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SSDQVMDWDSAYREQAHFEGPPPWNIGEPQPELAALIEQGKFRSDVLDAGCGCAELSLALAARGYTVVGI DLTPTAVAAATRAAAERGLTTASFVQADITSFTGYDGRFATVVDSTLFHSLPVEGRDGYLRSIHRAAAAG ASLFILVFAKGAFPAEMQPKPNEVDEDELRAAVGKYWVIDEIRPSFIVSNVPQIADAPFEFPAHERDERG RMKMPAYLLTAHKAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0404 | - | - | 100% (226) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. avium 104 | MAV_0119 | - | 1e-64 | 60.63% (221) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. avium 104 | MAV_0313 | - | 4e-59 | 55.80% (224) | thiopurine S-methyltransferase (tpmt) superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3725 | - | 4e-98 | 76.62% (231) | hypothetical protein Mb3725 |
| M. gilvum PYR-GCK | Mflv_1324 | - | 2e-81 | 66.97% (221) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3699 | - | 4e-98 | 76.62% (231) | hypothetical protein Rv3699 |
| M. leprae Br4923 | MLBr_00551 | - | 2e-05 | 35.71% (70) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_0961c | - | 2e-75 | 62.39% (226) | hypothetical protein MAB_0961c |
| M. marinum M | MMAR_5210 | - | 2e-97 | 76.32% (228) | hypothetical protein MMAR_5210 |
| M. smegmatis MC2 155 | MSMEG_6235 | - | 2e-90 | 70.72% (222) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_1722 | - | 5e-86 | 71.17% (222) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0662 | - | 6e-53 | 57.00% (200) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5471 | - | 1e-85 | 71.36% (220) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1324|M.gilvum_PYR-GCK ---MA-------EVMDWDSAYRGEG-EFEG--EPPWNIGEPQPELAALWR
Mvan_5471|M.vanbaalenii_PYR-1 MAHMT-------DVMDWDSAYRGEG-DFEG--EPPWNIGEPQPELAALWR
Mb3725|M.bovis_AF2122/97 ---MT------DEVMDWDSAYREQG-AFEG--PPPWNIGEPQPELATLIA
Rv3699|M.tuberculosis_H37Rv ---MT------DEVMDWDSAYREQG-AFEG--PPPWNIGEPQPELATLIA
MMAR_5210|M.marinum_M ---MT------SPVMDWDDAYQQQG-AFEG--PPPWNIGEPQPELAALIA
MAV_0404|M.avium_104 --MSS------DQVMDWDSAYREQA-HFEG--PPPWNIGEPQPELAALIE
MSMEG_6235|M.smegmatis_MC2_155 MGVMT------SHVLDWDGAYRGDT-GFQG--PPPWNIGEPQPELAALHR
TH_1722|M.thermoresistible__bu MATEDPGTGDPTDTIDWDSVYRQEAPGFDG--PPPWNIGEPQPELAALHR
MAB_0961c|M.abscessus_ATCC_199 ---MTS-----NELPDWDATYQGKGELFQG--EPPWNIGEPQPELAALID
MUL_0662|M.ulcerans_Agy99 ---MT-----ESLDLQFATAYRGESAEFGAGIRPPWSLGEPQPELATLIE
MLBr_00551|M.leprae_Br4923 MNLYTP-----IHEDQSLAAIHRAMWALGDYALMAEEVMAPLGPILVTAT
: . : : . .: * : .
Mflv_1324|M.gilvum_PYR-GCK DGRFRSEVLDAGCGHAELSLALAADGYTVTGVDISPTAMAAASAAAAERG
Mvan_5471|M.vanbaalenii_PYR-1 DGKFRSEVLDAGCGHAELSLALAADGYTVTGVDLSPTAVAAATAASAERG
Mb3725|M.bovis_AF2122/97 AGKVRSDVLDAGCGYAELSLALAADGYTVVGIDLTPTAVAAATKAAEERG
Rv3699|M.tuberculosis_H37Rv AGKVRSDVLDAGCGYAELSLALAADGYTVVGIDLTPTAVAAATKAAEERG
MMAR_5210|M.marinum_M AGKIHSDVLDAGCGYAELSLALAAEGYTVVGIDITPTAIAAATKAAAERG
MAV_0404|M.avium_104 QGKFRSDVLDAGCGCAELSLALAARGYTVVGIDLTPTAVAAATRAAAERG
MSMEG_6235|M.smegmatis_MC2_155 AGRFRSDVLDAGCGHAELSLALAADGYTVVGMDLSPSAIAAANRAAQERN
TH_1722|M.thermoresistible__bu AGAFRSDVLDAGCGHAEISMALAADGYTVVGIDLSPTAIAAANRTAQERG
MAB_0961c|M.abscessus_ATCC_199 AGKFHGTVLDVGCGHAETSLRLAALGHTTVGLDLSPTAIEAARAAAAERG
MUL_0662|M.ulcerans_Agy99 QGKVHGEVLDAGCGEAALAMALAGRGHPVVGLDISPTAVELAGREAARPG
MLBr_00551|M.leprae_Br4923 GIRPGMQVLDVAAGSGNISLPAAKTGATIVSTDLTPELLQRSQARATELG
***...* . :: * * . .. *::* : : : . .
Mflv_1324|M.gilvum_PYR-GCK LSEKASFVAADITALSGF----DGRFSTVVDSTLFHSLPVESRAGYLESV
Mvan_5471|M.vanbaalenii_PYR-1 LSERTSFVAADITTLTGF----DGRFATVVDSTLFHSLPVESRDGYLQSV
Mb3725|M.bovis_AF2122/97 LTT-ASFVQADITEFAAYPAGSAGRFSTVIDSTLFHSLPVDSRDRYLSSV
Rv3699|M.tuberculosis_H37Rv LTT-ASFVQADITEFAAYPAGSAGRFSTVIDSTLFHSLPVDSRDRYLSSV
MMAR_5210|M.marinum_M LGN-TSFMQADITDFNAYPAGSAGRFATVIDSTLFHSLPVSGRDDYLKSV
MAV_0404|M.avium_104 LTT-ASFVQADITSFTGY----DGRFATVVDSTLFHSLPVEGRDGYLRSI
MSMEG_6235|M.smegmatis_MC2_155 LAT-ASFVQGDITSFTGY----DGRFSTVIDSTLFHSLPVEGREGYLQSI
TH_1722|M.thermoresistible__bu LAT-ASFVQGDITDFGGY----DGRFNTIIDSTLFHSIPVQARDGYLRSI
MAB_0961c|M.abscessus_ATCC_199 LTN-ATFEVADITDFSGY----DGRFNTIVDSTLFHSIPVEAREAYLQSI
MUL_0662|M.ulcerans_Agy99 LTN-ASFAVADITDFASYPPESAGRFNTIMDSTLFHSMPVELREGCQRSI
MLBr_00551|M.leprae_Br4923 LTL--EYREADAQALPFG----DGEFDVVMSAIGVMFAPDHRR--AASEL
* : .* : *.* .::.: . * * .:
Mflv_1324|M.gilvum_PYR-GCK HRAARPGAGFFVLVFAKGAFPADTEQGP----------------------
Mvan_5471|M.vanbaalenii_PYR-1 HRAAAPGAGYFVLVFAKGAFPAEMEGGP----------------------
Mb3725|M.bovis_AF2122/97 HRAAAPGASYYVLVFAKGAFPAELEVKP----------------------
Rv3699|M.tuberculosis_H37Rv HRAAAPGASYYVLVFAKGAFPAELEVKP----------------------
