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TTLTSDFTDESTGERLRRWADEWRRMAAVAVSSADGPKTGMVYDIVGPQNLFGEESLFINFGYWRDHPTT LDEASRDLARLVASSAGFTASDVVVDCGCGYGDQDILWANEFKVKKITGVNIAEEQIAISTERVAEAGLS DTISYVKASATDLPFENESCTKVVALESAFHFPSRIDFFREALRVLKPGGRMVTADIVPRRTALTAFARS QVARRGWQGAPANAVPWAVDVQGYRDLLLDMGFARSETWSIANDVYPPLSKFLGKRLRQPDMKHVNPLLR AQFNSVGMRLFSLHSDYIVAVAHKA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0018c | - | - | 100% (306) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_4103c | - | 9e-12 | 30.00% (180) | methyltransferase |
| M. abscessus ATCC 19977 | MAB_1390c | - | 6e-08 | 31.33% (166) | putative UbiE/COQ5 methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1550 | - | 1e-11 | 29.95% (207) | methyltransferase |
| M. gilvum PYR-GCK | Mflv_4035 | - | 1e-08 | 26.55% (177) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1523 | - | 1e-11 | 29.95% (207) | methyltransferase |
| M. leprae Br4923 | MLBr_00130 | - | 2e-12 | 30.07% (153) | hypothetical protein MLBr_00130 |
| M. marinum M | MMAR_3170 | - | 5e-10 | 27.22% (158) | methyltransferase |
| M. avium 104 | MAV_4539 | - | 1e-07 | 26.92% (156) | methyltransferase small domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0393 | - | 1e-12 | 31.06% (161) | Fmt protein |
| M. thermoresistible (build 8) | TH_1636 | - | 5e-10 | 29.03% (155) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_2377 | - | 2e-10 | 27.22% (158) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2319 | - | 1e-09 | 30.73% (179) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0393|M.smegmatis_MC2_155 --------------------------------------------------
TH_1636|M.thermoresistible__bu --------------------------------------------------
MMAR_3170|M.marinum_M --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
Rv1523|M.tuberculosis_H37Rv MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
Mflv_4035|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2319|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0018c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4539|M.avium_104 --------------------------------------------------
MSMEG_0393|M.smegmatis_MC2_155 ----------------------------MEARDRVAWRL------NIKVA
TH_1636|M.thermoresistible__bu ---------------------------VRESRDQVFRKL------NEKLT
MMAR_3170|M.marinum_M -------------------------MAFSPAHRLLARMG------STSIY
MUL_2377|M.ulcerans_Agy99 -------------------------MAFSPAHRLLARLG------STSIY
MLBr_00130|M.leprae_Br4923 -------------------------MAFTRIHSFLASAG------NTSMY
Mb1550|M.bovis_AF2122/97 IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
Rv1523|M.tuberculosis_H37Rv IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
Mflv_4035|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2319|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0018c|M.abscessus_ATCC_199 -------------MTTLTSDFTDESTGERLRRWADEWRRMAAVAVSSADG
