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ILFATLLATAGTGISIVAFPWLALQHRHSATDASIVAAAMTLPLVLATLIAGTAVDFFGRRRVSLVCDWL SGAAVTAVPLTAWIFGAAAIDVAELAVLAFCAAAFDPAGMTARQSMLPEAAARAGWSLDRTNSSYEAMLN LAFIVGPGLGGLLIATLGGINTMWVTAGCFALSFLAIGALRLEGAGKPPRATRPVGLVTGIAEGVRFVWN LRVLRTLGLIDLAVTALYLPMESVLFPKYFADQHQPAQLGWALMALALGGVAGALGYAVLSARLRRRTAV LTATLTFGATTAGIAVLPPLPVILGLCAVTGVVYGPIQPIYNFVMQTRAPHHLRGRVVGVMAGLTYAAGP LGLLVAGPLADAAGLKATFLTLAVPILAIGVVACGLPSLRELDRAPQFADDPGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1406 | - | - | 100% (405) | transporter, major facilitator family protein |
| M. avium 104 | MAV_3974 | - | 2e-09 | 22.72% (383) | permease of the major facilitator superfamily protein |
| M. avium 104 | MAV_0138 | - | 2e-08 | 24.32% (403) | transporter, major facilitator family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 1e-162 | 72.86% (398) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_2234 | - | 1e-151 | 68.02% (394) | H+ antiporter protein |
| M. tuberculosis H37Rv | Rv1258c | - | 1e-162 | 72.86% (398) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1409c | - | 1e-130 | 56.68% (404) | putative drug antiporter protein precursor |
| M. marinum M | MMAR_4182 | - | 1e-163 | 72.54% (397) | hypothetical protein MMAR_4182 |
| M. smegmatis MC2 155 | MSMEG_0357 | - | 6e-17 | 23.38% (385) | transmembrane transport protein |
| M. thermoresistible (build 8) | TH_2406 | - | 1e-143 | 63.80% (395) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
| M. ulcerans Agy99 | MUL_1468 | - | 5e-06 | 26.94% (219) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_4461 | - | 1e-150 | 67.34% (395) | H+ antiporter protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2234|M.gilvum_PYR-GCK ---------MTPDTTPRSRTPLLLIMFAALMAGAGNGISIVAFPWLVLQR
Mvan_4461|M.vanbaalenii_PYR-1 ---------MTPNEAPSRRGPLLLILFAALMAGAGNGISLVAFPWLVLQR
TH_2406|M.thermoresistible__bu -------------MSTSTRGPVLLIYSAALTAGAGNGISIIAFPWLVLQR
Mb1288c|M.bovis_AF2122/97 -------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQR
Rv1258c|M.tuberculosis_H37Rv -------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQR
MMAR_4182|M.marinum_M -------------MRNSSRGPAFLILFATLAACAGNGISIVAFPWLVLER
MAV_1406|M.avium_104 -----------------------MILFATLLATAGTGISIVAFPWLALQH
MAB_1409c|M.abscessus_ATCC_199 ---MSTPTADSPTINQVNRGPVLLLLFASVVAAIGNGVSIVALPWLVLQR
MSMEG_0357|M.smegmatis_MC2_155 MTTATPAMGATSTWAPLASPIYRALWIAQFVSNLGTWMQTVGAQWMLVGD
MUL_1468|M.ulcerans_Agy99 -------------MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTF
. . . : :. :
Mflv_2234|M.gilvum_PYR-GCK TGSALDASIVAMAGTLPLLAATLIAGAAVDFLGRRRVSMISDALSALSVA
Mvan_4461|M.vanbaalenii_PYR-1 TGSALDASIVAMAGTLPLLAATLIAGAAVDFLGRRRVSMISDALSALSVA
TH_2406|M.thermoresistible__bu NGSALEASVVAMAATXPLLVATLFAGVAVDYLGRRRVSMISDLLSALSVA
Mb1288c|M.bovis_AF2122/97 EGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVA
Rv1258c|M.tuberculosis_H37Rv EGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVA
MMAR_4182|M.marinum_M EGSAGQASIVAGAITLPLLFSTLVAGTAVDYFGRRPVSMVSDALSGSAVA
MAV_1406|M.avium_104 RHSATDASIVAAAMTLPLVLATLIAGTAVDFFGRRRVSLVCDWLSGAAVT
MAB_1409c|M.abscessus_ATCC_199 NGSAADAAIVAAAGTLPLVFSTLISGTAVDYFGRRVMSIFSDVLSLVSVS
MSMEG_0357|M.smegmatis_MC2_155 PRAAVLVPLVQTATTLPVMLLALPSGVLADLVDRRRLLIAAQGATAAGVA
MUL_1468|M.ulcerans_Agy99 GVGEDGLQWVVAAYSLGMAVFIMSAATLADRYGRRRWYLMGIVLFTLGSI
. * * : : :.. .* .** : .
Mflv_2234|M.gilvum_PYR-GCK AVP-VIALVFGADAVNVAVLAALAALGAFFDPAGMTARETMLPEAAHRAG
Mvan_4461|M.vanbaalenii_PYR-1 AVP-VLALAFGTDVINVAVLAGLAALGAIFDPAGMTARETMLPEAANRAG
TH_2406|M.thermoresistible__bu AVP-VIALTFGVQAVNVAVLAALAALGAFFDPAGMTARETMLPEAAARAG
Mb1288c|M.bovis_AF2122/97 GVP-LVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAG
Rv1258c|M.tuberculosis_H37Rv GVP-LVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAG
MMAR_4182|M.marinum_M IVP-LIAWAFGDDAVSVAVLAALGACSATFDPAGITARQSMLPEAAARAG
MAV_1406|M.avium_104 AVP-LTAWIFGAAAIDVAELAVLAFCAAAFDPAGMTARQSMLPEAAARAG
MAB_1409c|M.abscessus_ATCC_199 AIP-ILAMTTG---LNVPLLAALAALGAIFDPAGITARESMLPAAAKSAG
MSMEG_0357|M.smegmatis_MC2_155 SLATLTGAGLATPTVLLTLLFLIGCGQALTAPAWQAIQPDLVPREQIPAA
MUL_1468|M.ulcerans_Agy99 ACG----------LAPSIAMLTAARGVQGFGAATVSVTSLALVSAAFPNP
: . .* : :
Mflv_2234|M.gilvum_PYR-GCK WTLDRANSFFEAVFNLAYIVGPGIGGLLIATLGGIDTMWVTAGAFVLSIA
Mvan_4461|M.vanbaalenii_PYR-1 WTLDHANSVFEAIFNLAYIVGPGIGGLLIATLGGIDTMWVTAGAFGLSIF
TH_2406|M.thermoresistible__bu WTLDKTNSGYEAIFNLAYIVGPGIGGLLIATLGGVNTMWVTAALFVVSIV
Mb1288c|M.bovis_AF2122/97 WSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSIL
Rv1258c|M.tuberculosis_H37Rv WSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSIL
MMAR_4182|M.marinum_M WSLDRINSSYEAILNLAFVVGPGIGGLMIATVGGITTMWITAGAFGLSLL
MAV_1406|M.avium_104 WSLDRTNSSYEAMLNLAFIVGPGLGGLLIATLGGINTMWVTAGCFALSFL
MAB_1409c|M.abscessus_ATCC_199 WSLDKMNSMYEATFNVAYIVGPGLGGLLIASVGGVNTMWVTAASFVVSII
MSMEG_0357|M.smegmatis_MC2_155 AALGSMS------MNGARAIGPAIAGALVSLSGPTLVFALNAVSFVGIVA
MUL_1468|M.ulcerans_Agy99 KEKARAIGIWTAVASVGTATGPTLGGLLVDTWGWRSIFYVNVPMGVFVIL
. . ** :.* :: * : :.. .
Mflv_2234|M.gilvum_PYR-GCK AIAVLRLEGTARPDPSTMSDGVWAGILEGLRFVWNNKVLRTLAFVDLAAT
Mvan_4461|M.vanbaalenii_PYR-1 AIAALKLEGAGRPDPTAMSDGVWAGIIEGLRFVWRNKVLRTLALVDLVAT
TH_2406|M.thermoresistible__bu TIAALRLEGAGLPDRALLTDSVLAGIVEGLRFVWRTPVLRALLIVDLVVT
Mb1288c|M.bovis_AF2122/97 AIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVT
Rv1258c|M.tuberculosis_H37Rv AIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVT
MMAR_4182|M.marinum_M AIGALRLEGAGRPHHETRPDGLVSGVTQGLRFVWNLRVLRALALIDLTVT
MAV_1406|M.avium_104 AIGALRLEGAGKPPRATRPVGLVTGIAEGVRFVWNLRVLRTLGLIDLAVT
MAB_1409c|M.abscessus_ATCC_199 AIALLKVDGAGKPAHETRPTGVFSGVLEGLRFFWNIKILRTIALVDMAIT
MSMEG_0357|M.smegmatis_MC2_155 VLLLWRRPAAERMLPAERP---LAALSAGGRYIRSAPIVRRILLRTVLFI
MUL_1468|M.ulcerans_Agy99 LTVGFVAESRN----------------------------ARAGQLDLSGQ
. :
Mflv_2234|M.gilvum_PYR-GCK GLYMPMESVLFPKYFTDRDEP-AQLGWVLMALSIGGLLGALGFAVLSKYL
Mvan_4461|M.vanbaalenii_PYR-1 GLYVPMESVLFPKYFTDRNEP-AQLGWVLMALSIGGLIGALGYAVMSRYM
TH_2406|M.thermoresistible__bu GLYMPMESVLFPKYFTDRDEP-AHLGWVLMALSIGGLTGALAYAWVSRFV
Mb1288c|M.bovis_AF2122/97 ALYLPMESVLFPKYFTDHQQP-VQLGWALMAIAGGGLVGALGYAVLAIRV
Rv1258c|M.tuberculosis_H37Rv ALYLPMESVLFPKYFTDHQQP-VQLGWALMAIAGGGLVGALGYAVLAIRV
MMAR_4182|M.marinum_M ALYLPMESVLFPTYFSDRQQP-AQLGSVLVALSLGSLVGALGYGMLSNYV
MAV_1406|M.avium_104 ALYLPMESVLFPKYFADQHQP-AQLGWALMALALGGVAGALGYAVLSARL
MAB_1409c|M.abscessus_ATCC_199 ALYLPIESVLLPKHFSDIGAP-QQLGWMLMAISVGGLLGALGYATMVRHF
MSMEG_0357|M.smegmatis_MC2_155 APGSALWGLLAVIAKDQLDLTSSGYGVLLGALGLGAVCGAFVLGRLQKMF
MUL_1468|M.ulcerans_Agy99 ALFIVTVGAFVYAVIEG-----PQIGWTSPLILTLLMTAIVGCALFLWLE
. . : * : : . . . .
Mflv_2234|M.gilvum_PYR-GCK KRRTVMLTAVLTLGVAMTVIAFLPPLPIILVLCALVGFVYGPIAPIYNYV
Mvan_4461|M.vanbaalenii_PYR-1 KRRTVMLTAVLTLGVAMTVIAFLPPLPIILVLCAIVGFVYGPIAPIYNYV
TH_2406|M.thermoresistible__bu SRRATLITAVLTLGATMTVIAFLPPLPLILAMAAVGGFAYGPIQPIYNYV
Mb1288c|M.bovis_AF2122/97 PRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYV
Rv1258c|M.tuberculosis_H37Rv PRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYV
MMAR_4182|M.marinum_M SRRTIMLTAVLTLGAATTGIALLPPLPVILVLCALIGVVYGPIQPIYNYV
MAV_1406|M.avium_104 RRRTAVLTATLTFGATTAGIAVLPPLPVILGLCAVTGVVYGPIQPIYNFV
MAB_1409c|M.abscessus_ATCC_199 QRRTIMLCATFTAGITTLGMSLLPPIAVLLVLAACLGFIYGPVAPIANFV
MSMEG_0357|M.smegmatis_MC2_155 ELNTLLVVAAIGFGGATVVLALVHQVAVVVIALVLGGTAWLLALSTLNAS
MUL_1468|M.ulcerans_Agy99 GRSADPMMDLTLFRDSSYALSIG-------TICTVFFAVYGMLLLTTQFL
. : ::. . : :
Mflv_2234|M.gilvum_PYR-GCK MQTRAPQHLRGRVVGVMGSLAYAAGPLGLILAGPLADSAGLHVTFLALSL
Mvan_4461|M.vanbaalenii_PYR-1 MQTRAPQHLRGRVVGVMGSLAYAAGPLGLILAGPLADATGLRTTFLALSL
TH_2406|M.thermoresistible__bu MQTRAPQHLRGRVVGVMGSLAYAAGPLGLVIAGPLADSAGLRVTFLALSL
Mb1288c|M.bovis_AF2122/97 IQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALAL
Rv1258c|M.tuberculosis_H37Rv IQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALAL
MMAR_4182|M.marinum_M MQTRAPHYLRGRVVGVMTSLAYAAGPLGLLLAGPVADAAGLKVAFFALAL
MAV_1406|M.avium_104 MQTRAPHHLRGRVVGVMAGLTYAAGPLGLLVAGPLADAAGLKATFLTLAV
MAB_1409c|M.abscessus_ATCC_199 MQTRSPEHLRGRVVGVMTSTAYCAGPLGFMLAGPIADKFGVATTLVILGA
MSMEG_0357|M.smegmatis_MC2_155 MQLSLPGWVRARGLSVYQLVFMGGQALGSLLWGLIAGAAGSVTALLVSAG
MUL_1468|M.ulcerans_Agy99 HNVRG----YTQGSGVVD--------------------------------
: : .*
Mflv_2234|M.gilvum_PYR-GCK PMLALGIVSVFLPALR---ELDTPHP------------------------
Mvan_4461|M.vanbaalenii_PYR-1 PMLALGIVAVFLPALR---DLDRPAAGP----------------------
TH_2406|M.thermoresistible__bu PMVALGLIAIGLPVLT---TLNQPAADQIDLQFDD---------------
Mb1288c|M.bovis_AF2122/97 PIVCTGLVAIRLPALR---ELDLAPQADIDRPVGSAQ-------------
Rv1258c|M.tuberculosis_H37Rv PIVCTGLVAIRLPALR---ELDLAPQADIDRPVGSAQ-------------
MMAR_4182|M.marinum_M PIAITGLMCIRLPSLR---ELDHAPTQDISETSLL---------------
MAV_1406|M.avium_104 PILAIGVVACGLPSLR---ELDRAPQFADDPGA-----------------
MAB_1409c|M.abscessus_ATCC_199 PMLLIAIASTRMRVLR---ELDQDEPQPDKEPTR----------------
MSMEG_0357|M.smegmatis_MC2_155 LMGVCAVSAIWWPLHARTGNLDMTPSAHWPEPALIFEPEPLDGPVVVLVS
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2234|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4461|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2406|M.thermoresistible__bu --------------------------------------------------
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4182|M.marinum_M --------------------------------------------------
MAV_1406|M.avium_104 --------------------------------------------------
MAB_1409c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0357|M.smegmatis_MC2_155 YRVEPAQETGFFEAMAALGRSRQRTGASQWQLFRSGEHAGTFVEAFIVRS
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2234|M.gilvum_PYR-GCK ------------------------------------------
Mvan_4461|M.vanbaalenii_PYR-1 ------------------------------------------
TH_2406|M.thermoresistible__bu ------------------------------------------
Mb1288c|M.bovis_AF2122/97 ------------------------------------------
Rv1258c|M.tuberculosis_H37Rv ------------------------------------------
MMAR_4182|M.marinum_M ------------------------------------------
MAV_1406|M.avium_104 ------------------------------------------
MAB_1409c|M.abscessus_ATCC_199 ------------------------------------------
MSMEG_0357|M.smegmatis_MC2_155 WEEHLRQHHTRLTGHDLLVEETVRRFTVGEPTSQHLIAAKTH
MUL_1468|M.ulcerans_Agy99 ------------------------------------------