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GTARQAVSDEQFWLVEHSPARTRVLDAALDLFAANGVSGTSLQMIADAVGITKAAVYHQFRTKEQIVIAV TERELGRLVPALEEAEAHDDGPQARDALLVRVIEMAVRDRRLVRTLQFDPVVVRLLAEHEPFQRFMDRLY RVLLSDAGLDGRIEAAMFSGALSTAVMHPLVVDIDDETLLDRVTDLSRRLLGLPRKPVE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0959 | - | - | 100% (200) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1611 | - | 1e-09 | 35.87% (92) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_3088 | - | 7e-08 | 35.53% (76) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 5e-08 | 27.74% (137) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0973 | - | 2e-25 | 37.78% (180) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0302 | - | 1e-07 | 27.01% (137) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 7e-07 | 32.31% (65) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2913 | - | 3e-08 | 25.00% (188) | TetR family regulatory protein |
| M. marinum M | MMAR_4699 | - | 2e-60 | 63.59% (184) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_0227 | - | 4e-30 | 40.91% (176) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2336 | - | 6e-22 | 34.46% (177) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_0293 | - | 1e-09 | 43.48% (69) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4249 | - | 1e-56 | 58.15% (184) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4699|M.marinum_M -----------------------MSSQSRNQFRVITRSAAQVRILDATLG
Mvan_4249|M.vanbaalenii_PYR-1 -----------------------MTTAG-TRFSAITRTAAQTRVLDAALD
MAV_0959|M.avium_104 -------------------MGTARQAVSDEQFWLVEHSPARTRVLDAALD
MSMEG_0227|M.smegmatis_MC2_155 ------------------------MAKS-----VAPRGFARERVLEAALN
Mflv_0973|M.gilvum_PYR-GCK ----------------------------MSGDSTRAGGPTRRRLIDVAIE
TH_2336|M.thermoresistible__bu --------------VSGVGKPISREAALLTSRASAGTGPTRQRLIEVAIE
Mb0310|M.bovis_AF2122/97 -------------------------MGVPAKKKQQQGERSRESILDATER
Rv0302|M.tuberculosis_H37Rv -------------------------MGVPAKKKQQQGERSRESILDATER
MUL_0293|M.ulcerans_Agy99 -------------------------------MVTKPRSDTRRRIQEVARE
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
MAB_2913|M.abscessus_ATCC_1997 -------------MYPYRFTVITTGRLLMSTGSTRRREHTRARLMQAALD
: : .:
MMAR_4699|M.marinum_M LIAEHGVGGTSLQMIADAVGVTKAAVYHQFKTKEQIVIALTERELGGLEE
Mvan_4249|M.vanbaalenii_PYR-1 LISEHGVSGTSLQMIADSMGVTKAAVYRQFKSKDDIVIALTEREFGRLED
MAV_0959|M.avium_104 LFAANGVSGTSLQMIADAVGITKAAVYHQFRTKEQIVIAVTERELGRLVP
MSMEG_0227|M.smegmatis_MC2_155 LFAEHGVNGTSLQMIADRLGVSKAAVYYQFHSKDDIVFAVVEPIFGDMRR
Mflv_0973|M.gilvum_PYR-GCK LFKRYSVAGTSLQMISDELGLTKSAIYHHFRTRDELLTAVMEPLIAEVAE
TH_2336|M.thermoresistible__bu LFKQHSVAGTSLQMISDALGLTKSAIYHHFRTRDELLTAVMEPLISEVAE
Mb0310|M.bovis_AF2122/97 LMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFA
Rv0302|M.tuberculosis_H37Rv LMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFA
MUL_0293|M.ulcerans_Agy99 LFLRQGVRGTSLQDIADRLGITKPALYYHFASREDLVRSIVVPLIEEGER
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
MAB_2913|M.abscessus_ATCC_1997 VFADRGFHGASIENICEKAGFTRGAFYSNFAGKDELFFTLFDASSEQLLT
:: . .:.:. * : *.: .* :* : : ::
MMAR_4699|M.marinum_M ALEAAEAHDHPS-QARELLLDRVIELAVERRGAASTLQF-------DPVI
Mvan_4249|M.vanbaalenii_PYR-1 ALEAAEAEESAP-RARELLLNQVIDEAIERRRHVATLQF-------DPVI
MAV_0959|M.avium_104 ALEEAEAHDDGP-QARDALLVRVIEMAVRDRRLVRTLQF-------DPVV
MSMEG_0227|M.smegmatis_MC2_155 VLRIAEAMSSPD-ARREAAVSGMVELAVRHRRVSAVFHG-------DPAI
Mflv_0973|M.gilvum_PYR-GCK IVDAAEEQRTPH-ARADHMLVGYASIAARHRTLIPLLSG-------DPGV
TH_2336|M.thermoresistible__bu IVSAAEARRGAR-TRADHFLRGYAALAAAHREVISLLTG-------DPGV
Mb0310|M.bovis_AF2122/97 AIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLLSMERSQDPVV
Rv0302|M.tuberculosis_H37Rv AIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLLSMERSQDPAV
MUL_0293|M.ulcerans_Agy99 FVAERERLADGN---VRGLLEGYFDFHYRHRQDLMLVVV-------ELTL
MLBr_00815|M.leprae_Br4923 SVQQALRTTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFE------NDNIT
MAB_2913|M.abscessus_ATCC_1997 QLRAALDECRKSPDPLSTFIRTIDDKGPTQRRWYLISMEFTLYAIREPSA
: : :
MMAR_4699|M.marinum_M VRLLAEHQ--PFQRFIERLYGVLIG--DAGQDTRVLAAMLSGAIAVGVLH
Mvan_4249|M.vanbaalenii_PYR-1 IKFLASHQ--PFQAFIARLYAVLVG--DAGREAKLTAAMLSGAIAVGVMH
MAV_0959|M.avium_104 VRLLAEHE--PFQRFMDRLYRVLLS--DAGLDGRIEAAMFSGALSTAVMH
MSMEG_0227|M.smegmatis_MC2_155 DNLVHSRK--DLHEVIERLTAILLGP-EPGTACRVMMSMLASGIFSSAMD
Mflv_0973|M.gilvum_PYR-GCK VALLRTRS--EWGDLVRRQLALFSEV-EPGLGGQVKAALAMSGIASAAGV
TH_2336|M.thermoresistible__bu VALLRTRP--DWAEVVQRQMALLGDV-QPGPGGRVKAAVVMAGIAAAAGV
Mb0310|M.bovis_AF2122/97 AAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLVVAELTAFAVALSDGV
Rv0302|M.tuberculosis_H37Rv AAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLVVAELTAFAVALSDGV
MUL_0293|M.ulcerans_Agy99 LSDLGLID--TVLARRERLGRLVFG------AAPTLGQATRAVLAFGGLQ
MLBr_00815|M.leprae_Br4923 EPRVAAQVRVATESCIDAVFALISADSRLDPHRARMVAVGLVGISVDCAR
MAB_2913|M.abscessus_ATCC_1997 AVVLAEHDARLRREAAGIINELMSIAHRELIIDTELIARLATALREGVAA
: :. :
MMAR_4699|M.marinum_M PLVADVDDAT-----LRTQLRRITSRLMDTGEG---------
Mvan_4249|M.vanbaalenii_PYR-1 PLVADIDDDT-----LRRELLHYTRRLIDLPE----------
MAV_0959|M.avium_104 PLVVDIDDET-----LLDRVTDLSRRLLGLPRKPVE------
MSMEG_0227|M.smegmatis_MC2_155 PELADIDDEE-----LHRVLLDCTQRLLNAPVSS--------
Mflv_0973|M.gilvum_PYR-GCK DYGGDVDDDT-----LRDQLIAAGRRALGLRNSRTGAVTARR
TH_2336|M.thermoresistible__bu DYG-DLDEAA-----LRDELLAAGRRTLGLR-----APHARG
Mb0310|M.bovis_AF2122/97 YFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET-------
Rv0302|M.tuberculosis_H37Rv YFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET-------
MUL_0293|M.ulcerans_Agy99 DCCMQFPDEP--YAQLRQYSVEAALAALGV------------
MLBr_00815|M.leprae_Br4923 YWLDTNRPISK-SDAVEGTVQFAWGGLSHVPLTRL-------
MAB_2913|M.abscessus_ATCC_1997 QFYVEPELAET--RMLERLAFPAMLRAFSQPVGAD-------
: