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MLLGMSPVKPLRSRPTRGEVRDRILDAAAKVFAAEGFAGATIDAIGQAAGFTKGAVYSNFESKDELFLAL LDREFELRGQQIAIALDRSAGDTTAAAREVSRSVLDSVRDHSDYYVLLVEYWLRAQRDPQLRERLIERRR AAADQALHIVESTDTVPGDRRLTDIAQLVVTLNLGVAMEEVLRPGTINPDLLAQLITALLESIPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1611 | - | - | 100% (205) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_0488 | - | 1e-11 | 34.00% (150) | putative transcriptional regulator |
| M. avium 104 | MAV_0959 | - | 1e-09 | 35.87% (92) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1561 | - | 4e-10 | 37.36% (91) | transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2460 | - | 3e-16 | 33.81% (139) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1534 | - | 4e-10 | 37.36% (91) | transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 2e-07 | 25.00% (168) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2913 | - | 2e-17 | 32.42% (182) | TetR family regulatory protein |
| M. marinum M | MMAR_4631 | - | 5e-17 | 32.95% (176) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_0148 | - | 3e-21 | 30.20% (202) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_4015 | - | 3e-09 | 28.06% (139) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0245 | - | 3e-13 | 32.26% (155) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4194 | - | 1e-15 | 35.07% (134) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4631|M.marinum_M --------------------MTPPANTATPARVTKRRAETRARLVDAAFR
MUL_0245|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2460|M.gilvum_PYR-GCK --------------------------MVERWTRERRLEHTRSVLLDAAEE
Mvan_4194|M.vanbaalenii_PYR-1 --------------------------MAERWTRERRLEHTRSVLLDAAEE
Mb1561|M.bovis_AF2122/97 --------------------MSRASARRRRAVSDEDKSQRRDEILAAAKI
Rv1534|M.tuberculosis_H37Rv --------------------MSRASARRRRAVSDEDKSQRRDEILAAAKI
MAB_2913|M.abscessus_ATCC_1997 -------------MYPYRFTVITTGRLLMSTGSTRRREHTRARLMQAALD
MSMEG_0148|M.smegmatis_MC2_155 ------------------------MVPRKRLTRAEARAQTRRRLLDAAAE
MAV_1611|M.avium_104 --------------------MLLGMSPVKPLRSRPTRGEVRDRILDAAAK
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
TH_4015|M.thermoresistible__bu -VVPRRRVDNGSNEQGVASDATGGDRMNRPLPPTARGRRSRRALLDAAKE
MMAR_4631|M.marinum_M VFADKGFGHVRIEDVCAAAGYTRGAFYSQFDSLEELFFTLYDQRATLISE
MUL_0245|M.ulcerans_Agy99 MFADKGFGHVRIEDVCAAAGYTRGAFYSQFDSLEELFFTLYDQRATLISE
Mflv_2460|M.gilvum_PYR-GCK VFAEKGFTPATLDDIARAAGYTKGAIYKHFDTKEELFLAVSDRYWRRYFD
Mvan_4194|M.vanbaalenii_PYR-1 VFAEKGFTPATLDDIARTAGYTKGAIYKHFATKEDLFLAVSDRYWRRYFD
Mb1561|M.bovis_AF2122/97 VFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRA
Rv1534|M.tuberculosis_H37Rv VFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRA
MAB_2913|M.abscessus_ATCC_1997 VFADRGFHGASIENICEKAGFTRGAFYSNFAGKDELFFTLFDASSEQLLT
MSMEG_0148|M.smegmatis_MC2_155 TFARKGYDAASVEEIAEAAGYSVGAVYSNFSSKEQLFSELRSERAALRLD
MAV_1611|M.avium_104 VFAAEGFAGATIDAIGQAAGFTKGAVYSNFESKDELFLALLDREFELRGQ
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
TH_4015|M.thermoresistible__bu VFARDGFADARITDIADAAGTAHGSFYRYFDSKEEIFIELLRELVEELRQ
*. *: . : : ** : .* * ::: :
MMAR_4631|M.marinum_M QVGTAMASVDDP-TDVPGTVDRIASTLLLDR---DWLLIKTDFLMHAARH
MUL_0245|M.ulcerans_Agy99 QVGTAMASVGDP-TDVPGTVDRIASTLLLDR---DWLLIKTDFLMHAARH
Mflv_2460|M.gilvum_PYR-GCK NFAEVMSSASRVGADELDEIAERWRQLSIDRGA-EHAALGLEFTLYLLRN
Mvan_4194|M.vanbaalenii_PYR-1 NFAEVMASASRVGAHELDEIAERWRQLSIDRGA-DHAALGLEFTLYLLRN
Mb1561|M.bovis_AF2122/97 HVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLFRDAYALG
Rv1534|M.tuberculosis_H37Rv HVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLFRDAYALG
MAB_2913|M.abscessus_ATCC_1997 QLRAALDECRKSPDPLSTFIRTIDDKGPTQR---RWYLISMEFTLYAIRE
MSMEG_0148|M.smegmatis_MC2_155 EVADALRSAQGDPGGPFAKLSRQLVEVADKN--IEVAALHTEFWLHAIRN
MAV_1611|M.avium_104 QIAIALDRSAGDTTAAAREVSRSVLDSVRDHS--DYYVLLVEYWLRAQRD
MLBr_00815|M.leprae_Br4923 SVQQALRTTTNN-----RQRLHAAVQAFFDFIEHDGQGYRLIFENDNITE
TH_4015|M.thermoresistible__bu PVRTDAGTEPKNPYERILRANRTYLEAYRAN-----RAIMIVWEQVASLN
. :
MMAR_4631|M.marinum_M PDLAQRLAAHRAQLRAAVEDRLAGSDVELPA-AIG-SVADAARAVVAAYD
MUL_0245|M.ulcerans_Agy99 PDLAQRLAAHRAQLRAAVEDRLAGSDVELPA-AIG-SVADAARAVVAAYD
Mflv_2460|M.gilvum_PYR-GCK PEARERVEAKRAEVVDQLAEFIVEGMSQLGA-TLLIEPSTFARALVATSD
Mvan_4194|M.vanbaalenii_PYR-1 PDARERVAAKRAEVVDQLAKFINEGMTRLGA-SLLISPLTFAQALVATSD
Mb1561|M.bovis_AF2122/97 GRFEEHLGGIYERFIDDIEAVVVAAQRRG---EVVEAPSRMAAYTLAALV
Rv1534|M.tuberculosis_H37Rv GRFEEHLGGIYERFIDDIEAVVVAAQRRG---EVVEAPSRMAAYTLAALV
MAB_2913|M.abscessus_ATCC_1997 PSAAVVLAEHDARLRREAAGIINELMSIAHR-ELIIDTELIARLATALRE
MSMEG_0148|M.smegmatis_MC2_155 PGAMDVLAESVGQTLQSLTGIAADLLAEHNVDQSVVRPETFAVSLLALHQ
MAV_1611|M.avium_104 PQLRERLIERRRAAADQALHIVESTDTVPGD----RRLTDIAQLVVTLNL
MLBr_00815|M.leprae_Br4923 PRVAAQVRVATESCIDAVFALISADSRLDPHRARMVAVGLVGISVDCARY
TH_4015|M.thermoresistible__bu EHVEQLRREYSDRFAARIERAIIRWQEAGLA-DPAIDPRYAAAALSGMLS
.
MMAR_4631|M.marinum_M GVSIQLLLDGDQDAARAWLSQLLGVVLIR-------------------
MUL_0245|M.ulcerans_Agy99 GVSIQLLLDGDQDAARAWLSQLLGVVLIR-------------------
Mflv_2460|M.gilvum_PYR-GCK SVVLGSQLD-AVDLYRPMVEMYVSVIKLPD------------------
Mvan_4194|M.vanbaalenii_PYR-1 SVVLASQLD-DIDLYRPVVEMYTSVIKLPD------------------
Mb1561|M.bovis_AF2122/97 GQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
Rv1534|M.tuberculosis_H37Rv GQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
MAB_2913|M.abscessus_ATCC_1997 GVAAQFYVEPELAETRMLERLAFPAMLRAFSQPVGAD-----------
MSMEG_0148|M.smegmatis_MC2_155 GLIRQRRTNPSWVPEELFGQLLSWLLAGMPKLPAH-------------
MAV_1611|M.avium_104 GVAMEEVLRPGTINPDLLAQLITALLESIPV-----------------
MLBr_00815|M.leprae_Br4923 WLDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL---------------
TH_4015|M.thermoresistible__bu NFAYRWSVQDADYDLDTAAEQLSLLWANALGVRVPAHHEPAHA-----