MMAR_5210|M.marinum_M HRAAAPGASYFVLVFAKGAFPAALETKP----------------------
MAV_0404|M.avium_104 HRAAAAGASLFILVFAKGAFPAEMQPKP----------------------
MSMEG_6235|M.smegmatis_MC2_155 HRASAPGARYFVLVFAKGAFPADLEVKP----------------------
TH_1722|M.thermoresistible__bu HRAAAPGARYFALVFAKGAFPEEMEQGPG---------------------
MAB_0961c|M.abscessus_ATCC_199 SRAAAPDASYFVLVFAVGAFPPGI--GP----------------------
MUL_0662|M.ulcerans_Agy99 VRAAAPGASYFVLVFDKAALSGDG---P----------------------
MLBr_00551|M.leprae_Br4923 VRVCRPNGTIGVISWTQEGFFGRMLATIRPYRPSLSAALPPAALWGREAY
*.. ... : : .:
Mflv_1324|M.gilvum_PYR-GCK ---------NEVSEIELREAVSPYWTIDDIRPALIHTN----VPKLPGMP
Mvan_5471|M.vanbaalenii_PYR-1 ---------NEVTELELREAVSRYWIIDDIRPALIDTN----VPKLPGMP
Mb3725|M.bovis_AF2122/97 ---------NEVDEDELRAAVSKYWKIDEIRPAFIHVNPVTIPPQLAGAP
Rv3699|M.tuberculosis_H37Rv ---------NEVDEDELRAAVSKYWKIDEIRPAFIHVNPVTIPPQLAGAP
MMAR_5210|M.marinum_M ---------NEVDEDELRAAVGKYWEIDEIRPAFIHANVPVIPPLPAGSP
MAV_0404|M.avium_104 ---------NEVDEDELRAAVGKYWVIDEIRPSFIVSN----VPQIADAP
MSMEG_6235|M.smegmatis_MC2_155 ---------NEVTEEELRTTVGKYWVVDDIRPAFIHANA-VVFPDAP---
TH_1722|M.thermoresistible__bu --------PNPVDEDELREAVSKYWEIDEIRPAFIHAN---MPPDVP---
MAB_0961c|M.abscessus_ATCC_199 ---------NAVTEDELRAAVEPYWAIDELSSAYIHSN---IPEVIPGAN
MUL_0662|M.ulcerans_Agy99 --------INGVTEEELRDAVSKHWVIDEIRPARIHAN---LPPEVPGCP
MLBr_00551|M.leprae_Br4923 IRGLLDDTVTNVKTERRQLEVKRFNSAEGVHNYFKNHYGPTIEAYTNIGD
. * . : * . : :
Mflv_1324|M.gilvum_PYR-GCK -PPPLDML-----DDRGHLR------MQAFLLSAHKEP
Mvan_5471|M.vanbaalenii_PYR-1 -PPPLDML-----DDRGRLR------MQAFLLQAHKES
Mb3725|M.bovis_AF2122/97 VEFPPYDH-----DEKGRVK------FPAYLLTAHKAG
Rv3699|M.tuberculosis_H37Rv VEFPPYDH-----DEKGRVK------FPAYLLTAHKAG
MMAR_5210|M.marinum_M IEFPPHQR-----DEKGRMK------FPAYLLTAHKA-
MAV_0404|M.avium_104 FEFPAHER-----DERGRMK------MPAYLLTAHKAQ
MSMEG_6235|M.smegmatis_MC2_155 -ELPPHGY-----DDKGRIM------FPAFLLEAHRD-
TH_1722|M.thermoresistible__bu -GVESFDT-----DEKGRTK------LPAFLLSAHKA-
MAB_0961c|M.abscessus_ATCC_199 FEMPVFHK-----DEKGRNK------QPAFLLQAHKR-
MUL_0662|M.ulcerans_Agy99 PSTLATNPRAASPSVRGCSQPIWADGTPHAVYSPANEG
MLBr_00551|M.leprae_Br4923 NSVLAAELDAQLTELAQKYLTNSTMGWEYLLLTAQKH-
. : . .