For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MHPMIPAEYISNIIYEGPGADSLSAAAEQLRLMYNSANMTAKSLTDRLGELQENWKGSSSDLMADAAGRY LDWLTKHSRQILETAYVIDFLAYVYEETRHKVVPPATIANNREEVHRLIASNVAGVNTPAIAGLDAQYQQ YRAQNIAVMNDYQSTARFILAYLPRWQEPPQIYGGGGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3429 | PPE59 | - | 100% (178) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3425 | PPE57 | 1e-64 | 69.89% (176) | PPE family protein |
| M. tuberculosis H37Rv | Rv3426 | PPE58 | 2e-44 | 72.00% (125) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3459 | PPE57 | 3e-77 | 79.21% (178) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-11 | 29.71% (175) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-14 | 28.12% (160) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 4e-13 | 28.74% (174) | PPE family protein |
| M. marinum M | MMAR_1904 | - | 8e-21 | 35.80% (176) | PPE family protein |
| M. avium 104 | MAV_4704 | - | 4e-22 | 35.09% (171) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 9e-12 | 29.14% (175) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-15 | 29.71% (175) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 3e-20 | 38.51% (174) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-10 | 28.00% (175) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3429|M.tuberculosis_H37Rv --------------MHPMIPAEYISNIIYEGPGADSLSAAAEQLRLMYNS
Mb3459|M.bovis_AF2122/97 --------------MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYS
MAV_4704|M.avium_104 ----------MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEE
MUL_3072|M.ulcerans_Agy99 ----------MID--FGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
MMAR_1904|M.marinum_M -------------MDFGRRPPEVTSALMYMGPGSTSMTAAASVWNRVAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
..* * : ***. .: *. : .
Rv3429|M.tuberculosis_H37Rv ANMTAKSLTDRLGELQEN-WKGSSSDLMADAAGRYLDWLTKHSRQILETA
Mb3459|M.bovis_AF2122/97 VETTAESLEDELDELDEN-WKGSSSDLLADAVERYLQWLSKHSSQLKHAA
MAV_4704|M.avium_104 LASSAQSFSSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVS
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
MMAR_1904|M.marinum_M LDSAATSYESLVIGLVEEGWLGPASVAMADAVAPYVVWMRATAAQAEHTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* : * .: * *: . ..
Rv3429|M.tuberculosis_H37Rv YVIDFLAYVYEETRHKVVPPATIANNREEVHRLIASNVAGVNTPAIAGLD
Mb3459|M.bovis_AF2122/97 WVINGLANAYNDTRRKVVPPEEIAANREEVHRLIASNVAGVNTPAIAGLD
MAV_4704|M.avium_104 HQASAIATAFEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
MMAR_1904|M.marinum_M MQARASAAAYETAFGAVVPPPLISANRVRLAELIASNVFGQNTAVITALE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* .. : : *: * :* * *: *: :
Rv3429|M.tuberculosis_H37Rv AQYQQYRAQNIAVMNDYQSTARFILAYLPRWQEPPQIYGGGGG-------
Mb3459|M.bovis_AF2122/97 AQYQQYRAQNIAVMNDYQSTARFILAYLPRWQEPPQIYGGGGG-------
MAV_4704|M.avium_104 AAYEQMWASDVAAMFGYHADASAAVAKLPPWNEVLQNLG-------FSNA
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAY-AGTAAAASALTPFTEPPQTTNPV-----AGAA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
MMAR_1904|M.marinum_M TEYGQMWAQDAAAMYEYAAATSSATELTPFTQPQQIVSPGAGSGQIAAVA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
: * . . :.* * :
Rv3429|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MAV_4704|M.avium_104 STAVTRPAGSGAVARGYTSRIAGFLA--PRAPQ-----------------
MUL_3072|M.ulcerans_Agy99 QSAAVAQASSTAASSDVVSQLAGLITSVPNALQTLATTSAAPTAASILPE
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
MMAR_1904|M.marinum_M HSAATLAGTSQTTLSRLISEIPKALHG-IVAPLAASTTPDSPLGWLW-QI
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPDPNDPIEMLLKNS-QHFLGMYRALKGLITDPV
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAP----LFPPGFADALPDGLL
Rv3429|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MUL_3072|M.ulcerans_Agy99 VSLPPWLATNLANWNTIMATLTGPFSLQGISS------------------
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSPINDTLSMIN------------------
MMAR_1904|M.marinum_M LFGTTFPTSISALLTDLQPYASFFYNTEGLPY------------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMGTPIYAAI
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGV
Rv3429|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MUL_3072|M.ulcerans_Agy99 -IPGGPFLSFGQVYAYVQNAQGLNAFYSPKAITGTLAPLVPEISPGGVGL
MLBr_01182|M.leprae_Br4923 -NHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGL
MMAR_1904|M.marinum_M -FSIGMANNFIQMSKTLG-LLSGTTAAATGGAASGLAGLGGLID------
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_4783|M.abscessus_ATCC_1997 MGPAAGISIPLAITLAS---LSQMPEAPPVDAPAETVPARIDQPHAVAMG
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
Rv3429|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MUL_3072|M.ulcerans_Agy99 TSASVSNSVSGTMGRAALVGSMSVPQGWTQAAPAMRLVSSVLSTNLAAAP
MLBr_01182|M.leprae_Br4923 LGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVA
MMAR_1904|M.marinum_M ----GGGQVSAHLGHAASLGRLSVPPSWAQSVPDLESMPARMPIETLKFA
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDP
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDP
MAB_4783|M.abscessus_ATCC_1997 GAPAPTASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEGLGYAVRGDGP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPP
Rv3429|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MUL_3072|M.ulcerans_Agy99 TAGLPGEAGVFGQMALSSLAGRAMGASTFGSSSGGAVANSLGGVVAEADP
MLBr_01182|M.leprae_Br4923 TESESAPLLGGGLPMAPMVPGGGSGTG----GVNTALRLQPRAFVMPRNP
MMAR_1904|M.marinum_M PDGGGAGNLLGGMPLG------GPGLG----ASGSGPRYGVRPTVMARPP
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
MAB_4783|M.abscessus_ATCC_1997 GFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRG
TH_3113|M.thermoresistible__bu AGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAG
Rv3429|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MUL_3072|M.ulcerans_Agy99 AAATIIVIPALDE-------------------------------------
MLBr_01182|M.leprae_Br4923 AAG-----------------------------------------------
MMAR_1904|M.marinum_M FAG-----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK YADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGG
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGG
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAG
MAB_4783|M.abscessus_ATCC_1997 YRHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATG
TH_3113|M.thermoresistible__bu SAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAP---SAAG
Rv3429|M.tuberculosis_H37Rv -----------------------------------------------
Mb3459|M.bovis_AF2122/97 -----------------------------------------------
MAV_4704|M.avium_104 -----------------------------------------------
MUL_3072|M.ulcerans_Agy99 -----------------------------------------------
MLBr_01182|M.leprae_Br4923 -----------------------------------------------
MMAR_1904|M.marinum_M -----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK LTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 LTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 LTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 LSTLDGDAEN--RTIPMLPGTWDVTDDDR------------------
TH_3113|M.thermoresistible__bu IRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN---