For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYSVETTAESLEDELDELDENWKGSSSDLLADAVERY LQWLSKHSSQLKHAAWVINGLANAYNDTRRKVVPPEEIAANREEVHRLIASNVAGVNTPAIAGLDAQYQQ YRAQNIAVMNDYQSTARFILAYLPRWQEPPQIYGGGGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3459 | PPE57 | - | 100% (178) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1817 | PPE26 | 7e-21 | 35.50% (169) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3562 | PPE61 | 9e-21 | 35.06% (154) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-10 | 28.57% (175) | PPE protein |
| M. tuberculosis H37Rv | Rv3425 | PPE57 | 5e-89 | 90.91% (176) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 6e-17 | 29.38% (160) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 2e-14 | 30.06% (173) | PPE-family protein |
| M. marinum M | MMAR_1904 | - | 2e-22 | 35.63% (174) | PPE family protein |
| M. avium 104 | MAV_2926 | - | 1e-23 | 38.73% (173) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-13 | 29.71% (175) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-13 | 29.14% (175) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 5e-22 | 38.69% (168) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-12 | 28.57% (175) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3459|M.bovis_AF2122/97 --------------MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYS
Rv3425|M.tuberculosis_H37Rv --------------MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYS
MMAR_1904|M.marinum_M -------------MDFGRRPPEVTSALMYMGPGSTSMTAAASVWNRVAAE
MAV_2926|M.avium_104 -----------MMLDYGTFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
..* * : ***. .: *. :. .
Mb3459|M.bovis_AF2122/97 VETTAESLEDELDELDEN-WKGSSSDLLADAVERYLQWLSKHSSQLKHAA
Rv3425|M.tuberculosis_H37Rv VETTAESLEDELDELDEN-WKGSSSDLLADAVERYLQWLSKHSSQLKHAA
MMAR_1904|M.marinum_M LDSAATSYESLVIGLVEEGWLGPASVAMADAVAPYVVWMRATAAQAEHTA
MAV_2926|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
* : : * .: . * *: . .
Mb3459|M.bovis_AF2122/97 WVINGLANAYNDTRRKVVPPEEIAANREEVHRLIASNVAGVNTPAIAGLD
Rv3425|M.tuberculosis_H37Rv WVINGLANAYNDTRRKVVPPEEIAANREERRRLIASNVAGVNTPAIADLD
MMAR_1904|M.marinum_M MQARASAAAYETAFGAVVPPPLISANRVRLAELIASNVFGQNTAVITALE
MAV_2926|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
* *: : . : *: * :*. * *: *: :
Mb3459|M.bovis_AF2122/97 AQYQQYRAQNIAVMNDYQSTARFILAYLPRWQEPPQIYGGGGG-------
Rv3425|M.tuberculosis_H37Rv AQYDQYRARNVAVMNAYVSWTRSALSDLPRWREPPQIYRGG---------
MMAR_1904|M.marinum_M TEYGQMWAQDAAAMYEYAAATSSATELTP-FTQPQQIVSPGAGSGQIAAV
MAV_2926|M.avium_104 AQYGEYWAQDAAAMYSYAGQSASASKVTP-FQKAPQVTNPSGQAAQSAAV
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAASALTP-FTEPPQTTNPVAGAAQSAAV
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
::* . : :.* * . .
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1904|M.marinum_M AHSAATL--------------------------------------AGTSQ
MAV_2926|M.avium_104 STATANS--------------------------------------TSTNT
MUL_3072|M.ulcerans_Agy99 AQASSTA--------------------------------------ASSDV
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0669|M.abscessus_ATCC_1997 DVPGSPDQIMKMLQG---------------------------FQQWFEKM
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 VVEEVVEE-------------------------------------VVEAE
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1904|M.marinum_M TTLSR-LISEIP--KALHGIVAP---------------------------
MAV_2926|M.avium_104 TKALQ-SLAQPASSSTTATKAAT---------------------------
MUL_3072|M.ulcerans_Agy99 VSQLAGLITSVP---NALQTLAT---------------------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGP------FLLAVVYQA----VSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGP------FLAAVAYQA----VSWVGASI
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWP------FLFGVAYQVFFNLVGWPTWGM
MAB_0669|M.abscessus_ATCC_1997 G--------FNPATSAVLAVIML------FLYDLLWYP---------YYA
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 QAISQAALDQAVNEGMEAT-VVP---------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1904|M.marinum_M ---LAASTTPDSPLG-----WLWQILFG-TTFPTSISALLTDLQPYASF-
MAV_2926|M.avium_104 ---TAASTTSTDPLS-----EIWFLLTGQTTLPTSLGSAVNGYSPFASL-
MUL_3072|M.ulcerans_Agy99 ---TSAAPTAASILP-----EVSLPPWLATNLANWNTIMATLTGPFSLQG
