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VTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEELASSAQSFSSVTSDLASGSWQGASSAAMMT VANQYVSWLSAAAAQAEEVSHQASAIATAFEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIE AAYEQMWASDVAAMFGYHADASAAVAKLPPWNEVLQNLGFSNASTAVTRPAGSGAVARGYTSRIAGFLAP RAPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4704 | - | - | 100% (214) | PPE family protein |
| M. avium 104 | MAV_0535 | - | 9e-52 | 53.89% (193) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 8e-48 | 50.25% (203) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0450c | PPE10 | 2e-67 | 71.93% (171) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-28 | 38.46% (169) | PPE protein |
| M. tuberculosis H37Rv | Rv0442c | PPE10 | 3e-72 | 72.07% (179) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 6e-30 | 43.75% (160) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 8e-29 | 40.59% (170) | PPE family protein |
| M. marinum M | MMAR_0761 | - | 8e-74 | 74.86% (179) | PPE family protein, PPE10 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-29 | 41.42% (169) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-30 | 39.30% (201) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1395 | - | 5e-74 | 74.86% (179) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-30 | 40.24% (169) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
Mb0450c|M.bovis_AF2122/97 ------------------MPPEINSALMFAGPGSGPLIAAATAWGELAEE
Rv0442c|M.tuberculosis_H37Rv ----------MTSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEK
MMAR_0761|M.marinum_M ----------MTNPHFAWLPPEINSALMFAGPGAGPLLAAAAAWGGLAEE
MUL_1395|M.ulcerans_Agy99 ----------MTNPHFAWLPPEINSALMFAGPGAGPLLAAAAAWGGLAEE
MAV_4704|M.avium_104 ----------MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** :*: : ***...:::*. :* *: :
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
Mb0450c|M.bovis_AF2122/97 LLASIASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAA
Rv0442c|M.tuberculosis_H37Rv LLASIASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAA
MMAR_0761|M.marinum_M LASAVSSFSSVTSELTSGSWLGPSAAAMMAVATQYMAWLGAAAAQAEQAA
MUL_1395|M.ulcerans_Agy99 LASAVSSFSSVTSELTSGSWLGPSAAAMMAVATQYMAWLGAAAAQAEQAA
MAV_4704|M.avium_104 LASSAQSFSSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVS
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
:: : : : : : * *: * ** :* . .:
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
Mb0450c|M.bovis_AF2122/97 AQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVE
Rv0442c|M.tuberculosis_H37Rv AQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVE
MMAR_0761|M.marinum_M AQAAVTAGAFESALAATVQPAVVTANRGLMQVLAATNWLGFNTPAIMDIE
MUL_1395|M.ulcerans_Agy99 AQAAVTAGAFESALAATVQPAVVTANRGLMQVLAATNWLGFNTPAIIDIE
MAV_4704|M.avium_104 HQASAIATAFEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: . * *: *:: : *: * :* :* *: .: *
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
Mb0450c|M.bovis_AF2122/97 AAYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINL
Rv0442c|M.tuberculosis_H37Rv AAYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINL
MMAR_0761|M.marinum_M AAYEQMWALDVAAMAAYHAEASAAASALAPWKQVLRNLGIDIGKNGQINL
MUL_1395|M.ulcerans_Agy99 AAYEQMWALDVAAMAAYHAEASAAASALAPWKQVLRNLGIDIGKNGQINL
MAV_4704|M.avium_104 AAYEQMWASDVAAMFGYHADASAAVAKLPPWNEVLQ------------NL
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVN---------EV
* * .** .: * *: :
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MAB_4783|M.abscessus_ATCC_1997 -------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLITDPV
Mb0450c|M.bovis_AF2122/97 GFGNTGSGNIGNNNIGNNNIGSGNTGTGNIG------------SGNTGSG
Rv0442c|M.tuberculosis_H37Rv GFGNTGSGNIGNNNIGNNNIGSGNTGTGNIG------------SGNTGSG
