For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PAIAQRRSLNELVTRYWTLMSRVYNFPLVQRHIYSPAQTDTIAQLCEHDARRVADIACGTGILASRIRAE LHQATVFGVDMSDGMLAKARARCAQVQWRKAPAEQLPFADSSLDAVVTTSAFHFFDQPAALAEFYRVLVP GGMASVATICPRERRWARNRTGERGPAHFPTATEMERLFAGAGFEVVVHRPVARPVTPPLVSVDWICVGL KT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1390c | - | - | 100% (213) | putative UbiE/COQ5 methyltransferase |
| M. abscessus ATCC 19977 | MAB_4613 | - | 1e-58 | 52.80% (214) | similarity with UbiE/COQ5 methyltransferase |
| M. abscessus ATCC 19977 | MAB_4018 | - | 2e-09 | 33.62% (116) | similarity with UbiE/COQ5 methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3756 | - | 8e-12 | 39.81% (108) | transferase |
| M. gilvum PYR-GCK | Mflv_4877 | - | 3e-09 | 35.09% (114) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3729 | - | 8e-12 | 39.81% (108) | transferase |
| M. leprae Br4923 | MLBr_00130 | - | 1e-10 | 32.71% (107) | hypothetical protein MLBr_00130 |
| M. marinum M | MMAR_3533 | - | 1e-53 | 49.76% (207) | methyltransferase (methylase) |
| M. avium 104 | MAV_2111 | - | 1e-55 | 51.69% (207) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 3e-11 | 42.86% (98) | methyltransferase |
| M. thermoresistible (build 8) | TH_1968 | - | 1e-09 | 32.58% (132) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_2765 | - | 5e-53 | 49.28% (207) | methyltransferase (methylase) |
| M. vanbaalenii PYR-1 | Mvan_5517 | - | 1e-11 | 31.25% (144) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4877|M.gilvum_PYR-GCK --------------------------------------------------
TH_1968|M.thermoresistible__bu --------------------------------------------------
MMAR_3533|M.marinum_M --------------------------------------------------
MUL_2765|M.ulcerans_Agy99 --------------------------------------------------
MAV_2111|M.avium_104 --------------------------------------------------
MAB_1390c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 MFVEYTKSICPVCKVVVDAQVNIRHDKVYLRKRCREHGSFEALVYGDAQM
Rv3729|M.tuberculosis_H37Rv MFVEYTKSICPVCKVVVDAQVNIRHDKVYLRKRCREHGSFEALVYGDAQM
Mvan_5517|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
Mflv_4877|M.gilvum_PYR-GCK --------------------------------------------------
TH_1968|M.thermoresistible__bu --------------------------------------------------
MMAR_3533|M.marinum_M --------------------------------------------------
MUL_2765|M.ulcerans_Agy99 --------------------------------------------------
MAV_2111|M.avium_104 --------------------------------------------------
MAB_1390c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 YLESARFNKPGTFPLRFQTEVRDGCPSDCGLCPDHKQHACLGLIEVNTHC
Rv3729|M.tuberculosis_H37Rv YLESARFNKPGTFPLRFQTEVRDGCPSDCGLCPDHKQHACLGLIEVNTHC
Mvan_5517|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
Mflv_4877|M.gilvum_PYR-GCK --------------------------------------------------
TH_1968|M.thermoresistible__bu --------------------------------------------------
MMAR_3533|M.marinum_M --------------------------------------------------
MUL_2765|M.ulcerans_Agy99 --------------------------------------------------
MAV_2111|M.avium_104 --------------------------------------------------
MAB_1390c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 NLDCPICFADSGHQPDGYAITAAQCERMLDTLVAAEGEPEVVMFSGGEPT
Rv3729|M.tuberculosis_H37Rv NLDCPICFADSGHQPDGYAITAAQCERMLDTLVAAEGEPEVVMFSGGEPT
Mvan_5517|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
Mflv_4877|M.gilvum_PYR-GCK --------------------------------------------------
TH_1968|M.thermoresistible__bu --------------------------------------------------
MMAR_3533|M.marinum_M --------------------------------------------------
MUL_2765|M.ulcerans_Agy99 --------------------------------------------------
MAV_2111|M.avium_104 --------------------------------------------------
MAB_1390c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 IHKQLLEFVDAAQARPVKTIIINTNGIRLASDRRFVDQLATRNRPGHPVH
Rv3729|M.tuberculosis_H37Rv IHKQLLEFVDAAQARPVKTVIINTNGIRLASDRRFVDQLATRNRPGHPVH
Mvan_5517|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
Mflv_4877|M.gilvum_PYR-GCK --------------------------------------------------
TH_1968|M.thermoresistible__bu --------------------------------------------------
MMAR_3533|M.marinum_M --------------------------------------------------
MUL_2765|M.ulcerans_Agy99 --------------------------------------------------
MAV_2111|M.avium_104 --------------------------------------------------
MAB_1390c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 IYLQFDGLDEATHRRIRGHDLRDVKQRALDNCAAAGLTVSLVAAVERGLN
Rv3729|M.tuberculosis_H37Rv IYLQFDGLDEATHRRIRGHDLRDVKQRALDNCAAAGLTVSLVAAVERGLN
Mvan_5517|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
Mflv_4877|M.gilvum_PYR-GCK --------------------------------------------------
TH_1968|M.thermoresistible__bu --------------------------------------------------
MMAR_3533|M.marinum_M --------------------------------------------------
MUL_2765|M.ulcerans_Agy99 --------------------------------------------------
MAV_2111|M.avium_104 --------------------------------------------------
MAB_1390c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 EHELGAVIRHGMAQPGVQSVVFQPVTHAGRHVQFDPLTRLTNSDIIACIT
Rv3729|M.tuberculosis_H37Rv EHELGAVIRHGMAQPGVQPVVFQPVTHAGRHVQFDPLTRLTNSDIIACIT
Mvan_5517|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
Mflv_4877|M.gilvum_PYR-GCK --------------------------------------------------
TH_1968|M.thermoresistible__bu --------------------------------------------------
MMAR_3533|M.marinum_M --------------------------------------------------
MUL_2765|M.ulcerans_Agy99 --------------------------------------------------
MAV_2111|M.avium_104 --------------------------------------------------
MAB_1390c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 AQLPEWFRPGDFFPVPCCFPSCRSITYLLTDGEHVVPIPRLLNVEDYLDY
Rv3729|M.tuberculosis_H37Rv AQLPEWFRPGDFFPVPCCFPSCRSITYLLTDGEHVVPIPRLLNVEDYLDY
Mvan_5517|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
Mflv_4877|M.gilvum_PYR-GCK --------------------------------------------------
TH_1968|M.thermoresistible__bu --------------------------------------------------
MMAR_3533|M.marinum_M --------------------------------------------------
MUL_2765|M.ulcerans_Agy99 --------------------------------------------------
MAV_2111|M.avium_104 --------------------------------------------------
MAB_1390c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 VSNRVIPDLAIREALENLWSASAVPGTDTMTAQLQRATAALNCAEGCGIN
Rv3729|M.tuberculosis_H37Rv VSNRVIPDLAIREALENLWSASAVPGTDTMTAQLQRATAALNCAEGCGIN
Mvan_5517|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
Mflv_4877|M.gilvum_PYR-GCK --------------------------------------------------
TH_1968|M.thermoresistible__bu --------------------------------------------------
MMAR_3533|M.marinum_M --------------------------------------------------
MUL_2765|M.ulcerans_Agy99 --------------------------------------------------
MAV_2111|M.avium_104 --------------------------------------------------
MAB_1390c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3756|M.bovis_AF2122/97 LPEALTHLTDRVFAIVIQDFQDPYTLNVKQLMKCCVQQITPDGRLIPFCA
Rv3729|M.tuberculosis_H37Rv LPEALTHLTDRVFAIVIQDFQDPYTLNVKQLMKCCVQQITPDGRLIPFCA
Mvan_5517|M.vanbaalenii_PYR-1 -----------------------------------MVSMDHMTENPPHPV
MSMEG_0098|M.smegmatis_MC2_155 --------------------------MDTALRRAMDLLIDPPAEPDFSKG
MLBr_00130|M.leprae_Br4923 ---------------------------------MAFTRIHSFLASAGNTS
Mflv_4877|M.gilvum_PYR-GCK MTAESDRRSLS---------------------------------------
TH_1968|M.thermoresistible__bu ---------LS---------------------------------------
MMAR_3533|M.marinum_M MTTVP-RRGFNDAVT-----------------------------------
MUL_2765|M.ulcerans_Agy99 MTTVP-RRGFNDAVT-----------------------------------
MAV_2111|M.avium_104 MTAPQ-RRGLNDVVT-----------------------------------
MAB_1390c|M.abscessus_ATCC_199 MPAIAQRRSLNELVT-----------------------------------
Mb3756|M.bovis_AF2122/97 YNSVGYREQVREQLTGVPVPDIVPNAIPLAGLLADAPHGSKQANTGGSIA
Rv3729|M.tuberculosis_H37Rv YNSVGYREQVREQLTGVPVPDIVPNAIPLAGLLADAPHGSKQANTGGSIA
Mvan_5517|M.vanbaalenii_PYR-1 ARTWGNRHDYLPAAG-----------------------------------
MSMEG_0098|M.smegmatis_MC2_155 YLDLLGRGDSTAPKN-----------------------------------
MLBr_00130|M.leprae_Br4923 MYKRVWRFWYPLMTHKLG--------------------------------
Mflv_4877|M.gilvum_PYR-GCK ------------------FGAEAAAYE------RGRPSYPPEAIDWLLAD
TH_1968|M.thermoresistible__bu ------------------FGAEAAAYE------RGRPSYPPEAIDWLLP-
MMAR_3533|M.marinum_M ----------------GIWSLLAPAYD---LAILQQWVYRPPHDEVLAQL
MUL_2765|M.ulcerans_Agy99 ----------------GIWSLLAPAYD---LAILQQWVYRPPHDEVLAQL
MAV_2111|M.avium_104 ----------------RMWSFLAPAYD---LPFLQQWVYRPPHNEVIAQL
MAB_1390c|M.abscessus_ATCC_199 ----------------RYWTLMSRVYN---FPLVQRHIYSPAQTDTIAQL
Mb3756|M.bovis_AF2122/97 RLAGPTRGAPMALPPQQIKACCADAYSRDIVALLLGDSFHPGGATLTRRL
Rv3729|M.tuberculosis_H37Rv RLAGPTRGAPMALPPQQIKACCADAYSRDIVALLLGDSFHPGGATLTRRL
Mvan_5517|M.vanbaalenii_PYR-1 ------------------RDFFLPAYD----LLVRLLGTYPLYDELVTQA
MSMEG_0098|M.smegmatis_MC2_155 ------------------TGLIQKAWASP-LGSKLYDRAQLLNRRLVAST
MLBr_00130|M.leprae_Br4923 ---------------TDEIMFINWAYEEDPPMALPLEASDEPNRAHINLY
.:
Mflv_4877|M.gilvum_PYR-GCK SGSRR-------LEVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLDLLR
TH_1968|M.thermoresistible__bu SDAR---------DVLDLGAGTGKLTTRLVERGLNVTAVDPIPEMLELLS
MMAR_3533|M.marinum_M RAHN-------SRRIADIACGTG-ILSDRIERELHPDEIYGVDMSHGMLD
MUL_2765|M.ulcerans_Agy99 RAHK-------SRRIADIACGTG-ILSARIERELHPDEIYGVDMSHGMLD
MAV_2111|M.avium_104 RNHG-------SRRIADIACGTG-ILSERIQRELNPDEIYGVDMSDGMLN
MAB_1390c|M.abscessus_ATCC_199 CEHD-------ARRVADIACGTG-ILASRIRAELHQATVFGVDMSDGMLA
Mb3756|M.bovis_AF2122/97 ADQLGLRSTGDPRRVADIAAGPG-ASARLLASDYG-VAVDGVDISEINVK
Rv3729|M.tuberculosis_H37Rv ADQLGLRSTGDPRRVADIAAGPG-ASARLLASDYG-VAVDGVDISEINVK
Mvan_5517|M.vanbaalenii_PYR-1 ELAG-------ELDVLEIGCGTG-NLTARALRAAPSARITATDPDPRAVT
MSMEG_0098|M.smegmatis_MC2_155 RPPVEWLRIPPGGTVLDIGCGPGNITAQLARAAGLDGLALGVDISEPMLA
MLBr_00130|M.leprae_Br4923 HRTATQVN-LSGKRILEVSCGHG-GGASYLTRALHPASYTGLDLNPAGIK
