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M. vanbaalenii PYR-1 Mvan_4580 (-)

annotation: H+ antiporter protein
coordinates: 4918144 - 4919475
length: 443

VVGNHRSVSTQYETGRSSARSDSEQPVAPAGWRVLAPFRYREYRLLIAAVSLSIFAEGMWAVVMALQVIE
LSNDPAALSLVATCLGAGLVGFVLVGGLAADRLSQRGIIIVVEAVNTVAVTAVAVLGFVDALRIWHMAVA
AAALGIAAAFFFPAYSAILPRILPPEQLLAANGIEGVVRPVFQRAVGPAIAGLVVGALFPSAGALVVAVL
FATGLALLVATRPPKAKDTGAQHEPRPHLLRDLRDGWVFMLRTPWLLWTLLFASLFVLVVLGPIEVLLPF
VVAERFTHGAQTYGFILAFFGLGSALGALGVSSRRLPRRYLTVMMAMWSVGSVPLVIVGVTSSFPLMALA
TFVIGVTDGTAMVIWGTLLQRRVPPELLGRVSSLDFFVSLAFMPVSFAIVGPLSKIVSMEAIFLAAGLLP
VLLAAVAVWAAKMHRDEVAHPLR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_4580--100% (443)H+ antiporter protein
M. vanbaalenii PYR-1Mvan_4461-9e-2427.25% (411) H+ antiporter protein
M. vanbaalenii PYR-1Mvan_1167-2e-1725.79% (380) protein of unknown function DUF894, DitE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1288c-6e-2127.43% (401) integral membrane transport protein
M. gilvum PYR-GCKMflv_2234-3e-2427.43% (412) H+ antiporter protein
M. tuberculosis H37RvRv1258c-6e-2127.43% (401) integral membrane transport protein
M. leprae Br4923MLBr_02143-8e-0524.17% (331) hypothetical protein MLBr_02143
M. abscessus ATCC 19977MAB_2780c-6e-9744.58% (415) putative transporter
M. marinum MMMAR_4182-4e-1926.77% (396) hypothetical protein MMAR_4182
M. avium 104MAV_1406-1e-1927.68% (401) transporter, major facilitator family protein
M. smegmatis MC2 155MSMEG_5187-0.076.67% (420) tetracycline-resistance determinant TetV
M. thermoresistible (build 8)TH_1986-1e-17772.18% (435) tetracycline-resistance determinant TetV
M. ulcerans Agy99MUL_0051-9e-0722.42% (397) integral membrane protein

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_5187|M.smegmatis_MC2_155      --------------------------------------------------
TH_1986|M.thermoresistible__bu      --------------------------------------------------
Mvan_4580|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2780c|M.abscessus_ATCC_199      --------------------------------------------------
Mb1288c|M.bovis_AF2122/97           --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_4182|M.marinum_M               --------------------------------------------------
MAV_1406|M.avium_104                --------------------------------------------------
Mflv_2234|M.gilvum_PYR-GCK          --------------------------------------------------
MUL_0051|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02143|M.leprae_Br4923          MSGRRRNHPGRLASIPGLRTRTGSRNQHPGIANYPADSSDFRPAQQRRAL
                                                                                      

MSMEG_5187|M.smegmatis_MC2_155      ---------------------------------------MRSPR------
TH_1986|M.thermoresistible__bu      --------------------------------VSTQYDIEPSAG------
Mvan_4580|M.vanbaalenii_PYR-1       -------------------------MVGNHRSVSTQYETGRSSARSDS--
MAB_2780c|M.abscessus_ATCC_199      --------------------------MDFPEQLKTEGVLGKNSGGSSGGE
Mb1288c|M.bovis_AF2122/97           --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_4182|M.marinum_M               --------------------------------------------------
MAV_1406|M.avium_104                --------------------------------------------------
Mflv_2234|M.gilvum_PYR-GCK          --------------------------------------------------
MUL_0051|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02143|M.leprae_Br4923          EQREQQAGQLDPARRSPSMPSANRYLPPLGQQQSEPQHNSAPPCGPYPGE
                                                                                      

MSMEG_5187|M.smegmatis_MC2_155      ----PVAGWRVLAPFRIREYRLLIAAVTLSIFA-----------------
TH_1986|M.thermoresistible__bu      ----TSGGWRVLAPFRIREYRLLITAVAITIFA-----------------
Mvan_4580|M.vanbaalenii_PYR-1       EQPVAPAGWRVLAPFRYREYRLLIAAVSLSIFA-----------------
MAB_2780c|M.abscessus_ATCC_199      SHPSTSGLPRALRPMRHRDYRLLTLGLAITLLG-----------------
Mb1288c|M.bovis_AF2122/97           -----------MRNSNRGPAFLILFATLMAAAG-----------------
Rv1258c|M.tuberculosis_H37Rv        -----------MRNSNRGPAFLILFATLMAAAG-----------------
MMAR_4182|M.marinum_M               -----------MRNSSRGPAFLILFATLAACAG-----------------
MAV_1406|M.avium_104                ---------------------MILFATLLATAG-----------------
Mflv_2234|M.gilvum_PYR-GCK          -------MTPDTTPRSRTPLLLIMFAALMAGAG-----------------
MUL_0051|M.ulcerans_Agy99           -MHASAPVELWRSVRSLPDFWRLLQVRIASQFG-----------------
MLBr_02143|M.leprae_Br4923          RIKVTRAAAQRSREMGYRMYWMVQRAATADGADKSGLTALTWPVVTNFAV
                                                          :                           

MSMEG_5187|M.smegmatis_MC2_155      EGMWSVVMALQVIAIDNDPASLSLVATCLGVGLVAFVLVGGITADRIN--
TH_1986|M.thermoresistible__bu      EGMWAVVMALQVIAIDNDPASLSLVATCMGVGLVAFVLVGGITADRIN--
Mvan_4580|M.vanbaalenii_PYR-1       EGMWAVVMALQVIELSNDPAALSLVATCLGAGLVGFVLVGGLAADRLS--
MAB_2780c|M.abscessus_ATCC_199      NGMWTVALVWQVIRMGLGPAQVAVVGTTFSVGLLLSVLPAGVAADRLP--
Mb1288c|M.bovis_AF2122/97           DGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFG--
Rv1258c|M.tuberculosis_H37Rv        DGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFG--
MMAR_4182|M.marinum_M               NGISIVAFPWLVLEREGSAGQASIVAGAITLPLLFSTLVAGTAVDYFG--
MAV_1406|M.avium_104                TGISIVAFPWLALQHRHSATDASIVAAAMTLPLVLATLIAGTAVDFFG--
Mflv_2234|M.gilvum_PYR-GCK          NGISIVAFPWLVLQRTGSALDASIVAMAGTLPLLAATLIAGAAVDFLG--
MUL_0051|M.ulcerans_Agy99           DGLFQAGLAGALLFNPDRAADPMAIARAFAVLFLPYSLLGPFAGALMDRW
MLBr_02143|M.leprae_Br4923          DSAMAVALANTLFFAAASGESKSKVALYLLITIAPFAVIAPLIGPALDRL
                                     .   . :    :           :.      :    : .      :   

MSMEG_5187|M.smegmatis_MC2_155      --QRTIIIAVEVVNFVTVAVISALALLGVLKIWH--MAVAAGILGIAAAF
TH_1986|M.thermoresistible__bu      --QRTIIIAVEAVNAVTVAVVAMLGLTGQLRIWH--LAVAAAVLGIAAAF
Mvan_4580|M.vanbaalenii_PYR-1       --QRGIIIVVEAVNTVAVTAVAVLGFVDALRIWH--MAVAAAALGIAAAF
MAB_2780c|M.abscessus_ATCC_199      --KLWVMRCSLAVQTALMLTTATLALTGAAHIWH--LALNSLLFGIAEGF
Mb1288c|M.bovis_AF2122/97           --RRRVSMVADALSGAAVAGVPLVAWGYGGDAVN--VLVLAVLAALAAAF
Rv1258c|M.tuberculosis_H37Rv        --RRRVSMVADALSGAAVAGVPLVAWGYGGDAVN--VLVLAVLAALAAAF
MMAR_4182|M.marinum_M               --RRPVSMVSDALSGSAVAIVPLIAWAFGDDAVS--VAVLAALGACSATF
MAV_1406|M.avium_104                --RRRVSLVCDWLSGAAVTAVPLTAWIFGAAAID--VAELAVLAFCAAAF
Mflv_2234|M.gilvum_PYR-GCK          --RRRVSMISDALSALSVAAVPVIALVFGADAVN--VAVLAALAALGAFF
MUL_0051|M.ulcerans_Agy99           --DRRLVIVGANIGRLILIAGIGTILAFEAGDLL--LLFVALLANGLARF
MLBr_02143|M.leprae_Br4923          QHGRRVALATSFVLRTGLATLLIMNYDGATGSYPSMVLYPCALAMMVLSK
                                         :      :    :                  :   .         

