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HDHRGEYGVDGSFHTVSARAQAIGIGAQAAGLAVWAGISWARGKRRRAALAALSSAGIAANTALYIYATR AGKFVVWDRILSDLRLAGDETLLDLGCGRGAVLLAAAKRLPRGRAIGVDLWQADQTDNSEQATLANAAAE GVADRVELHTADMTALPLADESVDVVVSNLAIHNIPTRAGRRQALHEAVRVLRPGGRLAIADLWETRQHA ARLRELGWRNVRRRNLGWRMWYGGPWFSTRIVTATKPE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4539 | - | - | 100% (249) | methyltransferase small domain-containing protein |
| M. avium 104 | MAV_5229 | - | 4e-11 | 30.29% (175) | methyltransferase type 11 |
| M. avium 104 | MAV_0854 | - | 3e-08 | 31.29% (147) | methyltransferase-UbiE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3064c | - | 5e-08 | 28.74% (167) | hypothetical protein Mb3064c |
| M. gilvum PYR-GCK | Mflv_0738 | - | 1e-09 | 37.60% (125) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3038c | - | 5e-08 | 28.74% (167) | hypothetical protein Rv3038c |
| M. leprae Br4923 | MLBr_00130 | - | 1e-07 | 29.87% (154) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_0018c | - | 7e-08 | 24.68% (154) | putative methyltransferase |
| M. marinum M | MMAR_1062 | - | 1e-09 | 30.65% (124) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 3e-09 | 37.82% (119) | methyltransferase |
| M. thermoresistible (build 8) | TH_2193 | - | 2e-07 | 34.88% (129) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0820 | - | 5e-10 | 30.65% (124) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5517 | - | 4e-13 | 34.85% (132) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0738|M.gilvum_PYR-GCK -------MTESALRMAERLLADPPEHPDVSKGYLDLLG--DRPAG-DAGA
MSMEG_0098|M.smegmatis_MC2_155 --------MDTALRRAMDLLIDPPAEPDFSKGYLDLLGRGDSTAPKNTGL
Mb3064c|M.bovis_AF2122/97 ------------MTRSSNIPADATPNPHATAEQVAAARHDSKLAQVLYHD
Rv3038c|M.tuberculosis_H37Rv ------------MTRSSNIPADATPNPHATAEQVAAARHDSKLAQVLYHD
MMAR_1062|M.marinum_M --------------MTNHHPRFGLQHSGESRDYLPAAG------------
MUL_0820|M.ulcerans_Agy99 --------------MTNHHPRFGLQHSGESRDYLPAAG------------
Mvan_5517|M.vanbaalenii_PYR-1 --------MVSMDHMTENPPHPVARTWGNRHDYLPAAG------------
MAV_4539|M.avium_104 MHDHRGEYGVDGSFHTVSARAQAIGIGAQAAGLAVWAGISWARGKRRRAA
MLBr_00130|M.leprae_Br4923 --------MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFI
MAB_0018c|M.abscessus_ATCC_199 -------MTTLTSDFTDESTGERLRRWADEWRRMAAVAVSSADGPKTGMV
TH_2193|M.thermoresistible__bu ----------------MSAFSTAGSDADGPISVLPLTG------------
Mflv_0738|M.gilvum_PYR-GCK IQALWASRLGSLF---------YDNAQTVMRRVLTAWHEPTEWLNLPVGG
MSMEG_0098|M.smegmatis_MC2_155 IQKAWASPLGSKL---------YDRAQLLNRRLVASTRPPVEWLRIPPGG
Mb3064c|M.bovis_AF2122/97 WEAENYDEKWSIS---------YDQRCVDYARGRFDAIVPDEVIAQLPYD
Rv3038c|M.tuberculosis_H37Rv WEAENYDEKWSIS---------YDQRCVDYARGRFDAIVPDEVIAQLPYD
MMAR_1062|M.marinum_M ------HDALLPA---------YDLLSRLLG-MNKIHRTLITQAELADCG
MUL_0820|M.ulcerans_Agy99 ------HDALLPA---------YDLLSRLLG-MNKIHRTLITQAELADCG
Mvan_5517|M.vanbaalenii_PYR-1 ------RDFFLPA---------YDLLVRLLG-TYPLYDELVTQAELAGEL
