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NLYTPIHEDQSLAAIHRAMWALGDYALMAEEVMAPLGPILVTATGIRPGMQVLDVAAGSGNISLPAAKTG ATIVSTDLTPELLQRSQARATELGLTLEYREADAQALPFGDGEFDVVMSAIGVMFAPDHRRAASELVRVC RPNGTIGVISWTQEGFFGRMLATIRPYRPSLSAALPPAALWGREAYIRGLLDDTVTNVKTERRQLEVKRF NSAEGVHNYFKNHYGPTIEAYTNIGDNSVLAAELDAQLTELAQKYLTNSTMGWEYLLLTAQKH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00551 | - | - | 100% (274) | putative methyltransferase |
| M. leprae Br4923 | MLBr_02273 | ubiE | 5e-12 | 33.33% (138) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. leprae Br4923 | MLBr_02584 | - | 5e-08 | 27.69% (130) | hypothetical protein MLBr_02584 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1440c | - | 1e-122 | 78.02% (273) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_4060 | - | 5e-63 | 47.04% (270) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1405c | - | 1e-122 | 78.02% (273) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_3930c | - | 4e-09 | 30.00% (110) | ubiquinone/menaquinone biosynthesis methlytransferase UbiE |
| M. marinum M | MMAR_2214 | - | 1e-121 | 77.29% (273) | methyltransferase |
| M. avium 104 | MAV_3373 | - | 1e-111 | 73.86% (264) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_2285 | - | 6e-73 | 48.48% (264) | methyltransferase type 11 |
| M. thermoresistible (build 8) | TH_2937 | - | 2e-13 | 31.33% (150) | PUTATIVE Methyltransferase type 11 |
| M. ulcerans Agy99 | MUL_1801 | - | 1e-119 | 76.56% (273) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2287 | - | 5e-63 | 47.17% (265) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4060|M.gilvum_PYR-GCK MATVDN-----EDDRALKAKHRALWASGDYPAVAAELIPSLGPELVRACG
Mvan_2287|M.vanbaalenii_PYR-1 MSTTATSASAHDADRQLKAKHRALWASGDYPAVAAELIAELGPELVRACG
MSMEG_2285|M.smegmatis_MC2_155 MGVVTV-------DRELEAKHRALWALGNYGAIAAHIVAPLGPVLVEACG
MMAR_2214|M.marinum_M MTIDTPIR----EDVSLAATHRAMWALGDYALMAEEVMAPLGPILVAAAG
MUL_1801|M.ulcerans_Agy99 MTIDTPIR----EDVSLAATHRAMWALGDYALMAEEVMAPLGPILVAAAG
Mb1440c|M.bovis_AF2122/97 MTIDTPAR----EDQTLAATHRAMWALGDYALMAEEVMAPLGPILVAAAG
Rv1405c|M.tuberculosis_H37Rv MTIDTPAR----EDQTLAATHRAMWALGDYALMAEEVMAPLGPILVAAAG
