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VVGNHRSVSTQYETGRSSARSDSEQPVAPAGWRVLAPFRYREYRLLIAAVSLSIFAEGMWAVVMALQVIE LSNDPAALSLVATCLGAGLVGFVLVGGLAADRLSQRGIIIVVEAVNTVAVTAVAVLGFVDALRIWHMAVA AAALGIAAAFFFPAYSAILPRILPPEQLLAANGIEGVVRPVFQRAVGPAIAGLVVGALFPSAGALVVAVL FATGLALLVATRPPKAKDTGAQHEPRPHLLRDLRDGWVFMLRTPWLLWTLLFASLFVLVVLGPIEVLLPF VVAERFTHGAQTYGFILAFFGLGSALGALGVSSRRLPRRYLTVMMAMWSVGSVPLVIVGVTSSFPLMALA TFVIGVTDGTAMVIWGTLLQRRVPPELLGRVSSLDFFVSLAFMPVSFAIVGPLSKIVSMEAIFLAAGLLP VLLAAVAVWAAKMHRDEVAHPLR
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_4580 | - | - | 100% (443) | H+ antiporter protein |
M. vanbaalenii PYR-1 | Mvan_4461 | - | 9e-24 | 27.25% (411) | H+ antiporter protein |
M. vanbaalenii PYR-1 | Mvan_1167 | - | 2e-17 | 25.79% (380) | protein of unknown function DUF894, DitE |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1288c | - | 6e-21 | 27.43% (401) | integral membrane transport protein |
M. gilvum PYR-GCK | Mflv_2234 | - | 3e-24 | 27.43% (412) | H+ antiporter protein |
M. tuberculosis H37Rv | Rv1258c | - | 6e-21 | 27.43% (401) | integral membrane transport protein |
M. leprae Br4923 | MLBr_02143 | - | 8e-05 | 24.17% (331) | hypothetical protein MLBr_02143 |
M. abscessus ATCC 19977 | MAB_2780c | - | 6e-97 | 44.58% (415) | putative transporter |
M. marinum M | MMAR_4182 | - | 4e-19 | 26.77% (396) | hypothetical protein MMAR_4182 |
M. avium 104 | MAV_1406 | - | 1e-19 | 27.68% (401) | transporter, major facilitator family protein |
M. smegmatis MC2 155 | MSMEG_5187 | - | 0.0 | 76.67% (420) | tetracycline-resistance determinant TetV |
M. thermoresistible (build 8) | TH_1986 | - | 1e-177 | 72.18% (435) | tetracycline-resistance determinant TetV |
M. ulcerans Agy99 | MUL_0051 | - | 9e-07 | 22.42% (397) | integral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_5187|M.smegmatis_MC2_155 -------------------------------------------------- TH_1986|M.thermoresistible__bu -------------------------------------------------- Mvan_4580|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2780c|M.abscessus_ATCC_199 -------------------------------------------------- Mb1288c|M.bovis_AF2122/97 -------------------------------------------------- Rv1258c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4182|M.marinum_M -------------------------------------------------- MAV_1406|M.avium_104 -------------------------------------------------- Mflv_2234|M.gilvum_PYR-GCK -------------------------------------------------- MUL_0051|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02143|M.leprae_Br4923 MSGRRRNHPGRLASIPGLRTRTGSRNQHPGIANYPADSSDFRPAQQRRAL MSMEG_5187|M.smegmatis_MC2_155 ---------------------------------------MRSPR------ TH_1986|M.thermoresistible__bu --------------------------------VSTQYDIEPSAG------ Mvan_4580|M.vanbaalenii_PYR-1 -------------------------MVGNHRSVSTQYETGRSSARSDS-- MAB_2780c|M.abscessus_ATCC_199 --------------------------MDFPEQLKTEGVLGKNSGGSSGGE Mb1288c|M.bovis_AF2122/97 -------------------------------------------------- Rv1258c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4182|M.marinum_M -------------------------------------------------- MAV_1406|M.avium_104 -------------------------------------------------- Mflv_2234|M.gilvum_PYR-GCK -------------------------------------------------- MUL_0051|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02143|M.leprae_Br4923 EQREQQAGQLDPARRSPSMPSANRYLPPLGQQQSEPQHNSAPPCGPYPGE MSMEG_5187|M.smegmatis_MC2_155 ----PVAGWRVLAPFRIREYRLLIAAVTLSIFA----------------- TH_1986|M.thermoresistible__bu ----TSGGWRVLAPFRIREYRLLITAVAITIFA----------------- Mvan_4580|M.vanbaalenii_PYR-1 EQPVAPAGWRVLAPFRYREYRLLIAAVSLSIFA----------------- MAB_2780c|M.abscessus_ATCC_199 SHPSTSGLPRALRPMRHRDYRLLTLGLAITLLG----------------- Mb1288c|M.bovis_AF2122/97 -----------MRNSNRGPAFLILFATLMAAAG----------------- Rv1258c|M.tuberculosis_H37Rv -----------MRNSNRGPAFLILFATLMAAAG----------------- MMAR_4182|M.marinum_M -----------MRNSSRGPAFLILFATLAACAG----------------- MAV_1406|M.avium_104 ---------------------MILFATLLATAG----------------- Mflv_2234|M.gilvum_PYR-GCK -------MTPDTTPRSRTPLLLIMFAALMAGAG----------------- MUL_0051|M.ulcerans_Agy99 -MHASAPVELWRSVRSLPDFWRLLQVRIASQFG----------------- MLBr_02143|M.leprae_Br4923 RIKVTRAAAQRSREMGYRMYWMVQRAATADGADKSGLTALTWPVVTNFAV : MSMEG_5187|M.smegmatis_MC2_155 EGMWSVVMALQVIAIDNDPASLSLVATCLGVGLVAFVLVGGITADRIN-- TH_1986|M.thermoresistible__bu EGMWAVVMALQVIAIDNDPASLSLVATCMGVGLVAFVLVGGITADRIN-- Mvan_4580|M.vanbaalenii_PYR-1 EGMWAVVMALQVIELSNDPAALSLVATCLGAGLVGFVLVGGLAADRLS-- MAB_2780c|M.abscessus_ATCC_199 NGMWTVALVWQVIRMGLGPAQVAVVGTTFSVGLLLSVLPAGVAADRLP-- Mb1288c|M.bovis_AF2122/97 DGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFG-- Rv1258c|M.tuberculosis_H37Rv DGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFG-- MMAR_4182|M.marinum_M NGISIVAFPWLVLEREGSAGQASIVAGAITLPLLFSTLVAGTAVDYFG-- MAV_1406|M.avium_104 TGISIVAFPWLALQHRHSATDASIVAAAMTLPLVLATLIAGTAVDFFG-- Mflv_2234|M.gilvum_PYR-GCK NGISIVAFPWLVLQRTGSALDASIVAMAGTLPLLAATLIAGAAVDFLG-- MUL_0051|M.ulcerans_Agy99 DGLFQAGLAGALLFNPDRAADPMAIARAFAVLFLPYSLLGPFAGALMDRW MLBr_02143|M.leprae_Br4923 DSAMAVALANTLFFAAASGESKSKVALYLLITIAPFAVIAPLIGPALDRL . . : : :. : : . : MSMEG_5187|M.smegmatis_MC2_155 --QRTIIIAVEVVNFVTVAVISALALLGVLKIWH--MAVAAGILGIAAAF TH_1986|M.thermoresistible__bu --QRTIIIAVEAVNAVTVAVVAMLGLTGQLRIWH--LAVAAAVLGIAAAF Mvan_4580|M.vanbaalenii_PYR-1 --QRGIIIVVEAVNTVAVTAVAVLGFVDALRIWH--MAVAAAALGIAAAF MAB_2780c|M.abscessus_ATCC_199 --KLWVMRCSLAVQTALMLTTATLALTGAAHIWH--LALNSLLFGIAEGF Mb1288c|M.bovis_AF2122/97 --RRRVSMVADALSGAAVAGVPLVAWGYGGDAVN--VLVLAVLAALAAAF Rv1258c|M.tuberculosis_H37Rv --RRRVSMVADALSGAAVAGVPLVAWGYGGDAVN--VLVLAVLAALAAAF MMAR_4182|M.marinum_M --RRPVSMVSDALSGSAVAIVPLIAWAFGDDAVS--VAVLAALGACSATF MAV_1406|M.avium_104 --RRRVSLVCDWLSGAAVTAVPLTAWIFGAAAID--VAELAVLAFCAAAF Mflv_2234|M.gilvum_PYR-GCK --RRRVSMISDALSALSVAAVPVIALVFGADAVN--VAVLAALAALGAFF MUL_0051|M.ulcerans_Agy99 --DRRLVIVGANIGRLILIAGIGTILAFEAGDLL--LLFVALLANGLARF MLBr_02143|M.leprae_Br4923 QHGRRVALATSFVLRTGLATLLIMNYDGATGSYPSMVLYPCALAMMVLSK : : : : . MSMEG_5187|M.smegmatis_MC2_155 FFPAYSAILPRILPPEQ--LLAANGVEGVVRPVFQRS--VGPAVAGMVIG TH_1986|M.thermoresistible__bu FFPAYSALLPRILPPEQ--LLAANGVEGVVRPVFQRA--VGPAVAGMLVG Mvan_4580|M.vanbaalenii_PYR-1 FFPAYSAILPRILPPEQ--LLAANGIEGVVRPVFQRA--VGPAIAGLVVG MAB_2780c|M.abscessus_ATCC_199 YIPAYTALLPSLLPADE--LLAANGIEGILRPVMQLA--AGPAVSAAIVS Mb1288c|M.bovis_AF2122/97 GPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIA Rv1258c|M.tuberculosis_H37Rv GPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIA MMAR_4182|M.marinum_M DPAGITARQSMLPEAAARAGWSLDRINSSYEAILNLAFVVGPGIGGLMIA MAV_1406|M.avium_104 DPAGMTARQSMLPEAAARAGWSLDRTNSSYEAMLNLAFIVGPGLGGLLIA Mflv_2234|M.gilvum_PYR-GCK DPAGMTARETMLPEAAHRAGWTLDRANSFFEAVFNLAYIVGPGIGGLLIA MUL_0051|M.ulcerans_Agy99 VASGLSASLPHVVPREQ--VVTMNSVATASGAVAAFVGANFMLLPRWLAG MLBr_02143|M.leprae_Br4923 SFSVLRSAVTPRVMPPSIDLVRVNSRLTVFGLLGGTIAGGAIAAGVEFVC . : . : : . MSMEG_5187|M.smegmatis_MC2_155 ATMPSIGAVVVAVLFALGLALLVATRPP--AQPASEHHERPHVLR----D TH_1986|M.thermoresistible__bu ATFPSLGSAVVATLFGVGLVLLVATRPP--ASPSVPGEHRSRVLR----D Mvan_4580|M.vanbaalenii_PYR-1 ALFPSAGALVVAVLFATGLALLVATRPPKAKDTGAQHEPRPHLLR----D MAB_2780c|M.abscessus_ATCC_199 VWSPGGAFLLEGMLVGAGLSCLLLVRHK--HEPPASAEVRQHPLRRALAD Mb1288c|M.bovis_AF2122/97 TVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSG----- Rv1258c|M.tuberculosis_H37Rv TVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSG----- MMAR_4182|M.marinum_M TVGGITTMWITAGAFGLSLLAIGALRLEGAGRPHHETRPDGLVSG----- MAV_1406|M.avium_104 TLGGINTMWVTAGCFALSFLAIGALRLEGAGKPPRATRPVGLVTG----- Mflv_2234|M.gilvum_PYR-GCK TLGGIDTMWVTAGAFVLSIAAIAVLRLEGTARPDPSTMSDGVWAG----- MUL_0051|M.ulcerans_Agy99 GGDHGAAAVIFTAMIPVAISLLLALRFAPRVLGPDDTKRAIHGSAVY--A MLBr_02143|M.leprae_Br4923 AHLFKLPGALFVVAAITISGALLSMRIPRWVEVTAGEIPATLSYRLHRKP : : : MSMEG_5187|M.smegmatis_MC2_155 LREGFAFVLKTPWLL---------WTVLFASMFVLVVLGPIEVLLPFIAQ TH_1986|M.thermoresistible__bu LRDGFMFMVATPWLL---------WTLLFASVFVLVVLGPIEVLLPFIAQ Mvan_4580|M.vanbaalenii_PYR-1 LRDGWVFMLRTPWLL---------WTLLFASLFVLVVLGPIEVLLPFVVA MAB_2780c|M.abscessus_ATCC_199 LAEGFRYMVRTTWFF---------ATLLFAIGYVLVVVGPIEILLPFVIR Mb1288c|M.bovis_AF2122/97 IAEGLRFVWNLRVLR---------TLGMIDLTVTALYLPMESVLFPKYFT Rv1258c|M.tuberculosis_H37Rv IAEGLRFVWNLRVLR---------TLGMIDLTVTALYLPMESVLFPKYFT MMAR_4182|M.marinum_M VTQGLRFVWNLRVLR---------ALALIDLTVTALYLPMESVLFPTYFS MAV_1406|M.avium_104 IAEGVRFVWNLRVLR---------TLGLIDLAVTALYLPMESVLFPKYFA Mflv_2234|M.gilvum_PYR-GCK ILEGLRFVWNNKVLR---------TLAFVDLAATGLYMPMESVLFPKYFT MUL_0051|M.ulcerans_Agy99 VITGWMHGVRTVVQIP------TVAAALSGLAAHRMVVGVNSLLILLLVH MLBr_02143|M.leprae_Br4923 LRQSWPEEVKKVSGRLRQPLGRNIITSLWGNCTIKVMVGFLFLYPAFVAK : . : : : : MSMEG_5187|M.smegmatis_MC2_155 DRFADGARAYGFILAFFGIGSAMGALTVSSRR--MPRRYLTTMMLMWGLG TH_1986|M.thermoresistible__bu ERFTDGARMYGFVLAAFGVGSAVGALTVSSRQ--MPRRYLTVMMLMWALG Mvan_4580|M.vanbaalenii_PYR-1 ERFTHGAQTYGFILAFFGLGSALGALGVSSRR--LPRRYLTVMMAMWSVG MAB_2780c|M.abscessus_ATCC_199 DHGGD-PGAHATVLALFGLAGAVGSFIVSSLP--LARRYLTVMILMWGAG Mb1288c|M.bovis_AF2122/97 D--HQQPVQLGWALMAIAGGGLVGALGYAVLA--IRVPRRVTMSTAVLTL Rv1258c|M.tuberculosis_H37Rv D--HQQPVQLGWALMAIAGGGLVGALGYAVLA--IRVPRRVTMSTAVLTL MMAR_4182|M.marinum_M D--RQQPAQLGSVLVALSLGSLVGALGYGMLS--NYVSRRTIMLTAVLTL MAV_1406|M.avium_104 D--QHQPAQLGWALMALALGGVAGALGYAVLS--ARLRRRTAVLTATLTF Mflv_2234|M.gilvum_PYR-GCK D--RDEPAQLGWVLMALSIGGLLGALGFAVLS--KYLKRRTVMLTAVLTL MUL_0051|M.ulcerans_Agy99 HMRDVDVEGLGTALLFFAATGLGAFLANVLTPGLIRRWGRYATTNGALAA MLBr_02143|M.leprae_Br4923 EHQANGWVQLGMLGLIGTAAAIGNFAGNFTSARLQLGRPAVLVVRCTIAV . . . MSMEG_5187|M.smegmatis_MC2_155 SIPLVIVGYTSSFPLMAAATFVIGVTDGAGMVIWGTLLQRRVPTEMLG-- TH_1986|M.thermoresistible__bu SVPLLVIGFTWSFLLMSAASFAIGVTDGAGMVIWGTLLQRRVPRELLG-- Mvan_4580|M.vanbaalenii_PYR-1 SVPLVIVGVTSSFPLMALATFVIGVTDGTAMVIWGTLLQRRVPPELLG-- MAB_2780c|M.abscessus_ATCC_199 SLPLIFIGFTGHVWMIAVAMIIVGGTMQAANVIWGTLMQRRVPEEMLG-- Mb1288c|M.bovis_AF2122/97 GLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRG-- Rv1258c|M.tuberculosis_H37Rv GLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRG-- MMAR_4182|M.marinum_M GAATTGIALLPPLPVILVLCALIGVVYGPIQPIYNYVMQTRAPHYLRG-- MAV_1406|M.avium_104 GATTAGIAVLPPLPVILGLCAVTGVVYGPIQPIYNFVMQTRAPHHLRG-- Mflv_2234|M.gilvum_PYR-GCK GVAMTVIAFLPPLPIILVLCALVGFVYGPIAPIYNYVMQTRAPQHLRG-- MUL_0051|M.ulcerans_Agy99 AAVTQLAGAGLLLPVMVVCGFLLGVAGQVVKLCADSAMQIDVDGALRG-- MLBr_02143|M.leprae_Br4923 TVLALAASVAGNLLMTTIATLITSGSSAIAKASLDASLQNDLPEESRASG . . : . . :* . MSMEG_5187|M.smegmatis_MC2_155 --RVSSLDFFVSLAFMPLSFAIVGPLSKVVSMEVIFATAGLVPVAIAAVA TH_1986|M.thermoresistible__bu --RVSSLDFFVSLVFMPVSFAIAGPLSKVVSMQTIFLVAGLAPLLFAVVA Mvan_4580|M.vanbaalenii_PYR-1 --RVSSLDFFVSLAFMPVSFAIVGPLSKIVSMEAIFLAAGLLPVLLAAVA MAB_2780c|M.abscessus_ATCC_199 --RAASMDFFVSLVGLPASFALVVPVAHVIGNTTVFVIAGVAPLVLAAAA Mb1288c|M.bovis_AF2122/97 --RVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVA Rv1258c|M.tuberculosis_H37Rv --RVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVA MMAR_4182|M.marinum_M --RVVGVMTSLAYAAGPLGLLLAGPVADAAGLKVAFFALALPIAITGLMC MAV_1406|M.avium_104 --RVVGVMAGLTYAAGPLGLLVAGPLADAAGLKATFLTLAVPILAIGVVA Mflv_2234|M.gilvum_PYR-GCK --RVVGVMGSLAYAAGPLGLILAGPLADSAGLHVTFLALSLPMLALGIVS MUL_0051|M.ulcerans_Agy99 --HVFAVQDALFWVSYIVSVTVAAALIPDDGRAPVFVLVGSLIYLLGLCV MLBr_02143|M.leprae_Br4923 FGRSESTLQLAWVLGGALGVMVYTDLWVGFTAVSALLILGLAQTVVSFRG : . .. : : : . . MSMEG_5187|M.smegmatis_MC2_155 FTAARMHRDEVANPLL------------- TH_1986|M.thermoresistible__bu MTAARMPRDELEHPLN------------- Mvan_4580|M.vanbaalenii_PYR-1 VWAAKMHRDEVAHPLR------------- MAB_2780c|M.abscessus_ATCC_199 HIVARLGRDEMAHPLG------------- Mb1288c|M.bovis_AF2122/97 IRLPALRELDLAPQADIDRPVGSAQ---- Rv1258c|M.tuberculosis_H37Rv IRLPALRELDLAPQADIDRPVGSAQ---- MMAR_4182|M.marinum_M IRLPSLRELDHAPTQDISETSLL------ MAV_1406|M.avium_104 CGLPSLRELDRAPQFADDPGA-------- Mflv_2234|M.gilvum_PYR-GCK VFLPALRELDTPHP--------------- MUL_0051|M.ulcerans_Agy99 HSIVGRRSSASNVEGC------------- MLBr_02143|M.leprae_Br4923 DSLIPGLGGNRPVMIEQESMRRAAAVSPQ