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TSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAEYASAAAELTSILAGVQSGAWE GPSSQQYVAAHTPYLAWLAQQSAVSAATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGI NTIPIALNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAADMSAFAAQPMA AQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQ AVSWVGASILYPSLFLLPLLATTLAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQSFPATMS APPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASG IAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQA GGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | - | 100% (540) | PPE protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 5e-35 | 38.78% (196) | PPE protein |
| M. gilvum PYR-GCK | Mflv_4039 | infB | 3e-08 | 30.69% (189) | translation initiation factor IF-2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0294 | PPE4 | 1e-115 | 46.69% (544) | PPE family protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 1e-115 | 46.69% (544) | PPE family protein |
| M. leprae Br4923 | MLBr_00539 | PPE | 9e-70 | 35.52% (549) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 1e-116 | 46.42% (530) | PPE family protein |
| M. marinum M | MMAR_0545 | - | 1e-119 | 48.66% (522) | PPE family protein, PPE4 |
| M. avium 104 | MAV_4867 | - | 1e-112 | 47.22% (521) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-165 | 58.52% (528) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-110 | 60.95% (338) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 1e-119 | 48.66% (524) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 0.0 | 76.14% (528) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
Mb0294|M.bovis_AF2122/97 ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
Rv0286|M.tuberculosis_H37Rv ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
MMAR_0545|M.marinum_M -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MAV_4867|M.avium_104 -------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSLSAQ
MLBr_00539|M.leprae_Br4923 -----------MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAE
*:* ****:*::*. *.* ..:: :. **.:
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
Mb0294|M.bovis_AF2122/97 YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
Rv0286|M.tuberculosis_H37Rv YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
MMAR_0545|M.marinum_M YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MAV_4867|M.avium_104 YATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSAGAA
MLBr_00539|M.leprae_Br4923 YRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDVA
* .*:*: :* . . .*:* : :..: *:: ** : :* *
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
Mb0294|M.bovis_AF2122/97 AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
Rv0286|M.tuberculosis_H37Rv AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
MMAR_0545|M.marinum_M AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MAV_4867|M.avium_104 AQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIAVNE
MLBr_00539|M.leprae_Br4923 TQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNE
::. *.**: *: :*** ** *: : **:.***:*:*:***::.*
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEMSRMSA
Mb0294|M.bovis_AF2122/97 ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
Rv0286|M.tuberculosis_H37Rv ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
MMAR_0545|M.marinum_M ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MAV_4867|M.avium_104 ADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGGE-------
MLBr_00539|M.leprae_Br4923 EEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDVEKD
:* :**::**: *. *.. : :*: :.. : *.* :: ..
Mflv_0325|M.gilvum_PYR-GCK DMS-AFAAQPMAAQAG----AAFDVSNIIADIIRLYGEVLRFLFEPIFNF
Mvan_0415|M.vanbaalenii_PYR-1 DVT-AFAAQAQAAEAG----SALDLSNIIADLIRAYGELLRFLFEPIFDF
MSMEG_0619|M.smegmatis_MC2_155 SVQ-QMSAQATAAESG----SSLDLSSIISDLLNQYLQGVPGGQ-AILDF
TH_3569|M.thermoresistible__bu TTQ-QIGSQATAADSG----TALNLSDLIANLLQYYQDYLDQLFGPIVDF
MAB_2230c|M.abscessus_ATCC_199 DMS-GMAAQAQAAESG----MALDDS----------ESFFDKLMRQIQEF
Mb0294|M.bovis_AF2122/97 -------AASTVGAVN----PWQWLLALLQQLWNAYTGFYGWMLQLIWQF
Rv0286|M.tuberculosis_H37Rv -------AASTVGAVN----PWQWLLALLQQLWNAYTGFYGWMLQLIWQF
MMAR_0545|M.marinum_M DAAQAQSGAAAAGGSD----PWQLLWQLLQYLWNAYTGFNTWMFDLIWEF
MUL_1208|M.ulcerans_Agy99 DAARAQSGAAAAGGSD----PWQLLWQLLQYLWNAYTGFNTWMFDLIWEF
MAV_4867|M.avium_104 ----ANNLAANAAQNS----SGDWWQNFIQQLS---------------QF
MLBr_00539|M.leprae_Br4923 SRHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYVY
.. . :
Mflv_0325|M.gilvum_PYR-GCK LRDPIGNTFALITDFLTN-------PVQALITWGPFLLAVVYQAVSWVGA
Mvan_0415|M.vanbaalenii_PYR-1 LRDPLGNTIKLITDFLTN-------PAQALITWGPFLAAVAYQAVSWVGA
MSMEG_0619|M.smegmatis_MC2_155 LKDPLGNLGRLLTDFMTN-------PAGALATWWPFLFGVAYQVFFNLVG
TH_3569|M.thermoresistible__bu LRDPIGNLFQLIDDFLTN-------PAGALVTWWPLLFAVAYQVFTNLVG
MAB_2230c|M.abscessus_ATCC_199 FSDPLGTLQKILQDFMRN-------PLEALVAWGPLLFFIAYEAFFIPFG
Mb0294|M.bovis_AF2122/97 LQDPIGNSIKIIIAFLTN-------PIQALITYGPLLFALGYQIFFNLVG
Rv0286|M.tuberculosis_H37Rv LQDPIGNSIKIIIAFLTN-------PIQALITYGPLLFALGYQIFFNLVG
MMAR_0545|M.marinum_M LQDPIGNTIKIIIAFLTN-------PLQAIITYGPLLFALSYQIFFNLVG
MUL_1208|M.ulcerans_Agy99 LQDPIGNTIKIIIAFLTN-------PLQAIITYGPLLFALSYQIFFNLVG
MAV_4867|M.avium_104 FQN----IQKMLQDFWAN-------LPAFLAANGPLLFFVAYQVFFNAVG
MLBr_00539|M.leprae_Br4923 PGQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTHIVQ
: : * . : :* : :
Mflv_0325|M.gilvum_PYR-GCK SILYPSLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSA
Mvan_0415|M.vanbaalenii_PYR-1 SILYPSLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPA
MSMEG_0619|M.smegmatis_MC2_155 WPTWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVA
TH_3569|M.thermoresistible__bu WPTWAMILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDV
MAB_2230c|M.abscessus_ATCC_199 FTFWGVMLSAPLWLP----LLLVGLAQLVN-PVPVEADAPADEPAPQQAR
Mb0294|M.bovis_AF2122/97 WPTWGMILSSPFLLPAGLGLGLAAIAFLPIVLAP--AVIPPASTPLAAAA
Rv0286|M.tuberculosis_H37Rv WPTWGMILSSPFLLPAGLGLGLAAIAFLPIVLAP--AVIPPASTPLAAAA
MMAR_0545|M.marinum_M WPTWALILSSPFLLPAALGLALSAIAFTPIQIA---AEVPAAAAPLAAAA
MUL_1208|M.ulcerans_Agy99 WPTWALILSSPFLLPAALGLALSAIAFTPIQIA---AEVPAAAAPLAAAA
MAV_4867|M.avium_104 WPTWGAILTAPFLLPLLLGIGLSSLLAAPAEIAP--VAAPAAITPVLASN
MLBr_00539|M.leprae_Br4923 LGTWLAEYPQLLLVALGGTIANLGAVTGLAGLSSGLSAGPSAAIPTVVPE
: . . : . .. .
Mflv_0325|M.gilvum_PYR-GCK PSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT----
Mvan_0415|M.vanbaalenii_PYR-1 PTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS----
MSMEG_0619|M.smegmatis_MC2_155 AAPRTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT----
TH_3569|M.thermoresistible__bu AAP-------------------VRAEPQNPLPLTXXX-------------
MAB_2230c|M.abscessus_ATCC_199 VERSSPQQQPFAMGGMPGGGGAPATPANAPATPANAPASPAAAAATP---
Mb0294|M.bovis_AF2122/97 VAAGSVWPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATAS----
Rv0286|M.tuberculosis_H37Rv VAAGSVWPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATAS----
MMAR_0545|M.marinum_M VTAKSVFPAASLASPGTGSAGAPASGAGAGAPGSAPPGPAAPAPAS----
MUL_1208|M.ulcerans_Agy99 VTAKSVFPAASLASPGTGSAGAPASGAGAGAPGTAPPGPGAPAPAS----
MAV_4867|M.avium_104 KPP-TLPAAVALAPSVATPAGAPASTVAAGSGAAAAPGP-AAAAGN----
MLBr_00539|M.leprae_Br4923 SAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASAASAAAAAPAPPGTG
.
Mflv_0325|M.gilvum_PYR-GCK ---FVPYVVAGRDPYEGFS----PTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 ---FVPYAVAGRDPGTGFS----PTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 ---FVPYAVANRDPGEGFT----PTLGNKSQVAAPASGVPAAASGVAASL
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 --AYMVYAVQEDPPAARFG----PTLNEGSGAKAPAAGISAAAA-AAASA
Mb0294|M.bovis_AF2122/97 ---FAYAVGGSGDWGPSLG----PTVGGRGGIKAPAATVPAAAAAAATRG
Rv0286|M.tuberculosis_H37Rv ---FAYAVGGSGDWGPSLG----PTVGGRGGIKAPAATVPAAAAAAATRG
MMAR_0545|M.marinum_M ---FLYAVGGSGDWGPSLG----PTVGGRSGAKAPAATIPAAGAAAASRA
MUL_1208|M.ulcerans_Agy99 ---FLYAVGGSGDWGPSLG----PTVGGRSGAKAPAVTIPAAGAAAASRA
MAV_4867|M.avium_104 ---FAYLVAFGGDPDTGVG----PTLSGRGGAKAPAATIPAAGAAAPARA
MLBr_00539|M.leprae_Br4923 FGGFSPYLVDGRGPGVGFGSGRQSAYANKVSESVSDSAVAEAAAQASARE
Mflv_0325|M.gilvum_PYR-GCK AERRKRRR-RQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGA
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRR-RQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGA
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRR-KKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGS
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 RSRARRKR-GARIKDPAPQFMDMNSPVDP-DFSEPATRHTAGVGASGRGA
Mb0294|M.bovis_AF2122/97 QSRARRRR-RSELRDYGDEFLDMDS-----DSGFGPSTGDHGAQASERGA
Rv0286|M.tuberculosis_H37Rv QSRARRRR-RSELRDYGDEFLDMDS-----DSGFGPSTGDHGAQASERGA
MMAR_0545|M.marinum_M SARSRRRR-RTEMRDYGDEFLDMDA-----NGVTGPAATDDAARASERGA
MUL_1208|M.ulcerans_Agy99 SARSRRRR-RTEMRDYGDEFLDMDA-----NGVTGPAATDDAARASERGA
MAV_4867|M.avium_104 EARARRRR-RAALHDYSDEFLDMDSGFGV-PPDYGAEEELAAAVASGQGA
MLBr_00539|M.leprae_Br4923 QARAWRRRSAAKERGYREEVITMNTG---FDAAIPSPVDQTGSRVSDCGA
Mflv_0325|M.gilvum_PYR-GCK GPMGFAGTVSRGDEQ---AGGLTTLAGDSFGGGPREPMLPGTWDPDATDD
Mvan_0415|M.vanbaalenii_PYR-1 GPMGFAGTVSRDAAQ---AGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD
MSMEG_0619|M.smegmatis_MC2_155 DAMGFTGTVTRHDVT---AAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 GQLGFAGTLPRTTSTTSAAGLIEREAASEMDGTRTVPMLPTSWGTDPEPD
Mb0294|M.bovis_AF2122/97 GTLGFAGTATKERRVR--AVGLTALAGDEFGNGPRMPMVPGTWEQGSNEP
Rv0286|M.tuberculosis_H37Rv GTLGFAGTATKERRVR--AVGLTALAGDEFGNGPRMPMVPGTWEQGSNEP
MMAR_0545|M.marinum_M GQFGFAGTVSTEAVLQ--AAGLTELAVDEFGNGPRMPMVPGSWDS----P
MUL_1208|M.ulcerans_Agy99 GQFGFAGTVSTEAVLQ--AAGLTELAVDEFGNGPRMPMVPGSWDS----P
MAV_4867|M.avium_104 GTLGFAGTQQRRKAFQ--AAGLTKLADDDFGGSPRMPMVPGTWEQD---T
MLBr_00539|M.leprae_Br4923 GSFGFAGTVSKEAVVE--VAGLTTLAGDDFGGGPTMPMVPGTWAPARESS
Mflv_0325|M.gilvum_PYR-GCK RHTDGRDGHDGHDGKEKP-----
Mvan_0415|M.vanbaalenii_PYR-1 ------ERHNHHDGKDSQ-----
MSMEG_0619|M.smegmatis_MC2_155 ------PSPDDPEGGPRR-----
TH_3569|M.thermoresistible__bu -----------------------
MAB_2230c|M.abscessus_ATCC_199 PDRAPSVPAPDEDWPPGERGAST
Mb0294|M.bovis_AF2122/97 EAPDGSGRGGGDGLPHDSK----
Rv0286|M.tuberculosis_H37Rv EAPDGSGRGGGDGLPHDSK----
MMAR_0545|M.marinum_M QE------GREDGLQSE------
MUL_1208|M.ulcerans_Agy99 QE------GREDGLQSE------
MAV_4867|M.avium_104 QN------GAHPTEPGKGG----
MLBr_00539|M.leprae_Br4923 DEGR-------------------