For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYSVETTAESLEDELDELDENWKGSSSDLLADAVERY LQWLSKHSSQLKHAAWVINGLANAYNDTRRKVVPPEEIAANREERRRLIASNVAGVNTPAIADLDAQYDQ YRARNVAVMNAYVSWTRSALSDLPRWREPPQIYRGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3425 | PPE57 | - | 100% (176) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3429 | PPE59 | 1e-64 | 69.89% (176) | PPE family protein |
| M. tuberculosis H37Rv | Rv3426 | PPE58 | 3e-41 | 68.00% (125) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3459 | PPE57 | 4e-89 | 90.91% (176) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-10 | 27.17% (173) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-16 | 28.75% (160) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-13 | 29.17% (168) | PPE family protein |
| M. marinum M | MMAR_1904 | - | 2e-22 | 36.63% (172) | PPE family protein |
| M. avium 104 | MAV_4273 | - | 1e-23 | 35.50% (169) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-13 | 28.32% (173) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 4e-12 | 28.32% (173) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 1e-21 | 38.69% (168) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-11 | 27.17% (173) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3425|M.tuberculosis_H37Rv --------------MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYS
Mb3459|M.bovis_AF2122/97 --------------MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYS
MMAR_1904|M.marinum_M -------------MDFGRRPPEVTSALMYMGPGSTSMTAAASVWNRVAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MAV_4273|M.avium_104 -------------MDFGILPPEVTSALIHAGPGAWSWIEAAGVWQQLSME
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
..* * : ***. . *. :: .
Rv3425|M.tuberculosis_H37Rv VETTAESLEDELDELDEN-WKGSSSDLLADAVERYLQWLSKHSSQLKHAA
Mb3459|M.bovis_AF2122/97 VETTAESLEDELDELDEN-WKGSSSDLLADAVERYLQWLSKHSSQLKHAA
MMAR_1904|M.marinum_M LDSAATSYESLVIGLVEEGWLGPASVAMADAVAPYVVWMRATAAQAEHTA
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MAV_4273|M.avium_104 LEQSASSYTAELAALSTT-WQGPSALAMTRALEPYVDWLRITAQQCQEIA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
* : : * .: * *: . .
Rv3425|M.tuberculosis_H37Rv WVINGLANAYNDTRRKVVPPEEIAANREERRRLIASNVAGVNTPAIADLD
Mb3459|M.bovis_AF2122/97 WVINGLANAYNDTRRKVVPPEEIAANREEVHRLIASNVAGVNTPAIAGLD
MMAR_1904|M.marinum_M MQARASAAAYETAFGAVVPPPLISANRVRLAELIASNVFGQNTAVITALE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MAV_4273|M.avium_104 TSVQTATAAFELTHWTVVHPSLVAANRARLAMLLATNFFGINYPAIAETE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: *. : : *: *: :*. * * *: :
Rv3425|M.tuberculosis_H37Rv AQYDQYRARNVAVMNAYVSWTRSALSDLPRWREPPQIYRGG---------
Mb3459|M.bovis_AF2122/97 AQYQQYRAQNIAVMNDYQSTARFILAYLPRWQEPPQIYGGGGG-------
MMAR_1904|M.marinum_M TEYGQMWAQDAAAMYEYAAATSSATELTP-FTQPQQIVSPGAGSGQIAAV
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAASALTP-FTEPPQTTNPVAGAAQSAAV
MAV_4273|M.avium_104 AEYHAMWVNNSAAMYRYAATSATAVRLPR-FTEPPQVANPSGVSTQAAMV
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
::* . :.* * . .
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1904|M.marinum_M AHSAATLAG-TSQTTLSRL-------------------------------
MUL_3072|M.ulcerans_Agy99 AQASSTAASSDVVSQLAGL-------------------------------
MAV_4273|M.avium_104 PATN---------AADSGT-------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFD-VSNIIADIIRLYG----------EVLRFLF
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALD-LSNIIADLIRAYG----------ELLRFLF
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLD-LSSIISDLLNQYL----------QGVPGG-
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPD-PNDPIEMLLKNS-----------QHFLGMY
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEG----------------------
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1904|M.marinum_M ------------------------ISEIPKALHGIVAPLAASTTPDSPLG
MUL_3072|M.ulcerans_Agy99 ------------------------ITSVPNALQTLATTSAAPTAASILPE
MAV_4273|M.avium_104 ------------------------QTGVAGTLQAASTAFFDPNTGWFKYW
Mflv_0325|M.gilvum_PYR-GCK EPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 EPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 QAILDFLK---DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_4783|M.abscessus_ATCC_1997 RALKGLIT---DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 ----------------------MEATVVPQVDQQVNVDVATPQTAVPDSS
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1904|M.marinum_M WLWQILFGTTFPTSISALLTDLQPYASF-FYNTEGLPYFSIGMANNFIQM
MUL_3072|M.ulcerans_Agy99 VSLPPWLATNLANWNTIMATLTGPFSLQGISSIPGGPFLSFGQVYAYVQN
MAV_4273|M.avium_104 STWGNQFLAASGFPINLIGVLAQLQTASGFQSLGADVAGGLAEG------
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT--LAIVAGVGQ---HLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT--LAIVLGVGA---YLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGITGLVLLIDH---VLNNPVDVPAEDEA
MAB_4783|M.abscessus_ATCC_1997 -TFAVMGTPIYAAIMGPAAGISIPLAITLAS------LSQMPEAPPVDAP
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MLBr_01182|M.leprae_Br4923 SAAAPQLWGGFAQHLSPINDTLSMINNHAGMAN-----AGLSLVNGMGSA
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1904|M.marinum_M SKTLG------LLSGTTAAATGGAASGLAGLGGLIDGGGQVSAH------
MUL_3072|M.ulcerans_Agy99 AQGLNAFYSPKAITGTLAPLVPEISPGGVGLTSASVSN-SVSGT------
MAV_4273|M.avium_104 -----------------TAALSAAEVRLVSAVGAAGSSLAPRAA------
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSP-----P
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTA-----P
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAG-----T
MAB_4783|M.abscessus_ATCC_1997 AETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPGSA-----P
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
MLBr_01182|M.leprae_Br4923 MKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLG------
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1904|M.marinum_M -LGHAASLGRLSVPPSWAQSVPDLESMPARMPIETLKFAPDGG--GAGNL
MUL_3072|M.ulcerans_Agy99 -MGRAALVGSMSVPQGWTQAAPAMRLVSSVLSTN-LAAAPTAGLPGEAGV
MAV_4273|M.avium_104 -LGVGISLGNLTMPPATVGMLG--SQAPVQLASAASPLATGAGQPPMLPM
Mflv_0325|M.gilvum_PYR-GCK APGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGI
Mvan_0415|M.vanbaalenii_PYR-1 APGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGV
MSMEG_0619|M.smegmatis_MC2_155 TVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGV
MAB_4783|M.abscessus_ATCC_1997 AP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQ-PAPGVARRSAGARRAASIVEPAGSAAAAA
MLBr_01182|M.leprae_Br4923 ---RAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGG
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1904|M.marinum_M LGGMPLG---GPGLGASGSGPRYG----------------VRPTVMARPP
MUL_3072|M.ulcerans_Agy99 FGQMALSSLAGRAMGASTFGSSSGGAVANSLGGVVAEADPAAATIIVIPA
MAV_4273|M.avium_104 TPMRPGGNGTRRRNGRDYDDIEYG--------------AELPGTVMQRPP
Mflv_0325|M.gilvum_PYR-GCK AASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTAST
Mvan_0415|M.vanbaalenii_PYR-1 AASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATE
MSMEG_0619|M.smegmatis_MC2_155 AASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASE
MAB_4783|M.abscessus_ATCC_1997 LACNPATGKSRRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTAVASG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-----------AATAPSA
MLBr_01182|M.leprae_Br4923 GLPMAPMVPGGGSGTGGVNTALRLQP---------------RAFVMPRNP
Rv3425|M.tuberculosis_H37Rv --------------------------------------------------
Mb3459|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1904|M.marinum_M FAG-----------------------------------------------
MUL_3072|M.ulcerans_Agy99 LDE-----------------------------------------------
MAV_4273|M.avium_104 SAG-----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK RGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATD
Mvan_0415|M.vanbaalenii_PYR-1 RGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEP
MSMEG_0619|M.smegmatis_MC2_155 RGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENP
MAB_4783|M.abscessus_ATCC_1997 TGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDVTDDD
TH_3113|M.thermoresistible__bu AGIRVLGGAGRISRT-RGSVPHAEITPGDPTE--PSSPTDRAHRPAEPN-
MLBr_01182|M.leprae_Br4923 AAG-----------------------------------------------
Rv3425|M.tuberculosis_H37Rv -------------------
Mb3459|M.bovis_AF2122/97 -------------------
MMAR_1904|M.marinum_M -------------------
MUL_3072|M.ulcerans_Agy99 -------------------
MAV_4273|M.avium_104 -------------------
Mflv_0325|M.gilvum_PYR-GCK DRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 D------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 AP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 R------------------
TH_3113|M.thermoresistible__bu -------------------
MLBr_01182|M.leprae_Br4923 -------------------