MSMEG_5187|M.smegmatis_MC2_155      FFPAYSAILPRILPPEQ--LLAANGVEGVVRPVFQRS--VGPAVAGMVIG
TH_1986|M.thermoresistible__bu      FFPAYSALLPRILPPEQ--LLAANGVEGVVRPVFQRA--VGPAVAGMLVG
Mvan_4580|M.vanbaalenii_PYR-1       FFPAYSAILPRILPPEQ--LLAANGIEGVVRPVFQRA--VGPAIAGLVVG
MAB_2780c|M.abscessus_ATCC_199      YIPAYTALLPSLLPADE--LLAANGIEGILRPVMQLA--AGPAVSAAIVS
Mb1288c|M.bovis_AF2122/97           GPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIA
Rv1258c|M.tuberculosis_H37Rv        GPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIA
MMAR_4182|M.marinum_M               DPAGITARQSMLPEAAARAGWSLDRINSSYEAILNLAFVVGPGIGGLMIA
MAV_1406|M.avium_104                DPAGMTARQSMLPEAAARAGWSLDRTNSSYEAMLNLAFIVGPGLGGLLIA
Mflv_2234|M.gilvum_PYR-GCK          DPAGMTARETMLPEAAHRAGWTLDRANSFFEAVFNLAYIVGPGIGGLLIA
MUL_0051|M.ulcerans_Agy99           VASGLSASLPHVVPREQ--VVTMNSVATASGAVAAFVGANFMLLPRWLAG
MLBr_02143|M.leprae_Br4923          SFSVLRSAVTPRVMPPSIDLVRVNSRLTVFGLLGGTIAGGAIAAGVEFVC
                                      .   :  .             :        :              .  

MSMEG_5187|M.smegmatis_MC2_155      ATMPSIGAVVVAVLFALGLALLVATRPP--AQPASEHHERPHVLR----D
TH_1986|M.thermoresistible__bu      ATFPSLGSAVVATLFGVGLVLLVATRPP--ASPSVPGEHRSRVLR----D
Mvan_4580|M.vanbaalenii_PYR-1       ALFPSAGALVVAVLFATGLALLVATRPPKAKDTGAQHEPRPHLLR----D
MAB_2780c|M.abscessus_ATCC_199      VWSPGGAFLLEGMLVGAGLSCLLLVRHK--HEPPASAEVRQHPLRRALAD
Mb1288c|M.bovis_AF2122/97           TVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSG-----
Rv1258c|M.tuberculosis_H37Rv        TVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSG-----
MMAR_4182|M.marinum_M               TVGGITTMWITAGAFGLSLLAIGALRLEGAGRPHHETRPDGLVSG-----
MAV_1406|M.avium_104                TLGGINTMWVTAGCFALSFLAIGALRLEGAGKPPRATRPVGLVTG-----
Mflv_2234|M.gilvum_PYR-GCK          TLGGIDTMWVTAGAFVLSIAAIAVLRLEGTARPDPSTMSDGVWAG-----
MUL_0051|M.ulcerans_Agy99           GGDHGAAAVIFTAMIPVAISLLLALRFAPRVLGPDDTKRAIHGSAVY--A
MLBr_02143|M.leprae_Br4923          AHLFKLPGALFVVAAITISGALLSMRIPRWVEVTAGEIPATLSYRLHRKP
                                             :           :   :                        

MSMEG_5187|M.smegmatis_MC2_155      LREGFAFVLKTPWLL---------WTVLFASMFVLVVLGPIEVLLPFIAQ
TH_1986|M.thermoresistible__bu      LRDGFMFMVATPWLL---------WTLLFASVFVLVVLGPIEVLLPFIAQ
Mvan_4580|M.vanbaalenii_PYR-1       LRDGWVFMLRTPWLL---------WTLLFASLFVLVVLGPIEVLLPFVVA
MAB_2780c|M.abscessus_ATCC_199      LAEGFRYMVRTTWFF---------ATLLFAIGYVLVVVGPIEILLPFVIR
Mb1288c|M.bovis_AF2122/97           IAEGLRFVWNLRVLR---------TLGMIDLTVTALYLPMESVLFPKYFT
Rv1258c|M.tuberculosis_H37Rv        IAEGLRFVWNLRVLR---------TLGMIDLTVTALYLPMESVLFPKYFT
MMAR_4182|M.marinum_M               VTQGLRFVWNLRVLR---------ALALIDLTVTALYLPMESVLFPTYFS
MAV_1406|M.avium_104                IAEGVRFVWNLRVLR---------TLGLIDLAVTALYLPMESVLFPKYFA
Mflv_2234|M.gilvum_PYR-GCK          ILEGLRFVWNNKVLR---------TLAFVDLAATGLYMPMESVLFPKYFT
MUL_0051|M.ulcerans_Agy99           VITGWMHGVRTVVQIP------TVAAALSGLAAHRMVVGVNSLLILLLVH
MLBr_02143|M.leprae_Br4923          LRQSWPEEVKKVSGRLRQPLGRNIITSLWGNCTIKVMVGFLFLYPAFVAK
                                    :  .                       :       : :    :       

MSMEG_5187|M.smegmatis_MC2_155      DRFADGARAYGFILAFFGIGSAMGALTVSSRR--MPRRYLTTMMLMWGLG
TH_1986|M.thermoresistible__bu      ERFTDGARMYGFVLAAFGVGSAVGALTVSSRQ--MPRRYLTVMMLMWALG
Mvan_4580|M.vanbaalenii_PYR-1       ERFTHGAQTYGFILAFFGLGSALGALGVSSRR--LPRRYLTVMMAMWSVG
MAB_2780c|M.abscessus_ATCC_199      DHGGD-PGAHATVLALFGLAGAVGSFIVSSLP--LARRYLTVMILMWGAG
Mb1288c|M.bovis_AF2122/97           D--HQQPVQLGWALMAIAGGGLVGALGYAVLA--IRVPRRVTMSTAVLTL
Rv1258c|M.tuberculosis_H37Rv        D--HQQPVQLGWALMAIAGGGLVGALGYAVLA--IRVPRRVTMSTAVLTL
MMAR_4182|M.marinum_M               D--RQQPAQLGSVLVALSLGSLVGALGYGMLS--NYVSRRTIMLTAVLTL
MAV_1406|M.avium_104                D--QHQPAQLGWALMALALGGVAGALGYAVLS--ARLRRRTAVLTATLTF
Mflv_2234|M.gilvum_PYR-GCK          D--RDEPAQLGWVLMALSIGGLLGALGFAVLS--KYLKRRTVMLTAVLTL
MUL_0051|M.ulcerans_Agy99           HMRDVDVEGLGTALLFFAATGLGAFLANVLTPGLIRRWGRYATTNGALAA
MLBr_02143|M.leprae_Br4923          EHQANGWVQLGMLGLIGTAAAIGNFAGNFTSARLQLGRPAVLVVRCTIAV
                                    .         .         .                             

