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AFSPAHRLLARLGSTSIYKRVWRYWYPLMTRGLGADKIAFLNWAYEEDPPIDLTLEVSDEPNRDHINMYH RTATHVELSGKRVLEVSCGHGGGASYLTRTLHPASYTGLDLNRAGIKLCQRRHNLPGLDFVRGDAENLPF EDESFDVVLKVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDLRPSNEIAEWEADLAGSPLRQLSQREINA EVVRGIEKNSHTSRVLVDRNLPAFLRFADRAVGRQLSRYLEGGELSYRMYCFTKDFAASR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2377 | - | - | 100% (271) | methyltransferase |
| M. ulcerans Agy99 | MUL_2009 | - | e-102 | 71.37% (241) | methyltransferase |
| M. ulcerans Agy99 | MUL_4668 | - | 4e-12 | 38.89% (108) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2976 | - | 1e-130 | 82.22% (270) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4060 | - | 2e-09 | 37.62% (101) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2952 | - | 1e-130 | 82.22% (270) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_00130 | - | 1e-121 | 76.30% (270) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_4103c | - | 1e-74 | 55.82% (249) | methyltransferase |
| M. marinum M | MMAR_3170 | - | 1e-159 | 99.26% (271) | methyltransferase |
| M. avium 104 | MAV_3903 | - | 2e-09 | 35.24% (105) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_0393 | - | 3e-75 | 57.26% (248) | Fmt protein |
| M. thermoresistible (build 8) | TH_1636 | - | 9e-75 | 56.33% (245) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | 3e-11 | 37.50% (96) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2377|M.ulcerans_Agy99 MAFSPAHRLLARLGSTSIYKRVWRYWYPLMTRGLGADK-IAFLNWAYEED
MMAR_3170|M.marinum_M MAFSPAHRLLARMGSTSIYKRVWRYWYPLMTRGLGADK-IAFLNWAYEED
Mb2976|M.bovis_AF2122/97 MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDE-IVFINWAYEED
Rv2952|M.tuberculosis_H37Rv MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDE-IVFINWAYEED
MLBr_00130|M.leprae_Br4923 MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDE-IMFINWAYEED
MSMEG_0393|M.smegmatis_MC2_155 ---MEARDRVAWRLNIKVAQQAQKLVYRYATRRLKDDD-VVFLNYGYEED
TH_1636|M.thermoresistible__bu --VRESRDQVFRKLNEKLTQHGQKFIYSYASRRLDDDD-VVFLNYGYEED
MAB_4103c|M.abscessus_ATCC_199 --MQRSRDWVMFKLNAVFTQRVQKFIYRHATRKLETED-VVFLNYGYEEE
Mvan_0109|M.vanbaalenii_PYR-1 MTHTVLRMTERLLIDPPEHPDTSKGYLDLLGDEPDSNRGAIQALWASRLG
Mflv_4060|M.gilvum_PYR-GCK ---------------MATVDNEDDRALKAKHRALWASG------------
MAV_3903|M.avium_104 ----MTRSTDAVPTPHATAEQVEAARHDSKLAQVLYHD---WEAETYDEK
MUL_2377|M.ulcerans_Agy99 PPIDLTLEVSDEPNRDHINMYHRTATHVELS-GKRVLEVSCGHGGGASYL
MMAR_3170|M.marinum_M PPIDLTLEVSDEPNRDHINMYHRTATHVELS-GKRVLEVSCGHGGGASYL
Mb2976|M.bovis_AF2122/97 PPMDLPLEASDEPNRAHINLYHRTATQVDLG-GKQVLEVSCGHGGGASYL
Rv2952|M.tuberculosis_H37Rv PPMDLPLEASDEPNRAHINLYHRTATQVDLG-GKQVLEVSCGHGGGASYL
MLBr_00130|M.leprae_Br4923 PPMALPLEASDEPNRAHINLYHRTATQVNLS-GKRILEVSCGHGGGASYL
MSMEG_0393|M.smegmatis_MC2_155 PPMGIPLSESDELNRYSIQLYHSTAAQADVE-GKRVLEVGCGHGGGASYL
TH_1636|M.thermoresistible__bu PPMGLPLSETDEPNRYSIQLYHRTAGQADLT-GKRVLEVGCGHGGGASYL
MAB_4103c|M.abscessus_ATCC_199 PAMGVPLSASDEPDRYSIQLYHSTATQADLG-GQRVLEVGCGHGGGASYL
Mvan_0109|M.vanbaalenii_PYR-1 ---SMFYDNAQTLARRLMTAWQQPTEWLNVPVGGTALDVGSGPGNVTGAL
Mflv_4060|M.gilvum_PYR-GCK -------DYPAVAAELIPSLGPELVRACGVRSGDRVLDVAAGSGN-ASIP
MAV_3903|M.avium_104 WSISYDQRCIDYARGRFDAIVPEHVLRELPY--DRALELGCGTGFFLLNL
. *::..* *
MUL_2377|M.ulcerans_Agy99 TRT-LHP-ASYTGLDLNRAGIKLCQRRHNLPGLDFVRGDAENLPFEDESF
MMAR_3170|M.marinum_M TRT-LHP-ASYTGLDLNRAGIKLCQRRHNLPGLDFVRGDAENLPFEDESF
Mb2976|M.bovis_AF2122/97 TRT-LHP-ASYTGLDLNQAGIKLCKKRHRLPGLDFVRGDAENLPFDDESF
Rv2952|M.tuberculosis_H37Rv TRT-LHP-ASYTGLDLNQAGIKLCKKRHRLPGLDFVRGDAENLPFDDESF
MLBr_00130|M.leprae_Br4923 TRA-LHP-ASYTGLDLNPAGIKLCQKRHQLPGLEFVRGDAENLPFDNESF
MSMEG_0393|M.smegmatis_MC2_155 ART-FRP-ATYTGLDLNSDGINFCRRRHNIAGLEFVQGDAQDLPFPDKNF
TH_1636|M.thermoresistible__bu MRT-LGP-MSYVGLDLNPAGIEFCRKKHRLPGLEFVVGDAQDLPFGAESF
MAB_4103c|M.abscessus_ATCC_199 VRA-LQP-ASYTGLDLNPDGISFCRRRHDLPGLEFVQGDAEDLPFPDESF
Mvan_0109|M.vanbaalenii_PYR-1 GRA-VGPGGLALGVDISEPMLARAVRAEAGPNVGFIRADAQHLPFRDESF
Mflv_4060|M.gilvum_PYR-GCK AAA-AGAVVTASDLTPELFDAGRRIAAERGVAVEWVEADAEALPFPDDSF
MAV_3903|M.avium_104 IQSGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYEDDTF
: .: : .**: :*: ..*
MUL_2377|M.ulcerans_Agy99 DVVLKVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDLRPS----------
MMAR_3170|M.marinum_M DVVLNVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDLRPS----------
Mb2976|M.bovis_AF2122/97 DVVLNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRPN----------
Rv2952|M.tuberculosis_H37Rv DVVLNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRPN----------
MLBr_00130|M.leprae_Br4923 DVVINIEASHCYPHFPRFLAEVVRVLRPGGHLAYADLRPS----------
MSMEG_0393|M.smegmatis_MC2_155 DAVLNVESSHLYPRFDVFLTEVARVLRPGGYFLYTDARPR----------
TH_1636|M.thermoresistible__bu DAVINIESSHLYPRFSRFLSEVARVLRPGGHFLYADARQP----------
MAB_4103c|M.abscessus_ATCC_199 DAVINVESSHLYPHFPVFLTEVARVLRPGGNFLYTDARSV----------
Mvan_0109|M.vanbaalenii_PYR-1 DAVVSIAMLQLIPDPAVALAEMVRVLRPGRRMAVMVP-------------
Mflv_4060|M.gilvum_PYR-GCK DVVMSCVGAMFAPHHQATADEIVRVTRPGGTLGLISWTPEGFIGHLFATM