MAV_4539|M.avium_104 LAALSSAGIAANT---------ALYIYATRAGKFVVWDRILSDLRLAGDE
MLBr_00130|M.leprae_Br4923 NWAYEEDPPMALP---------LEASDEPNRAHINLYHRTATQVNLSG-K
MAB_0018c|M.abscessus_ATCC_199 YDIVGPQNLFGEESLFINFGYWRDHPTTLDEASRDLARLVASSAGFTASD
TH_2193|M.thermoresistible__bu -------ERTVPG---------LERENYWFRRHEVVYQRLAHR---CAGR
Mflv_0738|M.gilvum_PYR-GCK VALDVGSGPGNVTAALGRA-VGPGGLALGV-------DVSEPMLARAVAA
MSMEG_0098|M.smegmatis_MC2_155 TVLDIGCGPGNITAQLARA-AGLDGLALGV-------DISEPMLARAVAA
Mb3064c|M.bovis_AF2122/97 RALELGCGTGFFLLNLIQAGVARRGSVTDL-------SPGMVKVATRNGQ
Rv3038c|M.tuberculosis_H37Rv RALELGCGTGFFLLNLIQAGVARRGSVTDL-------SPGMVKVATRNGQ
MMAR_1062|M.marinum_M RILEIGCGTGNLAIKAKRAQPRAEVIGSDP-------DPRALQRAQRKTG
MUL_0820|M.ulcerans_Agy99 RILEIGCGTGNLAIKAKRAQPRAEVIGSDP-------DPRALQRAQRKTG
Mvan_5517|M.vanbaalenii_PYR-1 DVLEIGCGTGNLTARALRAAPSARITATDP-------DPRAVTRARRKAA
MAV_4539|M.avium_104 TLLDLGCGRGAVLLAAAKRLPRGRAIGVDLWQADQTDNSEQATLANAAAE
MLBr_00130|M.leprae_Br4923 RILEVSCGHGGGASYLTRALHPASYTGLDL-------NPAGIKLCQKR--
MAB_0018c|M.abscessus_ATCC_199 VVVDCGCGYGDQDILWANEFKVKKITGVNIA-----EEQIAISTERVAEA
TH_2193|M.thermoresistible__bu VVLEAGCGEGYGADLLAEVAAHVIGLDYDA-------------ATVAHVR
:: ..* * . .
Mflv_0738|M.gilvum_PYR-GCK EAGPNVGFLRADAQDLPLSDESVDGVVSIAMLQLIPE---PARAVAEMVR
MSMEG_0098|M.smegmatis_MC2_155 EAGRQVGFVRADAQQLPFRDEVFDAATSLAVFQLIPD---PVAAVSEIVR
Mb3064c|M.bovis_AF2122/97 ALGLDIDGRVADAEGIPYDDDAFDLVVGHAVLHHIPD---VELSLREVVR
Rv3038c|M.tuberculosis_H37Rv ALGLDIDGRVADAEGIPYDDDAFDLVVGHAVLHHIPD---VELSLREVVR
MMAR_1062|M.marinum_M NVEG-VRFDQGYAQRLPYADGEFDRVLSSMMLHHLDEDA-KSAAAAEAFR
MUL_0820|M.ulcerans_Agy99 NVEE-VRFDQGYAQRLPYADGEFDRVLSSMMLHHLDEDA-KSAAAAEAFR
Mvan_5517|M.vanbaalenii_PYR-1 GEGP-VRFETAYAQELPFADASFDRVLSSLMLHHLDDGT-KVSALAEAWR
MAV_4539|M.avium_104 GVADRVELHTADMTALPLADESVDVVVSNLAIHNIPTRAGRRQALHEAVR
MLBr_00130|M.leprae_Br4923 HQLPGLEFVRGDAENLPFDNESFDVVINIEASHCYPHFP---RFLAEVVR
MAB_0018c|M.abscessus_ATCC_199 GLSDTISYVKASATDLPFENESCTKVVALESAFHFPS---RIDFFREALR
TH_2193|M.thermoresistible__bu ARYPRVDIRHGNLVDLPLADASVDVVVNFQVIEHLWD---QEKFIAECLR
: . :* : . * *
Mflv_0738|M.gilvum_PYR-GCK VLRSGRRVAVMVPTAGP---------------------------------
MSMEG_0098|M.smegmatis_MC2_155 VLKPGGRVAIMVPTAG----------------------------------
Mb3064c|M.bovis_AF2122/97 VLKPGGRFVFAGEPTTVGDGYARTLSTLTWRVVTNATKLPGLRGWRRPQG
Rv3038c|M.tuberculosis_H37Rv VLKPGGRFVFAGEPTTVGDGYARTLSTLTWRVVTNATKLPGLRGWRRPQG
MMAR_1062|M.marinum_M VLRPGGRLHLVDVGGDMSAHD-----------------------------
MUL_0820|M.ulcerans_Agy99 VLRPGGRLHLVDVGGDMSAHD-----------------------------
Mvan_5517|M.vanbaalenii_PYR-1 VLRPGGRLHIVDVGG-ADQPE-----------------------------
MAV_4539|M.avium_104 VLRPGGRLAIADLWETR---------------------------------
MLBr_00130|M.leprae_Br4923 VLRPGGHLAYADLRPSNKVGEWEVDFAN-------------SRLQQLSQR
MAB_0018c|M.abscessus_ATCC_199 VLKPGGRMVTADIVPRRTALTAFAR-------------------------
TH_2193|M.thermoresistible__bu VLRPGGQLLVSTPNRITFTPGSDTPVN----------------------P