MLBr_00551|M.leprae_Br4923 MNLYTPIH----EDQSLAAIHRAMWALGDYALMAEEVMAPLGPILVTATG
MAV_3373|M.avium_104 MTLDTTT-----ADASVAARHRTVWALGDYALMAEEVMAPLGPTLVEAAG
TH_2937|M.thermoresistible__bu --------------------VTTNWAAGRYEAVGERIAPIADEVLDAAAR
MAB_3930c|M.abscessus_ATCC_199 MNRATLEKDPHEVASMFDAVARRYDITNTVLSFGRDRFWRR--ATREALR
. .. *
Mflv_4060|M.gilvum_PYR-GCK VRS--GDRVLDVAAGSGNASIPAAAAGAVVTASDLTPELFDAGRRIAAER
Mvan_2287|M.vanbaalenii_PYR-1 IQA--GDRVLDVAAGSGNAAIPAAEVGAIVTASDLTPELFGAGRRIAAER
MSMEG_2285|M.smegmatis_MC2_155 IGP--GDRVLDIAAGTGNASIPAALAGAQVTASDLCPQLVDEGAHESAER
MMAR_2214|M.marinum_M IGP--GVRVLDVAAGSGNISLPAAKSGATVVSTDLTPELLQRSKARAAAQ
MUL_1801|M.ulcerans_Agy99 IGP--GVRVLDVAAGSGNISLPAAKSGATVVSTDLTSELLQRSKARAAAQ
Mb1440c|M.bovis_AF2122/97 IGP--GVRVLDVAAGSGNISLPAAKTGATVISTDLTPELLQRSQARAAQQ
Rv1405c|M.tuberculosis_H37Rv IGP--GVRVLDVAAGSGNISLPAAKTGATVISTDLTPELLQRSQARAAQQ
MLBr_00551|M.leprae_Br4923 IRP--GMQVLDVAAGSGNISLPAAKTGATIVSTDLTPELLQRSQARATEL
MAV_3373|M.avium_104 IGP--GVRVLDVAAGSGNITLPAAAAGASVVSTDLTPELLQRSRDRAAGM
TH_2937|M.thermoresistible__bu RTPLRGATLVDLACGTGSAALSATARGAAVTGVDITSELIALAAGKPGGS
MAB_3930c|M.abscessus_ATCC_199 LKP--GDKVLDIAAGTAVSTAELTQSGAWCVAADFSVGMLKAGARR----
. * ::*:*.*:. : : ** . *: :. .
Mflv_4060|M.gilvum_PYR-GCK GVAVEWVEADAEALPFPDDSFDVVMSCVGAMFAPHHQATADEIVRVTRPG
Mvan_2287|M.vanbaalenii_PYR-1 GVDLEWVEADAESLPFADGSFDVVMSCVGAMFAPHHQATADELIRVCRPG
MSMEG_2285|M.smegmatis_MC2_155 GVDITWKEANAEALPFSDGEFDVVMSCIGVMFAPHHDQSARELLRVTRSG
MMAR_2214|M.marinum_M GLTLDYQEANAQALPFGDSEFDTVISAIGVMFAPDHQCSANELARVCKTG
MUL_1801|M.ulcerans_Agy99 ELTLDYQEANAQALPFGDSEFDTVISAIGVMFAPDHQCSANELARVCKTG
Mb1440c|M.bovis_AF2122/97 GLTLQYQEANAQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRPG
Rv1405c|M.tuberculosis_H37Rv GLTLQYQEANAQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRPG
MLBr_00551|M.leprae_Br4923 GLTLEYREADAQALPFGDGEFDVVMSAIGVMFAPDHRRAASELVRVCRPN
MAV_3373|M.avium_104 GLTIDYREANAQALPFGDGEFDAVVSAIGVQFAPDHQRAADELVRVCRPG
TH_2937|M.thermoresistible__bu --TVTWVTADAADTGLKTASFDVAVSNMGIIFVPPDRQVA-ELARLLKPG
MAB_3930c|M.abscessus_ATCC_199 --DVPKVAGDATRLPFADHSFDAVTISFGLRNVVDHVEGLREMARVTKPG
: .:* : .**.. .* . . *: *: :..