MAV_4539|M.avium_104 ------------------MHDHRGEYGVDGSFHTVSARAQAIGIGAQAAG
MSMEG_0393|M.smegmatis_MC2_155 QQAQKLVYRYATRRLKDDDVVFLNYGYEEDPPMGIPLSESDELNRYSIQL
TH_1636|M.thermoresistible__bu QHGQKFIYSYASRRLDDDDVVFLNYGYEEDPPMGLPLSETDEPNRYSIQL
MMAR_3170|M.marinum_M KRVWRYWYPLMTRGLGADKIAFLNWAYEEDPPIDLTLEVSDEPNRDHINM
MUL_2377|M.ulcerans_Agy99 KRVWRYWYPLMTRGLGADKIAFLNWAYEEDPPIDLTLEVSDEPNRDHINM
MLBr_00130|M.leprae_Br4923 KRVWRFWYPLMTHKLGTDEIMFINWAYEEDPPMALPLEASDEPNRAHINL
Mb1550|M.bovis_AF2122/97 KLTTKYFLPLGTRQVG-DHVVFFNFGYEEDPPMALPLSESDEPNRYCIQL
Rv1523|M.tuberculosis_H37Rv KLTTKYFLPLGTRQVG-DHVVFFNFGYEEDPPMALPLSESDEPNRYCIQL
Mflv_4035|M.gilvum_PYR-GCK -------MDGSERPVNHHGDHPGFSGLTGQLCAVAFLLTGRETGRLAADL
Mvan_2319|M.vanbaalenii_PYR-1 ---------------------------------MLFLLAGRRTAGLAAAL
MAB_0018c|M.abscessus_ATCC_199 PKTGMVYDIVGPQNLFGEESLFINFGYWRDHPTTLDEAS-RDLARLVASS
MAV_4539|M.avium_104 LAVWAGISWARGKRRRAALAALSSAGIAANTALYIYATRAGKFVVWDRIL
MSMEG_0393|M.smegmatis_MC2_155 YHSTAAQADVEGKRVLEVGCGHGGGASYLARTFRPATYTGLDLNSDGINF
TH_1636|M.thermoresistible__bu YHRTAGQADLTGKRVLEVGCGHGGGASYLMRTLGPMSYVGLDLNPAGIEF
MMAR_3170|M.marinum_M YHRTATHVELSGKRVLEVSCGHGGGASYLTRTLHPASYTGLDLNRAGIKL
MUL_2377|M.ulcerans_Agy99 YHRTATHVELSGKRVLEVSCGHGGGASYLTRTLHPASYTGLDLNRAGIKL
MLBr_00130|M.leprae_Br4923 YHRTATQVNLSGKRILEVSCGHGGGASYLTRALHPASYTGLDLNPAGIKL
Mb1550|M.bovis_AF2122/97 YHQTASQVDLTGKEVLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDL
Rv1523|M.tuberculosis_H37Rv YHQTASQVDLTGKEVLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDL
Mflv_4035|M.gilvum_PYR-GCK TAVSAT------DHVLDIGCGPGNACRIAAARG--ARVTGVDPSAAMLRV
Mvan_2319|M.vanbaalenii_PYR-1 TEVTAS------DHVVDIGCGPGNGARIAAQRG--ARVTGVDPSRSMLRV
MAB_0018c|M.abscessus_ATCC_199 AGFTAS------DVVVDCGCGYGDQDILWANEFKVKKITGVNIAEEQIAI
MAV_4539|M.avium_104 SDLRLAG----DETLLDLGCGRGAVLLAAAKRLPRGRAIGVDLWQADQTD
. ::: .** * *::
MSMEG_0393|M.smegmatis_MC2_155 CR---------RRHNIAGLEFVQGDAQDLPFPDKNFDAVLNVESSHLYPR
TH_1636|M.thermoresistible__bu CR---------KKHRLPGLEFVVGDAQDLPFGAESFDAVINIESSHLYPR
MMAR_3170|M.marinum_M CQ---------RRHNLPGLDFVRGDAENLPFEDESFDVVLNVEASHCYPH
MUL_2377|M.ulcerans_Agy99 CQ---------RRHNLPGLDFVRGDAENLPFEDESFDVVLKVEASHCYPH
MLBr_00130|M.leprae_Br4923 CQ---------KRHQLPGLEFVRGDAENLPFDNESFDVVINIEASHCYPH
Mb1550|M.bovis_AF2122/97 CR---------AKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPD
Rv1523|M.tuberculosis_H37Rv CR---------AKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPD
Mflv_4035|M.gilvum_PYR-GCK ARI--------VTHG-ASVTWVRGGAEALPVPDAGATVAWALATVHHWPD
Mvan_2319|M.vanbaalenii_PYR-1 ARA--------VTRGRPAITWAEGTAEALPVPDASATVVWALATVHHWRD
MAB_0018c|M.abscessus_ATCC_199 STERV-----AEAGLSDTISYVKASATDLPFENESCTKVVALESAFHFPS
MAV_4539|M.avium_104 NSEQATLANAAAEGVADRVELHTADMTALPLADESVDVVVSNLAIHNIPT
: . **. . . : .
