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MDFGRRPPEVTSALMYMGPGSTSMTAAASVWNRVAAELDSAATSYESLVIGLVEEGWLGPASVAMADAVA PYVVWMRATAAQAEHTAMQARASAAAYETAFGAVVPPPLISANRVRLAELIASNVFGQNTAVITALETEY GQMWAQDAAAMYEYAAATSSATELTPFTQPQQIVSPGAGSGQIAAVAHSAATLAGTSQTTLSRLISEIPK ALHGIVAPLAASTTPDSPLGWLWQILFGTTFPTSISALLTDLQPYASFFYNTEGLPYFSIGMANNFIQMS KTLGLLSGTTAAATGGAASGLAGLGGLIDGGGQVSAHLGHAASLGRLSVPPSWAQSVPDLESMPARMPIE TLKFAPDGGGAGNLLGGMPLGGPGLGASGSGPRYGVRPTVMARPPFAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1904 | - | - | 100% (398) | PPE family protein |
| M. marinum M | MMAR_2516 | - | e-100 | 48.40% (405) | PPE family protein |
| M. marinum M | MMAR_2671 | - | 6e-99 | 47.43% (409) | PPE family protein, PPE26 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1817 | PPE26 | 1e-134 | 61.54% (403) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 8e-28 | 28.12% (409) | PPE protein |
| M. tuberculosis H37Rv | Rv1789 | PPE26 | 1e-134 | 61.54% (403) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 6e-44 | 33.02% (424) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 4e-26 | 36.02% (186) | PPE family protein |
| M. avium 104 | MAV_2926 | - | 1e-107 | 51.95% (410) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-29 | 30.74% (283) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 8e-38 | 32.32% (396) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1701 | - | 1e-101 | 48.40% (405) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-29 | 34.60% (211) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1817|M.bovis_AF2122/97 -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
Rv1789|M.tuberculosis_H37Rv -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
MMAR_1904|M.marinum_M -------------MDFGRRPPEVTSALMYMGPGSTSMTAAASVWNRVAAE
MAV_2926|M.avium_104 -----------MMLDYGTFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
MUL_1701|M.ulcerans_Agy99 -------------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0047|M.abscessus_ATCC_1997 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSTQ
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.** * : ***. .: :*. * :: :
Mb1817|M.bovis_AF2122/97 LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
Rv1789|M.tuberculosis_H37Rv LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
MMAR_1904|M.marinum_M LDSAATSYESLVIGLVEEGWLGPASVAMADAVAPYVVWMRATAAQAEHTA
MAV_2926|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
MUL_1701|M.ulcerans_Agy99 LSFTADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAERAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0047|M.abscessus_ATCC_1997 YATAATELTELLGSTVAGSWQGPSAMQYAASHAPYLAWLTQQSAMSATNA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : * .: ** *: :. . .
Mb1817|M.bovis_AF2122/97 TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
Rv1789|M.tuberculosis_H37Rv TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
MMAR_1904|M.marinum_M MQARASAAAYETAFGAVVPPPLISANRVRLAELIASNVFGQNTAVITALE
MAV_2926|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
MUL_1701|M.ulcerans_Agy99 KQAEAAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0047|M.abscessus_ATCC_1997 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.:. *. :*: . : *: * *. * : *: *
Mb1817|M.bovis_AF2122/97 AQYGEMWAQDSAAMYAYAGSSASAS-AVTPFSTPPQIANPTAQGTQAAAV
Rv1789|M.tuberculosis_H37Rv AQYGEMWAQDSAAMYAYAGSSASAS-AVTPFSTPPQIANPTAQGTQAAAV
MMAR_1904|M.marinum_M TEYGQMWAQDAAAMYEYAAATSSAT-ELTPFTQPQQIVSPGAGSGQIAAV
MAV_2926|M.avium_104 AQYGEYWAQDAAAMYSYAGQSASAS-KVTPFQKAPQVTNPSGQAAQSAAV
MUL_1701|M.ulcerans_Agy99 AQYAEMWAQDARAMYTYAGSSASAT-KITAFTPPPETANPAASALQSNAT
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0047|M.abscessus_ATCC_1997 ADYIRMWIQAATTMGVYQGVSSAALAATTPTQPSPMIMAPG-GEMSRMSA
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
::* . * * : :* * . * .
Mb1817|M.bovis_AF2122/97 A----TAAGTAQSTLTEMITGLPNALQSLTSPLLQ----SSN--GPLSWL
Rv1789|M.tuberculosis_H37Rv A----TAAGTAQSTLTEMITGLPNALQSLTSPLLQ----SSN--GPLSWL
MMAR_1904|M.marinum_M AHSAATLAGTSQTTLSRLISEIPKALHGIVAPLAA----STTPDSPLGWL
MAV_2926|M.avium_104 S--TATANSTSTNTTKALQSLAQPASSSTTATKAATTAASTTSTDPLSEI
MUL_1701|M.ulcerans_Agy99 STAAATAAGAAQSTLAGVISQLPNALTSLTSPIAS---------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0047|M.abscessus_ATCC_1997 DMMSMAAQPQAAESGSALDSSNNIMDQL--------------MRFMTNPL
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG-------FADALPD
Mb1817|M.bovis_AF2122/97 WQILFGTPNFPTSISALLTDLQPY---ASFFYNTEGLPYFSIGMGNNFIQ
Rv1789|M.tuberculosis_H37Rv WQILFGTPNFPTSISALLTDLQPY---ASFFYNTEGLPYFSIGMGNNFIQ
MMAR_1904|M.marinum_M WQILFGTT-FPTSISALLTDLQPY---ASFFYNTEGLPYFSIGMANNFIQ
MAV_2926|M.avium_104 WFLLTGQTTLPTSLGSAVNGYSPF---ASLFYNTEGLPYFSTGMANTFTQ
MUL_1701|M.ulcerans_Agy99 --ALTSAASPATWIDWLVNWYLPI---SQLFYNTVGLPYFAIGIGSSLIT
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGS
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_0047|M.abscessus_ATCC_1997 GTLQDMIEDFMRNPVAAFFAWFPLLFFIAYEAFFIPFGFTFWGVLLSAPA
TH_3113|M.thermoresistible__bu GLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGV
.
Mb1817|M.bovis_AF2122/97 AAKTLGLIG---------------------SAAPAAVAAAGDAAKGLPGL
Rv1789|M.tuberculosis_H37Rv SAKTLGLIG---------------------SAAPAAVAAAGDAAKGLPGL
MMAR_1904|M.marinum_M MSKTLGLLS---------------------GTT---AAATGGAASGLAGL
MAV_2926|M.avium_104 IAKSVGAIG---------------------GAAP----AAAKALPGLGGL
MUL_1701|M.ulcerans_Agy99 SERALGLIG---------------------PEAEAAAAGAGAAEAAAGAA
MLBr_01182|M.leprae_Br4923 AMKSLAPTT---------------------TKAAESAFKAMGSAVQSTGR
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_0047|M.abscessus_ATCC_1997 WLPIVLGLALSALVPPAG-----IEEPGQEDEPGREPTRIE---RRSPQQ
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
: .
Mb1817|M.bovis_AF2122/97 GGML--GGGPVAAG----LGNAASVG-KLSVPPVWSGPLPGSVTPGAAPL
Rv1789|M.tuberculosis_H37Rv GGML--GGGPVAAG----LGNAASVG-KLSVPPVWSGPLPGSVTPGAAPL
MMAR_1904|M.marinum_M GGLID-GGGQVSAH----LGHAASLG-RLSVPPSWAQSVP-DLESMPARM
MAV_2926|M.avium_104 GGML--GGGAAAAHPVAALGGAGSIGGKLSVPVAWSGAPA--TPALGHAI
MUL_1701|M.ulcerans_Agy99 PAALG-GAGPIGAG----LGNASALG-KLSVPPSWPGSGLDVPPSVSAGG
MLBr_01182|M.leprae_Br4923 GLLGSSSGGHVTAQ----LGRAASIG-SLRVPQTWTTASQPVTAATRALS
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAG-SPPAPGAPAAAAATFVPYVVAGRD
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATG-TAPAPGAPAAATASFVPYAVAGRD
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAP-AGTTVAAPAPAAATFVPYAVANRD
MAB_0047|M.abscessus_ATCC_1997 DLQLAHVPSGSPTPGGSTTTTVTSGGSAPPAPAPATATPAYMVYAVQEDP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAG--GPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSP
: . .
Mb1817|M.bovis_AF2122/97 PVSTVSAAPEAA--PGSLLGGLPLAG--AGGAGA----------------
Rv1789|M.tuberculosis_H37Rv PVSTVSAAPEAA--PGSLLGGLPLAG--AGGAGA----------------
MMAR_1904|M.marinum_M PIETLKFAPDGGG-AGNLLGGMPLGGPGLGASGS----------------
MAV_2926|M.avium_104 PVSSISAAPEAAGGPGNLLGGMPLAGAGAGGHGAA---------------
MUL_1701|M.ulcerans_Agy99 PLASDIVNPPEASAPGSLLGGMPLAGGPGGAAAGA---------------
MLBr_01182|M.leprae_Br4923 PARVAVATESES--APLLGGGLPMAPMVPGGGSGTG--------------
Mflv_0325|M.gilvum_PYR-GCK PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGR
Mvan_0415|M.vanbaalenii_PYR-1 PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGR
MSMEG_0619|M.smegmatis_MC2_155 PGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEER
MAB_0047|M.abscessus_ATCC_1997 PAARFGPTLNEGSGAKAPAAGISAAA---AAAASARSRARRKRAARIKDP
TH_3113|M.thermoresistible__bu PPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEP
* . . .
Mb1817|M.bovis_AF2122/97 ------------------------GPRYGFRPTVMARPPFAG--------
Rv1789|M.tuberculosis_H37Rv ------------------------GPRYGFRPTVMARPPFAG--------
MMAR_1904|M.marinum_M ------------------------GPRYGVRPTVMARPPFAG--------
MAV_2926|M.avium_104 ------------------------GPKYGFRPTVMARPPFAG--------
MUL_1701|M.ulcerans_Agy99 ------------------------GPRYGFRVTVMARPPFAG--------
MLBr_01182|M.leprae_Br4923 --------------------GVNTALRLQPRAFVMPRNPAAG--------
Mflv_0325|M.gilvum_PYR-GCK G--YADAYADYEELPDDGP-PEQPAPRVTASTRGAGPMGFAGTVSRGD--
Mvan_0415|M.vanbaalenii_PYR-1 A--YADAYADYEPEPDDEP-PVRQEPRIAATERGAGPMGFAGTVSRDA--
MSMEG_0619|M.smegmatis_MC2_155 G--YADAYMDYEE-PDEDP-APQPEPRVRASERGSDAMGFTGTVTRHD--
MAB_0047|M.abscessus_ATCC_1997 A--PQFMDMNSSVAPDFSESAARQTTGVGASARGAGRLGFAGTAPAAAGT
TH_3113|M.thermoresistible__bu AGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAPSAAGI
:.
Mb1817|M.bovis_AF2122/97 --------------------------------------------------
Rv1789|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1904|M.marinum_M --------------------------------------------------
MAV_2926|M.avium_104 --------------------------------------------------
MUL_1701|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK EQAGGLT---TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHD
Mvan_0415|M.vanbaalenii_PYR-1 AQAGGLT---TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHD
MSMEG_0619|M.smegmatis_MC2_155 VTAAGLT---TLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPE
MAB_0047|M.abscessus_ATCC_1997 TAAAGLVERDSGTAEALDGARTVPMLPTSWGTDSEHGP-------DRPAE
TH_3113|M.thermoresistible__bu RVLGGAG----RISRTRGSVPHAEITPGDPTEPSSPTDR-----AHRPAE
Mb1817|M.bovis_AF2122/97 -----
Rv1789|M.tuberculosis_H37Rv -----
MMAR_1904|M.marinum_M -----
MAV_2926|M.avium_104 -----
MUL_1701|M.ulcerans_Agy99 -----
MLBr_01182|M.leprae_Br4923 -----
Mflv_0325|M.gilvum_PYR-GCK GKEKP
Mvan_0415|M.vanbaalenii_PYR-1 GKDSQ
MSMEG_0619|M.smegmatis_MC2_155 GGPRR
MAB_0047|M.abscessus_ATCC_1997 GGSST
TH_3113|M.thermoresistible__bu PN---