MSMEG_5187|M.smegmatis_MC2_155      SIPLVIVGYTSSFPLMAAATFVIGVTDGAGMVIWGTLLQRRVPTEMLG--
TH_1986|M.thermoresistible__bu      SVPLLVIGFTWSFLLMSAASFAIGVTDGAGMVIWGTLLQRRVPRELLG--
Mvan_4580|M.vanbaalenii_PYR-1       SVPLVIVGVTSSFPLMALATFVIGVTDGTAMVIWGTLLQRRVPPELLG--
MAB_2780c|M.abscessus_ATCC_199      SLPLIFIGFTGHVWMIAVAMIIVGGTMQAANVIWGTLMQRRVPEEMLG--
Mb1288c|M.bovis_AF2122/97           GLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRG--
Rv1258c|M.tuberculosis_H37Rv        GLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRG--
MMAR_4182|M.marinum_M               GAATTGIALLPPLPVILVLCALIGVVYGPIQPIYNYVMQTRAPHYLRG--
MAV_1406|M.avium_104                GATTAGIAVLPPLPVILGLCAVTGVVYGPIQPIYNFVMQTRAPHHLRG--
Mflv_2234|M.gilvum_PYR-GCK          GVAMTVIAFLPPLPIILVLCALVGFVYGPIAPIYNYVMQTRAPQHLRG--
MUL_0051|M.ulcerans_Agy99           AAVTQLAGAGLLLPVMVVCGFLLGVAGQVVKLCADSAMQIDVDGALRG--
MLBr_02143|M.leprae_Br4923          TVLALAASVAGNLLMTTIATLITSGSSAIAKASLDASLQNDLPEESRASG
                                           .    . :        .          .  :*        .  

MSMEG_5187|M.smegmatis_MC2_155      --RVSSLDFFVSLAFMPLSFAIVGPLSKVVSMEVIFATAGLVPVAIAAVA
TH_1986|M.thermoresistible__bu      --RVSSLDFFVSLVFMPVSFAIAGPLSKVVSMQTIFLVAGLAPLLFAVVA
Mvan_4580|M.vanbaalenii_PYR-1       --RVSSLDFFVSLAFMPVSFAIVGPLSKIVSMEAIFLAAGLLPVLLAAVA
MAB_2780c|M.abscessus_ATCC_199      --RAASMDFFVSLVGLPASFALVVPVAHVIGNTTVFVIAGVAPLVLAAAA
Mb1288c|M.bovis_AF2122/97           --RVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVA
Rv1258c|M.tuberculosis_H37Rv        --RVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVA
MMAR_4182|M.marinum_M               --RVVGVMTSLAYAAGPLGLLLAGPVADAAGLKVAFFALALPIAITGLMC
MAV_1406|M.avium_104                --RVVGVMAGLTYAAGPLGLLVAGPLADAAGLKATFLTLAVPILAIGVVA
Mflv_2234|M.gilvum_PYR-GCK          --RVVGVMGSLAYAAGPLGLILAGPLADSAGLHVTFLALSLPMLALGIVS
MUL_0051|M.ulcerans_Agy99           --HVFAVQDALFWVSYIVSVTVAAALIPDDGRAPVFVLVGSLIYLLGLCV
MLBr_02143|M.leprae_Br4923          FGRSESTLQLAWVLGGALGVMVYTDLWVGFTAVSALLILGLAQTVVSFRG
                                      :  .            .. :   :         :   .      .   

MSMEG_5187|M.smegmatis_MC2_155      FTAARMHRDEVANPLL-------------
TH_1986|M.thermoresistible__bu      MTAARMPRDELEHPLN-------------
Mvan_4580|M.vanbaalenii_PYR-1       VWAAKMHRDEVAHPLR-------------
MAB_2780c|M.abscessus_ATCC_199      HIVARLGRDEMAHPLG-------------
Mb1288c|M.bovis_AF2122/97           IRLPALRELDLAPQADIDRPVGSAQ----
Rv1258c|M.tuberculosis_H37Rv        IRLPALRELDLAPQADIDRPVGSAQ----
MMAR_4182|M.marinum_M               IRLPSLRELDHAPTQDISETSLL------
MAV_1406|M.avium_104                CGLPSLRELDRAPQFADDPGA--------
Mflv_2234|M.gilvum_PYR-GCK          VFLPALRELDTPHP---------------
MUL_0051|M.ulcerans_Agy99           HSIVGRRSSASNVEGC-------------
MLBr_02143|M.leprae_Br4923          DSLIPGLGGNRPVMIEQESMRRAAAVSPQ