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATT-------LAIVAGVGQHLLSLLNTPPAEEAAEEPAP
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATT-------LAIVLGVGAYLLENLPAPAEDAPAEEPAA
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAALG-----ITGLVLLIDHVLNNPVDVPAEDEAPQEVAA
MAB_0669|M.abscessus_ATCC_1997 SYLLPFLIPALSGLS-----GLAALMHLRPAAPGPVPA-AALSPGDRPIR
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MLBr_01182|M.leprae_Br4923 ------------------------QVDQQVNVDVATPQTAVPDSSSAAAP
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1904|M.marinum_M FYNTEGLPYFSIGMANNFIQMSKTLG------LLSGTTAAATGGAASGLA
MAV_2926|M.avium_104 FYNTEGLPYFSTGMANTFTQIAKSVG------AIGG-AAPAAAKALPGLG
MUL_3072|M.ulcerans_Agy99 ISSIPGGPFLSFGQVYAYVQNAQGLNAFYSPKAITGTLAPLVPEISPGGV
Mflv_0325|M.gilvum_PYR-GCK AQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT
Mvan_0415|M.vanbaalenii_PYR-1 SSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS
MSMEG_0619|M.smegmatis_MC2_155 AP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT
MAB_0669|M.abscessus_ATCC_1997 RPTQHVEPNLAALPLPTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAA-
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTG-SAAPTTGTAPGGAGSPPPAGHSVP
MLBr_01182|M.leprae_Br4923 QLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTK
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1904|M.marinum_M GLGGLIDGGGQVS---AHLGHAASLG-RLSVPPSWAQSVPDLESMPARMP
MAV_2926|M.avium_104 GLGGMLGGGAAAAHPVAALGGAGSIGGKLSVPVAWSG-APATPALGHAIP
MUL_3072|M.ulcerans_Agy99 GLTSASVSNSVSG----TMGRAALVG-SMSVPQGWTQAAPAMRLVSSVLS
Mflv_0325|M.gilvum_PYR-GCK FVPYVVAGRDP-YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKR
Mvan_0415|M.vanbaalenii_PYR-1 FVPYAVAGRDP-GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKR
MSMEG_0619|M.smegmatis_MC2_155 FVPYAVANRDP-GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKR
MAB_0669|M.abscessus_ATCC_1997 -ISYAIPGLVPPGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRL
TH_3113|M.thermoresistible__bu PAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAA
MLBr_01182|M.leprae_Br4923 AAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTT
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1904|M.marinum_M IETLKFAPDG-GGAGNLLGGMPLG-------GP---GLGASGS-GPRYG-
MAV_2926|M.avium_104 VSSISAAPEAAGGPGNLLGGMPLA-------GA---GAGGHGAAGPKYG-
MUL_3072|M.ulcerans_Agy99 TNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFGSSSGGAVANSLGG
Mflv_0325|M.gilvum_PYR-GCK RRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAG
Mvan_0415|M.vanbaalenii_PYR-1 RRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAG
MSMEG_0619|M.smegmatis_MC2_155 RRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTG
MAB_0669|M.abscessus_ATCC_1997 RGKNKAEAGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGFAG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-AATAPSAAGIRVLGGAG
MLBr_01182|M.leprae_Br4923 ASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVN
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1904|M.marinum_M -------VRPTVMARPPFAG------------------------------
MAV_2926|M.avium_104 -------FRPTVMARPPFAG------------------------------
MUL_3072|M.ulcerans_Agy99 VVAEADPAAATIIVIPALDE------------------------------
Mflv_0325|M.gilvum_PYR-GCK TVSRGD-EQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGH
Mvan_0415|M.vanbaalenii_PYR-1 TVSRDA-AQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERH
MSMEG_0619|M.smegmatis_MC2_155 TVTRHD-VTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SP
MAB_0669|M.abscessus_ATCC_1997 TAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDAD-------------
TH_3113|M.thermoresistible__bu RISRTR-GSVPHAEITPGDPTEPSSPTDRAHRPAEPN-------------
MLBr_01182|M.leprae_Br4923 TALRLQPRAFVMPRNPAAG-------------------------------
Mb3459|M.bovis_AF2122/97 ---------
Rv3425|M.tuberculosis_H37Rv ---------
MMAR_1904|M.marinum_M ---------
MAV_2926|M.avium_104 ---------
MUL_3072|M.ulcerans_Agy99 ---------
Mflv_0325|M.gilvum_PYR-GCK DGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 NHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DDPEGGPRR
MAB_0669|M.abscessus_ATCC_1997 ----GGDQN
TH_3113|M.thermoresistible__bu ---------
MLBr_01182|M.leprae_Br4923 ---------