**:.* :.
Mflv_0738|M.gilvum_PYR-GCK ----AAAALRYLPHAGAHSFGDDELADVFEGLGLTSVRANTVGTIQWVRG
MSMEG_0098|M.smegmatis_MC2_155 ----AVKPVTFLARGGARIFGDDELGDIFENVGLVGVRVKTHGFIQWVRG
Mb3064c|M.bovis_AF2122/97 ELDESSRAAALEALVDLHTFTPQDLQRIAHNAGAVEVQTATEEFTAAMLG
Rv3038c|M.tuberculosis_H37Rv ELDESSRAAALEALVDLHTFTPQDLQRIAHNAGAVEVQTATEEFTAAMLG
MMAR_1062|M.marinum_M ----GLASRFIRHNLHVAGNLGDGIRRLLDTAGFDVAEVGAQRHPLLGRL
MUL_0820|M.ulcerans_Agy99 ----GLASRFIRHNLHVAGNLGDGIRRLLDTAGFDVAEVGAQRHPLLGRL
Mvan_5517|M.vanbaalenii_PYR-1 ----GLMSRLTGHRHAAAG---ARLPQLVEAAGFDTTVVATRRLRVFGPV
MAV_4539|M.avium_104 -----QHAARLRELGWRNVRRRNLGWRMWYGGPWFSTRIVTATKPE----
MLBr_00130|M.leprae_Br4923 EINAEVLRGIASNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEG
MAB_0018c|M.abscessus_ATCC_199 SQVARRGWQGAPANAVPWAVDVQGYRDLLLDMGFARSETWSIANDVYPPL
TH_2193|M.thermoresistible__bu FHTRELNAAELTELLTDGGFGLSAMYGVFHGPRLAELDARHGGSIIDAQI
.
Mflv_0738|M.gilvum_PYR-GCK KKP-----------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 TKL-----------------------------------------------
Mb3064c|M.bovis_AF2122/97 WPLRTFECTVPPGRLGWGWARFAFTSWKTLGWVDANVWRHVVPKGWFYNV
Rv3038c|M.tuberculosis_H37Rv WPLRTFECTVPPGRLGWGWARFAFTSWKTLGWVDANVWRHVVPKGWFYNV
MMAR_1062|M.marinum_M VYYRATRPCA----------------------------------------
MUL_0820|M.ulcerans_Agy99 VYYRATRPCA----------------------------------------
Mvan_5517|M.vanbaalenii_PYR-1 SFIRATRPGE----------------------------------------
MAV_4539|M.avium_104 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 GELSYRMYSFAKD-------------------------------------
MAB_0018c|M.abscessus_ATCC_199 SKFLGKRLRQPDMKHVNPLLRAQFNSVGMRLFSLHSDYIVAVAHKA----
TH_2193|M.thermoresistible__bu SRALADEPWPAELLADVASVRTEDFDLIRCDEDDRDRDGHNIDDSLDLVA
Mflv_0738|M.gilvum_PYR-GCK --------
MSMEG_0098|M.smegmatis_MC2_155 --------
Mb3064c|M.bovis_AF2122/97 MITGVKPS
Rv3038c|M.tuberculosis_H37Rv MITGVKPS
MMAR_1062|M.marinum_M --------
MUL_0820|M.ulcerans_Agy99 --------
Mvan_5517|M.vanbaalenii_PYR-1 --------
MAV_4539|M.avium_104 --------
MLBr_00130|M.leprae_Br4923 --------
MAB_0018c|M.abscessus_ATCC_199 --------
TH_2193|M.thermoresistible__bu IAVRP---