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M. ulcerans Agy99 MUL_3787 (-)

annotation: integral membrane leucine and alanine rich protein
coordinates: 4227809 - 4229137
length: 442

TNPATGTFVRSRVVAWALWDCGSTGLNAMVTTFVFSVYLTSMVGEGMPGGSDPASWLGRAAAAAGLTIAL
LAPLVGVWVESPHRRRVALGVLTSVTVALTCAMFLIHDSPGYLWAGLALLAATAACSDLASVPYNSMLRQ
LSTPTTASRISGFGWASGYVGSVVLLILIYLGFVAGSGAHRGLLQLPAHDGFNIRVAMLLAAAWLAVLAS
PLLLVAHRLPDVGTVPQPATRMLGAYRKLWADISSEWRRDRNLVYFLIASAIFRDGLAAMFAFGAVLGAN
VYGLTQADVLLFGVAASVVAAVGAVVGGFVDHRVGSKPVIVASLASILISAIVLMVLSGATAFWVCGLLL
CLFIGPSQSSARALLLRMAPHGKEGVAFGLYTMTGHAVAFLGPWLFSIFVDIFSAVRAGLGGICLVLAVG
LVGMLVVGVPRHGGVVVTETT*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_3787--100% (442)integral membrane leucine and alanine rich protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2536c-0.076.64% (441) hypothetical protein Mb2536c
M. gilvum PYR-GCKMflv_2546-1e-15762.70% (437) major facilitator transporter
M. tuberculosis H37RvRv2508c-0.076.64% (441) hypothetical protein Rv2508c
M. leprae Br4923MLBr_00430-0.074.35% (425) hypothetical protein MLBr_00430
M. abscessus ATCC 19977MAB_1538-1e-12751.41% (426) hypothetical protein MAB_1538
M. marinum MMMAR_3855-0.098.87% (442) integral membrane leucine and alanine rich protein
M. avium 104MAV_1667-0.073.89% (429) permease of the major facilitator superfamily protein
M. smegmatis MC2 155MSMEG_4721-1e-15762.65% (431) permease of the major facilitator superfamily protein
M. thermoresistible (build 8)TH_1384-1e-16064.00% (425) PROBABLE CONSERVED INTEGRAL MEMBRANE LEUCINE AND ALANINE RICH
M. vanbaalenii PYR-1Mvan_4097-1e-15262.71% (421) major facilitator superfamily transporter

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2546|M.gilvum_PYR-GCK          MSQVPSTTGPPT----------DAAPRARVWAWAMWDFGATAVNAIVITF
Mvan_4097|M.vanbaalenii_PYR-1       MSELSPTIGPPVGS--------AGAKRSRVLAWAMWDFGATAINAIVITF
MSMEG_4721|M.smegmatis_MC2_155      MINPG---------------------RARVVAWALWDCGSAGLNAIVITF
TH_1384|M.thermoresistible__bu      MSQTRRVGRPPS----------QPAQRSQVLAWALWDCGSTGFNAIVITF
MUL_3787|M.ulcerans_Agy99           MTNP--ATGTFV--------------RSRVVAWALWDCGSTGLNAMVTTF
MMAR_3855|M.marinum_M               MTNP--ATGTFV--------------RSRVVAWALWDCGSTGLNAIVTTF
MLBr_00430|M.leprae_Br4923          MNQPESVAGTMV--------------RSWVVAWAMWDCGSTGLTAIVATF
MAV_1667|M.avium_104                -----------------------------MVAWALWDCGSTGLNAIVATF
Mb2536c|M.bovis_AF2122/97           MNNPGSRAGTLL--------------HFRVVAWAMWDCGSTGLNAIVTTF
Rv2508c|M.tuberculosis_H37Rv        MNNPGSRAGTLL--------------HFRVVAWAMWDCGSTGLNAIVTTF
MAB_1538|M.abscessus_ATCC_1997      MSMPGVEEPKGRQDPGPGRQLDTPTSRGRIAAWAAFDWGSAAFNTVIVMF
                                                                 : *** :* *::...:::  *

Mflv_2546|M.gilvum_PYR-GCK          VFTVYLTAVVGDDLPGDTTPASWLGRALAAAGIVVALLAPVTGVWVDAPA
Mvan_4097|M.vanbaalenii_PYR-1       VFTVYLTSTVGDDLPGETSPASWLGRALAVAGLVVALLAPVTGVWVDAPA
MSMEG_4721|M.smegmatis_MC2_155      VFSVYLTGSVGAGLPGDTTPASWLGRALTVAGIAVAFLAPATGVWVDAPE
TH_1384|M.thermoresistible__bu      VFAVYLTGTVGADLPGDTSAAGWLGRAMAAGGLAVAVLAPATGVWVEAPR
MUL_3787|M.ulcerans_Agy99           VFSVYLTSMVGEGMPGGSDPASWLGRAAAAAGLTIALLAPLVGVWVESPH
MMAR_3855|M.marinum_M               VFSVYLTSMVGEGMPGGSDPASWLGRAAAAAGLTIALLAPLVGVWVESPH
MLBr_00430|M.leprae_Br4923          VFSVYLTSSVGVGMPDGISLVSWLGRAGAVAGLTIAVLAPAIGVWVESPH
MAV_1667|M.avium_104                VFAVYLTSSVGVGIGGSTTPASWLGRAAAIAGLTVALLAPAVGVWVESPH
Mb2536c|M.bovis_AF2122/97           VFSVYLTSAVGQGLPGGTSPASWLGRAGAVAGLTIGVLAPVVGVWVESPH
Rv2508c|M.tuberculosis_H37Rv        VFSVYLTSAVGQGLPGGTSPASWLGRAGAVAGLTIGVLAPVVGVWVESPH
MAB_1538|M.abscessus_ATCC_1997      IFTPYLTGRVGAGLPDG-VPQGLLGWMMGLGGVLVFLLAPVIGVWADTPQ
                                    :*: ***. ** .: .     . **     .*: : .***  ***.::* 

Mflv_2546|M.gilvum_PYR-GCK          RRRRALTVLTGMVVLLTASLSLIRDDHHYLWPALVLLACTAACSELATVP
Mvan_4097|M.vanbaalenii_PYR-1       RRRRALAILTGLVVMLTASMSLIRDDHRYLWPGLILLACTAACGELSTVP
MSMEG_4721|M.smegmatis_MC2_155      RRRPALAVLTGCVVVVTASMSLIRDDHSYLWAGLVLLALAGACGELASVP
TH_1384|M.thermoresistible__bu      RRRAALGVLTGLTVALTAAMSLIRDDHRYLWPALVLLACAAATSELATVP
MUL_3787|M.ulcerans_Agy99           RRRVALGVLTSVTVALTCAMFLIHDSPGYLWAGLALLAATAACSDLASVP
MMAR_3855|M.marinum_M               RRRVALGVLTSVTVVLTCAMFLIHDSPGYLWAGLALLAATAACSDLASVP
MLBr_00430|M.leprae_Br4923          RRRVTLGVLTVLAVALTCGMSFIRDQPSYLWAGLMLLAGTAACGDLASVP
MAV_1667|M.avium_104                RRRVALSVLTALAVTLTGSMFFIRDRPGYLWAGLVLLGATAACGDLASVP
Mb2536c|M.bovis_AF2122/97           RRRVALSVLTGTAVALTCAMFLIRDDPRYLWAGLVLLAATAASSDLSSVP
Rv2508c|M.tuberculosis_H37Rv        RRRVALSVLTGTAVALTCAMFLIRDDPRYLWAGLVLLAATAASSDLSSVP
MAB_1538|M.abscessus_ATCC_1997      RRRVALGTLTTLVVAVATAMSMVREDNRYLWLGLGLYCAGSVFNELAQVP
                                    *** :*  **  .* :: .: ::::   *** .* *    .. .:*: **

Mflv_2546|M.gilvum_PYR-GCK          YNAMLRELSTPRTSGRISGFGLALGYFGSVLALLVVYLGFISGGG----D
Mvan_4097|M.vanbaalenii_PYR-1       YNAMLRDLSTPQTSGRVSGFGLALGYFGSVLALLVVYVGFIAGAG----D
MSMEG_4721|M.smegmatis_MC2_155      YNAMLRQLSTPDNSGRVSALGLALGYSGIVVLLVLVYFGFIAGDG----D
TH_1384|M.thermoresistible__bu      YNAMLRQLSTPQNSGRVSGFGWAMGYFGSVTLLLVVYAGFIAGEG----D
MUL_3787|M.ulcerans_Agy99           YNSMLRQLSTPTTASRISGFGWASGYVGSVVLLILIYLGFVAGSG----A
MMAR_3855|M.marinum_M               YNSMLRQLSTPTTASRISGFGWASGYVGSVVLLILIYLGFVAGSG----A
MLBr_00430|M.leprae_Br4923          YNAMLRQLSTPATAGRISGLGWASGYVGSVVLLLLIYLGFISGTG----E
MAV_1667|M.avium_104                YNAMLRQLSTPRTAGRISGFGWAAGYVGSVLLLLVIYTGFIAGSGSGPDA
Mb2536c|M.bovis_AF2122/97           YNAMLRQLSTPSTAGRISGFGWASGYVGSVALLLVIYLGFMSGSG----S
Rv2508c|M.tuberculosis_H37Rv        YNAMLRQLSTPSTAGRISGFGWASGYVGSVALLLVIYLGFMSGSG----S
MAB_1538|M.abscessus_ATCC_1997      YNAMLHGLTTPANASRVSGLGLAAAYIGGVLVLLLCYLGFISGDG----P
                                    **:**: *:** .:.*:*.:* * .* * *  *:: * **::* *     

Mflv_2546|M.gilvum_PYR-GCK          TRGLLALPAADGQNVRAAMLLVAAWFALFALPLLISAPRHT--GPETAPA
Mvan_4097|M.vanbaalenii_PYR-1       TRGLLHLPVADGQNVRAAMLLVAAWFAVFALPLLISPPPVL--AQTPPPR
MSMEG_4721|M.smegmatis_MC2_155      TRGLLGLPVADGQNVRAVMLLAAAWLALFAVPVFFAVPSPH--VSVPSAR
TH_1384|M.thermoresistible__bu      RRGLLGLPVADGLNVRAAMLLTAAWFLLFALPVLITVPSPP--DDGHRAR
MUL_3787|M.ulcerans_Agy99           HRGLLQLPAHDGFNIRVAMLLAAAWLAVLASPLLLVAHRLPDVGTVPQPA
MMAR_3855|M.marinum_M               HRGLLQLPAHDGFNIRVAMLLAAAWLAVLASPLLLVAHRLPDVGTVPQPA
MLBr_00430|M.leprae_Br4923          LRGLLQLPTHDGIYVRAAMLLAAAWLALLALPLLLTAHRLPSLGEVSHPT
MAV_1667|M.avium_104                TRGLLRVPLRDGLYVREAMLVAAAWLALFALPLLFVAHRLTESAEGYRPT
Mb2536c|M.bovis_AF2122/97           QRGLLQLPVANGLNVRMAMLVAAAWLALLGLPLLLVAHRLPDSGAASHPS
Rv2508c|M.tuberculosis_H37Rv        QRGLLQLPVANGLNVRMAMLVAAAWLALLGLPLLLVAHRLPDSGAASHPS
MAB_1538|M.abscessus_ATCC_1997      TRGLFQVPAADGYDVRVSALLAAAWFAVFALPLVLTR-PVPDPAAPPPSS
                                     ***: :*  :*  :*   *:.***: ::. *:.:             . 

Mflv_2546|M.gilvum_PYR-GCK          VGFLGAYRRLWQEIGREWRRDRNFVYYLGSSAVFRDGLTGVFTFGAVLGV
Mvan_4097|M.vanbaalenii_PYR-1       VGFIGAYRRLWHDLRAEWRRDRNLVYYLGASAIFRDGLTGVFTFGAVLGV
MSMEG_4721|M.smegmatis_MC2_155      TSFIGAYRKLWSEVRSEWERDRNIVYYLLASAVFRDGLAGVFTFGAVLGV
TH_1384|M.thermoresistible__bu      TGFLGAYRRLAAELAGEWRRDRNVVYYLIASAVFRDGLAGVFAFGAVLGV
MUL_3787|M.ulcerans_Agy99           TRMLGAYRKLWADISSEWRRDRNLVYFLIASAIFRDGLAAMFAFGAVLGA
MMAR_3855|M.marinum_M               TRMLGAYRKLWADISSEWRRDRNLVYFLIASAIFRDGLAAMFAFGAVLGV
MLBr_00430|M.leprae_Br4923          S-MLGGYRKLWSEVSAEWRRDRNLVYFLVASALFRDGLAATLGFGAVLGV
MAV_1667|M.avium_104                S-MLGGYRKLWTEVREEWRRDRNLVYFLFASALFRDGLAAIFAFGAVLGV
Mb2536c|M.bovis_AF2122/97           TGLLGGYRKLWTEISAEWRRDRNLVYFLVASAIFRDGLAAIFAFGAVLGV
Rv2508c|M.tuberculosis_H37Rv        TGLLGGYRKLWTEISAEWRRDRNLVYFLVASAIFRDGLAAIFAFGAVLGV
MAB_1538|M.abscessus_ATCC_1997      PGVLGVYRELWRDLVEQWHMDRRIIYFLVASAIFRDGMVAMFALTPVIAN
                                      .:* **.*  ::  :*. **..:*:* :**:****:.. : : .*:. 

Mflv_2546|M.gilvum_PYR-GCK          NVYGVSQADVLLFGVAACVVAALGSVAGGRVDDRVGSKPVIVASLVALIA
Mvan_4097|M.vanbaalenii_PYR-1       QVYGVSSADVLLFGVAACVVAAVGSVIGGRLDDRVGSKHVIVASLVSMIV
MSMEG_4721|M.smegmatis_MC2_155      SVYGISDADVLLFGISACVIAAIGAVVGGQLDDRIGSKPIIVGSLAAMIT
TH_1384|M.thermoresistible__bu      TVYGVSEADVLLFGVCASVIAAIGAVLGGLVDDRVGSKPVIIGSLAAMIA
MUL_3787|M.ulcerans_Agy99           NVYGLTQADVLLFGVAASVVAAVGAVVGGFVDHRVGSKPVIVASLASILI
MMAR_3855|M.marinum_M               NVYGLTQADVLLFGVAASVVAAVGAVVGGFVDHRVGSKPVIVASLASILI
MLBr_00430|M.leprae_Br4923          NAYGISQANVLMFGVVASLVAAVGAVLGGFVDHRIGSKRVIVGSLVAIIV
MAV_1667|M.avium_104                NVYGISQADVLVFGVAASVVAAVGAVLGGFVDHRVGSKPVIVASLLAIVV
Mb2536c|M.bovis_AF2122/97           NAYGLTQADVLIFGAAASVVAAVGAVLGGFVDHRIGSKPVIVGSLAAIIA
Rv2508c|M.tuberculosis_H37Rv        NAYGLTQADVLIFGAAASVVAAVGAVLGGFVDHRIGSKPVIVGSLAAIIA
MAB_1538|M.abscessus_ATCC_1997      GVFHLSGADITLFGVAGNVMAAVGAVVGGLVDTRLGSKGIIVGSLAVIVS
                                     .: :: *:: :**  . ::**:*:* ** :* *:*** :*:.**  :: 

Mflv_2546|M.gilvum_PYR-GCK          VGLTLMVLSGPMAFWACGLLLCLFIGPTLSSARTLMMRMSAHGKEGVTFG
Mvan_4097|M.vanbaalenii_PYR-1       VGLVLMVLSGVLAFWVCGLLLCLFIGPTLSSARTLMLRMCAHGKEGVTFG
MSMEG_4721|M.smegmatis_MC2_155      AGVVMMVLSGPVAFWACGLALCLFIGPTQSSARTLMLRMSAEGKEGVAFG
TH_1384|M.thermoresistible__bu      TGLTLLNLSGAAAFWICGLLLCMFIGPTQSSARTLMLRMATLGKEGVAFG
MUL_3787|M.ulcerans_Agy99           SAIVLMVLSGATAFWVCGLLLCLFIGPSQSSARALLLRMAPHGKEGVAFG
MMAR_3855|M.marinum_M               SAIVLMVLSGATAFWVCGLLLCLFIGPSQSSARALLLRMAPHGKEGVAFG
MLBr_00430|M.leprae_Br4923          TALTLMTLSGPLAFWVCGLVLCLFIGPSQSSSRALLLHMAKHGREGVAFG
MAV_1667|M.avium_104                LGLTLMALSGPVAFWACGLLLCMFIGPSQSSSRALLLQMAKHGREGVAFG
Mb2536c|M.bovis_AF2122/97           AALTLLTLSGPTAFWACGLLLCVFIGPAQSSARALLLHMAQHGKEGVAFG
Rv2508c|M.tuberculosis_H37Rv        AALTLLTLSGPTAFWACGLLLCVFIGPAQSSARALLLHMAQHGKEGVAFG
MAB_1538|M.abscessus_ATCC_1997      LGIVMMFLTGQPAFWICGLAIAAFVGPPQSAARTLVLRMAPVGREAFVFG
                                     .:.:: *:*  *** *** :. *:**. *::*:*:::*.  *:*...**

Mflv_2546|M.gilvum_PYR-GCK          LYTTAGRAATFLAPWLFSVFIDVFDSYRAGMGGLVFVLALGLLLFLPVRV
Mvan_4097|M.vanbaalenii_PYR-1       FYTTAGRAATFLAPWLFSLSIDVFDSPRAGMGGLVAVLVLGLLLFLPVRA
MSMEG_4721|M.smegmatis_MC2_155      LYTTVGRAVSFLAPWLFFMFIDIFGTDRAGMGGLCLVLVAGLVGMAAVRT
TH_1384|M.thermoresistible__bu      LYTTTGRAMSFLSPWMFFTFIDLFGTDRAGMAGLCVVLVAGLVAMLAVRV
MUL_3787|M.ulcerans_Agy99           LYTMTGHAVAFLGPWLFSIFVDIFSAVRAGLGGICLVLAVGLVGMLVVGV
MMAR_3855|M.marinum_M               LYTMTGRAVAFLGPWLFSIFVDIFSAVRAGLGGICLVLAVGLVGMLVVRV
MLBr_00430|M.leprae_Br4923          LYTMTGRAASFVAPWSFSIFVDGFGVVRAGLGGISVVLLAGLLGMLMVRV
MAV_1667|M.avium_104                LYTMTGRAVSFVAPWLFSVFVDAFGAVRAGLGGISLVLTAGLLAMLAVRV
Mb2536c|M.bovis_AF2122/97           LYTMTGRAVSFLGPWLFSVFVDVFHTVRAGLGGVCLVLTTGLLLMLRVQV
Rv2508c|M.tuberculosis_H37Rv        LYTMTGRAVSFLGPWLFSVFVDVFHTVRAGLGGVCLVLTTGLLLMLRVQV
MAB_1538|M.abscessus_ATCC_1997      LYTMTGRAVSFVGPWLFATFALLFHATRAGIAGPVLMIGLGMVAVILVKV
                                    :** .*:* :*:.** *      *   ***:.*   ::  *:: .  * .

Mflv_2546|M.gilvum_PYR-GCK          PPRHGATVSASARRS--------
Mvan_4097|M.vanbaalenii_PYR-1       PHRRDPV----------------
MSMEG_4721|M.smegmatis_MC2_155      PERVTAR----------------
TH_1384|M.thermoresistible__bu      PRRAG------------------
MUL_3787|M.ulcerans_Agy99           PRHGGVVVTETT-----------
MMAR_3855|M.marinum_M               PRHGGVVVTETT-----------
MLBr_00430|M.leprae_Br4923          PTRREAAAVGLSWWRSQARRGQV
MAV_1667|M.avium_104                P-RRAPVAVEAA-----------
Mb2536c|M.bovis_AF2122/97           SRHGGALTTAQSS----------
Rv2508c|M.tuberculosis_H37Rv        SRHGGALTTAQSS----------
MAB_1538|M.abscessus_ATCC_1997      PRYDPVRDEIVSGAG--------
                                    .