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MTSPVSTSTWAPLQSPVFRALWIAQFVSNLGTWMQTVGAQWMLVDDPAAAVLVPLVQTATTLPVMLLALP SGVLADLVDRRRLLIATQGAMAAGVGLLATLTGAGLTTPTVLLTLLFVIGCGQALTAPAWQAIQPDLVPS DQIPAAAALGSMSMNGARAIGPAIAGALVSLTGPTIVFALNAVSFVGIVLVLMWWRRPPVRSDYPPERAL AALSAGGRYIRSSPIVRRILLRTVLFIAPGSAVWGLLPVIARDQLGLGSAGYGALLGALGVGAVLGAFAL SRLRARFGQNKLLIAGAAGFGMATAVLALVHNVALVAAALVVGGAAWLLTLSTLNASMQLSLPSWVRARG LSVYQLIFMGGQAVGSLLWGLLAGGTSSVISLLVSAGLLIFCGLSLWWWPLHAGTGNLDLTPSSHWPEPT LLFEPEPLDGPVLVITAYRVLPENEEPFMSAMARLGRSRQRTGASMWQLFRSIEQESTFVETFIVRSWGE HMHQHYTRLTGQDQLIEQDVERYTEGEAVAEHYLAVRDAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5163 | - | - | 100% (530) | protein of unknown function DUF894, DitE |
| M. gilvum PYR-GCK | Mflv_1033 | - | 6e-31 | 27.53% (385) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_2234 | - | 1e-13 | 21.71% (410) | H+ antiporter protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 4e-14 | 21.80% (422) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv1258c | - | 4e-14 | 21.80% (422) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_02143 | - | 9e-08 | 23.97% (388) | hypothetical protein MLBr_02143 |
| M. abscessus ATCC 19977 | MAB_0880 | - | 4e-48 | 33.89% (419) | hypothetical protein MAB_0880 |
| M. marinum M | MMAR_4182 | - | 9e-15 | 21.23% (424) | hypothetical protein MMAR_4182 |
| M. avium 104 | MAV_1406 | - | 1e-16 | 23.97% (388) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0357 | - | 0.0 | 77.59% (522) | transmembrane transport protein |
| M. thermoresistible (build 8) | TH_1317 | - | 0.0 | 68.18% (506) | transmembrane transport protein |
| M. ulcerans Agy99 | MUL_0274 | - | 8e-07 | 32.28% (127) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_1167 | - | 0.0 | 87.00% (523) | protein of unknown function DUF894, DitE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1288c|M.bovis_AF2122/97 -----------------MRNSNRGPAFLILFATL----------------
Rv1258c|M.tuberculosis_H37Rv -----------------MRNSNRGPAFLILFATL----------------
MMAR_4182|M.marinum_M -----------------MRNSSRGPAFLILFATL----------------
MAV_1406|M.avium_104 ---------------------------MILFATL----------------
Mflv_5163|M.gilvum_PYR-GCK ----MTSP----VSTSTWAPLQSPVFRALWIAQF----------------
Mvan_1167|M.vanbaalenii_PYR-1 ----MALA----GSTSTWAPLGSPIFRALWIAQF----------------
MSMEG_0357|M.smegmatis_MC2_155 ----MTTATPAMGATSTWAPLASPIYRALWIAQF----------------
TH_1317|M.thermoresistible__bu ----------------------------LWIAQF----------------
MLBr_02143|M.leprae_Br4923 MSGRRRNHPGRLASIPGLRTRTGSRNQHPGIANYPADSSDFRPAQQRRAL
MUL_0274|M.ulcerans_Agy99 MSGWRRDHQGRMAASPGRRTRNGSVSEHPGMANYPTDG----PGNRR---
MAB_0880|M.abscessus_ATCC_1997 -----------MADRGGIFVSLRTRNYRLWISGQ----------------
::
Mb1288c|M.bovis_AF2122/97 ------------------MAAAGDGVSIVAFPWLVLQREGSAGQAS----
Rv1258c|M.tuberculosis_H37Rv ------------------MAAAGDGVSIVAFPWLVLQREGSAGQAS----
MMAR_4182|M.marinum_M ------------------AACAGNGISIVAFPWLVLEREGSAGQAS----
MAV_1406|M.avium_104 ------------------LATAGTGISIVAFPWLALQHRHSATDAS----
Mflv_5163|M.gilvum_PYR-GCK ------------------VSNLGTWMQTVGAQWMLVDDPAAAVLVP----
Mvan_1167|M.vanbaalenii_PYR-1 ------------------VSNLGTWMQTVGAQWMLVDDPRAAVLVP----
MSMEG_0357|M.smegmatis_MC2_155 ------------------VSNLGTWMQTVGAQWMLVGDPRAAVLVP----
TH_1317|M.thermoresistible__bu ------------------VSNLGTWMQTVGAQWMLVSTPAAEVLVP----
MLBr_02143|M.leprae_Br4923 EQREQQAGQLDPARRSPSMPSANRYLPPLGQQ---QSEPQHNSAPP---C
MUL_0274|M.ulcerans_Agy99 ------------TRRPPPMPSANRYLPPLDREPESEDDAEGNEAPPPPPR
MAB_0880|M.abscessus_ATCC_1997 -----------------MVSLIGTWMQRVAQDWLVLDLSHGNAFLLG---
. . : :
Mb1288c|M.bovis_AF2122/97 --IVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVP-LV
Rv1258c|M.tuberculosis_H37Rv --IVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVP-LV
MMAR_4182|M.marinum_M --IVAGAITLPLLFSTLVAGTAVDYFGRRPVSMVSDALSGSAVAIVP-LI
MAV_1406|M.avium_104 --IVAAAMTLPLVLATLIAGTAVDFFGRRRVSLVCDWLSGAAVTAVP-LT
Mflv_5163|M.gilvum_PYR-GCK --LVQTATTLPVMLLALPSGVLADLVDRRRLLIATQGAMAAGVGLLATLT
Mvan_1167|M.vanbaalenii_PYR-1 --LVQTATTLPVMLLALPSGVLADLIDRRRLLIATQGAMAAGVGLLAVLT
MSMEG_0357|M.smegmatis_MC2_155 --LVQTATTLPVMLLALPSGVLADLVDRRRLLIAAQGATAAGVASLATLT
TH_1317|M.thermoresistible__bu --LVQTATTLPIMLLSLPSGVVADLVDRRRLLLATQSMMAAAVAILAALT
MLBr_02143|M.leprae_Br4923 GPYPGERIKVTRAAAQRSREMGYRMYWMVQRAATADGADKSGLTALTWPV
MUL_0274|M.ulcerans_Agy99 GLSSGERITVTRAAAMRSREMGSRMYWMVQRAATADGADKSGLTALTWPT
MAB_0880|M.abscessus_ATCC_1997 --VVMALQFGPTLLLSVWGGMLADRYDKRRMLMLTQALMALFALTVGLLQ
. : :
Mb1288c|M.bovis_AF2122/97 AWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAA------ARAG
Rv1258c|M.tuberculosis_H37Rv AWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAA------ARAG
MMAR_4182|M.marinum_M AWAFGDDAVSVAVLAALGACSATFDPAGITARQSMLPEAA------ARAG
MAV_1406|M.avium_104 AWIFGAAAIDVAELAVLAFCAAAFDPAGMTARQSMLPEAA------ARAG
Mflv_5163|M.gilvum_PYR-GCK GAGLTTPTVLLTLLFVIGCGQALTAPAWQAIQPDLVPSDQ------IPAA
Mvan_1167|M.vanbaalenii_PYR-1 GAGLTTPTVLLMLLFVIGCGQALTAPAWQAIQPDLVPAHQ------IPAA
MSMEG_0357|M.smegmatis_MC2_155 GAGLATPTVLLTLLFLIGCGQALTAPAWQAIQPDLVPREQ------IPAA
TH_1317|M.thermoresistible__bu AAQLTTPTVLLILLFLIGCGQAFTAPAWQAIQPELVPREQ------IPAA
MLBr_02143|M.leprae_Br4923 VTNFAVDSAMAVALANTLFFAAASGESKSKVALYLLITIAPFAVIAPLIG
MUL_0274|M.ulcerans_Agy99 MANFAVDSSMAVALANTLFFAAASGESKSKVALYLLITIAPFAVVAPLIG
MAB_0880|M.abscessus_ATCC_1997 VTGLVRIWHVMAVAFAMGCAAAIEAPTRQSFTIEMVGPEH------LPNA
* : :: .
