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LFLLAGRRTAGLAAALTEVTASDHVVDIGCGPGNGARIAAQRGARVTGVDPSRSMLRVARAVTRGRPAIT WAEGTAEALPVPDASATVVWALATVHHWRDVGAGLSEIHRVLVPGGRLLAVERQVAPDATGFASHGWTGQ QAETFAALCVTAGLADAKVNADRAGRREVWTVHAVRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2319 | - | - | 100% (178) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_1552 | - | 2e-11 | 40.43% (94) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_4620 | - | 2e-10 | 34.91% (106) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3374 | - | 6e-11 | 39.80% (98) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4035 | - | 3e-70 | 71.35% (178) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3342 | - | 6e-11 | 39.80% (98) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_01723 | - | 3e-06 | 30.69% (101) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_3689 | - | 3e-11 | 40.43% (94) | putative methyltransferase |
| M. marinum M | MMAR_1183 | - | 2e-10 | 40.43% (94) | methyltransferase |
| M. avium 104 | MAV_4426 | - | 9e-12 | 36.61% (112) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_2632 | - | 6e-56 | 59.22% (179) | SAM-dependent methyltransferase |
| M. thermoresistible (build 8) | TH_1968 | - | 3e-12 | 41.49% (94) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_2765 | - | 1e-10 | 35.06% (154) | methyltransferase (methylase) |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2319|M.vanbaalenii_PYR-1 -------------------------------------------------M
Mflv_4035|M.gilvum_PYR-GCK -----------------------MDGSERPVNHHGDHPGFSGLTGQLCAV
MSMEG_2632|M.smegmatis_MC2_155 -----------------------MNDSPIVVNHHADHPGFSGVTGAIFGV
Mb3374|M.bovis_AF2122/97 ---------------------------------MTCSRRDMSLSFGSAVG
Rv3342|M.tuberculosis_H37Rv ---------------------------------MTCSRRDMSLSFGSAVG
MMAR_1183|M.marinum_M ---------------------------------MSGSAQDPSLSFGSAAA
TH_1968|M.thermoresistible__bu ------------------------------------------LSFGAEAA
MAB_3689|M.abscessus_ATCC_1997 ---------------------------------MPDAQAEPSLSFGSQAA
MUL_2765|M.ulcerans_Agy99 ----------------------MTTVPRRGFNDAVTGIWSLLAPAYDLAI
MLBr_01723|M.leprae_Br4923 MTRSTEISANAVPNPHATAEQVAAARKDSKLAQVLYHDWEAENYDEKWSI
MAV_4426|M.avium_104 ----------------------------------------MRFRNVLFPY
Mvan_2319|M.vanbaalenii_PYR-1 LFLLAGRRTAGLAAALTEVTAS------DHVVDIGCGPGNGARIAAQRG-
Mflv_4035|M.gilvum_PYR-GCK AFLLTGRETGRLAADLTAVSAT------DHVLDIGCGPGNACRIAAARG-