: ::..* * : :
Mflv_4877|M.gilvum_PYR-GCK TSLPDTPA---------LLGTAEEIPLPDDSVDAVLVAQAWHWF---DET
TH_1968|M.thermoresistible__bu KSLPDTPA---------LLGTAEEIPLPDNSVDAVLVAQAWHWF---DVD
MMAR_3533|M.marinum_M QARAKSDR------VRWLRGPAEQLPFDDGALDAVVTTTAFHFF---DQP
MUL_2765|M.ulcerans_Agy99 QARAKSDR------VRWLRGPAEQLPFDDGALDAVVTITAFHFF---DQP
MAV_2111|M.avium_104 QARAKSDR------VQWLRAPAEQLPFDDGALDAVVTTSAFHFF---DQP
MAB_1390c|M.abscessus_ATCC_199 KARARCAQ------VQWRKAPAEQLPFADSSLDAVVTTSAFHFF---DQP
Mb3756|M.bovis_AF2122/97 RAQAAVAQTGLTERVRFHLGDAESVPLPDDTFDALVCECAFCTFP--DKN
Rv3729|M.tuberculosis_H37Rv RAQAAVAQTGLTERVRFHLGDAESVPLPDDTFDALVCECAFCTFP--DKN
Mvan_5517|M.vanbaalenii_PYR-1 RARRKAAGEG---PVRFETAYAQELPFADASFDRVLSSLMLHHLDDGTKV
MSMEG_0098|M.smegmatis_MC2_155 RAVAAEAG----RQVGFVRADAQQLPFRDEVFDAATSLAVFQLIP--DPV
MLBr_00130|M.leprae_Br4923 LCQKRHQLPG----LEFVRGDAENLPFDNESFDVVINIEASHCYP--HFP
. . *:.:*: : .*
Mflv_4877|M.gilvum_PYR-GCK RAVKEIARVLRPGGSLGLVWNNRDE-----RLGWVKDLGDIIGHEGDPWS
TH_1968|M.thermoresistible__bu RAVREVARVLRPGGRLGLVWNTRDE-----RMGWVKELGRIIGDEHDPLS
MMAR_3533|M.marinum_M AALREFHRVLAPGGLVAVSSLSARQ----PLLQLPAASKWKPQHSPSPAE
MUL_2765|M.ulcerans_Agy99 AALREFHRVLAPGGLVAVSSLSARQ----PLLQLPAASKWKPQHSPSPAE
MAV_2111|M.avium_104 AALREFHRVLAPGGLVAVSALSTRR----PLLQASADSRWKPQHNASAPE
MAB_1390c|M.abscessus_ATCC_199 AALAEFYRVLVPGGMASVATICPRE----RRWARNRTGERGPAHFPTATE
Mb3756|M.bovis_AF2122/97 AAAQQFARILRPGGLAGITDVTVGDGGLPAELTPLAAWVACIADARTVTD
Rv3729|M.tuberculosis_H37Rv AAAQQFARILRPGGLAGITDVTVGDGGLPAELTPLAAWVACIADARTVTD
Mvan_5517|M.vanbaalenii_PYR-1 SALAEAWRVLRPGGRLHIVDVGGAD-----QPEGLMSRLTGHRHAAAGAR
MSMEG_0098|M.smegmatis_MC2_155 AAVSEIVRVLKPGGRVAIMVPTAGA------VKPVTFLARGGARIFGDDE
MLBr_00130|M.leprae_Br4923 RFLAEVVRVLRPGGHLAYADLRPSNKVGEWEVDFANSRLQQLSQREINAE
: *:* ***
Mflv_4877|M.gilvum_PYR-GCK QSVELPAPFTGVERHHVEWTSYLTPQALIDLVASRSYCITSPERVRARTL
TH_1968|M.thermoresistible__bu KTVTLPEPFTDVQRHQVEWTNYLTPQALIDLVASRSYCITSPAKVRARTL
MMAR_3533|M.marinum_M MRALFEGAGFTISDQHRVRRPVWTRLVP-DLITVGAKS------------
MUL_2765|M.ulcerans_Agy99 MRALFEGAGFTISDQHRVRRPVWTRLVP-DLITVGTKS------------
MAV_2111|M.avium_104 MRKLFEDAGFVIGDQYRIPRPAWTRLVS-DLLTVGTKRD-----------
MAB_1390c|M.abscessus_ATCC_199 MERLFAGAGFEVVVHRPVARPVTPPLVSVDWICVGLKT------------
Mb3756|M.bovis_AF2122/97 YTDILEGAGLRTRHIESHDESLLDMIDRIDARITALHVAAPEILADNGIR
Rv3729|M.tuberculosis_H37Rv YTDILEGAGLRTRHIESHDESLLDMIDRIDARITALHVAAPEILADNGIR
Mvan_5517|M.vanbaalenii_PYR-1 LPQLVEAAGFDTTVVATRRLRVFGPVSFIRATRPGE--------------
MSMEG_0098|M.smegmatis_MC2_155 LGDIFENVGLVGVRVKTHGFIQWVRGTKL---------------------
MLBr_00130|M.leprae_Br4923 VLRGIASNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSY
.
Mflv_4877|M.gilvum_PYR-GCK DRVRELLTTHPALANSSGLALPYVTVCVRATLA
TH_1968|M.thermoresistible__bu ERVRELLATHPALANNSGLALPYITVCIRATLA
MMAR_3533|M.marinum_M ---------------------------------
MUL_2765|M.ulcerans_Agy99 ---------------------------------
MAV_2111|M.avium_104 ---------------------------------
MAB_1390c|M.abscessus_ATCC_199 ---------------------------------
Mb3756|M.bovis_AF2122/97 HDSVRDFTALARAAVQTGRIGYTLMIAEKP---
Rv3729|M.tuberculosis_H37Rv HDSVRDFTALARAAVQTGRIGYTLMIAEKP---
Mvan_5517|M.vanbaalenii_PYR-1 ---------------------------------
MSMEG_0098|M.smegmatis_MC2_155 ---------------------------------
MLBr_00130|M.leprae_Br4923 RMYSFAKD-------------------------