For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRNSSRGPAFLILFATLAACAGNGISIVAFPWLVLEREGSAGQASIVAGAITLPLLFSTLVAGTAVDYFG RRPVSMVSDALSGSAVAIVPLIAWAFGDDAVSVAVLAALGACSATFDPAGITARQSMLPEAAARAGWSLD RINSSYEAILNLAFVVGPGIGGLMIATVGGITTMWITAGAFGLSLLAIGALRLEGAGRPHHETRPDGLVS GVTQGLRFVWNLRVLRALALIDLTVTALYLPMESVLFPTYFSDRQQPAQLGSVLVALSLGSLVGALGYGM LSNYVSRRTIMLTAVLTLGAATTGIALLPPLPVILVLCALIGVVYGPIQPIYNYVMQTRAPHYLRGRVVG VMTSLAYAAGPLGLLLAGPVADAAGLKVAFFALALPIAITGLMCIRLPSLRELDHAPTQDISETSLL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4182 | - | - | 100% (417) | hypothetical protein MMAR_4182 |
| M. marinum M | MMAR_0690 | - | 4e-08 | 25.07% (367) | putative transport protein |
| M. marinum M | MMAR_3855 | - | 1e-06 | 24.41% (381) | integral membrane leucine and alanine rich protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 1e-179 | 77.37% (411) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_2234 | - | 1e-157 | 69.75% (400) | H+ antiporter protein |
| M. tuberculosis H37Rv | Rv1258c | - | 1e-179 | 77.37% (411) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1409c | - | 1e-135 | 56.97% (409) | putative drug antiporter protein precursor |
| M. avium 104 | MAV_1406 | - | 1e-163 | 72.54% (397) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0357 | - | 5e-19 | 23.21% (405) | transmembrane transport protein |
| M. thermoresistible (build 8) | TH_2406 | - | 1e-148 | 64.23% (411) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
| M. ulcerans Agy99 | MUL_3787 | - | 6e-07 | 24.15% (381) | integral membrane leucine and alanine rich protein |
| M. vanbaalenii PYR-1 | Mvan_4461 | - | 1e-158 | 68.83% (401) | H+ antiporter protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2234|M.gilvum_PYR-GCK ---------MTPDTTPRSRTPLLLIMFAALMAGAGNGISIVAFPWLVLQ-
Mvan_4461|M.vanbaalenii_PYR-1 ---------MTPNEAPSRRGPLLLILFAALMAGAGNGISLVAFPWLVLQ-
TH_2406|M.thermoresistible__bu -------------MSTSTRGPVLLIYSAALTAGAGNGISIIAFPWLVLQ-
Mb1288c|M.bovis_AF2122/97 -------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQ-
Rv1258c|M.tuberculosis_H37Rv -------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQ-
MMAR_4182|M.marinum_M -------------MRNSSRGPAFLILFATLAACAGNGISIVAFPWLVLE-
MAV_1406|M.avium_104 -----------------------MILFATLLATAGTGISIVAFPWLALQ-
MAB_1409c|M.abscessus_ATCC_199 ---MSTPTADSPTINQVNRGPVLLLLFASVVAAIGNGVSIVALPWLVLQ-
MSMEG_0357|M.smegmatis_MC2_155 MTTATPAMGATSTWAPLASPIYRALWIAQFVSNLGTWMQTVGAQWMLVG-
MUL_3787|M.ulcerans_Agy99 ---MTNPATGTFVRSRVVAWALWDCGSTGLNAMVTTFVFSVYLTSMVGEG
: . : : : :
Mflv_2234|M.gilvum_PYR-GCK ---RTGSALDASIVAMAGTLPLLAATLIAGAAVDFLGRRRVSMISDALSA
Mvan_4461|M.vanbaalenii_PYR-1 ---RTGSALDASIVAMAGTLPLLAATLIAGAAVDFLGRRRVSMISDALSA
TH_2406|M.thermoresistible__bu ---RNGSALEASVVAMAATXPLLVATLFAGVAVDYLGRRRVSMISDLLSA
Mb1288c|M.bovis_AF2122/97 ---REGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSG
Rv1258c|M.tuberculosis_H37Rv ---REGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSG
MMAR_4182|M.marinum_M ---REGSAGQASIVAGAITLPLLFSTLVAGTAVDYFGRRPVSMVSDALSG
MAV_1406|M.avium_104 ---HRHSATDASIVAAAMTLPLVLATLIAGTAVDFFGRRRVSLVCDWLSG
MAB_1409c|M.abscessus_ATCC_199 ---RNGSAADAAIVAAAGTLPLVFSTLISGTAVDYFGRRVMSIFSDVLSL
MSMEG_0357|M.smegmatis_MC2_155 ---DPRAAVLVPLVQTATTLPVMLLALPSGVLADLVDRRRLLIAAQGATA
MUL_3787|M.ulcerans_Agy99 MPGGSDPASWLGRAAAAAGLTIALLAPLVGVWVESPHRRRVALGVLTSVT
.* . * .: : *. .: ** : :
Mflv_2234|M.gilvum_PYR-GCK LSVAAVP-VIALVFGADAVNVAVLAALAALGAFFDPAGMTARETMLPEAA
Mvan_4461|M.vanbaalenii_PYR-1 LSVAAVP-VLALAFGTDVINVAVLAGLAALGAIFDPAGMTARETMLPEAA
TH_2406|M.thermoresistible__bu LSVAAVP-VIALTFGVQAVNVAVLAALAALGAFFDPAGMTARETMLPEAA
Mb1288c|M.bovis_AF2122/97 AAVAGVP-LVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAA
Rv1258c|M.tuberculosis_H37Rv AAVAGVP-LVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAA
MMAR_4182|M.marinum_M SAVAIVP-LIAWAFGDDAVSVAVLAALGACSATFDPAGITARQSMLPEAA
MAV_1406|M.avium_104 AAVTAVP-LTAWIFGAAAIDVAELAVLAFCAAAFDPAGMTARQSMLPEAA
MAB_1409c|M.abscessus_ATCC_199 VSVSAIP-ILAMTTG---LNVPLLAALAALGAIFDPAGITARESMLPAAA
MSMEG_0357|M.smegmatis_MC2_155 AGVASLATLTGAGLATPTVLLTLLFLIGCGQALTAPAWQAIQPDLVPREQ
MUL_3787|M.ulcerans_Agy99 VALTCAMFLIHDSPGYLWAGLALLAATAACSDLASVPYNSMLRQLSTPTT
.:: : . : * . . : : .
Mflv_2234|M.gilvum_PYR-GCK HR----AGWTLDRANSFFEAVFNLAYIVG-----------PGIGGLLIAT
Mvan_4461|M.vanbaalenii_PYR-1 NR----AGWTLDHANSVFEAIFNLAYIVG-----------PGIGGLLIAT
TH_2406|M.thermoresistible__bu AR----AGWTLDKTNSGYEAIFNLAYIVG-----------PGIGGLLIAT
Mb1288c|M.bovis_AF2122/97 AR----AGWSLDRINGAYEAILNLAFIVG-----------PAIGGLMIAT
Rv1258c|M.tuberculosis_H37Rv AR----AGWSLDRINGAYEAILNLAFIVG-----------PAIGGLMIAT
MMAR_4182|M.marinum_M AR----AGWSLDRINSSYEAILNLAFVVG-----------PGIGGLMIAT
MAV_1406|M.avium_104 AR----AGWSLDRTNSSYEAMLNLAFIVG-----------PGLGGLLIAT
MAB_1409c|M.abscessus_ATCC_199 KS----AGWSLDKMNSMYEATFNVAYIVG-----------PGLGGLLIAS
MSMEG_0357|M.smegmatis_MC2_155 IP----AAAALGSMS------MNGARAIG-----------PAIAGALVSL
MUL_3787|M.ulcerans_Agy99 ASRISGFGWASGYVGSVVLLILIYLGFVAGSGAHRGLLQLPAHDGFNIRV
. : . . : :. *. * :
Mflv_2234|M.gilvum_PYR-GCK LGGIDTMWVTAGAFVLSIAAIAVLRLEGTARPDPSTMSDGVWAGILEGLR
Mvan_4461|M.vanbaalenii_PYR-1 LGGIDTMWVTAGAFGLSIFAIAALKLEGAGRPDPTAMSDGVWAGIIEGLR
TH_2406|M.thermoresistible__bu LGGVNTMWVTAALFVVSIVTIAALRLEGAGLPDRALLTDSVLAGIVEGLR
Mb1288c|M.bovis_AF2122/97 VGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLR
Rv1258c|M.tuberculosis_H37Rv VGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLR
MMAR_4182|M.marinum_M VGGITTMWITAGAFGLSLLAIGALRLEGAGRPHHETRPDGLVSGVTQGLR
MAV_1406|M.avium_104 LGGINTMWVTAGCFALSFLAIGALRLEGAGKPPRATRPVGLVTGIAEGVR
MAB_1409c|M.abscessus_ATCC_199 VGGVNTMWVTAASFVVSIIAIALLKVDGAGKPAHETRPTGVFSGVLEGLR
MSMEG_0357|M.smegmatis_MC2_155 SGPTLVFALNAVSFVGIVAVLLLWRRPAAERMLPAERP---LAALSAGGR
MUL_3787|M.ulcerans_Agy99 AMLLAAAWLAVLASPLLLVAHRLPDVG--TVPQPATRMLGAYRKLWADIS
. : . . . : .
Mflv_2234|M.gilvum_PYR-GCK FVWN-NKVLRTLAFVDLAATGLYMPMESVLFPKYFTDRDEP-AQLGWVLM
Mvan_4461|M.vanbaalenii_PYR-1 FVWR-NKVLRTLALVDLVATGLYVPMESVLFPKYFTDRNEP-AQLGWVLM
TH_2406|M.thermoresistible__bu FVWR-TPVLRALLIVDLVVTGLYMPMESVLFPKYFTDRDEP-AHLGWVLM
Mb1288c|M.bovis_AF2122/97 FVWN-LRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQP-VQLGWALM
Rv1258c|M.tuberculosis_H37Rv FVWN-LRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQP-VQLGWALM
MMAR_4182|M.marinum_M FVWN-LRVLRALALIDLTVTALYLPMESVLFPTYFSDRQQP-AQLGSVLV
MAV_1406|M.avium_104 FVWN-LRVLRTLGLIDLAVTALYLPMESVLFPKYFADQHQP-AQLGWALM
MAB_1409c|M.abscessus_ATCC_199 FFWN-IKILRTIALVDMAITALYLPIESVLLPKHFSDIGAP-QQLGWMLM
MSMEG_0357|M.smegmatis_MC2_155 YIRS-APIVRRILLRTVLFIAPGSALWGLLAVIAKDQLDLTSSGYGVLLG
MUL_3787|M.ulcerans_Agy99 SEWRRDRNLVYFLIASAIFRDGLAAMFAFGAVLGANVYGLTQADVLLFGV
: : : .: .. .
Mflv_2234|M.gilvum_PYR-GCK ALSIGGLLGALGFAVLSKYLKRRTVMLTAVLTLGVAMTVIAFLPPLPIIL
Mvan_4461|M.vanbaalenii_PYR-1 ALSIGGLIGALGYAVMSRYMKRRTVMLTAVLTLGVAMTVIAFLPPLPIIL
TH_2406|M.thermoresistible__bu ALSIGGLTGALAYAWVSRFVSRRATLITAVLTLGATMTVIAFLPPLPLIL
Mb1288c|M.bovis_AF2122/97 AIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIM
Rv1258c|M.tuberculosis_H37Rv AIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIM
MMAR_4182|M.marinum_M ALSLGSLVGALGYGMLSNYVSRRTIMLTAVLTLGAATTGIALLPPLPVIL
MAV_1406|M.avium_104 ALALGGVAGALGYAVLSARLRRRTAVLTATLTFGATTAGIAVLPPLPVIL
MAB_1409c|M.abscessus_ATCC_199 AISVGGLLGALGYATMVRHFQRRTIMLCATFTAGITTLGMSLLPPIAVLL
MSMEG_0357|M.smegmatis_MC2_155 ALGLGAVCGAFVLGRLQKMFELNTLLVVAAIGFGGATVVLALVHQVAVVV
MUL_3787|M.ulcerans_Agy99 AASVVAAVGAVVGGFVDHRVGSKPVIVASLASILISAIVLMVLSGATAFW
* . . **. . : . . : : : : .: . .
Mflv_2234|M.gilvum_PYR-GCK VLCALVGFVYGPIAPIYNYVMQTRAPQHLRGRVVGVMGSLAYAAGPLGLI
Mvan_4461|M.vanbaalenii_PYR-1 VLCAIVGFVYGPIAPIYNYVMQTRAPQHLRGRVVGVMGSLAYAAGPLGLI
TH_2406|M.thermoresistible__bu AMAAVGGFAYGPIQPIYNYVMQTRAPQHLRGRVVGVMGSLAYAAGPLGLV
Mb1288c|M.bovis_AF2122/97 VLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLL
Rv1258c|M.tuberculosis_H37Rv VLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLL
MMAR_4182|M.marinum_M VLCALIGVVYGPIQPIYNYVMQTRAPHYLRGRVVGVMTSLAYAAGPLGLL
MAV_1406|M.avium_104 GLCAVTGVVYGPIQPIYNFVMQTRAPHHLRGRVVGVMAGLTYAAGPLGLL
MAB_1409c|M.abscessus_ATCC_199 VLAACLGFIYGPVAPIANFVMQTRSPEHLRGRVVGVMTSTAYCAGPLGFM
MSMEG_0357|M.smegmatis_MC2_155 IALVLGGTAWLLALSTLNASMQLSLPGWVRARGLSVYQLVFMGGQALGSL
MUL_3787|M.ulcerans_Agy99 VCGLLLCLFIGPSQSSARALLLRMAPHGKEGVAFGLYTMTGHAVAFLGPW
. . : . .. ..: **
Mflv_2234|M.gilvum_PYR-GCK LAGPLADSAGLHVTFLALSLPMLALGIVSVFLPALR---ELDTPHP----
Mvan_4461|M.vanbaalenii_PYR-1 LAGPLADATGLRTTFLALSLPMLALGIVAVFLPALR---DLDRPAAGP--
TH_2406|M.thermoresistible__bu IAGPLADSAGLRVTFLALSLPMVALGLIAIGLPVLT---TLNQPAADQID
Mb1288c|M.bovis_AF2122/97 LAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALR---ELDLAPQADID
Rv1258c|M.tuberculosis_H37Rv LAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALR---ELDLAPQADID
MMAR_4182|M.marinum_M LAGPVADAAGLKVAFFALALPIAITGLMCIRLPSLR---ELDHAPTQDIS
MAV_1406|M.avium_104 VAGPLADAAGLKATFLTLAVPILAIGVVACGLPSLR---ELDRAPQFADD
MAB_1409c|M.abscessus_ATCC_199 LAGPIADKFGVATTLVILGAPMLLIAIASTRMRVLR---ELDQDEPQPDK
MSMEG_0357|M.smegmatis_MC2_155 LWGLIAGAAGSVTALLVSAGLMGVCAVSAIWWPLHARTGNLDMTPSAHWP
MUL_3787|M.ulcerans_Agy99 LFSIFVDIFSAVRAGLGGICLVLAVGLVGMLVVGVP------RHGGVVVT
: . ... . : . : .:
Mflv_2234|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4461|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2406|M.thermoresistible__bu LQFDD---------------------------------------------
Mb1288c|M.bovis_AF2122/97 RPVGSAQ-------------------------------------------
Rv1258c|M.tuberculosis_H37Rv RPVGSAQ-------------------------------------------
MMAR_4182|M.marinum_M ETSLL---------------------------------------------
MAV_1406|M.avium_104 PGA-----------------------------------------------
MAB_1409c|M.abscessus_ATCC_199 EPTR----------------------------------------------
MSMEG_0357|M.smegmatis_MC2_155 EPALIFEPEPLDGPVVVLVSYRVEPAQETGFFEAMAALGRSRQRTGASQW
MUL_3787|M.ulcerans_Agy99 ETT-----------------------------------------------
Mflv_2234|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4461|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2406|M.thermoresistible__bu --------------------------------------------------
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4182|M.marinum_M --------------------------------------------------
MAV_1406|M.avium_104 --------------------------------------------------
MAB_1409c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0357|M.smegmatis_MC2_155 QLFRSGEHAGTFVEAFIVRSWEEHLRQHHTRLTGHDLLVEETVRRFTVGE
MUL_3787|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2234|M.gilvum_PYR-GCK ------------
Mvan_4461|M.vanbaalenii_PYR-1 ------------
TH_2406|M.thermoresistible__bu ------------
Mb1288c|M.bovis_AF2122/97 ------------
Rv1258c|M.tuberculosis_H37Rv ------------
MMAR_4182|M.marinum_M ------------
MAV_1406|M.avium_104 ------------
MAB_1409c|M.abscessus_ATCC_199 ------------
MSMEG_0357|M.smegmatis_MC2_155 PTSQHLIAAKTH
MUL_3787|M.ulcerans_Agy99 ------------