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MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFG RRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLD RINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVS GIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAV LAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVG VMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | - | 100% (419) | integral membrane transport protein |
| M. bovis AF2122 / 97 | Mb0038c | - | 3e-07 | 23.98% (392) | integral membrane protein |
| M. bovis AF2122 / 97 | Mb1282 | - | 2e-05 | 22.09% (326) | drug-transport integral membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2234 | - | 1e-157 | 69.25% (400) | H+ antiporter protein |
| M. tuberculosis H37Rv | Rv1258c | - | 0.0 | 100.00% (419) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1409c | - | 1e-133 | 56.27% (407) | putative drug antiporter protein precursor |
| M. marinum M | MMAR_4182 | - | 1e-179 | 77.37% (411) | hypothetical protein MMAR_4182 |
| M. avium 104 | MAV_1406 | - | 1e-162 | 72.86% (398) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_5187 | - | 8e-17 | 23.76% (404) | tetracycline-resistance determinant TetV |
| M. thermoresistible (build 8) | TH_2406 | - | 1e-148 | 65.12% (410) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
| M. ulcerans Agy99 | MUL_0838 | - | 5e-09 | 23.79% (412) | transmembrane carbohydrate transport protein |
| M. vanbaalenii PYR-1 | Mvan_4461 | - | 1e-159 | 69.83% (401) | H+ antiporter protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2234|M.gilvum_PYR-GCK ----------MTPDTTPRSRTPLLLIMFAALMAGAGNGISIVAFPWLVLQ
Mvan_4461|M.vanbaalenii_PYR-1 ----------MTPNEAPSRRGPLLLILFAALMAGAGNGISLVAFPWLVLQ
TH_2406|M.thermoresistible__bu --------------MSTSTRGPVLLIYSAALTAGAGNGISIIAFPWLVLQ
Mb1288c|M.bovis_AF2122/97 --------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQ
Rv1258c|M.tuberculosis_H37Rv --------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQ
MMAR_4182|M.marinum_M --------------MRNSSRGPAFLILFATLAACAGNGISIVAFPWLVLE
MAV_1406|M.avium_104 ------------------------MILFATLLATAGTGISIVAFPWLALQ
MAB_1409c|M.abscessus_ATCC_199 ----MSTPTADSPTINQVNRGPVLLLLFASVVAAIGNGVSIVALPWLVLQ
MSMEG_5187|M.smegmatis_MC2_155 --MRSPRPVAGWRVLAPFRIREYRLLIAAVTLSIFAEGMWSVVMALQVIA
MUL_0838|M.ulcerans_Agy99 MTASPQVNETEGRPVVGRPGAVLFTVCAALFLVVVDVTVLHVAAPRIAEE
: * : :. . .
Mflv_2234|M.gilvum_PYR-GCK RTGSALDASIVAMAGTLPLLAATLIAGAAVDFLGRRRVSMISDALSALSV
Mvan_4461|M.vanbaalenii_PYR-1 RTGSALDASIVAMAGTLPLLAATLIAGAAVDFLGRRRVSMISDALSALSV
TH_2406|M.thermoresistible__bu RNGSALEASVVAMAATXPLLVATLFAGVAVDYLGRRRVSMISDLLSALSV
Mb1288c|M.bovis_AF2122/97 REGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAV
Rv1258c|M.tuberculosis_H37Rv REGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAV
MMAR_4182|M.marinum_M REGSAGQASIVAGAITLPLLFSTLVAGTAVDYFGRRPVSMVSDALSGSAV
MAV_1406|M.avium_104 HRHSATDASIVAAAMTLPLVLATLIAGTAVDFFGRRRVSLVCDWLSGAAV
MAB_1409c|M.abscessus_ATCC_199 RNGSAADAAIVAAAGTLPLVFSTLISGTAVDYFGRRVMSIFSDVLSLVSV
MSMEG_5187|M.smegmatis_MC2_155 IDNDPASLSLVATCLGVGLVAFVLVGGITADRINQRTIIIAVEVVNFVTV
MUL_0838|M.ulcerans_Agy99 LSPSPTEFLWIVDIYPLIMASLMLMAGAASDRFGRKRLLMTG-----LVI
.. . :. : *..* : * :.:: : : :
Mflv_2234|M.gilvum_PYR-GCK AAVPVIALVFGADAVNVAVLA-ALAALGAFFDPAGMTARETMLPEAAHRA
Mvan_4461|M.vanbaalenii_PYR-1 AAVPVLALAFGTDVINVAVLA-GLAALGAIFDPAGMTARETMLPEAANRA
TH_2406|M.thermoresistible__bu AAVPVIALTFGVQAVNVAVLA-ALAALGAFFDPAGMTARETMLPEAAARA
Mb1288c|M.bovis_AF2122/97 AGVPLVAWGYGGDAVNVLVLA-VLAALAAAFGPAGMTARDSMLPEAAARA
Rv1258c|M.tuberculosis_H37Rv AGVPLVAWGYGGDAVNVLVLA-VLAALAAAFGPAGMTARDSMLPEAAARA
MMAR_4182|M.marinum_M AIVPLIAWAFGDDAVSVAVLA-ALGACSATFDPAGITARQSMLPEAAARA
MAV_1406|M.avium_104 TAVPLTAWIFGAAAIDVAELA-VLAFCAAAFDPAGMTARQSMLPEAAARA
MAB_1409c|M.abscessus_ATCC_199 SAIPILAMTTG---LNVPLLA-ALAALGAIFDPAGITARESMLPAAAKSA
MSMEG_5187|M.smegmatis_MC2_155 AVISALALLGVLKIWHMAVAAGILGIAAAFFFPAYSAILPRILPPEQLLA
MUL_0838|M.ulcerans_Agy99 FGLVSIPAAFAATPLMLILARSVMAVGAAMILPATVSLLRVAFPDRAERM
: . : :. .* : ** : :*
Mflv_2234|M.gilvum_PYR-GCK GWTLDRANSFFEAVFNLAYIVGPGIGGLLIATLGG---------------
Mvan_4461|M.vanbaalenii_PYR-1 GWTLDHANSVFEAIFNLAYIVGPGIGGLLIATLGG---------------
TH_2406|M.thermoresistible__bu GWTLDKTNSGYEAIFNLAYIVGPGIGGLLIATLGG---------------
Mb1288c|M.bovis_AF2122/97 GWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGG---------------
Rv1258c|M.tuberculosis_H37Rv GWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGG---------------
MMAR_4182|M.marinum_M GWSLDRINSSYEAILNLAFVVGPGIGGLMIATVGG---------------
MAV_1406|M.avium_104 GWSLDRTNSSYEAMLNLAFIVGPGLGGLLIATLGG---------------
MAB_1409c|M.abscessus_ATCC_199 GWSLDKMNSMYEATFNVAYIVGPGLGGLLIASVGG---------------
MSMEG_5187|M.smegmatis_MC2_155 ---ANGVEGVVRPVFQRS--VGPAVAGMVIGATMP---------------
MUL_0838|M.ulcerans_Agy99 R-----AVGIWSAVSAVGAAIGPLMGGLLVEYFWWGAIFLINVPLALLVL
. . . :** :.*:::
Mflv_2234|M.gilvum_PYR-GCK ------------IDTMWVTAGAFVLSIAAIAVLRLEGTARPDPSTMSDGV
Mvan_4461|M.vanbaalenii_PYR-1 ------------IDTMWVTAGAFGLSIFAIAALKLEGAGRPDPTAMSDGV
TH_2406|M.thermoresistible__bu ------------VNTMWVTAALFVVSIVTIAALRLEGAGLPDRALLTDSV
Mb1288c|M.bovis_AF2122/97 ------------ITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGL
Rv1258c|M.tuberculosis_H37Rv ------------ITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGL
MMAR_4182|M.marinum_M ------------ITTMWITAGAFGLSLLAIGALRLEGAGRPHHETRPDGL
MAV_1406|M.avium_104 ------------INTMWVTAGCFALSFLAIGALRLEGAGKPPRATRPVGL
MAB_1409c|M.abscessus_ATCC_199 ------------VNTMWVTAASFVVSIIAIALLKVDGAGKPAHETRPTGV
MSMEG_5187|M.smegmatis_MC2_155 ------------SIGAVVVAVLFALGLALLVATRPPAQPASEHHERP-HV
MUL_0838|M.ulcerans_Agy99 LLVWRLVPESRSQARLVLDGLSVSLSIVAVLTSVLAIKQATHHGIDPAAV
: . . :.: : . . :
Mflv_2234|M.gilvum_PYR-GCK WAGILEGLRFVWNNKVLR---------------------TLAFVDLAATG
Mvan_4461|M.vanbaalenii_PYR-1 WAGIIEGLRFVWRNKVLR---------------------TLALVDLVATG
TH_2406|M.thermoresistible__bu LAGIVEGLRFVWRTPVLR---------------------ALLIVDLVVTG
Mb1288c|M.bovis_AF2122/97 VSGIAEGLRFVWNLRVLR---------------------TLGMIDLTVTA
Rv1258c|M.tuberculosis_H37Rv VSGIAEGLRFVWNLRVLR---------------------TLGMIDLTVTA
MMAR_4182|M.marinum_M VSGVTQGLRFVWNLRVLR---------------------ALALIDLTVTA
MAV_1406|M.avium_104 VTGIAEGVRFVWNLRVLR---------------------TLGLIDLAVTA
MAB_1409c|M.abscessus_ATCC_199 FSGVLEGLRFFWNIKILR---------------------TIALVDMAITA
MSMEG_5187|M.smegmatis_MC2_155 LRDLREGFAFVLKTPWLL---------------------WTVLFASMFVL
MUL_0838|M.ulcerans_Agy99 GYVVIASVGLWWFIRRQISRQRRGIEPLLNVHLFTRAPFTSAVLAVLLAV
: .. : .. .
Mflv_2234|M.gilvum_PYR-GCK LYMPMESVLFPKYFTD--RDEPAQLGWVLMALSIGGLLGALGFAVLSKYL
Mvan_4461|M.vanbaalenii_PYR-1 LYVPMESVLFPKYFTD--RNEPAQLGWVLMALSIGGLIGALGYAVMSRYM
TH_2406|M.thermoresistible__bu LYMPMESVLFPKYFTD--RDEPAHLGWVLMALSIGGLTGALAYAWVSRFV
Mb1288c|M.bovis_AF2122/97 LYLPMESVLFPKYFTD--HQQPVQLGWALMAIAGGGLVGALGYAVLAIRV
Rv1258c|M.tuberculosis_H37Rv LYLPMESVLFPKYFTD--HQQPVQLGWALMAIAGGGLVGALGYAVLAIRV
MMAR_4182|M.marinum_M LYLPMESVLFPTYFSD--RQQPAQLGSVLVALSLGSLVGALGYGMLSNYV
MAV_1406|M.avium_104 LYLPMESVLFPKYFAD--QHQPAQLGWALMALALGGVAGALGYAVLSARL
MAB_1409c|M.abscessus_ATCC_199 LYLPIESVLLPKHFSD--IGAPQQLGWMLMAISVGGLLGALGYATMVRHF
MSMEG_5187|M.smegmatis_MC2_155 VVLGPIEVLLPFIAQDRFADGARAYGFILAFFGIGSAMGALTVSSRRMPR
MUL_0838|M.ulcerans_Agy99 FSIVGLDLVFAQYLQNFLGFTPIKAALLLTPMAAATVVGSLSAHLIVGRC
. : .:::. : . . * :. . *:*
Mflv_2234|M.gilvum_PYR-GCK KRRTVMLTAVLTLG---VAMTVIAFLPPLPIILVLCALVGFVYGPIAPIY
Mvan_4461|M.vanbaalenii_PYR-1 KRRTVMLTAVLTLG---VAMTVIAFLPPLPIILVLCAIVGFVYGPIAPIY
TH_2406|M.thermoresistible__bu SRRATLITAVLTLG---ATMTVIAFLPPLPLILAMAAVGGFAYGPIQPIY
Mb1288c|M.bovis_AF2122/97 PRRVTMSTAVLTLG---LASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIY
Rv1258c|M.tuberculosis_H37Rv PRRVTMSTAVLTLG---LASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIY
MMAR_4182|M.marinum_M SRRTIMLTAVLTLG---AATTGIALLPPLPVILVLCALIGVVYGPIQPIY
MAV_1406|M.avium_104 RRRTAVLTATLTFG---ATTAGIAVLPPLPVILGLCAVTGVVYGPIQPIY
MAB_1409c|M.abscessus_ATCC_199 QRRTIMLCATFTAG---ITTLGMSLLPPIAVLLVLAACLGFIYGPVAPIA
MSMEG_5187|M.smegmatis_MC2_155 RYLTTMMLMWGLGS---IPLVIVGYTSSFPLMAAATFVIGVTDGAGMVIW
MUL_0838|M.ulcerans_Agy99 GTRVAISAGLGLTASALLPLLTPGHNGQLLVFVGSLAVVGFALDVVLVSA
. : . . . : :: *. .
Mflv_2234|M.gilvum_PYR-GCK NYVMQTRAPQHLRGRVVGVMGSLAYAAGPLGLILAGPLADS---------
Mvan_4461|M.vanbaalenii_PYR-1 NYVMQTRAPQHLRGRVVGVMGSLAYAAGPLGLILAGPLADA---------
TH_2406|M.thermoresistible__bu NYVMQTRAPQHLRGRVVGVMGSLAYAAGPLGLVIAGPLADS---------
Mb1288c|M.bovis_AF2122/97 NYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDA---------
Rv1258c|M.tuberculosis_H37Rv NYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDA---------
MMAR_4182|M.marinum_M NYVMQTRAPHYLRGRVVGVMTSLAYAAGPLGLLLAGPVADA---------
MAV_1406|M.avium_104 NFVMQTRAPHHLRGRVVGVMAGLTYAAGPLGLLVAGPLADA---------
MAB_1409c|M.abscessus_ATCC_199 NFVMQTRSPEHLRGRVVGVMTSTAYCAGPLGFMLAGPIADK---------
MSMEG_5187|M.smegmatis_MC2_155 GTLLQRRVPTEMLGRVSSLDFFVSLAFMPLSFAIVGPLSKV---------
MUL_0838|M.ulcerans_Agy99 NDAIISAVSEDYVGQAAGVEEVAYDLGGGLGIAVLGSVLTATYTAAFDPI
. : . *:. .: *.: : *.:
Mflv_2234|M.gilvum_PYR-GCK -------------------------------------------AGLHVTF
Mvan_4461|M.vanbaalenii_PYR-1 -------------------------------------------TGLRTTF
TH_2406|M.thermoresistible__bu -------------------------------------------AGLRVTF
Mb1288c|M.bovis_AF2122/97 -------------------------------------------AGLHATF
Rv1258c|M.tuberculosis_H37Rv -------------------------------------------AGLHATF
MMAR_4182|M.marinum_M -------------------------------------------AGLKVAF
MAV_1406|M.avium_104 -------------------------------------------AGLKATF
MAB_1409c|M.abscessus_ATCC_199 -------------------------------------------FGVATTL
MSMEG_5187|M.smegmatis_MC2_155 -------------------------------------------VSMEVIF
MUL_0838|M.ulcerans_Agy99 SGLIDSQLATAQESIRTANDLADATSAPALASQIRIEAHTAFLAGFHTTI
.. . :
Mflv_2234|M.gilvum_PYR-GCK LALSLPMLALGIVSVFLPALRELDTPHP-----------
Mvan_4461|M.vanbaalenii_PYR-1 LALSLPMLALGIVAVFLPALRDLDRPAAGP---------
TH_2406|M.thermoresistible__bu LALSLPMVALGLIAIGLPVLTTLNQPAADQIDLQFDD--
Mb1288c|M.bovis_AF2122/97 LALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ
Rv1258c|M.tuberculosis_H37Rv LALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ
MMAR_4182|M.marinum_M FALALPIAITGLMCIRLPSLRELDHAPTQDISETSLL--
MAV_1406|M.avium_104 LTLAVPILAIGVVACGLPSLRELDRAPQFADDPGA----
MAB_1409c|M.abscessus_ATCC_199 VILGAPMLLIAIASTRMRVLRELDQDEPQPDKEPTR---
MSMEG_5187|M.smegmatis_MC2_155 ATAGLVPVAIAAVAFTAARMHRDEVANPLL---------
MUL_0838|M.ulcerans_Agy99 VVAIAILAAAAVAAGALLSTKTLPEPAGQDAPDPSA---
. .