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IDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAELQSMAASYGSTVQGLTVAPWTGASSITMAAAAA PYVTWINTTGVQAEQAATQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAEAQY LEMWAQDAAAMYAYAGTAAAASALTPFTEPPQTTNPVAGAAQSAAVAQASSTAASSDVVSQLAGLITSVP NALQTLATTSAAPTAASILPEVSLPPWLATNLANWNTIMATLTGPFSLQGISSIPGGPFLSFGQVYAYVQ NAQGLNAFYSPKAITGTLAPLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQAAPAMRLV SSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFGSSSGGAVANSLGGVVAEADPAAATIIVI PALDE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3072 | - | - | 100% (426) | PPE family protein |
| M. ulcerans Agy99 | MUL_3071 | - | 6e-77 | 45.52% (391) | PPE family protein |
| M. ulcerans Agy99 | MUL_4672 | - | 2e-74 | 44.67% (394) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1837 | PPE32 | 1e-132 | 59.95% (422) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-29 | 37.14% (210) | PPE protein |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | 1e-132 | 59.95% (422) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-47 | 35.58% (385) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-29 | 29.51% (427) | PPE family protein |
| M. marinum M | MMAR_2684 | - | 0.0 | 99.77% (426) | PPE family protein, PPE32 |
| M. avium 104 | MAV_2910 | - | 1e-138 | 62.09% (430) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-34 | 30.17% (421) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-35 | 32.73% (385) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 7e-31 | 36.65% (221) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1837|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
Rv1808|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MMAR_2684|M.marinum_M ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MAV_2910|M.avium_104 ------------MLDFGAYPPEYNSGRMYVGAGSGPLLAAAAAWDELAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
* .** :* : *.*...: :*. :* *: *
Mb1837|M.bovis_AF2122/97 LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
Rv1808|M.tuberculosis_H37Rv LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MMAR_2684|M.marinum_M LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MAV_2910|M.avium_104 LQSVGASYGSTVETLTTGPWTGPSSIAMAAAAAPYVAWLQATGAQAEQAG
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
: . : : : * .: ** *: . . ..
Mb1837|M.bovis_AF2122/97 AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
Rv1808|M.tuberculosis_H37Rv AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MMAR_2684|M.marinum_M TQAKLAAGAYETAFAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MAV_2910|M.avium_104 AQAKLAAAAYETAFAATVPPPVIAANRALLATLVATNILGQNTPAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
.* ** .: * : . : *:: *: :*::* *: .** *
Mb1837|M.bovis_AF2122/97 AHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSAT--------
Rv1808|M.tuberculosis_H37Rv AHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSAT--------
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAASALTPFTEPPQTTNPVAG--------
MMAR_2684|M.marinum_M AQYLEMWAQDAAAMYAYAGTAAAASALTPFTEPPQTTNPVAG--------
MAV_2910|M.avium_104 AHYMEMWAQDAAAMYAYAASSASAAQLTPFTEPPRTTNESAG--------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVG--------
*.* .** * *:.* * . : : ..
Mb1837|M.bovis_AF2122/97 -----AAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATS
Rv1808|M.tuberculosis_H37Rv -----AAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATS
MUL_3072|M.ulcerans_Agy99 -----AAQSAAVAQASSTAASSDVVSQLAGLITSVPNALQTLATTSAAPT
MMAR_2684|M.marinum_M -----AAQSAAVAQASSTAASSDVVSQLAGLITSVPNALQTLATTSAAPT
MAV_2910|M.avium_104 -----PLQSAAVAQSAAQSGS-NTAAHLSQLSATAQPAAQAAGNAASTTA
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPDPNDPIEMLLKNS-QHFLGMYRALKGLITDPV
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAP----LFPPGFADALPDGLL
MLBr_01182|M.leprae_Br4923 ----LAQEVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVD
. : :
Mb1837|M.bovis_AF2122/97 ASAGWDTVLQ---------SITTILANLTGPYS-----------------
Rv1808|M.tuberculosis_H37Rv ASAGWDTVLQ---------SITTILANLTGPYS-----------------
MUL_3072|M.ulcerans_Agy99 AASILPEVSLPPWLATNLANWNTIMATLTGPFS-----------------
MMAR_2684|M.marinum_M AASILPEVSLPPWLATNLANWNTIMATLTGPFS-----------------
MAV_2910|M.avium_104 ASTQLTTPSF-------ITNWNEFWSVVTGVYS-----------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMGTPIYAAI
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGV
MLBr_01182|M.leprae_Br4923 QQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLS----------------
Mb1837|M.bovis_AF2122/97 -----------IIGLGAIPGGWWLTFGQILGLAQNAPGVAALLG--PKAA
Rv1808|M.tuberculosis_H37Rv -----------IIGLGAIPGGWWLTFGQILGLAQNAPGVAALLG--PKAA
MUL_3072|M.ulcerans_Agy99 -----------LQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYS--PKAI
MMAR_2684|M.marinum_M -----------LQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYS--PKAI
MAV_2910|M.avium_104 -----------PQSWTTIPGGPFLSFGQAYAWGQNGQGAAAYLAG-PKAI
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPS-RPDQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPT-RADQ
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP-----RTDQ
MAB_4783|M.abscessus_ATCC_1997 MGPAAGISIPLAITLAS---LSQMPEAPPVDAPAETVPARIDQPH-AVAM
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGL-AGLT
MLBr_01182|M.leprae_Br4923 ---------PINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKAA
Mb1837|M.bovis_AF2122/97 AGALSPLAP--LRGGYIADITPLGGGATGGIARAIYVGSLSVPQGWAEAA
Rv1808|M.tuberculosis_H37Rv AGALSPLAP--LRGGYIGDITPLGGGATGGIARAIYVGSLSVPQGWAEAA
MUL_3072|M.ulcerans_Agy99 TGTLAPLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQAA
MMAR_2684|M.marinum_M TGTLAPLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQAA
MAV_2910|M.avium_104 SGALAPLASGGNAVKPMLSSAVGAGQVSGSMGKAALVGSMSVPQGWTEAA
Mflv_0325|M.gilvum_PYR-GCK QSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRD
Mvan_0415|M.vanbaalenii_PYR-1 PSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRD
MSMEG_0619|M.smegmatis_MC2_155 P-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRD
MAB_4783|M.abscessus_ATCC_1997 GGAPAPTASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEGLGYAVRGDG
TH_3113|M.thermoresistible__bu AVPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPP
MLBr_01182|M.leprae_Br4923 ESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTAS
. . :
Mb1837|M.bovis_AF2122/97 PVMRAVASVLPG-TGAAPALAAEAPGALFGEMALSSLAGRALAGTAVR--
Rv1808|M.tuberculosis_H37Rv PVMRAVASVLPG-TGAAPALAAEAPGALFGEMALSSLAGRALAGTAVR--
MUL_3072|M.ulcerans_Agy99 PAMRLVSSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFG--
MMAR_2684|M.marinum_M PAMRLVSSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFG--
MAV_2910|M.avium_104 PAIRTLAQVLPGNMAAAP-AAMAGEEGVFSQMALSSLAGRAVAAAATR--
Mflv_0325|M.gilvum_PYR-GCK PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGR
Mvan_0415|M.vanbaalenii_PYR-1 PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGR
MSMEG_0619|M.smegmatis_MC2_155 PGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEER
MAB_4783|M.abscessus_ATCC_1997 PGFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDR
TH_3113|M.thermoresistible__bu PAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPA
MLBr_01182|M.leprae_Br4923 QPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVN--
.
Mb1837|M.bovis_AF2122/97 --------------------------SGAGAARVA---GGSVTEDVASTT
Rv1808|M.tuberculosis_H37Rv --------------------------SGAGAARVA---GGSVTEDVASTT
MUL_3072|M.ulcerans_Agy99 --------------------------SSSGGAVAN-SLGGVVAEADPAAA
MMAR_2684|M.marinum_M --------------------------SSSGGAVAN-SLGGVVAEADPAAA
MAV_2910|M.avium_104 --------------------------PVGGAASAASSLGGVAAEADPAAA
Mflv_0325|M.gilvum_PYR-GCK GYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAG
Mvan_0415|M.vanbaalenii_PYR-1 AYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAG
MSMEG_0619|M.smegmatis_MC2_155 GYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAA
MAB_4783|M.abscessus_ATCC_1997 GYRHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEAT
TH_3113|M.thermoresistible__bu GSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAP---SAA
MLBr_01182|M.leprae_Br4923 ----------------------------------------TALRLQPRAF
:
Mb1837|M.bovis_AF2122/97 TIIVIPAD----------------------------------------
Rv1808|M.tuberculosis_H37Rv TIIVIPAD----------------------------------------
MUL_3072|M.ulcerans_Agy99 TIIVIPALDE--------------------------------------
MMAR_2684|M.marinum_M TIIVIPALDE--------------------------------------
MAV_2910|M.avium_104 TIIVIPCIEE--------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 GLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 GLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 GLSTLDGDAEN--RTIPMLPGTWDVTDDDR------------------
TH_3113|M.thermoresistible__bu GIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN---
MLBr_01182|M.leprae_Br4923 VMPRNPAAG---------------------------------------
: