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VRSPRPVAGWRVLAPFRIREYRLLIAAVTLSIFAEGMWSVVMALQVIAIDNDPASLSLVATCLGVGLVAF VLVGGITADRINQRTIIIAVEVVNFVTVAVISALALLGVLKIWHMAVAAGILGIAAAFFFPAYSAILPRI LPPEQLLAANGVEGVVRPVFQRSVGPAVAGMVIGATMPSIGAVVVAVLFALGLALLVATRPPAQPASEHH ERPHVLRDLREGFAFVLKTPWLLWTVLFASMFVLVVLGPIEVLLPFIAQDRFADGARAYGFILAFFGIGS AMGALTVSSRRMPRRYLTTMMLMWGLGSIPLVIVGYTSSFPLMAAATFVIGVTDGAGMVIWGTLLQRRVP TEMLGRVSSLDFFVSLAFMPLSFAIVGPLSKVVSMEVIFATAGLVPVAIAAVAFTAARMHRDEVANPLL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5187 | - | - | 100% (419) | tetracycline-resistance determinant TetV |
| M. smegmatis MC2 155 | MSMEG_6390 | - | 6e-22 | 24.74% (384) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_5674 | - | 2e-19 | 24.59% (423) | membrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 5e-17 | 23.76% (404) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_5163 | - | 1e-22 | 26.73% (404) | protein of unknown function DUF894, DitE |
| M. tuberculosis H37Rv | Rv1258c | - | 5e-17 | 23.76% (404) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 3e-05 | 22.83% (438) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2780c | - | 9e-98 | 43.20% (412) | putative transporter |
| M. marinum M | MMAR_4182 | - | 5e-16 | 23.98% (392) | hypothetical protein MMAR_4182 |
| M. avium 104 | MAV_1406 | - | 1e-16 | 24.37% (398) | transporter, major facilitator family protein |
| M. thermoresistible (build 8) | TH_1986 | - | 0.0 | 79.27% (410) | tetracycline-resistance determinant TetV |
| M. ulcerans Agy99 | MUL_0051 | - | 2e-06 | 22.88% (354) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_4580 | - | 0.0 | 76.67% (420) | H+ antiporter protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5187|M.smegmatis_MC2_155 -------------------------------MRS------PRPVAGWRVL
Mvan_4580|M.vanbaalenii_PYR-1 -------------MVGNHRSVSTQYETGRSSARSDS--EQPVAPAGWRVL
TH_1986|M.thermoresistible__bu --------------------VSTQYDIEPSAGTS----------GGWRVL
MAB_2780c|M.abscessus_ATCC_199 --------------MDFPEQLKTEGVLGKNSGGSSGGESHPSTSGLPRAL
Mb1288c|M.bovis_AF2122/97 -------------------------------------------------M
Rv1258c|M.tuberculosis_H37Rv -------------------------------------------------M
MMAR_4182|M.marinum_M -------------------------------------------------M
MAV_1406|M.avium_104 --------------------------------------------------
Mflv_5163|M.gilvum_PYR-GCK ----------------------------------------MTSPVSTSTW
MUL_0051|M.ulcerans_Agy99 ----------------------------------------MHASAPVELW
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MSMEG_5187|M.smegmatis_MC2_155 APFR-IREYRLLIAAVTLSIFAEGMWSVVMALQVIAIDNDPASLSLVATC
Mvan_4580|M.vanbaalenii_PYR-1 APFR-YREYRLLIAAVSLSIFAEGMWAVVMALQVIELSNDPAALSLVATC
TH_1986|M.thermoresistible__bu APFR-IREYRLLITAVAITIFAEGMWAVVMALQVIAIDNDPASLSLVATC
MAB_2780c|M.abscessus_ATCC_199 RPMR-HRDYRLLTLGLAITLLGNGMWTVALVWQVIRMGLGPAQVAVVGTT
Mb1288c|M.bovis_AF2122/97 RNSN-RGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASA
Rv1258c|M.tuberculosis_H37Rv RNSN-RGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASA
MMAR_4182|M.marinum_M RNSS-RGPAFLILFATLAACAGNGISIVAFPWLVLEREGSAGQASIVAGA
MAV_1406|M.avium_104 ----------MILFATLLATAGTGISIVAFPWLALQHRHSATDASIVAAA
Mflv_5163|M.gilvum_PYR-GCK APLQ-SPVFRALWIAQFVSNLGTWMQTVGAQWMLVDDPAAAVLVPLVQTA
MUL_0051|M.ulcerans_Agy99 RSVRSLPDFWRLLQVRIASQFGDGLFQAGLAGALLFNPDRAADPMAIARA
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
: : : .
MSMEG_5187|M.smegmatis_MC2_155 LGVGLVAFVLVG---------------GITADRINQRTIIIAVEVVNFVT
Mvan_4580|M.vanbaalenii_PYR-1 LGAGLVGFVLVG---------------GLAADRLSQRGIIIVVEAVNTVA
TH_1986|M.thermoresistible__bu MGVGLVAFVLVG---------------GITADRINQRTIIIAVEAVNAVT
MAB_2780c|M.abscessus_ATCC_199 FSVGLLLSVLPA---------------GVAADRLPKLWVMRCSLAVQTAL
Mb1288c|M.bovis_AF2122/97 TMLPLLFATLVA---------------GTAVDYFGRRRVSMVADALSGAA
Rv1258c|M.tuberculosis_H37Rv TMLPLLFATLVA---------------GTAVDYFGRRRVSMVADALSGAA
MMAR_4182|M.marinum_M ITLPLLFSTLVA---------------GTAVDYFGRRPVSMVSDALSGSA
MAV_1406|M.avium_104 MTLPLVLATLIA---------------GTAVDFFGRRRVSLVCDWLSGAA
Mflv_5163|M.gilvum_PYR-GCK TTLPVMLLALPS---------------GVLADLVDRRRLLIATQGAMAAG
MUL_0051|M.ulcerans_Agy99 FAVLFLPYSLLGPFA------------GALMDRWDRRLVIVGANIGRLIL
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
. * . *
MSMEG_5187|M.smegmatis_MC2_155 VAVISALALLGVLKIWHMAVAAGILGIAAAFFFPAYSAILPRILPPEQLL
Mvan_4580|M.vanbaalenii_PYR-1 VTAVAVLGFVDALRIWHMAVAAAALGIAAAFFFPAYSAILPRILPPEQLL
TH_1986|M.thermoresistible__bu VAVVAMLGLTGQLRIWHLAVAAAVLGIAAAFFFPAYSALLPRILPPEQLL
MAB_2780c|M.abscessus_ATCC_199 MLTTATLALTGAAHIWHLALNSLLFGIAEGFYIPAYTALLPSLLPADELL
Mb1288c|M.bovis_AF2122/97 VAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDS-MLPEAAAR
Rv1258c|M.tuberculosis_H37Rv VAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDS-MLPEAAAR
MMAR_4182|M.marinum_M VAIVPLIAWAFGDDAVSVAVLAALGACSATFDPAGITARQS-MLPEAAAR
MAV_1406|M.avium_104 VTAVPLTAWIFGAAAIDVAELAVLAFCAAAFDPAGMTARQS-MLPEAAAR
Mflv_5163|M.gilvum_PYR-GCK VGLLATLTGAGLTTPTVLLTLLFVIGCGQALTAPAWQAIQPDLVPSDQIP
MUL_0051|M.ulcerans_Agy99 IAGIGTILAFEAGDLLLLFVALLANGLAR-FVASGLSASLPHVVPREQVV
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
. .. * . : .
MSMEG_5187|M.smegmatis_MC2_155 AANGVEGVVRP-----VFQRSVGP-AVAGMVIGATMPSIGAVVVAVLFAL
Mvan_4580|M.vanbaalenii_PYR-1 AANGIEGVVRP-----VFQRAVGP-AIAGLVVGALFPSAGALVVAVLFAT
TH_1986|M.thermoresistible__bu AANGVEGVVRP-----VFQRAVGP-AVAGMLVGATFPSLGSAVVATLFGV
MAB_2780c|M.abscessus_ATCC_199 AANGIEGILRP-----VMQLAAGP-AVSAAIVSVWSPGGAFLLEGMLVGA
Mb1288c|M.bovis_AF2122/97 AGWSLDRINGAYEAILNLAFIVGP-AIGGLMIATVGGITTMWITATAFGL
Rv1258c|M.tuberculosis_H37Rv AGWSLDRINGAYEAILNLAFIVGP-AIGGLMIATVGGITTMWITATAFGL
MMAR_4182|M.marinum_M AGWSLDRINSSYEAILNLAFVVGP-GIGGLMIATVGGITTMWITAGAFGL
MAV_1406|M.avium_104 AGWSLDRTNSSYEAMLNLAFIVGP-GLGGLLIATLGGINTMWVTAGCFAL
Mflv_5163|M.gilvum_PYR-GCK AAAALGSMSMN------GARAIGP-AIAGALVSLTGPTIVFALNAVSFVG
MUL_0051|M.ulcerans_Agy99 TMNSVATASGAVAAFVGANFMLLPRWLAGGGDHGAAAVIFTAMIPVAISL
MLBr_01562|M.leprae_Br4923 VGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKLDAAGAILA
. .: :. .
MSMEG_5187|M.smegmatis_MC2_155 GLALLVATRPP--AQPASEHHERPHVLR----DLREGFAFVLKTPWLLWT
Mvan_4580|M.vanbaalenii_PYR-1 GLALLVATRPPKAKDTGAQHEPRPHLLR----DLRDGWVFMLRTPWLLWT
TH_1986|M.thermoresistible__bu GLVLLVATRPP--ASPSVPGEHRSRVLR----DLRDGFMFMVATPWLLWT
MAB_2780c|M.abscessus_ATCC_199 GLSCLLLVRHK--HEPPASAEVRQHPLRRALADLAEGFRYMVRTTWFFAT
Mb1288c|M.bovis_AF2122/97 SILAIAALQLEGAGKPHHTSRPQGLVSG-----IAEGLRFVWNLRVLRTL
Rv1258c|M.tuberculosis_H37Rv SILAIAALQLEGAGKPHHTSRPQGLVSG-----IAEGLRFVWNLRVLRTL
MMAR_4182|M.marinum_M SLLAIGALRLEGAGRPHHETRPDGLVSG-----VTQGLRFVWNLRVLRAL
MAV_1406|M.avium_104 SFLAIGALRLEGAGKPPRATRPVGLVTG-----IAEGVRFVWNLRVLRTL
Mflv_5163|M.gilvum_PYR-GCK IVLVLMWWRRP----PVRSDYPPERALA----ALSAGGRYIRSSPIVRRI
MUL_0051|M.ulcerans_Agy99 LLALRFAPRVLGPDDTKRAIHGSAVYAVITG--WMHGVRTVVQIPTVAAA
MLBr_01562|M.leprae_Br4923 TLACTAAVFAFSMGPEKGWISLTTIGSG--LVALVAAIAFAVVERTAENP
. .
MSMEG_5187|M.smegmatis_MC2_155 V--------------LFASMFVLVVLGPIEVLLPFIAQDRFADGARAYGF
Mvan_4580|M.vanbaalenii_PYR-1 L--------------LFASLFVLVVLGPIEVLLPFVVAERFTHGAQTYGF
TH_1986|M.thermoresistible__bu L--------------LFASVFVLVVLGPIEVLLPFIAQERFTDGARMYGF
MAB_2780c|M.abscessus_ATCC_199 L--------------LFAIGYVLVVVGPIEILLPFVIRDHGGD-PGAHAT
Mb1288c|M.bovis_AF2122/97 G--------------MIDLTVTALYLPMESVLFPKYFTD--HQQPVQLGW
Rv1258c|M.tuberculosis_H37Rv G--------------MIDLTVTALYLPMESVLFPKYFTD--HQQPVQLGW
MMAR_4182|M.marinum_M A--------------LIDLTVTALYLPMESVLFPTYFSD--RQQPAQLGS
MAV_1406|M.avium_104 G--------------LIDLAVTALYLPMESVLFPKYFAD--QHQPAQLGW
Mflv_5163|M.gilvum_PYR-GCK L--------------LRTVLFIAPGS-AVWGLLPVIARDQLGLGSAGYGA
MUL_0051|M.ulcerans_Agy99 LS------------GLAAHRMVVGVNSLLILLLVHHMRDVDVEGLGTALL
MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI
: : :
MSMEG_5187|M.smegmatis_MC2_155 ILAFFGIGSAMGALTVSSRRMPRRYLTTMMLMWGLGSIPLVI-----VGY
Mvan_4580|M.vanbaalenii_PYR-1 ILAFFGLGSALGALGVSSRRLPRRYLTVMMAMWSVGSVPLVI-----VGV
TH_1986|M.thermoresistible__bu VLAAFGVGSAVGALTVSSRQMPRRYLTVMMLMWALGSVPLLV-----IGF
MAB_2780c|M.abscessus_ATCC_199 VLALFGLAGAVGSFIVSSLPLARRYLTVMILMWGAGSLPLIF-----IGF
Mb1288c|M.bovis_AF2122/97 ALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMV-----IAF
Rv1258c|M.tuberculosis_H37Rv ALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMV-----IAF
MMAR_4182|M.marinum_M VLVALSLGSLVGALGYGMLSNYVSRRTIMLTAVLTLGAATTG-----IAL
MAV_1406|M.avium_104 ALMALALGGVAGALGYAVLSARLRRRTAVLTATLTFGATTAG-----IAV
Mflv_5163|M.gilvum_PYR-GCK LLGALGVGAVLGAFALSRLRARFGQNKLLIAGAAGFGMATAV-----LAL
MUL_0051|M.ulcerans_Agy99 FFAATGLGAFLANVLTPGLIRRWG-RYATTNGALAAAAVTQL-----AGA
MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG
: . .
MSMEG_5187|M.smegmatis_MC2_155 TSSFPLMAAATFVIGVTDGAGMVIWGTLLQRRVPTEMLGRVSSLDFFVSL
Mvan_4580|M.vanbaalenii_PYR-1 TSSFPLMALATFVIGVTDGTAMVIWGTLLQRRVPPELLGRVSSLDFFVSL
TH_1986|M.thermoresistible__bu TWSFLLMSAASFAIGVTDGAGMVIWGTLLQRRVPRELLGRVSSLDFFVSL
MAB_2780c|M.abscessus_ATCC_199 TGHVWMIAVAMIIVGGTMQAANVIWGTLMQRRVPEEMLGRAASMDFFVSL
Mb1288c|M.bovis_AF2122/97 LPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAY
Rv1258c|M.tuberculosis_H37Rv LPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAY
MMAR_4182|M.marinum_M LPPLPVILVLCALIGVVYGPIQPIYNYVMQTRAPHYLRGRVVGVMTSLAY
MAV_1406|M.avium_104 LPPLPVILGLCAVTGVVYGPIQPIYNFVMQTRAPHHLRGRVVGVMAGLTY
Mflv_5163|M.gilvum_PYR-GCK VHNVALVAAALVVGGAAWLLTLSTLNASMQLSLPSWVRARGLSVYQLIFM
MUL_0051|M.ulcerans_Agy99 GLLLPVMVVCGFLLGVAGQVVKLCADSAMQIDVDGALRGHVFAVQDALFW
MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS
. : * . .: :
MSMEG_5187|M.smegmatis_MC2_155 AFMPLSFAIVGPLSKV------------------------VSMEVIFATA
Mvan_4580|M.vanbaalenii_PYR-1 AFMPVSFAIVGPLSKI------------------------VSMEAIFLAA
TH_1986|M.thermoresistible__bu VFMPVSFAIAGPLSKV------------------------VSMQTIFLVA
MAB_2780c|M.abscessus_ATCC_199 VGLPASFALVVPVAHV------------------------IGNTTVFVIA
Mb1288c|M.bovis_AF2122/97 AAGPLGLLLAGPLTDA------------------------AGLHATFLAL
Rv1258c|M.tuberculosis_H37Rv AAGPLGLLLAGPLTDA------------------------AGLHATFLAL
MMAR_4182|M.marinum_M AAGPLGLLLAGPVADA------------------------AGLKVAFFAL
MAV_1406|M.avium_104 AAGPLGLLVAGPLADA------------------------AGLKATFLTL
Mflv_5163|M.gilvum_PYR-GCK GGQAVGSLLWGLLAGG------------------------TSSVISLLVS
MUL_0051|M.ulcerans_Agy99 VSYIVSVTVAAALIPD------------------------DGRAPVFVLV
MLBr_01562|M.leprae_Br4923 LGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYGLLWV
: : . :
MSMEG_5187|M.smegmatis_MC2_155 GLVPVAIAAVAFTAARMH---RDEVANPLL--------------------
Mvan_4580|M.vanbaalenii_PYR-1 GLLPVLLAAVAVWAAKMH---RDEVAHPLR--------------------
TH_1986|M.thermoresistible__bu GLAPLLFAVVAMTAARMP---RDELEHPLN--------------------
MAB_2780c|M.abscessus_ATCC_199 GVAPLVLAAAAHIVARLG---RDEMAHPLG--------------------
Mb1288c|M.bovis_AF2122/97 ALPIVCTGLVAIRLPALR---ELDLAPQADIDRPVGSAQ-----------
Rv1258c|M.tuberculosis_H37Rv ALPIVCTGLVAIRLPALR---ELDLAPQADIDRPVGSAQ-----------
MMAR_4182|M.marinum_M ALPIAITGLMCIRLPSLR---ELDHAPTQDISETSLL-------------
MAV_1406|M.avium_104 AVPILAIGVVACGLPSLR---ELDRAPQFADDPGA---------------
Mflv_5163|M.gilvum_PYR-GCK AGLLIFCGLSLWWWPLHAGTGNLDLTPSSHWPEPTLLFEPEPLDGPVLVI
MUL_0051|M.ulcerans_Agy99 GSLIYLLGLCVHSIVGRR----SSASNVEGC-------------------
MLBr_01562|M.leprae_Br4923 AGAVVIVGVAALFIGYTP----EQVAYAQEVKEAVDAGEL----------
. . .
MSMEG_5187|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4580|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1986|M.thermoresistible__bu --------------------------------------------------
MAB_2780c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4182|M.marinum_M --------------------------------------------------
MAV_1406|M.avium_104 --------------------------------------------------
Mflv_5163|M.gilvum_PYR-GCK TAYRVLPENEEPFMSAMARLGRSRQRTGASMWQLFRSIEQESTFVETFIV
MUL_0051|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
MSMEG_5187|M.smegmatis_MC2_155 ---------------------------------------------
Mvan_4580|M.vanbaalenii_PYR-1 ---------------------------------------------
TH_1986|M.thermoresistible__bu ---------------------------------------------
MAB_2780c|M.abscessus_ATCC_199 ---------------------------------------------
Mb1288c|M.bovis_AF2122/97 ---------------------------------------------
Rv1258c|M.tuberculosis_H37Rv ---------------------------------------------
MMAR_4182|M.marinum_M ---------------------------------------------
MAV_1406|M.avium_104 ---------------------------------------------
Mflv_5163|M.gilvum_PYR-GCK RSWGEHMHQHYTRLTGQDQLIEQDVERYTEGEAVAEHYLAVRDAR
MUL_0051|M.ulcerans_Agy99 ---------------------------------------------
MLBr_01562|M.leprae_Br4923 ---------------------------------------------