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DFPEQLKTEGVLGKNSGGSSGGESHPSTSGLPRALRPMRHRDYRLLTLGLAITLLGNGMWTVALVWQVIR MGLGPAQVAVVGTTFSVGLLLSVLPAGVAADRLPKLWVMRCSLAVQTALMLTTATLALTGAAHIWHLALN SLLFGIAEGFYIPAYTALLPSLLPADELLAANGIEGILRPVMQLAAGPAVSAAIVSVWSPGGAFLLEGML VGAGLSCLLLVRHKHEPPASAEVRQHPLRRALADLAEGFRYMVRTTWFFATLLFAIGYVLVVVGPIEILL PFVIRDHGGDPGAHATVLALFGLAGAVGSFIVSSLPLARRYLTVMILMWGAGSLPLIFIGFTGHVWMIAV AMIIVGGTMQAANVIWGTLMQRRVPEEMLGRAASMDFFVSLVGLPASFALVVPVAHVIGNTTVFVIAGVA PLVLAAAAHIVARLGRDEMAHPLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2780c | - | - | 100% (445) | putative transporter |
| M. abscessus ATCC 19977 | MAB_0940 | - | 2e-19 | 25.13% (398) | hypothetical protein MAB_0940 |
| M. abscessus ATCC 19977 | MAB_0880 | - | 3e-18 | 25.56% (403) | hypothetical protein MAB_0880 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 1e-10 | 21.96% (387) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_5163 | - | 1e-21 | 26.27% (354) | protein of unknown function DUF894, DitE |
| M. tuberculosis H37Rv | Rv1258c | - | 1e-10 | 21.96% (387) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_02143 | - | 4e-06 | 22.26% (319) | hypothetical protein MLBr_02143 |
| M. marinum M | MMAR_4182 | - | 6e-12 | 22.52% (373) | hypothetical protein MMAR_4182 |
| M. avium 104 | MAV_1406 | - | 2e-10 | 21.55% (399) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_5187 | - | 1e-97 | 43.20% (412) | tetracycline-resistance determinant TetV |
| M. thermoresistible (build 8) | TH_1986 | - | 1e-102 | 46.92% (422) | tetracycline-resistance determinant TetV |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4580 | - | 8e-97 | 44.58% (415) | H+ antiporter protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5187|M.smegmatis_MC2_155 ----------------------MRS------PRPVAGWRVLAPFRIR---
Mvan_4580|M.vanbaalenii_PYR-1 ----MVGNHRSVSTQYETGRSSARSDS--EQPVAPAGWRVLAPFRYR---
TH_1986|M.thermoresistible__bu -----------VSTQYDIEPSAGTS----------GGWRVLAPFRIR---
MAB_2780c|M.abscessus_ATCC_199 -----MDFPEQLKTEGVLGKNSGGSSGGESHPSTSGLPRALRPMRHR---
Mb1288c|M.bovis_AF2122/97 ----------------------------------------MRNSNRG---
Rv1258c|M.tuberculosis_H37Rv ----------------------------------------MRNSNRG---
MMAR_4182|M.marinum_M ----------------------------------------MRNSSRG---
MAV_1406|M.avium_104 --------------------------------------------------
Mflv_5163|M.gilvum_PYR-GCK -------------------------------MTSPVSTSTWAPLQSP---
MLBr_02143|M.leprae_Br4923 MSGRRRNHPGRLASIPGLRTRTGSRNQHPGIANYPADSSDFRPAQQRRAL
MSMEG_5187|M.smegmatis_MC2_155 -EYRLLIAAVTLSIFAEGMWSVVMALQVIAIDNDPASLSLVATCLGVG--
Mvan_4580|M.vanbaalenii_PYR-1 -EYRLLIAAVSLSIFAEGMWAVVMALQVIELSNDPAALSLVATCLGAG--
TH_1986|M.thermoresistible__bu -EYRLLITAVAITIFAEGMWAVVMALQVIAIDNDPASLSLVATCMGVG--
MAB_2780c|M.abscessus_ATCC_199 -DYRLLTLGLAITLLGNGMWTVALVWQVIRMGLGPAQVAVVGTTFSVG--
Mb1288c|M.bovis_AF2122/97 -PAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLP--
Rv1258c|M.tuberculosis_H37Rv -PAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLP--
MMAR_4182|M.marinum_M -PAFLILFATLAACAGNGISIVAFPWLVLEREGSAGQASIVAGAITLP--
MAV_1406|M.avium_104 ----MILFATLLATAGTGISIVAFPWLALQHRHSATDASIVAAAMTLP--
Mflv_5163|M.gilvum_PYR-GCK -VFRALWIAQFVSNLGTWMQTVGAQWMLVDDPAAAVLVPLVQTATTLP--
MLBr_02143|M.leprae_Br4923 EQREQQAGQLDPARRSPSMPSANRYLPPLGQQQSEPQHNSAPPCGPYPGE
: . : . : .
MSMEG_5187|M.smegmatis_MC2_155 LVAFVLVGGITADRINQRTIIIAVEVVNFVTVAVISALALLGVLKIWHMA
Mvan_4580|M.vanbaalenii_PYR-1 LVGFVLVGGLAADRLSQRGIIIVVEAVNTVAVTAVAVLGFVDALRIWHMA
TH_1986|M.thermoresistible__bu LVAFVLVGGITADRINQRTIIIAVEAVNAVTVAVVAMLGLTGQLRIWHLA
MAB_2780c|M.abscessus_ATCC_199 LLLSVLPAGVAADRLPKLWVMRCSLAVQTALMLTTATLALTGAAHIWHLA
Mb1288c|M.bovis_AF2122/97 LLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVL
Rv1258c|M.tuberculosis_H37Rv LLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVL
MMAR_4182|M.marinum_M LLFSTLVAGTAVDYFGRRPVSMVSDALSGSAVAIVPLIAWAFGDDAVSVA
MAV_1406|M.avium_104 LVLATLIAGTAVDFFGRRRVSLVCDWLSGAAVTAVPLTAWIFGAAAIDVA
Mflv_5163|M.gilvum_PYR-GCK VMLLALPSGVLADLVDRRRLLIATQGAMAAGVGLLATLTGAGLTTPTVLL
MLBr_02143|M.leprae_Br4923 RIKVTRAAAQRSREMGYRMYWMVQRAATADGADKSGLTALTWPVVTNFAV
: . .. .
MSMEG_5187|M.smegmatis_MC2_155 VAAGILGIAAAFFFPAYSAILPR-----------ILPPEQLLAANGVEGV
Mvan_4580|M.vanbaalenii_PYR-1 VAAAALGIAAAFFFPAYSAILPR-----------ILPPEQLLAANGIEGV
TH_1986|M.thermoresistible__bu VAAAVLGIAAAFFFPAYSALLPR-----------ILPPEQLLAANGVEGV
MAB_2780c|M.abscessus_ATCC_199 LNSLLFGIAEGFYIPAYTALLPS-----------LLPADELLAANGIEGI
Mb1288c|M.bovis_AF2122/97 VLAVLAALAAAFGPAGMTARDS------------MLPEAAARAGWSLDRI
Rv1258c|M.tuberculosis_H37Rv VLAVLAALAAAFGPAGMTARDS------------MLPEAAARAGWSLDRI
MMAR_4182|M.marinum_M VLAALGACSATFDPAGITARQS------------MLPEAAARAGWSLDRI
MAV_1406|M.avium_104 ELAVLAFCAAAFDPAGMTARQS------------MLPEAAARAGWSLDRT
Mflv_5163|M.gilvum_PYR-GCK TLLFVIGCGQALTAPAWQAIQPD-----------LVPSDQIPAAAALGSM
MLBr_02143|M.leprae_Br4923 DSAMAVALANTLFFAAASGESKSKVALYLLITIAPFAVIAPLIGPALDRL
. : .. . .. . .:
MSMEG_5187|M.smegmatis_MC2_155 VRP-----VFQRSVGPAVAGMVIGATMPSIGAVVVAVLFALGLALLVATR
Mvan_4580|M.vanbaalenii_PYR-1 VRP-----VFQRAVGPAIAGLVVGALFPSAGALVVAVLFATGLALLVATR
TH_1986|M.thermoresistible__bu VRP-----VFQRAVGPAVAGMLVGATFPSLGSAVVATLFGVGLVLLVATR
MAB_2780c|M.abscessus_ATCC_199 LRP-----VMQLAAGPAVSAAIVSVWSPGGAFLLEGMLVGAGLSCLLLVR
Mb1288c|M.bovis_AF2122/97 NGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILAIAALQ
Rv1258c|M.tuberculosis_H37Rv NGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILAIAALQ
MMAR_4182|M.marinum_M NSSYEAILNLAFVVGPGIGGLMIATVGGITTMWITAGAFGLSLLAIGALR
MAV_1406|M.avium_104 NSSYEAMLNLAFIVGPGLGGLLIATLGGINTMWVTAGCFALSFLAIGALR
Mflv_5163|M.gilvum_PYR-GCK SMN------GARAIGPAIAGALVSLTGPTIVFALNAVSFVGIVLVLMWWR
MLBr_02143|M.leprae_Br4923 QHGRRVALATSFVLRTGLATLLIMNYDGATGSYPSMVLYPCALAMMVLSK
..:. :: . : :
MSMEG_5187|M.smegmatis_MC2_155 PP--AQPASEHHERPHVLR---------------------DLREGFAFVL
Mvan_4580|M.vanbaalenii_PYR-1 PPKAKDTGAQHEPRPHLLR---------------------DLRDGWVFML
TH_1986|M.thermoresistible__bu PP--ASPSVPGEHRSRVLR---------------------DLRDGFMFMV
MAB_2780c|M.abscessus_ATCC_199 HK--HEPPASAEVRQHPLRRALA-----------------DLAEGFRYMV
Mb1288c|M.bovis_AF2122/97 LEGAGKPHHTSRPQGLVSG----------------------IAEGLRFVW
Rv1258c|M.tuberculosis_H37Rv LEGAGKPHHTSRPQGLVSG----------------------IAEGLRFVW
MMAR_4182|M.marinum_M LEGAGRPHHETRPDGLVSG----------------------VTQGLRFVW
MAV_1406|M.avium_104 LEGAGKPPRATRPVGLVTG----------------------IAEGVRFVW
Mflv_5163|M.gilvum_PYR-GCK RP----PVRSDYPPERALA---------------------ALSAGGRYIR
MLBr_02143|M.leprae_Br4923 SFSVLRSAVTPRVMPPSIDLVRVNSRLTVFGLLGGTIAGGAIAAGVEFVC
. : * ::
MSMEG_5187|M.smegmatis_MC2_155 KTPWLLWTVLFASMFVLVVLGPIEVLLPFIAQDRFADGARAYGFILAFFG
Mvan_4580|M.vanbaalenii_PYR-1 RTPWLLWTLLFASLFVLVVLGPIEVLLPFVVAERFTHGAQTYGFILAFFG
TH_1986|M.thermoresistible__bu ATPWLLWTLLFASVFVLVVLGPIEVLLPFIAQERFTDGARMYGFVLAAFG
MAB_2780c|M.abscessus_ATCC_199 RTTWFFATLLFAIGYVLVVVGPIEILLPFVIRDHGGD-PGAHATVLALFG
Mb1288c|M.bovis_AF2122/97 NLRVLRTLGMIDLTVTALYLPMESVLFPKYFTD--HQQPVQLGWALMAIA
Rv1258c|M.tuberculosis_H37Rv NLRVLRTLGMIDLTVTALYLPMESVLFPKYFTD--HQQPVQLGWALMAIA
MMAR_4182|M.marinum_M NLRVLRALALIDLTVTALYLPMESVLFPTYFSD--RQQPAQLGSVLVALS
MAV_1406|M.avium_104 NLRVLRTLGLIDLAVTALYLPMESVLFPKYFAD--QHQPAQLGWALMALA
Mflv_5163|M.gilvum_PYR-GCK SSPIVRRILLRTVLFIAPGS-AVWGLLPVIARDQLGLGSAGYGALLGALG
MLBr_02143|M.leprae_Br4923 AHLFKLPGALFVVAAITISGALLSMRIPRWVEVTAGEIPATLSYRLHRKP
: :* . . *
MSMEG_5187|M.smegmatis_MC2_155 IGSAMGALTVSSR-RMPRRYLTTMMLMWGLGSIPLVIVGYTSSFPLMAAA
Mvan_4580|M.vanbaalenii_PYR-1 LGSALGALGVSSR-RLPRRYLTVMMAMWSVGSVPLVIVGVTSSFPLMALA
TH_1986|M.thermoresistible__bu VGSAVGALTVSSR-QMPRRYLTVMMLMWALGSVPLLVIGFTWSFLLMSAA
MAB_2780c|M.abscessus_ATCC_199 LAGAVGSFIVSSL-PLARRYLTVMILMWGAGSLPLIFIGFTGHVWMIAVA
Mb1288c|M.bovis_AF2122/97 GGGLVGALGYAVL-AIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVL
Rv1258c|M.tuberculosis_H37Rv GGGLVGALGYAVL-AIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVL
MMAR_4182|M.marinum_M LGSLVGALGYGML-SNYVSRRTIMLTAVLTLGAATTGIALLPPLPVILVL
MAV_1406|M.avium_104 LGGVAGALGYAVL-SARLRRRTAVLTATLTFGATTAGIAVLPPLPVILGL
Mflv_5163|M.gilvum_PYR-GCK VGAVLGAFALSRL-RARFGQNKLLIAGAAGFGMATAVLALVHNVALVAAA
MLBr_02143|M.leprae_Br4923 LRQSWPEEVKKVSGRLRQPLGRNIITSLWGNCTIKVMVGFLFLYPAFVAK
: :. .
MSMEG_5187|M.smegmatis_MC2_155 TFVIG---------------VTDGAGMVIWGTLLQRRVPTEMLGRVSSLD
Mvan_4580|M.vanbaalenii_PYR-1 TFVIG---------------VTDGTAMVIWGTLLQRRVPPELLGRVSSLD
TH_1986|M.thermoresistible__bu SFAIG---------------VTDGAGMVIWGTLLQRRVPRELLGRVSSLD
MAB_2780c|M.abscessus_ATCC_199 MIIVG---------------GTMQAANVIWGTLMQRRVPEEMLGRAASMD
Mb1288c|M.bovis_AF2122/97 CAVVG---------------LVYGPIQPIYNYVIQTRAAQHLRGRVVGVM
Rv1258c|M.tuberculosis_H37Rv CAVVG---------------LVYGPIQPIYNYVIQTRAAQHLRGRVVGVM
MMAR_4182|M.marinum_M CALIG---------------VVYGPIQPIYNYVMQTRAPHYLRGRVVGVM
MAV_1406|M.avium_104 CAVTG---------------VVYGPIQPIYNFVMQTRAPHHLRGRVVGVM
Mflv_5163|M.gilvum_PYR-GCK LVVGG---------------AAWLLTLSTLNASMQLSLPSWVRARGLSVY
MLBr_02143|M.leprae_Br4923 EHQANGWVQLGMLGLIGTAAAIGNFAGNFTSARLQLGRPAVLVVRCTIAV
. . :* . : *
MSMEG_5187|M.smegmatis_MC2_155 FFVSLAFMPLSFAIVGPLSKVVSMEVIFATAGLVPVAIAAVAFTAARMH-
Mvan_4580|M.vanbaalenii_PYR-1 FFVSLAFMPVSFAIVGPLSKIVSMEAIFLAAGLLPVLLAAVAVWAAKMH-
TH_1986|M.thermoresistible__bu FFVSLVFMPVSFAIAGPLSKVVSMQTIFLVAGLAPLLFAVVAMTAARMP-
MAB_2780c|M.abscessus_ATCC_199 FFVSLVGLPASFALVVPVAHVIGNTTVFVIAGVAPLVLAAAAHIVARLG-
Mb1288c|M.bovis_AF2122/97 TSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALR-
Rv1258c|M.tuberculosis_H37Rv TSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALR-
MMAR_4182|M.marinum_M TSLAYAAGPLGLLLAGPVADAAGLKVAFFALALPIAITGLMCIRLPSLR-
MAV_1406|M.avium_104 AGLTYAAGPLGLLVAGPLADAAGLKATFLTLAVPILAIGVVACGLPSLR-
Mflv_5163|M.gilvum_PYR-GCK QLIFMGGQAVGSLLWGLLAGGTSSVISLLVSAGLLIFCGLSLWWWPLHAG
MLBr_02143|M.leprae_Br4923 TVLALAASVAGNLLMTTIATLITSGSSAIAKASLDASLQNDLPEESRASG
: . : :: . .
MSMEG_5187|M.smegmatis_MC2_155 --RDEVANPLL---------------------------------------
Mvan_4580|M.vanbaalenii_PYR-1 --RDEVAHPLR---------------------------------------
TH_1986|M.thermoresistible__bu --RDELEHPLN---------------------------------------
MAB_2780c|M.abscessus_ATCC_199 --RDEMAHPLG---------------------------------------
Mb1288c|M.bovis_AF2122/97 --ELDLAPQADIDRPVGSAQ------------------------------
Rv1258c|M.tuberculosis_H37Rv --ELDLAPQADIDRPVGSAQ------------------------------
MMAR_4182|M.marinum_M --ELDHAPTQDISETSLL--------------------------------
MAV_1406|M.avium_104 --ELDRAPQFADDPGA----------------------------------
Mflv_5163|M.gilvum_PYR-GCK TGNLDLTPSSHWPEPTLLFEPEPLDGPVLVITAYRVLPENEEPFMSAMAR
MLBr_02143|M.leprae_Br4923 FGRSESTLQLAWVLGGALGVMVYTDLWVGFTAVSALLILGLAQTVVSFRG
. :
MSMEG_5187|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4580|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1986|M.thermoresistible__bu --------------------------------------------------
MAB_2780c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4182|M.marinum_M --------------------------------------------------
MAV_1406|M.avium_104 --------------------------------------------------
Mflv_5163|M.gilvum_PYR-GCK LGRSRQRTGASMWQLFRSIEQESTFVETFIVRSWGEHMHQHYTRLTGQDQ
MLBr_02143|M.leprae_Br4923 DSLIPGLGGNRPVMIEQESMRRAAAVSPQ---------------------
MSMEG_5187|M.smegmatis_MC2_155 --------------------------
Mvan_4580|M.vanbaalenii_PYR-1 --------------------------
TH_1986|M.thermoresistible__bu --------------------------
MAB_2780c|M.abscessus_ATCC_199 --------------------------
Mb1288c|M.bovis_AF2122/97 --------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------
MMAR_4182|M.marinum_M --------------------------
MAV_1406|M.avium_104 --------------------------
Mflv_5163|M.gilvum_PYR-GCK LIEQDVERYTEGEAVAEHYLAVRDAR
MLBr_02143|M.leprae_Br4923 --------------------------