For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MHLMIPAEYISNVIYEGPRADSLYAADQRLRQLADSVRTTAESLNTTLDELHENWKGSSSEWMADAALRY LDWLSKHSRQILRTARVIESLVMAYEETLLRVVPPATIANNREEVRRLIASNVAGGKHSSNRRPRGTIRA VPGRKYPSNGPLSKLDPICAIEAAPMAGAAADPQERVGPRGRRGLAGQQQCRGRPGPSLRCSHDTPRFQM NQAFHTMVNMLLTCFACQEKPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3426 | PPE58 | - | 100% (232) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3429 | PPE59 | 2e-44 | 72.00% (125) | PPE family protein |
| M. tuberculosis H37Rv | Rv3425 | PPE57 | 5e-41 | 68.00% (125) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3459 | PPE57 | 3e-41 | 68.00% (125) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-05 | 26.61% (124) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-08 | 26.96% (115) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 4e-09 | 31.40% (121) | PPE family protein |
| M. marinum M | MMAR_0191 | - | 1e-14 | 36.59% (123) | PPE family protein, PPE51_2 |
| M. avium 104 | MAV_3355 | - | 3e-15 | 39.34% (122) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-07 | 29.03% (124) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 4e-07 | 28.23% (124) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3087 | - | 2e-13 | 32.52% (123) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-06 | 27.42% (124) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3426|M.tuberculosis_H37Rv --------------MHLMIPAEYISNVIYEGPRADSLYAADQRLRQLADS
Mb3459|M.bovis_AF2122/97 --------------MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYS
MMAR_0191|M.marinum_M -------------MDFAMLPPEVNSGLMYTGPGAGSLLAAANSWDELAIE
MUL_3087|M.ulcerans_Agy99 -------------MDYGMLPPEVTSALMYAGPGSSSMVAAASAWNALAAE
MAV_3355|M.avium_104 ----------MVFSDFATLPPEVISTQIHVGPGAVPLLAAAAAWDGLAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
..* * : ** . .: * *: .
Rv3426|M.tuberculosis_H37Rv VRTTAESLNTTLDELHEN-WKGSSSEWMADAALRYLDWLSKHSRQILRTA
Mb3459|M.bovis_AF2122/97 VETTAESLEDELDELDEN-WKGSSSDLLADAVERYLQWLSKHSSQLKHAA
MMAR_0191|M.marinum_M LGTTAQTYESVLSGLTSMYWAGPASESMAAKAAPYVWWLHSTAEQTQQTA
MUL_3087|M.ulcerans_Agy99 LNSTAQGYLTVITQLSSEEWMGPASATMAQAVEPFMTWMSVTAGQAEHAA
MAV_3355|M.avium_104 LHGTAASYASVISELVGESWQGSSSESMAAAAAPYVAWLSATAGLAEQTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
:* : : : * :: : *: : .*
Rv3426|M.tuberculosis_H37Rv RVIESLVMAYEETLLRVVPPATIANNREEVRRLIASNVAGGKHSSNRRPR
Mb3459|M.bovis_AF2122/97 WVINGLANAYNDTRRKVVPPEEIAANREEVHRLIASNVAG----------
MMAR_0191|M.marinum_M TQCRAAAMAFEQAYAMTVPPPVILANRMQLMSLVATNFFGQNTAAIAALE
MUL_3087|M.ulcerans_Agy99 TQAQSAAAAFETAFAAVVPPPLIATNLAELTQALQTNMFGLNNGVIAQLE
MAV_3355|M.avium_104 AQARAAAAAYESAVAATVPPAVVAANRSLLATLLQTNILGQNDAAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
. *: : . : * : :*. *
Rv3426|M.tuberculosis_H37Rv GTIRAVPGRKYPSNGPLSKLDPICAIEAAPMAGAAADPQERVGPRGRRGL
Mb3459|M.bovis_AF2122/97 -------------------------VNTPAIAGLDAQ-------------
MMAR_0191|M.marinum_M AQYAEMWEQDAAAMYGYATSAAMAAQLVPFSSPQQTTNPAGLSAQSAAVN
MUL_3087|M.ulcerans_Agy99 AQYAEMWAQDASAMYNYAASSALATKIESFTEAPTIASPAASTTQGAAVS
MAV_3355|M.avium_104 DEYGQMWAQDVAAMFSYAAASESAGELTPFEQAPATTNDAGPATQAAAAA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Rv3426|M.tuberculosis_H37Rv AGQQQCRGRPGPSLRCSHDTPR----------------------------
Mb3459|M.bovis_AF2122/97 --YQQYRAQNIAVMNDYQSTAR----------------------------
MMAR_0191|M.marinum_M QADATAAAANP--LSDLIALVQKGLAALAG-----AFPNLLPDDFSILDG
MUL_3087|M.ulcerans_Agy99 AAQATSAASTQSTVQSFLSQITSQLGQLASPSGTQSFVSQLGASNPILTE
MAV_3355|M.avium_104 AAESTSLSSWLKQLEAYITSLTGQYTQFWQNLIGGATGSTEIAPFWETLY
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
MAB_4783|M.abscessus_ATCC_1997 -------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLITDPV
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVN-----EGMEATVVPQVDQQVNVDV
Rv3426|M.tuberculosis_H37Rv -FQMNQAFHTMVNMLLTCFACQEKPR------------------------
Mb3459|M.bovis_AF2122/97 -FIL--AYLPRWQEPPQIYGGGGG--------------------------
MMAR_0191|M.marinum_M IFAGYATVGVS-QDCESIIAGIIGAES-------------NLGMLGAASE
MUL_3087|M.ulcerans_Agy99 IWFLLTGQTVLPNNLGTFMQGYSNYASFFYNTEGLPYFSVGMGNFGVQMA
MAV_3355|M.avium_104 SSISQVGTQATWTNVVNATIGLGVSQWKNFFIYAPWSAAMAKSSLGAGLA
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGPAA
MLBr_01182|M.leprae_Br4923 ATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLV
Rv3426|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0191|M.marinum_M NPAELAPG-DIGIG-SVLSSAP----------------------------
MUL_3087|M.ulcerans_Agy99 KTLGLITQPAAAAA-AALPKVP----------------------------
MAV_3355|M.avium_104 SPGHIASGIAAKPVSAVLGNAP----------------------------
Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------
MAB_4783|M.abscessus_ATCC_1997 GISIPLAITLASLSQMPEAPPV---------DAPAETVPARIDQPHAVAM
MLBr_01182|M.leprae_Br4923 NGMGSAMKSLAPTTTKAAESAFKAMG--------------------SAVQ
Rv3426|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0191|M.marinum_M -SVGGAVSGPG----AVLVSVG-RAGSIGQLSVPASWAAPATRQVAALSS
MUL_3087|M.ulcerans_Agy99 -GLGGALGAIGSAGSQVAAGLG-SGAHVGHLAVPASWPGASVAEAVRPTV
MAV_3355|M.avium_104 -TVGELSVPAGWATAAPAIRLASTALPATSLAAAAATDFSGVVNEATLGS
Mflv_0325|M.gilvum_PYR-GCK MSAPPPPSGAPIAANTVSAGSPPAPG---APAAAAATFVPYVVAGRDPYE
Mvan_0415|M.vanbaalenii_PYR-1 VSAPPPPSSAAATVGTVATGTAPAPG---APAAATASFVPYAVAGRDPGT
MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVA---APAPAAATFVPYAVANRDPGE
TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX-------------------------
MAB_4783|M.abscessus_ATCC_1997 GGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGPGF
MLBr_01182|M.leprae_Br4923 STGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSP
Rv3426|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0191|M.marinum_M AGLTTIPGTEEAAHGIPGMPGMPVGSSSRASSV-----------------
MUL_3087|M.ulcerans_Agy99 QAVSEPITSPEAANVIGGMPVGATGAG-RGVGS-----------------
MAV_3355|M.avium_104 LAGGALGSPAARVVSTTGIPTRAITGERRQGPVKLDRIIAQLQQMPEQVQ
Mflv_0325|M.gilvum_PYR-GCK GFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYA
Mvan_0415|M.vanbaalenii_PYR-1 GFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYA
MSMEG_0619|M.smegmatis_MC2_155 GFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 GFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYR
MLBr_01182|M.leprae_Br4923 ARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVN--------------
Rv3426|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0191|M.marinum_M ------------VPRYGVRLTVMAHPPAAG--------------------
MUL_3087|M.ulcerans_Agy99 ------------GPRYGFKPTVMARPLPAG--------------------
MAV_3355|M.avium_104 HWNVDEAGLDDLVARLRTTPGVHAVHVTDGEQVAVGSPASKLG-------
Mflv_0325|M.gilvum_PYR-GCK DAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLT
Mvan_0415|M.vanbaalenii_PYR-1 DAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLT
MSMEG_0619|M.smegmatis_MC2_155 DAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 HEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLS
MLBr_01182|M.leprae_Br4923 -----------TALRLQPRAFVMPRNPAAG--------------------
Rv3426|M.tuberculosis_H37Rv ---------------------------------------------
Mb3459|M.bovis_AF2122/97 ---------------------------------------------
MMAR_0191|M.marinum_M ---------------------------------------------
MUL_3087|M.ulcerans_Agy99 ---------------------------------------------
MAV_3355|M.avium_104 ---------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 TLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ---------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 TLDGDAEN--RTIPMLPGTWDVTDDDR------------------
MLBr_01182|M.leprae_Br4923 ---------------------------------------------