MAV_3903|M.avium_104 DLVVGHAVLHHIPDVELSLREVIRVLRPGGRFVFAGEPTSAG--DVYARE
* *: * *: ** *** :
MUL_2377|M.ulcerans_Agy99 NEIAEWEADLAGSPLRQL-SQREINAEVVRGIEKNSHTSRVLVDRNLPAF
MMAR_3170|M.marinum_M NEIAEWEADLAGSPLRQL-SQREINAEVVRGIEKNSHTSRVLVDRNLPAF
Mb2976|M.bovis_AF2122/97 NEIAAWEADLAATPLRQL-SQRQINAEVLRGIGNNSQKSRDLVDRHLPAF
Rv2952|M.tuberculosis_H37Rv NEIAAWEADLAATPLRQL-SQRQINAEVLRGIGNNSQKSRDLVDRHLPAF
MLBr_00130|M.leprae_Br4923 NKVGEWEVDFANSRLQQL-SQREINAEVLRGIASNSQKSRDLVDRHLPAF
MSMEG_0393|M.smegmatis_MC2_155 YDIPEWERALADAPLQML-SQRAINFEVVRGMEKNLDALESVVDRVAPAL
TH_1636|M.thermoresistible__bu HEFAEWEAALAAAPLDMV-SARVINAEVVRGMEQILPVWEDVIERVAPAF
MAB_4103c|M.abscessus_ATCC_199 QDVAGWKVALANAPLRMV-SERGINAEVRRGMEKNLARWRYVIDRATPAP
Mvan_0109|M.vanbaalenii_PYR-1 ------TAGPAAGLLRYL-PNAGAHAFGDDELGDTFES------------
Mflv_4060|M.gilvum_PYR-GCK KPYAPPPPPGASPPPMWG-SENHVEALFGDRVRDLTMRRQTVRFDHCASP
MAV_3903|M.avium_104 LSTLTWRIATNVTKLPGLGSWRRPQAELDESSRAAALEAIVDLHTFTPGD
. .
MUL_2377|M.ulcerans_Agy99 LRFADR----------AVGRQLSRYLEGGELSYRMYCFTKDFAASR----
MMAR_3170|M.marinum_M LRFADR----------AVGRQLSRYLEGGELSYRMYCFTKDFAASR----
Mb2976|M.bovis_AF2122/97 LRFAGREFI------GVQGTQLSRYLEGGELSYRMYCFTKD---------
Rv2952|M.tuberculosis_H37Rv LRFAGREFI------GVQGTQLSRYLEGGELSYRMYCFTKD---------
MLBr_00130|M.leprae_Br4923 LRFAGREFI------GVQGTQLSRYLEGGELSYRMYSFAKD---------
MSMEG_0393|M.smegmatis_MC2_155 LRDWIQKY-------GPARRAYEELR-ENTTEYRMYCFVKPAE-------
TH_1636|M.thermoresistible__bu LRRRVREF-------APARRAWEELRTEGSTEYRMYCFTKPPEHADIP--
MAB_4103c|M.abscessus_ATCC_199 LRGIVRRF-------APAQRAYDDLRAGGSVEYRMYRFVKA---------
Mvan_0109|M.vanbaalenii_PYR-1 -----------------LGLAGVRINTVGTIQWVRGRKS-----------
Mflv_4060|M.gilvum_PYR-GCK LDFREYWKRNYGPTLAAYRFNEDRPERLAELDAAFLDFLTTWNQADGTDG
MAV_3903|M.avium_104 LERMAANAG------ATEVRTVSEEFTAAMFGWPVRTFEASVPPGRLGWG
MUL_2377|M.ulcerans_Agy99 ----------------------------------------
MMAR_3170|M.marinum_M ----------------------------------------
Mb2976|M.bovis_AF2122/97 ----------------------------------------
Rv2952|M.tuberculosis_H37Rv ----------------------------------------
MLBr_00130|M.leprae_Br4923 ----------------------------------------
MSMEG_0393|M.smegmatis_MC2_155 ----------------------------------------
TH_1636|M.thermoresistible__bu ----------------------------------------
MAB_4103c|M.abscessus_ATCC_199 ----------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 ----------------------------------------
Mflv_4060|M.gilvum_PYR-GCK TAYDAEYLLVTATKR-------------------------
MAV_3903|M.avium_104 WAKFAFNGWKTLSWVDANIWRRVVPKGWFYNVMVTGVKPT