Mflv_4060|M.gilvum_PYR-GCK GTLGLISWTPEGFIGHLFATMKPYAPPPPPGASPPPMWGSENHVEALFGD
Mvan_2287|M.vanbaalenii_PYR-1 GTIGMVNWTPGGFIGNLFATMKPYAPPPPPGANPPPLWGDTDHVTTLFGD
MSMEG_2285|M.smegmatis_MC2_155 GRIGLISWTPEGFIGQLFATMKPFVPAPPPGVSPPPLWGNADHVRTLLGD
MMAR_2214|M.marinum_M GTIGVISWTPEGFFGRMLATIRPYRPSLSAALPPSALWGREAYARGLFGN
MUL_1801|M.ulcerans_Agy99 GTIGVISWTPEGFFGRMLATIRPYRPSLSAALPPSALWGREAYARGLFGN
Mb1440c|M.bovis_AF2122/97 GTIGVISWTCEGFFGRMLATIRPYRPSVSADLPPSALWGREAYVTGLLGD
Rv1405c|M.tuberculosis_H37Rv GTIGVISWTCEGFFGRMLATIRPYRPSVSADLPPSALWGREAYVTGLLGD
MLBr_00551|M.leprae_Br4923 GTIGVISWTQEGFFGRMLATIRPYRPSLSAALPPAALWGREAYIRGLLDD
MAV_3373|M.avium_104 GRIGLISWTPEGFFGRMLATIRPYRPSLSHPVPPAALWGRPGYVRALLGE
TH_2937|M.thermoresistible__bu GVLSFSAWIRTDEN-PFSDPVAEVLGPPPAGFSPD-QWGDAETLTERLTP
MAB_3930c|M.abscessus_ATCC_199 GRLAVCEFS--------TPVNRPFR----------------TLYMEYLMK
* :.. : :
Mflv_4060|M.gilvum_PYR-GCK RVRDLTMRRQTVRFDHCASPLDFREYWKRNYGPTLAAYRFNEDRPERLAE
Mvan_2287|M.vanbaalenii_PYR-1 RVGDLTTRRQTVRMDHCADPAGFREYWKRNYGPTIAAYRFNAGHADRIGA
MSMEG_2285|M.smegmatis_MC2_155 GIEDFETQRRSLTVDMFADGAAFRDFFKANYGPTIAAYRAVGDDAERTAA
MMAR_2214|M.marinum_M HVSDIQTQRGQLEVTRFQTAQAVHDYFKNHYGPTIEAYANIGDNAVLAAE
MUL_1801|M.ulcerans_Agy99 HVSDIQTQRGQLEVTRFQTAQAVHDYFKNHYGPTIEAYANIGDNAVLAAE
Mb1440c|M.bovis_AF2122/97 GVTGLKTARGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAE
Rv1405c|M.tuberculosis_H37Rv GVTGLKTARGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAE
MLBr_00551|M.leprae_Br4923 TVTNVKTERRQLEVKRFNSAEGVHNYFKNHYGPTIEAYTNIGDNSVLAAE
MAV_3373|M.avium_104 RIGEITTARGMLPVNRFGSAEDVHAYFKQHYGPTIEAYANIGHNRVLAAE
TH_2937|M.thermoresistible__bu HFDAIDLIRG-LHPWEFDSPATALHFLRTESPVHVEIFRRAG--PARRER
MAB_3930c|M.abscessus_ATCC_199 TLPEVARAVSSNPDAYVYLAESIRAWPDQE--ALAHQIASAGWSNVRWRN
. . : .
Mflv_4060|M.gilvum_PYR-GCK LDAAFLDFLTTWNQADGTDGTAYDAEYLLVTATKR--
Mvan_2287|M.vanbaalenii_PYR-1 LDRDFLALLTEWNRGDETN-AFWEAEYLLVTMTRL--
MSMEG_2285|M.smegmatis_MC2_155 LDEAIALLGDRYLDS-----GAMQWEYLVVTAHKR--
MMAR_2214|M.marinum_M LDAQLVELADQYLTD-----GVMEWEYLVLTGTKK--
MUL_1801|M.ulcerans_Agy99 LDAQLVELADQYLTD-----GVMEWEYLVLTGTKK--
Mb1440c|M.bovis_AF2122/97 LDRQLVELAAQYLSD-----GVMEWEYLLLTAEKR--
Rv1405c|M.tuberculosis_H37Rv LDRQLVELAAQYLSD-----GVMEWEYLLLTAEKR--
MLBr_00551|M.leprae_Br4923 LDAQLTELAQKYLTN-----STMGWEYLLLTAQKH--
MAV_3373|M.avium_104 LDAQLVELAAQHLSD-----GTMGWEYLLVTAEKRSG
TH_2937|M.thermoresistible__bu LAAAFRSALRPHAGPAG--TVGFTAPYVIVTARRRG-
MAB_3930c|M.abscessus_ATCC_199 LTGGIVALHIATL------------------------
* :