MSMEG_0393|M.smegmatis_MC2_155 FD---VFLTEVARVLRPGGYFLYTDARPRYDIPEWERALADAPLQMLSQR
TH_1636|M.thermoresistible__bu FS---RFLSEVARVLRPGGHFLYADARQPHEFAEWEAALAAAPLDMVSAR
MMAR_3170|M.marinum_M FS---RFLAEVVRVLRPGGYLLYTDLRPSNEIAEWEADLAGSPLRQLSQR
MUL_2377|M.ulcerans_Agy99 FS---RFLAEVVRVLRPGGYLLYTDLRPSNEIAEWEADLAGSPLRQLSQR
MLBr_00130|M.leprae_Br4923 FP---RFLAEVVRVLRPGGHLAYADLRPSNKVGEWEVDFANSRLQQLSQR
Mb1550|M.bovis_AF2122/97 FR---GFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQR
Rv1523|M.tuberculosis_H37Rv FR---GFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQR
Mflv_4035|M.gilvum_PYR-GCK VD---AGLAEIHRALGPGARFLAVER---------QTEPDATGISSHGWT
Mvan_2319|M.vanbaalenii_PYR-1 VG---AGLSEIHRVLVPGGRLLAVER---------QVAPDATGFASHGWT
MAB_0018c|M.abscessus_ATCC_199 RI---DFFREALRVLKPGGRMVTADIVPRR---TALTAFARSQVARRGWQ
MAV_4539|M.avium_104 RAGRRQALHEAVRVLRPGGRLAIADL--------WETRQHAARLRELGWR
: * *.* **. : .: : . .
MSMEG_0393|M.smegmatis_MC2_155 AINFEVVRGMEKNLDALESVVDRVAPALLRDWIQKYG-PARRAYEELR-E
TH_1636|M.thermoresistible__bu VINAEVVRGMEQILPVWEDVIERVAPAFLRRRVREFA-PARRAWEELRTE
MMAR_3170|M.marinum_M EINAEVVRGIEKNSHTSRVLVDRNLPAFLRFADR----AVGRQLSRYLEG
MUL_2377|M.ulcerans_Agy99 EINAEVVRGIEKNSHTSRVLVDRNLPAFLRFADR----AVGRQLSRYLEG
MLBr_00130|M.leprae_Br4923 EINAEVLRGIASNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEG
Mb1550|M.bovis_AF2122/97 DIGAQAKRGLDANTARSQEAIGRRAPVLLAGLTR---CAVRVLDWDLRRG
Rv1523|M.tuberculosis_H37Rv DIGAQAKRGLDANTARSQEAIGRRAPVLLAGLTR---CAVRVLDWDLRRG
Mflv_4035|M.gilvum_PYR-GCK GAQAETFAAMCESAGLTTVRVG-----------------------SGRAG
Mvan_2319|M.vanbaalenii_PYR-1 GQQAETFAALCVTAGLADAKVN-----------------------ADRAG
MAB_0018c|M.abscessus_ATCC_199 GAPANAVPWAVDVQGYRDLLLDMGFARSETWSIANDVYPPLSKFLGKRLR
MAV_4539|M.avium_104 NVRRRNLGWRMWYG-----------------------------------G
.
MSMEG_0393|M.smegmatis_MC2_155 NTTEYRMYCFVKPAE----------------------
TH_1636|M.thermoresistible__bu GSTEYRMYCFTKPPEHADIP-----------------
MMAR_3170|M.marinum_M GELSYRMYCFTKDFAASR-------------------
MUL_2377|M.ulcerans_Agy99 GELSYRMYCFTKDFAASR-------------------
MLBr_00130|M.leprae_Br4923 GELSYRMYSFAKD------------------------
Mb1550|M.bovis_AF2122/97 GGFSYRIYLFAKD------------------------
Rv1523|M.tuberculosis_H37Rv GGFSYRIYLFAKD------------------------
Mflv_4035|M.gilvum_PYR-GCK KRRVWTVHATRP-------------------------
Mvan_2319|M.vanbaalenii_PYR-1 RREVWTVHAVRP-------------------------
MAB_0018c|M.abscessus_ATCC_199 QPDMKHVNPLLRAQFNSVGMRLFSLHSDYIVAVAHKA
MAV_4539|M.avium_104 PWFSTRIVTATKPE-----------------------
: