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FDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAAAQGLQSAVEALLTTFEGESAAALAERVTP YEKWLTQNAASAELTATQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYT EMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEEVVEEVVEEVVEAEQAISQAALDQA VNEGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSL VNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQ PVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01182 | - | - | 100% (417) | PPE-family protein |
| M. leprae Br4923 | MLBr_00411 | - | 1e-43 | 31.48% (413) | serine-rich antigen |
| M. leprae Br4923 | MLBr_01991 | PPE | 3e-21 | 34.90% (192) | PPE-family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1396c | PPE19 | 3e-79 | 42.38% (420) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 4e-22 | 24.58% (419) | PPE protein |
| M. tuberculosis H37Rv | Rv1361c | PPE19 | 8e-82 | 43.10% (420) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-22 | 35.12% (168) | PPE family protein |
| M. marinum M | MMAR_4240 | - | 1e-64 | 39.95% (423) | PPE family protein, PPE18 |
| M. avium 104 | MAV_4014 | - | 2e-48 | 34.13% (419) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-24 | 36.17% (188) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-26 | 28.90% (429) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0947 | - | 7e-65 | 39.48% (423) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-23 | 36.19% (210) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1396c|M.bovis_AF2122/97 --------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASDLFSA
Rv1361c|M.tuberculosis_H37Rv --------MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSA
MMAR_4240|M.marinum_M ---------MDFGSLPPEINSAKMYAGAGSGSILVAAEAWDSVAVDLYSA
MUL_0947|M.ulcerans_Agy99 ---------MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVDLYSA
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MAV_4014|M.avium_104 ---------MDWAFLPPEINSARMYTGAGAASLLAAAGSWDALSAELTAT
MSMEG_0619|M.smegmatis_MC2_155 ------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAEYAAA
Mvan_0415|M.vanbaalenii_PYR-1 ------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAEYAAA
MAB_0809c|M.abscessus_ATCC_199 -----MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAHYSAT
TH_3113|M.thermoresistible__bu ------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDEYRAA
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
.** :: : *.*. .: ** * .. :
Mb1396c|M.bovis_AF2122/97 ASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTAAQVR
Rv1361c|M.tuberculosis_H37Rv ASAFQSVVWGLTTGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTAAQVR
MMAR_4240|M.marinum_M ASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATRAELAANQAR
MUL_0947|M.ulcerans_Agy99 ASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATQAELAANQAR
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MAV_4014|M.avium_104 ADGYESVLSGLGL-QWHGPAADAMAFAAARYLTWLRATAEQTKQTAMQAR
MSMEG_0619|M.smegmatis_MC2_155 AAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAAVQHE
Mvan_0415|M.vanbaalenii_PYR-1 AAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAAAQHE
MAB_0809c|M.abscessus_ATCC_199 AQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARAVQHG
TH_3113|M.thermoresistible__bu AVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLE
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQ-NWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
* : : : * .: *: : . *
Mb1396c|M.bovis_AF2122/97 VAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAEYG
Rv1361c|M.tuberculosis_H37Rv VAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAEYG
MMAR_4240|M.marinum_M GAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTEAEYG
MUL_0947|M.ulcerans_Agy99 GAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTEAEYG
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYT
MAV_4014|M.avium_104 TAAAAYEQAYAMTVPPPVIAANRTLLASLVATNIMGQNTAAIADTEAQYA
MSMEG_0619|M.smegmatis_MC2_155 TAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNEADYV
Mvan_0415|M.vanbaalenii_PYR-1 AAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTEADYV
MAB_0809c|M.abscessus_ATCC_199 AAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATEADYV
TH_3113|M.thermoresistible__bu AAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNEADYA
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADYI
* : * : *: * :*::* * .* .**:*
Mb1396c|M.bovis_AF2122/97 EMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGGL-----------
Rv1361c|M.tuberculosis_H37Rv EMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGGL-----------
MMAR_4240|M.marinum_M EMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGGL-----------
MUL_0947|M.ulcerans_Agy99 EMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGGL-----------
MLBr_01182|M.leprae_Br4923 EMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEEVVEE
MAV_4014|M.avium_104 DFWAQDTAAMAGYSASSTAATQLPR-FASANNSTNESGV-----------
MSMEG_0619|M.smegmatis_MC2_155 RMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASASVQQ
Mvan_0415|M.vanbaalenii_PYR-1 RMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAADVTA
MAB_0809c|M.abscessus_ATCC_199 RMWVQAATTMATYQTASEVALASAPPSTPPPSILHD------------HD
TH_3113|M.thermoresistible__bu RMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAITGAH
Mflv_0768|M.gilvum_PYR-GCK RMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGSE-----------
:* * ::.* *
Mb1396c|M.bovis_AF2122/97 -LEQAAAVEEASDTAAAN--------------------------------
Rv1361c|M.tuberculosis_H37Rv -LEQAVAVEEAIDTAAAN--------------------------------
MMAR_4240|M.marinum_M -VNQTAAVGQAIDSAAAG--------------------------------
MUL_0947|M.ulcerans_Agy99 -VKQTAAVGQAIDSAAAG--------------------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEAEQAISQAALD--------------------------------
MAV_4014|M.avium_104 -TAQNAAVSAANANAAAN--------------------------------
MSMEG_0619|M.smegmatis_MC2_155 MSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK-------
Mvan_0415|M.vanbaalenii_PYR-1 FAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR-------
MAB_0809c|M.abscessus_ATCC_199 HGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG-------
TH_3113|M.thermoresistible__bu VTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLLAPLL
Mflv_0768|M.gilvum_PYR-GCK --AAFAGAMSGAVPGAGE--------------------------------
Mb1396c|M.bovis_AF2122/97 -------QLMNN------VPQALQQL--AQPT-QGTTP---SSKLGGLWK
Rv1361c|M.tuberculosis_H37Rv -------QLMNN------VPQALQQL--AQPT-KSIWP---FDQLSELWK
MMAR_4240|M.marinum_M -------QLMSN------VPQALQQL--AAPAPQGAST---ATAPKSLLQ
MUL_0947|M.ulcerans_Agy99 -------QLMSN------VPQALQQL--AATAPQGAST---ATAPKSLLQ
MLBr_01182|M.leprae_Br4923 -------QAVNEGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWG
MAV_4014|M.avium_104 -------KAVTQS----FSPLADNPP--GTTINNYYVDASSTSAANSNAF
MSMEG_0619|M.smegmatis_MC2_155 -------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWP
Mvan_0415|M.vanbaalenii_PYR-1 -------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWV
MAB_0809c|M.abscessus_ATCC_199 -------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIG
TH_3113|M.thermoresistible__bu PGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAVSGML
Mflv_0768|M.gilvum_PYR-GCK -------AVMRN----AIISKVSSTAKLDTANQIAGRAEGTLRGVVDRAG
:
Mb1396c|M.bovis_AF2122/97 TVSPHLSP--ISNIVSMLNNHVSMTNSGVSMTNTLHSMLKG---------
Rv1361c|M.tuberculosis_H37Rv AISPHLSP--LSNIVSMLNNHVSMTNSGVSMASTLHSMLKG---------
MMAR_4240|M.marinum_M SVTSSFSLSNLSTIVGMENTHLSMANSGASIFKTMGDSVKG---------
MUL_0947|M.ulcerans_Agy99 SVTSSFSSSNLSTIVGMENTHLSMANSGASILKTMGDSVKG---------
MLBr_01182|M.leprae_Br4923 GFAQHLSP--INDTLSMINNHAGMANAGLSLVNGMGSAMKS---------
MAV_4014|M.avium_104 RVLDVIQG--TGLGFSAPYNMEQFVSGIIGAENNLGMLAKP---------
MSMEG_0619|M.smegmatis_MC2_155 TWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAA
Mvan_0415|M.vanbaalenii_PYR-1 GASILYPSLLLLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAAS
MAB_0809c|M.abscessus_ATCC_199 QFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMA
TH_3113|M.thermoresistible__bu AQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGGASAA
Mflv_0768|M.gilvum_PYR-GCK SHAEKSQGLEQAPQQGMQMGMQMASQLGSTLGQMPQQMMQG---------
.
Mb1396c|M.bovis_AF2122/97 ----------FAPAAAQAVETAAQNGVQ-AMSSLGSQLGSSLGSSGLGAG
Rv1361c|M.tuberculosis_H37Rv ----------FAPAAAQAVETAAQNGVQ-AMSSLGSQLGSSLGSSGLGAG
MMAR_4240|M.marinum_M ----------FIPSASKAAETAVEHAARNAVSMVGGGGPAGIG----GWA
MUL_0947|M.ulcerans_Agy99 ----------FIPSASKAAETAVEHAARNAVSMVGGGGPAGIG----GWA
MLBr_01182|M.leprae_Br4923 ----------LAPTTTKAAESAFKAMGS-AVQSTGRGLLGSSS----GGH
MAV_4014|M.avium_104 ----------GAAAANIAPALAAPALRG-ATAGLGGGLGGGLG------N
MSMEG_0619|M.smegmatis_MC2_155 P----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATF
Mvan_0415|M.vanbaalenii_PYR-1 SPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASF
MAB_0809c|M.abscessus_ATCC_199 ASAG-TALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PPVGDPGFS
TH_3113|M.thermoresistible__bu P---VPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSP-PPAGHSVPP
Mflv_0768|M.gilvum_PYR-GCK -----------VTQPFQQLTQPLQQMSSLFGGMMNGDKGAQIGMVGATPF
. .
Mb1396c|M.bovis_AF2122/97 VAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM
Rv1361c|M.tuberculosis_H37Rv VAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGHM
MMAR_4240|M.marinum_M PQGGVGQALSVGGLKVPQAWAEANQSVVPAARALPISPVTGAVEGAHGAP
MUL_0947|M.ulcerans_Agy99 PQGGVGQALSVGGLKVPQAWAEANQAVVPAARALPISPVTGAVEGAHGAP
MLBr_01182|M.leprae_Br4923 VTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPL
MAV_4014|M.avium_104 VTATLSHAGTIGPMSVPATWSAPTSTHVSPLAPAGFTTLP-GTEEPMASG
MSMEG_0619|M.smegmatis_MC2_155 VPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRR
Mvan_0415|M.vanbaalenii_PYR-1 VPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRR
MAB_0809c|M.abscessus_ATCC_199 FPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARR
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
Mflv_0768|M.gilvum_PYR-GCK SNHPAIGGTGPATGSGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPTSPV
. . :
Mb1396c|M.bovis_AF2122/97 LGG----------------------------LPLGQLTNSGGG-FGGVSN
Rv1361c|M.tuberculosis_H37Rv LGG----------------------------LPLGQLTNSGGG-FGGVSN
MMAR_4240|M.marinum_M LPG----------------------------MPFGQLAGNGG---NGVSG
MUL_0947|M.ulcerans_Agy99 LPG----------------------------MPFGQLAGNGG---NGVSG
MLBr_01182|M.leprae_Br4923 LGGG---------------------------LPMAPMVPGGGSGTGGVNT
MAV_4014|M.avium_104 YPG------------------------------YPGMPGGGAARSAGVGV
MSMEG_0619|M.smegmatis_MC2_155 RKKGAQIEERGYADAYMDYE-EPDEDPAPQPEPRVRASERGSDAMGFTGT
Mvan_0415|M.vanbaalenii_PYR-1 RRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGT
MAB_0809c|M.abscessus_ATCC_199 RRDKGKQQGRG--IEYMDMN---ATARCEEPAPDTTASHRGAGTMGFAGT
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHGH-RHEHQQPASMSAATAPSAAGIRVLGGAGR
Mflv_0768|M.gilvum_PYR-GCK AVG----------------------------AGAGPGAGVGLAPVGTGGG
* .
Mb1396c|M.bovis_AF2122/97 ALRMPPRAYVMPRVPAAG--------------------------------
Rv1361c|M.tuberculosis_H37Rv ALRMPPRAYVMPRVPAAG--------------------------------
MMAR_4240|M.marinum_M VLRVTPKAYVMPRPPAAG--------------------------------
MUL_0947|M.ulcerans_Agy99 VLRVTPKAYVMPRPPAAG--------------------------------
MLBr_01182|M.leprae_Br4923 ALRLQPRAFVMPRNPAAG--------------------------------
MAV_4014|M.avium_104 PPRYGVRLTVMPRPPAAG--------------------------------
MSMEG_0619|M.smegmatis_MC2_155 VTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGP
Mvan_0415|M.vanbaalenii_PYR-1 VSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPDERHNHHDGKD
MAB_0809c|M.abscessus_ATCC_199 VIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD---------
TH_3113|M.thermoresistible__bu ISRTRGSVPHAEITP------GDPTEPSSPTDRAHRPAEPN---------
Mflv_0768|M.gilvum_PYR-GCK MGAGGPMGMFGQRGKSGGNKPGLNAPAPLDHDLGEDEDEEW---------
Mb1396c|M.bovis_AF2122/97 --
Rv1361c|M.tuberculosis_H37Rv --
MMAR_4240|M.marinum_M --
MUL_0947|M.ulcerans_Agy99 --
MLBr_01182|M.leprae_Br4923 --
MAV_4014|M.avium_104 --
MSMEG_0619|M.smegmatis_MC2_155 RR
Mvan_0415|M.vanbaalenii_PYR-1 SQ
MAB_0809c|M.abscessus_ATCC_199 --
TH_3113|M.thermoresistible__bu --
Mflv_0768|M.gilvum_PYR-GCK --