560c|M.tuberculosis_H37Rv RHEAAKRGLAN-ASFEVADASSFTGY----DGRFDTIVDSTLFHSMPVES
MMAR_0909|M.marinum_M GREAARRGLTN-ASFAVADITDFASYPPESAGRFNTIMDSTLFHSMPVEL
MUL_0662|M.ulcerans_Agy99 GREAARPGLTN-ASFAVADITDFASYPPESAGRFNTIMDSTLFHSMPVEL
Mflv_1324|M.gilvum_PYR-GCK SAAAAERGLSEKASFVAADITALSGF----DGRFSTVVDSTLFHSLPVES
Mvan_5471|M.vanbaalenii_PYR-1 TAASAERGLSERTSFVAADITTLTGF----DGRFATVVDSTLFHSLPVES
TH_1722|M.thermoresistible__bu NRTAQERGLAT-ASFVQGDITDFGGY----DGRFNTIIDSTLFHSIPVQA
: . **: .:* .* : : .: *** *::*******:**:
MSMEG_2539|M.smegmatis_MC2_155 RDGYQQSIVRAAAPGATYVVLVFDKTTMG---DTGP-ANPVTDDELRDVV
MAV_0119|M.avium_104 REGYQRSIVQAAAPGASYFVLVFDRNAMP---AEGP-VNAVTEDELREVV
MAB_2834c|M.abscessus_ATCC_199 REGYQQSIVRAAAPGANYIVLVFDKAAFPP--DIDG-PHPVSEPELREIV
Mb0575c|M.bovis_AF2122/97 REGYLQSIVRAAAPGASYFVLVFDRAAIP----EGP-INAVTEDELRAAV
Rv0560c|M.tuberculosis_H37Rv REGYLQSIVRAAAPGASYFVLVFDRAAIP----EGP-INAVTEDELRAAV
MMAR_0909|M.marinum_M REGYQRSIVRAAAPGASYFVLVFDKAALS---GDGP-INGVTEEELRDAV
MUL_0662|M.ulcerans_Agy99 REGCQRSIVRAAAPGASYFVLVFDKAALS---GDGP-INGVTEEELRDAV
Mflv_1324|M.gilvum_PYR-GCK RAGYLESVHRAARPGAGFFVLVFAKGAFPADTEQGP--NEVSEIELREAV
Mvan_5471|M.vanbaalenii_PYR-1 RDGYLQSVHRAAAPGAGYFVLVFAKGAFPAEMEGGP--NEVTELELREAV
TH_1722|M.thermoresistible__bu RDGYLRSIHRAAAPGARYFALVFAKGAFPEEMEQGPGPNPVDEDELREAV
* * .*: :** *** :..*** : :: . : * : *** *
MSMEG_2539|M.smegmatis_MC2_155 GRYWVIDDISPARIHANVPAEFT-DFAAFAGSDIRDEGNGRKSVAG----
MAV_0119|M.avium_104 GKYWVIDEIRPARIHANVPENFLAAFEAFAGADIRDEDNGRKSVGA----
MAB_2834c|M.abscessus_ATCC_199 SKYWTVDDISPARLYANG-DGFQ-DGGAQRFAEFREESNGWVSMAG----
Mb0575c|M.bovis_AF2122/97 SKYWIIDEIKPARLYARFPAGFA---GMPALLDIREEPNGLQSIGG----
Rv0560c|M.tuberculosis_H37Rv SKYWIIDEIKPARLYARFPAGFA---GMPALLDIREEPNGLQSIGG----
MMAR_0909|M.marinum_M SKYWVIDEIRPARIHANLPPEVS---GMPAFDARDEP-EGRKSVG-----
MUL_0662|M.ulcerans_Agy99 SKHWVIDEIRPARIHANLPPEVP---GCPPSTLATNPRAASPSVRGCSQP
Mflv_1324|M.gilvum_PYR-GCK SPYWTIDDIRPALIHTNVPKLPG----MPPPPLDMLDDRGHLRMQA----
Mvan_5471|M.vanbaalenii_PYR-1 SRYWIIDDIRPALIDTNVPKLPG----MPPPPLDMLDDRGRLRMQA----
TH_1722|M.thermoresistible__bu SKYWEIDEIRPAFIHANMP--PD----VPGVESFDTDEKGRTKLPA----
. :* :*:* ** : :. . :
MSMEG_2539|M.smegmatis_MC2_155 ---------WLLQAHLG-
MAV_0119|M.avium_104 ---------WLLSAHLG-
MAB_2834c|M.abscessus_ATCC_199 ---------WLLQAHRD-
Mb0575c|M.bovis_AF2122/97 ---------WLLSAHLG-
Rv0560c|M.tuberculosis_H37Rv ---------WLLSAHLG-
MMAR_0909|M.marinum_M --------AWLLSAHLG-
MUL_0662|M.ulcerans_Agy99 IWADGTPHAVYSPANEG-
Mflv_1324|M.gilvum_PYR-GCK ---------FLLSAHKEP
Mvan_5471|M.vanbaalenii_PYR-1 ---------FLLQAHKES
TH_1722|M.thermoresistible__bu ---------FLLSAHKA-
*: