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M. thermoresistible (build 8) TH_1986 (-)

annotation: tetracycline-resistance determinant TetV
coordinates: 3845129 - 3846409
length: 427

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1986--100% (427)tetracycline-resistance determinant TetV
M. thermoresistible (build 8)TH_1317-3e-2430.00% (270) transmembrane transport protein
M. thermoresistible (build 8)TH_2406-6e-2327.53% (396) PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1288c-2e-1724.23% (421) integral membrane transport protein
M. gilvum PYR-GCKMflv_5163-3e-2430.82% (279) protein of unknown function DUF894, DitE
M. tuberculosis H37RvRv1258c-2e-1724.23% (421) integral membrane transport protein
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2780c-1e-10246.92% (422) putative transporter
M. marinum MMMAR_4182-6e-1523.72% (409) hypothetical protein MMAR_4182
M. avium 104MAV_1406-5e-1323.02% (404) transporter, major facilitator family protein
M. smegmatis MC2 155MSMEG_5187-0.079.27% (410) tetracycline-resistance determinant TetV
M. ulcerans Agy99MUL_3787-5e-0525.74% (202) integral membrane leucine and alanine rich protein
M. vanbaalenii PYR-1Mvan_4580-1e-17772.18% (435) H+ antiporter protein

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_5187|M.smegmatis_MC2_155      ------------------MRS------PRPVAGWRVLAPFRIREYRLLIA
Mvan_4580|M.vanbaalenii_PYR-1       MVGNHRSVSTQYETGRSSARSDS--EQPVAPAGWRVLAPFRYREYRLLIA
TH_1986|M.thermoresistible__bu      -------VSTQYDIEPSAGTS----------GGWRVLAPFRIREYRLLIT
MAB_2780c|M.abscessus_ATCC_199      -MDFPEQLKTEGVLGKNSGGSSGGESHPSTSGLPRALRPMRHRDYRLLTL
Mb1288c|M.bovis_AF2122/97           ------------------------------------MRNSNRGPAFLILF
Rv1258c|M.tuberculosis_H37Rv        ------------------------------------MRNSNRGPAFLILF
MMAR_4182|M.marinum_M               ------------------------------------MRNSSRGPAFLILF
MAV_1406|M.avium_104                ----------------------------------------------MILF
Mflv_5163|M.gilvum_PYR-GCK          ---------------------------MTSPVSTSTWAPLQSPVFRALWI
MUL_3787|M.ulcerans_Agy99           -----------------------MTNPATGTFVRSRVVAWALWDCGSTGL
                                                                                      

MSMEG_5187|M.smegmatis_MC2_155      AVTLSIFAEGMWSVVMALQVIAIDND-PASLSLVATCLGVGLVAFVLVGG
Mvan_4580|M.vanbaalenii_PYR-1       AVSLSIFAEGMWAVVMALQVIELSND-PAALSLVATCLGAGLVGFVLVGG
TH_1986|M.thermoresistible__bu      AVAITIFAEGMWAVVMALQVIAIDND-PASLSLVATCMGVGLVAFVLVGG
MAB_2780c|M.abscessus_ATCC_199      GLAITLLGNGMWTVALVWQVIRMGLG-PAQVAVVGTTFSVGLLLSVLPAG
Mb1288c|M.bovis_AF2122/97           ATLMAAAGDGVSIVAFPWLVLQREGS-AGQASIVASATMLPLLFATLVAG
Rv1258c|M.tuberculosis_H37Rv        ATLMAAAGDGVSIVAFPWLVLQREGS-AGQASIVASATMLPLLFATLVAG
MMAR_4182|M.marinum_M               ATLAACAGNGISIVAFPWLVLEREGS-AGQASIVAGAITLPLLFSTLVAG
MAV_1406|M.avium_104                ATLLATAGTGISIVAFPWLALQHRHS-ATDASIVAAAMTLPLVLATLIAG
Mflv_5163|M.gilvum_PYR-GCK          AQFVSNLGTWMQTVGAQWMLVDDPAA-AVLVPLVQTATTLPVMLLALPSG
MUL_3787|M.ulcerans_Agy99           NAMVTTFVFSVYLTSMVGEGMPGGSDPASWLGRAAAAAGLTIALLAPLVG
                                        :     :  .      :      .     .       :   .   *

MSMEG_5187|M.smegmatis_MC2_155      ITADRINQRTIIIAVEVVNFVTVAVISALALLGVLKIWHMAVAAGILGIA
Mvan_4580|M.vanbaalenii_PYR-1       LAADRLSQRGIIIVVEAVNTVAVTAVAVLGFVDALRIWHMAVAAAALGIA
TH_1986|M.thermoresistible__bu      ITADRINQRTIIIAVEAVNAVTVAVVAMLGLTGQLRIWHLAVAAAVLGIA
MAB_2780c|M.abscessus_ATCC_199      VAADRLPKLWVMRCSLAVQTALMLTTATLALTGAAHIWHLALNSLLFGIA
Mb1288c|M.bovis_AF2122/97           TAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALA
Rv1258c|M.tuberculosis_H37Rv        TAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALA
MMAR_4182|M.marinum_M               TAVDYFGRRPVSMVSDALSGSAVAIVPLIAWAFGDDAVSVAVLAALGACS
MAV_1406|M.avium_104                TAVDFFGRRRVSLVCDWLSGAAVTAVPLTAWIFGAAAIDVAELAVLAFCA
Mflv_5163|M.gilvum_PYR-GCK          VLADLVDRRRLLIATQGAMAAGVGLLATLTGAGLTTPTVLLTLLFVIGCG
MUL_3787|M.ulcerans_Agy99           VWVESPHRRRVALGVLTSVTVALTCAMFLIHDSPGYLWAGLALLAATAAC
                                      .:   :  :           :                           

MSMEG_5187|M.smegmatis_MC2_155      AAFFFPAYSAILPRILPPEQLLAANGVEGVVRP----------VFQRSVG
Mvan_4580|M.vanbaalenii_PYR-1       AAFFFPAYSAILPRILPPEQLLAANGIEGVVRP----------VFQRAVG
TH_1986|M.thermoresistible__bu      AAFFFPAYSALLPRILPPEQLLAANGVEGVVRP----------VFQRAVG
MAB_2780c|M.abscessus_ATCC_199      EGFYIPAYTALLPSLLPADELLAANGIEGILRP----------VMQLAAG
Mb1288c|M.bovis_AF2122/97           AAFGPAGMTARDS-MLPEAAARAGWSLDRINGAY-----EAILNLAFIVG
Rv1258c|M.tuberculosis_H37Rv        AAFGPAGMTARDS-MLPEAAARAGWSLDRINGAY-----EAILNLAFIVG
MMAR_4182|M.marinum_M               ATFDPAGITARQS-MLPEAAARAGWSLDRINSSY-----EAILNLAFVVG
MAV_1406|M.avium_104                AAFDPAGMTARQS-MLPEAAARAGWSLDRTNSSY-----EAMLNLAFIVG
Mflv_5163|M.gilvum_PYR-GCK          QALTAPAWQAIQPDLVPSDQIPAAAALGSMSMN-----------GARAIG
MUL_3787|M.ulcerans_Agy99           SDLASVPYNSMLRQLSTPTTASRISGFGWASGYVGSVVLLILIYLGFVAG
                                      :      :    : .        ..                      *

MSMEG_5187|M.smegmatis_MC2_155      PAVAGMVIGATMPSIGAVVVAVLFALGLALLVATRPP--AQPASEH----
Mvan_4580|M.vanbaalenii_PYR-1       PAIAGLVVGALFPSAGALVVAVLFATGLALLVATRPPKAKDTGAQH----
TH_1986|M.thermoresistible__bu      PAVAGMLVGATFPSLGSAVVATLFGVGLVLLVATRPP--ASPSVPG----
MAB_2780c|M.abscessus_ATCC_199      PAVSAAIVSVWSPGGAFLLEGMLVGAGLSCLLLVRHK--HEPPASA----
Mb1288c|M.bovis_AF2122/97           PAIGGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTS----
Rv1258c|M.tuberculosis_H37Rv        PAIGGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTS----
MMAR_4182|M.marinum_M               PGIGGLMIATVGGITTMWITAGAFGLSLLAIGALRLEGAGRPHHET----
MAV_1406|M.avium_104                PGLGGLLIATLGGINTMWVTAGCFALSFLAIGALRLEGAGKPPRAT----
Mflv_5163|M.gilvum_PYR-GCK          PAIAGALVSLTGPTIVFALNAVSFVGIVLVLMWWRRP----PVRSD----
MUL_3787|M.ulcerans_Agy99           SGAHRGLLQLPAHDGFNIRVAMLLAAAWLAVLASPLLLVAHRLPDVGTVP
                                    ..    ::            .  .      :                   

MSMEG_5187|M.smegmatis_MC2_155      HERPHVLR----DLREGFAFVLKTPWLLWTVLFASMFVLVVLGPIEVLLP
Mvan_4580|M.vanbaalenii_PYR-1       EPRPHLLR----DLRDGWVFMLRTPWLLWTLLFASLFVLVVLGPIEVLLP
TH_1986|M.thermoresistible__bu      EHRSRVLR----DLRDGFMFMVATPWLLWTLLFASVFVLVVLGPIEVLLP
MAB_2780c|M.abscessus_ATCC_199      EVRQHPLRRALADLAEGFRYMVRTTWFFATLLFAIGYVLVVVGPIEILLP
Mb1288c|M.bovis_AF2122/97           RPQGLVSG-----IAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFP
Rv1258c|M.tuberculosis_H37Rv        RPQGLVSG-----IAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFP
MMAR_4182|M.marinum_M               RPDGLVSG-----VTQGLRFVWNLRVLRALALIDLTVTALYLPMESVLFP
MAV_1406|M.avium_104                RPVGLVTG-----IAEGVRFVWNLRVLRTLGLIDLAVTALYLPMESVLFP
Mflv_5163|M.gilvum_PYR-GCK          YPPERALA----ALSAGGRYIRSSPIVRRILLRTVLFIAPGS-AVWGLLP
MUL_3787|M.ulcerans_Agy99           QPATRMLG-AYRKLWADISSEWRRDRNLVYFLIASAIFRDGLAAMFAFGA
                                                 :  .              :               : .

MSMEG_5187|M.smegmatis_MC2_155      FIAQDRFADGARAYGFILAFFGIGSAMGALTVSSRRMPRRYLTTMMLMWG
Mvan_4580|M.vanbaalenii_PYR-1       FVVAERFTHGAQTYGFILAFFGLGSALGALGVSSRRLPRRYLTVMMAMWS
TH_1986|M.thermoresistible__bu      FIAQERFTDGARMYGFVLAAFGVGSAVGALTVSSRQMPRRYLTVMMLMWA
MAB_2780c|M.abscessus_ATCC_199      FVIRDHGGD-PGAHATVLALFGLAGAVGSFIVSSLPLARRYLTVMILMWG
Mb1288c|M.bovis_AF2122/97           KYFTD--HQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVL
Rv1258c|M.tuberculosis_H37Rv        KYFTD--HQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVL
MMAR_4182|M.marinum_M               TYFSD--RQQPAQLGSVLVALSLGSLVGALGYGMLSNYVSRRTIMLTAVL
MAV_1406|M.avium_104                KYFAD--QHQPAQLGWALMALALGGVAGALGYAVLSARLRRRTAVLTATL
Mflv_5163|M.gilvum_PYR-GCK          VIARDQLGLGSAGYGALLGALGVGAVLGAFALSRLRARFGQNKLLIAGAA
MUL_3787|M.ulcerans_Agy99           VLGANVYGLTQADVLLFGVAASVVAAVGAVVGGFVDHRVGSKPVIVASLA
                                        :                .  .  *:.  .           :     

MSMEG_5187|M.smegmatis_MC2_155      LGSIPLVIVGYTSSFPLMAAATFVIGVTDGAGMVIWGTLLQRRVPTEMLG
Mvan_4580|M.vanbaalenii_PYR-1       VGSVPLVIVGVTSSFPLMALATFVIGVTDGTAMVIWGTLLQRRVPPELLG
TH_1986|M.thermoresistible__bu      LGSVPLLVIGFTWSFLLMSAASFAIGVTDGAGMVIWGTLLQRRVPRELLG
MAB_2780c|M.abscessus_ATCC_199      AGSLPLIFIGFTGHVWMIAVAMIIVGGTMQAANVIWGTLMQRRVPEEMLG
Mb1288c|M.bovis_AF2122/97           TLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRG
Rv1258c|M.tuberculosis_H37Rv        TLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRG
MMAR_4182|M.marinum_M               TLGAATTGIALLPPLPVILVLCALIGVVYGPIQPIYNYVMQTRAPHYLRG
MAV_1406|M.avium_104                TFGATTAGIAVLPPLPVILGLCAVTGVVYGPIQPIYNFVMQTRAPHHLRG
Mflv_5163|M.gilvum_PYR-GCK          GFGMATAVLALVHNVALVAAALVVGGAAWLLTLSTLNASMQLSLPSWVRA
MUL_3787|M.ulcerans_Agy99           SILISAIVLMVLSGATAFWVCGLLLCLFIGPSQSSARALLLRMAPHGKEG
                                        .   :        .                     :    .    .

MSMEG_5187|M.smegmatis_MC2_155      RVSSLDFFVSLAFMPLSFAIVGPLSKVVSMEVIFATAGLVPVAIAAVAFT
Mvan_4580|M.vanbaalenii_PYR-1       RVSSLDFFVSLAFMPVSFAIVGPLSKIVSMEAIFLAAGLLPVLLAAVAVW
TH_1986|M.thermoresistible__bu      RVSSLDFFVSLVFMPVSFAIAGPLSKVVSMQTIFLVAGLAPLLFAVVAMT
MAB_2780c|M.abscessus_ATCC_199      RAASMDFFVSLVGLPASFALVVPVAHVIGNTTVFVIAGVAPLVLAAAAHI
Mb1288c|M.bovis_AF2122/97           RVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIR
Rv1258c|M.tuberculosis_H37Rv        RVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIR
MMAR_4182|M.marinum_M               RVVGVMTSLAYAAGPLGLLLAGPVADAAGLKVAFFALALPIAITGLMCIR
MAV_1406|M.avium_104                RVVGVMAGLTYAAGPLGLLVAGPLADAAGLKATFLTLAVPILAIGVVACG
Mflv_5163|M.gilvum_PYR-GCK          RGLSVYQLIFMGGQAVGSLLWGLLAGGTSSVISLLVSAGLLIFCGLSLWW
MUL_3787|M.ulcerans_Agy99           VAFGLYTMTGHAVAFLGPWLFSIFVDIFSAVRAGLGGICLVLAVGLVGML
                                       .:           .  :   .    .               .     

MSMEG_5187|M.smegmatis_MC2_155      AARMH---RDEVANPLL---------------------------------
Mvan_4580|M.vanbaalenii_PYR-1       AAKMH---RDEVAHPLR---------------------------------
TH_1986|M.thermoresistible__bu      AARMP---RDELEHPLN---------------------------------
MAB_2780c|M.abscessus_ATCC_199      VARLG---RDEMAHPLG---------------------------------
Mb1288c|M.bovis_AF2122/97           LPALR---ELDLAPQADIDRPVGSAQ------------------------
Rv1258c|M.tuberculosis_H37Rv        LPALR---ELDLAPQADIDRPVGSAQ------------------------
MMAR_4182|M.marinum_M               LPSLR---ELDHAPTQDISETSLL--------------------------
MAV_1406|M.avium_104                LPSLR---ELDRAPQFADDPGA----------------------------
Mflv_5163|M.gilvum_PYR-GCK          WPLHAGTGNLDLTPSSHWPEPTLLFEPEPLDGPVLVITAYRVLPENEEPF
MUL_3787|M.ulcerans_Agy99           VVGVPRHGGVVVTETT----------------------------------
                                                                                      

MSMEG_5187|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_4580|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_1986|M.thermoresistible__bu      --------------------------------------------------
MAB_2780c|M.abscessus_ATCC_199      --------------------------------------------------
Mb1288c|M.bovis_AF2122/97           --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_4182|M.marinum_M               --------------------------------------------------
MAV_1406|M.avium_104                --------------------------------------------------
Mflv_5163|M.gilvum_PYR-GCK          MSAMARLGRSRQRTGASMWQLFRSIEQESTFVETFIVRSWGEHMHQHYTR
MUL_3787|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MSMEG_5187|M.smegmatis_MC2_155      --------------------------------
Mvan_4580|M.vanbaalenii_PYR-1       --------------------------------
TH_1986|M.thermoresistible__bu      --------------------------------
MAB_2780c|M.abscessus_ATCC_199      --------------------------------
Mb1288c|M.bovis_AF2122/97           --------------------------------
Rv1258c|M.tuberculosis_H37Rv        --------------------------------
MMAR_4182|M.marinum_M               --------------------------------
MAV_1406|M.avium_104                --------------------------------
Mflv_5163|M.gilvum_PYR-GCK          LTGQDQLIEQDVERYTEGEAVAEHYLAVRDAR
MUL_3787|M.ulcerans_Agy99           --------------------------------