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AFSPAHRLLARMGSTSIYKRVWRYWYPLMTRGLGADKIAFLNWAYEEDPPIDLTLEVSDEPNRDHINMYH RTATHVELSGKRVLEVSCGHGGGASYLTRTLHPASYTGLDLNRAGIKLCQRRHNLPGLDFVRGDAENLPF EDESFDVVLNVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDLRPSNEIAEWEADLAGSPLRQLSQREINA EVVRGIEKNSHTSRVLVDRNLPAFLRFADRAVGRQLSRYLEGGELSYRMYCFTKDFAASR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3170 | - | - | 100% (271) | methyltransferase |
| M. marinum M | MMAR_1766 | - | e-110 | 69.26% (270) | methyltransferase |
| M. marinum M | MMAR_4497 | - | 6e-12 | 38.89% (108) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2976 | - | 1e-131 | 82.59% (270) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4060 | - | 1e-09 | 37.62% (101) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2952 | - | 1e-131 | 82.59% (270) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_00130 | - | 1e-122 | 76.67% (270) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_4103c | - | 2e-75 | 56.22% (249) | methyltransferase |
| M. avium 104 | MAV_3877 | - | 7e-10 | 29.49% (156) | hypothetical protein MAV_3877 |
| M. smegmatis MC2 155 | MSMEG_0393 | - | 6e-76 | 57.66% (248) | Fmt protein |
| M. thermoresistible (build 8) | TH_1636 | - | 2e-75 | 56.73% (245) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_2377 | - | 1e-159 | 99.26% (271) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | 3e-11 | 37.50% (96) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3170|M.marinum_M MAFSPAHRLLARMGSTSIYKRVWRYWYPLMTRGLGADK-IAFLNWAYEED
MUL_2377|M.ulcerans_Agy99 MAFSPAHRLLARLGSTSIYKRVWRYWYPLMTRGLGADK-IAFLNWAYEED
Mb2976|M.bovis_AF2122/97 MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDE-IVFINWAYEED
Rv2952|M.tuberculosis_H37Rv MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDE-IVFINWAYEED
MLBr_00130|M.leprae_Br4923 MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDE-IMFINWAYEED
MSMEG_0393|M.smegmatis_MC2_155 ---MEARDRVAWRLNIKVAQQAQKLVYRYATRRLKDDD-VVFLNYGYEED
TH_1636|M.thermoresistible__bu --VRESRDQVFRKLNEKLTQHGQKFIYSYASRRLDDDD-VVFLNYGYEED
MAB_4103c|M.abscessus_ATCC_199 --MQRSRDWVMFKLNAVFTQRVQKFIYRHATRKLETED-VVFLNYGYEEE
Mvan_0109|M.vanbaalenii_PYR-1 MTHTVLRMTERLLIDPPEHPDTSKGYLDLLGDEPDSNRGAIQALWASRLG
Mflv_4060|M.gilvum_PYR-GCK ---------------MATVDNEDDRALKAKHRALWASG------------
MAV_3877|M.avium_104 --MSALVPDLPPHPPAGAAPAGDAVMMLTGERTIPG--------------
MMAR_3170|M.marinum_M PPIDLTLEVSDEPNRDHINMYHRTATHVELS-GKRVLEVSCGHGGGASYL
MUL_2377|M.ulcerans_Agy99 PPIDLTLEVSDEPNRDHINMYHRTATHVELS-GKRVLEVSCGHGGGASYL
Mb2976|M.bovis_AF2122/97 PPMDLPLEASDEPNRAHINLYHRTATQVDLG-GKQVLEVSCGHGGGASYL
Rv2952|M.tuberculosis_H37Rv PPMDLPLEASDEPNRAHINLYHRTATQVDLG-GKQVLEVSCGHGGGASYL
MLBr_00130|M.leprae_Br4923 PPMALPLEASDEPNRAHINLYHRTATQVNLS-GKRILEVSCGHGGGASYL
MSMEG_0393|M.smegmatis_MC2_155 PPMGIPLSESDELNRYSIQLYHSTAAQADVE-GKRVLEVGCGHGGGASYL
TH_1636|M.thermoresistible__bu PPMGLPLSETDEPNRYSIQLYHRTAGQADLT-GKRVLEVGCGHGGGASYL
MAB_4103c|M.abscessus_ATCC_199 PAMGVPLSASDEPDRYSIQLYHSTATQADLG-GQRVLEVGCGHGGGASYL
Mvan_0109|M.vanbaalenii_PYR-1 ---SMFYDNAQTLARRLMTAWQQPTEWLNVPVGGTALDVGSGPGNVTGAL
Mflv_4060|M.gilvum_PYR-GCK -------DYPAVAAELIPSLGPELVRACGVRSGDRVLDVAAGSGN-ASIP
MAV_3877|M.avium_104 ------LDIENYWFRRHEVVYQRLARHCAGR---DVLEAGCGEGYGADLI
. . . *:...* * :.
MMAR_3170|M.marinum_M TRTLHP-ASYTGLDLNRAGIKLCQRRHNLPGLDFVRGDAENLPFEDESFD
MUL_2377|M.ulcerans_Agy99 TRTLHP-ASYTGLDLNRAGIKLCQRRHNLPGLDFVRGDAENLPFEDESFD
Mb2976|M.bovis_AF2122/97 TRTLHP-ASYTGLDLNQAGIKLCKKRHRLPGLDFVRGDAENLPFDDESFD
Rv2952|M.tuberculosis_H37Rv TRTLHP-ASYTGLDLNQAGIKLCKKRHRLPGLDFVRGDAENLPFDDESFD
MLBr_00130|M.leprae_Br4923 TRALHP-ASYTGLDLNPAGIKLCQKRHQLPGLEFVRGDAENLPFDNESFD
MSMEG_0393|M.smegmatis_MC2_155 ARTFRP-ATYTGLDLNSDGINFCRRRHNIAGLEFVQGDAQDLPFPDKNFD
TH_1636|M.thermoresistible__bu MRTLGP-MSYVGLDLNPAGIEFCRKKHRLPGLEFVVGDAQDLPFGAESFD
MAB_4103c|M.abscessus_ATCC_199 VRALQP-ASYTGLDLNPDGISFCRRRHDLPGLEFVQGDAEDLPFPDESFD
Mvan_0109|M.vanbaalenii_PYR-1 GRAVGPGGLALGVDISEPMLARAVRAEAGPNVGFIRADAQHLPFRDESFD
Mflv_4060|M.gilvum_PYR-GCK AAAAGAVVTASDLTPELFDAGRRIAAERGVAVEWVEADAEALPFPDDSFD
MAV_3877|M.avium_104 AGVARR---VIAVDYDEAAVAHVRG--RYPRVDVMQANLAQLPLPDSSVD
. : . : : .: **: ...*
MMAR_3170|M.marinum_M VVLNVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDLRPS----------N
MUL_2377|M.ulcerans_Agy99 VVLKVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDLRPS----------N
Mb2976|M.bovis_AF2122/97 VVLNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRPN----------N
Rv2952|M.tuberculosis_H37Rv VVLNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRPN----------N
MLBr_00130|M.leprae_Br4923 VVINIEASHCYPHFPRFLAEVVRVLRPGGHLAYADLRPS----------N
MSMEG_0393|M.smegmatis_MC2_155 AVLNVESSHLYPRFDVFLTEVARVLRPGGYFLYTDARPR----------Y
TH_1636|M.thermoresistible__bu AVINIESSHLYPRFSRFLSEVARVLRPGGHFLYADARQP----------H
MAB_4103c|M.abscessus_ATCC_199 AVINVESSHLYPHFPVFLTEVARVLRPGGNFLYTDARSV----------Q
Mvan_0109|M.vanbaalenii_PYR-1 AVVSIAMLQLIPDPAVALAEMVRVLRPGRRMAVMVP--------------
Mflv_4060|M.gilvum_PYR-GCK VVMSCVGAMFAPHHQATADEIVRVTRPGGTLGLISWTPEGFIGHLFATMK
MAV_3877|M.avium_104 VVVNFQVIEHLWDQTQFVVECARVLRPSGLLLMSTPNRIT----------
.*:. * .** **. :
MMAR_3170|M.marinum_M EIAEWEADLAGSPLRQLSQREINAEVVRGIEKNSHTSRVLVDRNLPAFLR
MUL_2377|M.ulcerans_Agy99 EIAEWEADLAGSPLRQLSQREINAEVVRGIEKNSHTSRVLVDRNLPAFLR
Mb2976|M.bovis_AF2122/97 EIAAWEADLAATPLRQLSQRQINAEVLRGIGNNSQKSRDLVDRHLPAFLR
Rv2952|M.tuberculosis_H37Rv EIAAWEADLAATPLRQLSQRQINAEVLRGIGNNSQKSRDLVDRHLPAFLR
MLBr_00130|M.leprae_Br4923 KVGEWEVDFANSRLQQLSQREINAEVLRGIASNSQKSRDLVDRHLPAFLR
MSMEG_0393|M.smegmatis_MC2_155 DIPEWERALADAPLQMLSQRAINFEVVRGMEKNLDALESVVDRVAPALLR
TH_1636|M.thermoresistible__bu EFAEWEAALAAAPLDMVSARVINAEVVRGMEQILPVWEDVIERVAPAFLR
MAB_4103c|M.abscessus_ATCC_199 DVAGWKVALANAPLRMVSERGINAEVRRGMEKNLARWRYVIDRATPAPLR
Mvan_0109|M.vanbaalenii_PYR-1 -----TAGPAAGLLRYLPNAGAHAFGDDELGDTFES--------------
Mflv_4060|M.gilvum_PYR-GCK PYAPPPPPGASPPPMWGSENHVEALFGDRVRDLTMRRQTVRFDHCASPLD
MAV_3877|M.avium_104 FSPGRDTPINPFHTRELNAVELTELLVGGGFRDVSISGLFHGPRLREMDA
MMAR_3170|M.marinum_M FADR----------AVGRQLSRYLEGGELSYRMYCFTKDFAASR------
MUL_2377|M.ulcerans_Agy99 FADR----------AVGRQLSRYLEGGELSYRMYCFTKDFAASR------
Mb2976|M.bovis_AF2122/97 FAGREFI------GVQGTQLSRYLEGGELSYRMYCFTKD-----------
Rv2952|M.tuberculosis_H37Rv FAGREFI------GVQGTQLSRYLEGGELSYRMYCFTKD-----------
MLBr_00130|M.leprae_Br4923 FAGREFI------GVQGTQLSRYLEGGELSYRMYSFAKD-----------
MSMEG_0393|M.smegmatis_MC2_155 DWIQKY-------GPARRAYEELR-ENTTEYRMYCFVKPAE---------
TH_1636|M.thermoresistible__bu RRVREF-------APARRAWEELRTEGSTEYRMYCFTKPPEHADIP----
MAB_4103c|M.abscessus_ATCC_199 GIVRRF-------APAQRAYDDLRAGGSVEYRMYRFVKA-----------
Mvan_0109|M.vanbaalenii_PYR-1 ---------------LGLAGVRINTVGTIQWVRGRKS-------------
Mflv_4060|M.gilvum_PYR-GCK FREYWKRNYGPTLAAYRFNEDRPERLAELDAAFLDFLTTWNQADGTDGTA
MAV_3877|M.avium_104 RHGGSIIDAQIARAVADAPWPPQLAADVAAVTVDDFELVPSGADAASGHH
MMAR_3170|M.marinum_M --------------
MUL_2377|M.ulcerans_Agy99 --------------
Mb2976|M.bovis_AF2122/97 --------------
Rv2952|M.tuberculosis_H37Rv --------------
MLBr_00130|M.leprae_Br4923 --------------
MSMEG_0393|M.smegmatis_MC2_155 --------------
TH_1636|M.thermoresistible__bu --------------
MAB_4103c|M.abscessus_ATCC_199 --------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------
Mflv_4060|M.gilvum_PYR-GCK YDAEYLLVTATKR-
MAV_3877|M.avium_104 IDDSLDLIAIAVAP