MSMEG_2632|M.smegmatis_MC2_155 LFVALGRANAKVAIEATQVGPI------DHVVDVGCGPGTAARMAARRG-
Mb3374|M.bovis_AF2122/97 AYERGRPSYPPEAIDWLLPAAA------RRVLDLGAGTGKLTTRLVERG-
Rv3342|M.tuberculosis_H37Rv AYERGRPSYPPEAIDWLLPAAA------RRVLDLGAGTGKLTTRLVERG-
MMAR_1183|M.marinum_M AYERGRPSYPPEAIDWLLPAGA------RDVLDLGAGTGKLTTRLVERG-
TH_1968|M.thermoresistible__bu AYERGRPSYPPEAIDWLLPSDA------RDVLDLGAGTGKLTTRLVERG-
MAB_3689|M.abscessus_ATCC_1997 AYERGRPSYPPEAIDWLLPPGA------HDVLDLGAGTGKLTTRLVERG-
MUL_2765|M.ulcerans_Agy99 LQQWVYRPPHDEVLAQLRAHKS------RRIADIACGTGILSARIERELH
MLBr_01723|M.leprae_Br4923 SYDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLIQSGV
MAV_4426|M.avium_104 VYRFGQPVFDRLFYQRYRRQAMS--HATGRLLMVGLGPGTDLMFLPAAV-
:. *.*
Mvan_2319|M.vanbaalenii_PYR-1 -ARVTGVDPSRSMLRVARAVTRGR--PAITWAEGTAEALPVPDASATVVW
Mflv_4035|M.gilvum_PYR-GCK -ARVTGVDPSAAMLRVARIVTHG---ASVTWVRGGAEALPVPDAGATVAW
MSMEG_2632|M.smegmatis_MC2_155 -ARVTAVDPSAEMLRVGRLVTPSAAGKNITWRPGTAEDVPVDDGTATVVW
Mb3374|M.bovis_AF2122/97 -LDVVAVDPIPEMLDVLRAALPQT-----VALLGTAEEIPLDDN-SVDAV
Rv3342|M.tuberculosis_H37Rv -LDVVAVDPIPEMLDVLRAALPQT-----VALLGTAEEIPLDDN-SVDAV
MMAR_1183|M.marinum_M -LDVVAVDPIPEMLEVLRASLPRT-----LALLGTAEEIPLEDN-SVDAV
TH_1968|M.thermoresistible__bu -LNVTAVDPIPEMLELLSKSLPDT-----PALLGTAEEIPLPDN-SVDAV
MAB_3689|M.abscessus_ATCC_1997 -LNVVAVDPLAEMLEVLSNSLPDT-----PALLGTAEEIPLPDN-SVDAV
MUL_2765|M.ulcerans_Agy99 PDEIYGVDMSHGMLDQARAKSDRVR-----WLRGPAEQLPFDDG-ALDAV
MLBr_01723|M.leprae_Br4923 ARRGSVTDLSPGMVKIATRNGQSLG-LDINGRVADAEGIPYDDNTFDLVV
MAV_4426|M.avium_104 -TSVAAVEPEASFRRMAARLAARQG-VAVDVVAGSGESIPFPDNSFDSVH
.: : . .* :* * .
Mvan_2319|M.vanbaalenii_PYR-1 ALATVHHWRDVGAGLSEIHRVLVPGGRL--------------LAVERQVA
Mflv_4035|M.gilvum_PYR-GCK ALATVHHWPDVDAGLAEIHRALGPGARF--------------LAVERQTE
MSMEG_2632|M.smegmatis_MC2_155 ALATVHHWQDVVRALQQANRVLAPGGRL--------------LAIERQVA
Mb3374|M.bovis_AF2122/97 LVAQAWHWVDPARAIPEVARVLRPGGRLGLVWNTRDERLGWVRELGEIIG
Rv3342|M.tuberculosis_H37Rv LVAQAWHWVDPARAIPEVARVLRPGGRLGLVWNTRDERLGWVRELGEIIG
MMAR_1183|M.marinum_M LVAQAWHWVDPARAIPEVARVLRPGGRLGLVWNTRDERLGWVRELGRIIG
TH_1968|M.thermoresistible__bu LVAQAWHWFDVDRAVREVARVLRPGGRLGLVWNTRDERMGWVKELGRIIG
MAB_3689|M.abscessus_ATCC_1997 LVAQAWHWVDPERAIPEVARVLRPGGRLGLVWNVRDERLGWVSDLGHIIG
MUL_2765|M.ulcerans_Agy99 VTITAFHFFDQPAALREFHRVLAPGGLV---------------AVSSLSA
MLBr_01723|M.leprae_Br4923 GHAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTDVGNRYARVFADLTW
MAV_4426|M.avium_104 IGLVLCSVRDVGATLAEIRRVLVPGGRL--------------VVLEHVRG
* : : *.* **. . .
Mvan_2319|M.vanbaalenii_PYR-1 PDAT------GFASHG----------------WTG--QQAET--FAALCV
Mflv_4035|M.gilvum_PYR-GCK PDAT------GISSHG----------------WTG--AQAET--FAAMCE
MSMEG_2632|M.smegmatis_MC2_155 RGAT------GFASHG----------------WTR--EQADA--FATLCR
Mb3374|M.bovis_AF2122/97 RDGD------PVRDRV-TLPEPFTTVQRHQVEWTNYLTPQAL--IDLVAS
Rv3342|M.tuberculosis_H37Rv RDGD------PVRDRV-TLPEPFTTVQRHQVEWTNYLTPQAL--IDLVAS
MMAR_1183|M.marinum_M RDSD------PVRDKV-TLPEPFTGVARHHVEWTNYLTPQAL--IDLVAS
TH_1968|M.thermoresistible__bu DEHD------PLSKTV-TLPEPFTDVQRHQVEWTNYLTPQAL--IDLVAS
MAB_3689|M.abscessus_ATCC_1997 HENA------ADSADVGALPAPFTGQERHQVEWTNYLTPQAL--LDMVAS
MUL_2765|M.ulcerans_Agy99 RQPL------LQLPAA--------------SKWKP--QHSPS--PAEMRA
MLBr_01723|M.leprae_Br4923 KVTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLETMAT
MAV_4426|M.avium_104 DGLTG-----RLQDLIARP-------------WSWLAGGCEP------NR
*
Mvan_2319|M.vanbaalenii_PYR-1 TAGLADAKVNADRAGRREVWTVHAVRP-----------------------
Mflv_4035|M.gilvum_PYR-GCK SAGLTTVRVGSGRAGKRRVWTVHATRP-----------------------
MSMEG_2632|M.smegmatis_MC2_155 DAGFGEVEVSERPRGRKSVWLVSAIKR-----------------------
Mb3374|M.bovis_AF2122/97 RSYCITSPAQVRTKTLDRVRQLLATHPALANSNGLALPYVTVCVRATLA-
Rv3342|M.tuberculosis_H37Rv RSYCITSPAQVRTKTLDRVRQLLATHPALANSNGLALPYVTVCVRATLA-
MMAR_1183|M.marinum_M RSYCITSPAEVRTKTLDQVRELLATHPALANSAGLALPYVTVCVSATLAA
TH_1968|M.thermoresistible__bu RSYCITSPAKVRARTLERVRELLATHPALANNSGLALPYITVCIRATLA-
MAB_3689|M.abscessus_ATCC_1997 RSYCITAPEAARKKTLQQVRELLATHPALAQSAGLALPYVTVSIRATLNR
MUL_2765|M.ulcerans_Agy99 LFEGAGFTISDQHRVRRPVWTRLVPDLITVGTKS----------------
MLBr_01723|M.leprae_Br4923 NAGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTSWKTL
MAV_4426|M.avium_104 RTGAAIAAAGFDTSMLRSVPRTPVPFPCKPHLQGFAVLSSR---------
:
Mvan_2319|M.vanbaalenii_PYR-1 ----------------------------
Mflv_4035|M.gilvum_PYR-GCK ----------------------------
MSMEG_2632|M.smegmatis_MC2_155 ----------------------------
Mb3374|M.bovis_AF2122/97 ----------------------------
Rv3342|M.tuberculosis_H37Rv ----------------------------
MMAR_1183|M.marinum_M ----------------------------
TH_1968|M.thermoresistible__bu ----------------------------
MAB_3689|M.abscessus_ATCC_1997 ----------------------------
MUL_2765|M.ulcerans_Agy99 ----------------------------
MLBr_01723|M.leprae_Br4923 SWVDANVWRRVIPKSWFYNIIITGVKPS
MAV_4426|M.avium_104 ----------------------------