Mb1288c|M.bovis_AF2122/97 WSLDRINGAYEAILNLAFIVGPAIGGLMIATVG------GITTMWITATA
Rv1258c|M.tuberculosis_H37Rv WSLDRINGAYEAILNLAFIVGPAIGGLMIATVG------GITTMWITATA
MMAR_4182|M.marinum_M WSLDRINSSYEAILNLAFVVGPGIGGLMIATVG------GITTMWITAGA
MAV_1406|M.avium_104 WSLDRTNSSYEAMLNLAFIVGPGLGGLLIATLG------GINTMWVTAGC
Mflv_5163|M.gilvum_PYR-GCK AALGSMS------MNGARAIGPAIAGALVSLTG------PTIVFALNAVS
Mvan_1167|M.vanbaalenii_PYR-1 AALGSMS------MNGARAIGPAIAGALVSLTG------PTLVFALNAVS
MSMEG_0357|M.smegmatis_MC2_155 AALGSMS------MNGARAIGPAIAGALVSLSG------PTLVFALNAVS
TH_1317|M.thermoresistible__bu AALTSMS------LNAARAVGPAVAGVLVAISG------PTLVFTLNAVS
MLBr_02143|M.leprae_Br4923 PALDRLQHGRRVALATSFVLRTGLATLLIMNYDGATGSYPSMVLYPCALA
MUL_0274|M.ulcerans_Agy99 PALDKLQHGRRVALALSFGLRTVLALVLIMNYDGASGSFPSWVLYPCALA
MAB_0880|M.abscessus_ATCC_1997 VGLNSMV------FNLAGIIGPATSGVLIGLIG------TGWVFLLNFVS
.* : : : . . :: . .: .
Mb1288c|M.bovis_AF2122/97 FGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGM
Rv1258c|M.tuberculosis_H37Rv FGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGM
MMAR_4182|M.marinum_M FGLSLLAIGALRLEGAGRPHHETRPDGLVSGVTQGLRFVWNLRVLRALAL
MAV_1406|M.avium_104 FALSFLAIGALRLEGAGKPPRATRPVGLVTGIAEGVRFVWNLRVLRTLGL
Mflv_5163|M.gilvum_PYR-GCK FVGIVLVLMWWRRPPVRSDYPPERA---LAALSAGGRYIRSSPIVRRILL
Mvan_1167|M.vanbaalenii_PYR-1 FIGIVLVLISWRRPAVQRDFPPERA---LAALSAGGRYIRSSPIVRRILL
MSMEG_0357|M.smegmatis_MC2_155 FVGIVAVLLLWRRPAAERMLPAERP---LAALSAGGRYIRSAPIVRRILL
TH_1317|M.thermoresistible__bu FAGIVVVLLLWKRSSAEQTLAAERP---LAALQAGHRYVRSSPVVRRILF
MLBr_02143|M.leprae_Br4923 MMVLSKSFSVLRSAVTPRVMPPSIDLVRVNSRLTVFGLLGGTIAGGAIAA
MUL_0274|M.ulcerans_Agy99 MMVLSKSFSVLRSAMTPRVMPPSIDLVRVNSRLTVFGLLGGTMAGGAVAA
MAB_0880|M.abscessus_ATCC_1997 FIAVGIALWRMRPGELHSSEPIPAAKG---QLRQGFSYVWRRRDLFMIML
: : : : :
Mb1288c|M.bovis_AF2122/97 IDLTVTALYLPMESVLFPKYFTDH-QQPVQLGW-ALMAIAGGGLVGALGY
Rv1258c|M.tuberculosis_H37Rv IDLTVTALYLPMESVLFPKYFTDH-QQPVQLGW-ALMAIAGGGLVGALGY
MMAR_4182|M.marinum_M IDLTVTALYLPMESVLFPTYFSDR-QQPAQLGS-VLVALSLGSLVGALGY
MAV_1406|M.avium_104 IDLAVTALYLPMESVLFPKYFADQ-HQPAQLGW-ALMALALGGVAGALGY
Mflv_5163|M.gilvum_PYR-GCK RTVLFIAPGSAVWGLLPVIARDQLGLGSAGYGA-LLGALGVGAVLGAFAL
Mvan_1167|M.vanbaalenii_PYR-1 RTVLFIAPASALWGLLPVIAANQLGLGSAGYGL-LLGALGAGAVLGAFVL
MSMEG_0357|M.smegmatis_MC2_155 RTVLFIAPGSALWGLLAVIAKDQLDLTSSGYGV-LLGALGLGAVCGAFVL
TH_1317|M.thermoresistible__bu RAALFILPASALWGLLPVVASSGLGLSSSGYGL-MLGALGAGAVLGALTL
MLBr_02143|M.leprae_Br4923 GVEFVCAHLFKLPGALFVVAAITISGALLSMRIPRWVEVTAGEIPATLSY
MUL_0274|M.ulcerans_Agy99 GVEFACTRLFELPGALFVVVAVTVAGALLSMRIPRWVEVTAGEVPATLSY
MAB_0880|M.abscessus_ATCC_1997 TVFLVSTFGLNFSLTLAVLARETFGRGAESYGL-LSTALAIGTLLGAT-F
. * : * : .:
Mb1288c|M.bovis_AF2122/97 AVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPI
Rv1258c|M.tuberculosis_H37Rv AVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPI
MMAR_4182|M.marinum_M GMLSNYVSRRTIMLTAVLTLGAATTGIALLPPLPVILVLCALIGVVYGPI
MAV_1406|M.avium_104 AVLSARLRRRTAVLTATLTFGATTAGIAVLPPLPVILGLCAVTGVVYGPI
Mflv_5163|M.gilvum_PYR-GCK SRLRARFGQNKLLIAGAAGFGMATAVLALVHNVALVAAALVVGGAAWLLT
Mvan_1167|M.vanbaalenii_PYR-1 SGLRTRFGQNVLLTAGAAGFAVATAVLALVPDFAAVLAALVVGGGAWLLS
MSMEG_0357|M.smegmatis_MC2_155 GRLQKMFELNTLLVVAAIGFGGATVVLALVHQVAVVVIALVLGGTAWLLA
TH_1317|M.thermoresistible__bu SAWQSAFRQNTLLALAAVGFAAATAVAVLVPDVVVVLIGLTVGGMSWLLA
MLBr_02143|M.leprae_Br4923 RLHRKPLRQS--WPEEVKKVSGRLRQPLGRNIITSLWGNCTIKVMVGFLF
MUL_0274|M.ulcerans_Agy99 HRDRGRQRRS--WPEEVKNLSGALRQPLGRNIITSLWGNCTIKVMVGFLF
MAB_0880|M.abscessus_ATCC_1997 AARRTKKVRMTLFYGAAMAFGLSEVVVSVMPTYLSVALALVPAGLLALTF
. .. : .
Mb1288c|M.bovis_AF2122/97 QPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAG-PLTDAAGLH
Rv1258c|M.tuberculosis_H37Rv QPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAG-PLTDAAGLH
MMAR_4182|M.marinum_M QPIYNYVMQTRAPHYLRGRVVGVMTSLAYAAGPLGLLLAG-PVADAAGLK
MAV_1406|M.avium_104 QPIYNFVMQTRAPHHLRGRVVGVMAGLTYAAGPLGLLVAG-PLADAAGLK
Mflv_5163|M.gilvum_PYR-GCK LSTLNASMQLSLPSWVRARGLSVYQLIFMGGQAVGSLLWG-LLAGGTSSV
Mvan_1167|M.vanbaalenii_PYR-1 LSTLNASMQLSLPAWVRARGLSVYQLIFMGGQAIGSLLWG-LLAGATNSV
MSMEG_0357|M.smegmatis_MC2_155 LSTLNASMQLSLPGWVRARGLSVYQLVFMGGQALGSLLWG-LIAGAAGSV
TH_1317|M.thermoresistible__bu LATLNASMQLSLPAWVRARGLSVYLLIFMGGQALGSTMWG-LVAGSTSTV
MLBr_02143|M.leprae_Br4923 LYPAFVAKEHQANGWVQLGMLGLIGTAAAIGNFAGNFTSARLQLGRPAVL
MUL_0274|M.ulcerans_Agy99 LYPAFVAKAHDANGWVQLGMLGLIGAAAAIGNFAGNFASARLQLGRPAVL
MAB_0880|M.abscessus_ATCC_1997 TTSAMNIIQLSVDSQLRGRVMGIYMVAFLGGTPLGSPLVG-WLADLHGGR
:: :.: . * . .
Mb1288c|M.bovis_AF2122/97 ATFLALALPIVCTGLVAIRLPALR---ELDLAPQADIDRPVGSAQ-----
Rv1258c|M.tuberculosis_H37Rv ATFLALALPIVCTGLVAIRLPALR---ELDLAPQADIDRPVGSAQ-----
MMAR_4182|M.marinum_M VAFFALALPIAITGLMCIRLPSLR---ELDHAPTQDISETSLL-------
MAV_1406|M.avium_104 ATFLTLAVPILAIGVVACGLPSLR---ELDRAPQFADDPGA---------
Mflv_5163|M.gilvum_PYR-GCK ISLLVSAGLLIFCGLSLWWWPLHAGTGNLDLTPSSHWPEPTLLFEPEPLD
Mvan_1167|M.vanbaalenii_PYR-1 TSLLVSAGLLVVCALSSLWWPLHAGTGNLDLTPSSHWPEPTLVFEPEPLD
MSMEG_0357|M.smegmatis_MC2_155 TALLVSAGLMGVCAVSAIWWPLHARTGNLDMTPSAHWPEPALIFEPEPLD
TH_1317|M.thermoresistible__bu VAMLISAGLLVVSGLSAWWWPLHPQTGQLDVSPSAHWPEPALVFEPEPRD
MLBr_02143|M.leprae_Br4923 VVRCTIAVTVLALAASVAGNLLMTTIATLITSGSSAIAKASLDAS-----
MUL_0274|M.ulcerans_Agy99 VVRCTMVVTAFALAAAVAGNLVTAAIATLVTSASSAIAKASLDAS-----
MAB_0880|M.abscessus_ATCC_1997 MPLLVGGLVSAAAGLVCATYLHRHP----CPVVAGEVPEADDMVPPAPAA
.
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4182|M.marinum_M --------------------------------------------------
MAV_1406|M.avium_104 --------------------------------------------------
Mflv_5163|M.gilvum_PYR-GCK GPVLVITAYRVLPENEEPFMSAMARLGRSRQRTGASMWQLFRSIEQESTF
Mvan_1167|M.vanbaalenii_PYR-1 GPVLVLTSYCVPAHNEGAFLAAMAVLGRSRQRTGASQWRLFRSVEQESTF
MSMEG_0357|M.smegmatis_MC2_155 GPVVVLVSYRVEPAQETGFFEAMAALGRSRQRTGASQWQLFRSGEHAGTF
TH_1317|M.thermoresistible__bu GPVLVLSTYRVAPEDEPAFLVAMQRQARSRQRTGAALWRLYRHLEREHTF
MLBr_02143|M.leprae_Br4923 -----LQNDLPEESRASGFGRSESTLQLAWVLGGALGVMVYTDLWVGFTA
MUL_0274|M.ulcerans_Agy99 -----LQHDLPEESRASGFGRSESTLQLAWVLGGAVGVLIYTDLWIGFTT
MAB_0880|M.abscessus_ATCC_1997 TPVCEPTPLARRS-------------------------------------
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4182|M.marinum_M --------------------------------------------------
MAV_1406|M.avium_104 --------------------------------------------------
Mflv_5163|M.gilvum_PYR-GCK VETFIVRSWGEHMHQHYTRLTGQDQLIEQDVERYTEGEAVAEHYLAVRDA
Mvan_1167|M.vanbaalenii_PYR-1 VETFIVRSWGEHMHQHYTRLTGQDQLIEQNVEQYTDGTPVSQHYLAVRDV
MSMEG_0357|M.smegmatis_MC2_155 VEAFIVRSWEEHLRQHHTRLTGHDLLVEETVRRFTVGEPTSQHLIAAKTH
TH_1317|M.thermoresistible__bu VEAFLVRSWDEHLRQHHVRLTLVDQRVEEEVRRYAEGPPLVEHLIAVNFD
MLBr_02143|M.leprae_Br4923 VSALLILGLAQTVVSFRGDSLIPGLGGNRPVMIEQESMRR---AAAVSPQ
MUL_0274|M.ulcerans_Agy99 VSALLILGLAQTIVSFRGDSLIPGLGGNRPVMAEQETTRRGTATAGVGPQ
MAB_0880|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1288c|M.bovis_AF2122/97 -------
Rv1258c|M.tuberculosis_H37Rv -------
MMAR_4182|M.marinum_M -------
MAV_1406|M.avium_104 -------
Mflv_5163|M.gilvum_PYR-GCK R------
Mvan_1167|M.vanbaalenii_PYR-1 -------
MSMEG_0357|M.smegmatis_MC2_155 -------
TH_1317|M.thermoresistible__bu EITRRGV
MLBr_02143|M.leprae_Br4923 -------
MUL_0274|M.ulcerans_Agy99 -------
MAB_0880|M.abscessus_ATCC_1997 -------