MMAR_0761|M.marinum_M GFGNSGTGNVGNNNVGNNNWGSGNTGSSNVGTGNTGSSNI--GSGNTGNS
MUL_1395|M.ulcerans_Agy99 GFGNSGTGNVGNNNVGNDNWGSGNTGSSNVGTGNTGSSNIGIGSGNTGNS
MAV_4704|M.avium_104 GFSNASTAVTR---------------------------------------
MLBr_01182|M.leprae_Br4923 GLAQEVVEEVVEEVVEEVVEAEQAISQAALD-------------------
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGPAA
Mb0450c|M.bovis_AF2122/97 NLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSG
Rv0442c|M.tuberculosis_H37Rv NLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSG
MMAR_0761|M.marinum_M NVGLGNLGSGNVGFGNTGNGDFGFGLTGDHQFGFGGFNSGSGNVGIGNSG
MUL_1395|M.ulcerans_Agy99 NVGLGNLGSGNVGFGNTGNGDFGFGLTGDHQFGFGGFNSGSGNVGIGNSG
MAV_4704|M.avium_104 -------------------------------------PAGSGAVARG---
MLBr_01182|M.leprae_Br4923 -------QAVNEGMEATVVPQVDQQVN---------VDVATPQTAVPDSS
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------
Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA
MAB_4783|M.abscessus_ATCC_1997 GISIPLAITLASLSQMPEAPPV---------DAPAETVPARIDQPHAVAM
Mb0450c|M.bovis_AF2122/97 TGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAG
Rv0442c|M.tuberculosis_H37Rv TGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAG
MMAR_0761|M.marinum_M TGNVGFFNSGNGNMGIGNSGSLNSGLGNSGSMSTGFGTAS------MSSG
MUL_1395|M.ulcerans_Agy99 TGNVGFFNSGNGNMGIGNSGSLNSGLGNSGSMSTGFGTAS------MSSG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 SAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVN----------
MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVA---APAPAAATFVPYAVANRDPGE
TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX-------------------------
Mflv_0325|M.gilvum_PYR-GCK MSAPPPPSGAPIAANTVSAGSPPAPG---APAAAAATFVPYVVAGRDPYE
Mvan_0415|M.vanbaalenii_PYR-1 VSAPPPPSSAAATVGTVATGTAPAPG---APAAATASFVPYAVAGRDPGT
MAB_4783|M.abscessus_ATCC_1997 GGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGPGF
Mb0450c|M.bovis_AF2122/97 MQNAALGSAAGSEAALVSSAGYATGG-----MSTAALSSGILASALGSTG
Rv0442c|M.tuberculosis_H37Rv MQNAALGSAAGSEAALVSSAGYATGG-----MSTAALSSGILASALGSTG
MMAR_0761|M.marinum_M MWQSMHGSDMASSTSLASSATYATG-------GTATLSSGILSSALAHTG
MUL_1395|M.ulcerans_Agy99 MWQSMHGSDMASSTSLASSATYATG-------GTATLSSGILSSALAHTG
MAV_4704|M.avium_104 ---------------------YTSR-------------------------
MLBr_01182|M.leprae_Br4923 GMGSAMKSLAPTTTKAAESAFKAMG--------SAVQSTGRGLLGSSSGG
MSMEG_0619|M.smegmatis_MC2_155 GFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYA
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYA
Mvan_0415|M.vanbaalenii_PYR-1 GFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYA
MAB_4783|M.abscessus_ATCC_1997 GFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYR
Mb0450c|M.bovis_AF2122/97 GLQHGLANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGS-----------
Rv0442c|M.tuberculosis_H37Rv GLQHGLANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGS-----------
MMAR_0761|M.marinum_M GLNPALAGGLTPTAATPAAAAPAAAAPVAAAAADAGPVS-----------
MUL_1395|M.ulcerans_Agy99 GLNPALAGGLTPTAATPAAAAPAAAAPVAAAAADAGPVS-----------
MAV_4704|M.avium_104 -----IAGFLAPRAPQ----------------------------------
MLBr_01182|M.leprae_Br4923 HVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPAR-----------
MSMEG_0619|M.smegmatis_MC2_155 DAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLT
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLT
Mvan_0415|M.vanbaalenii_PYR-1 DAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLT
MAB_4783|M.abscessus_ATCC_1997 HEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLS
Mb0450c|M.bovis_AF2122/97 -GSAAAGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAVRE-PSTPGSGI
Rv0442c|M.tuberculosis_H37Rv -GSAAAGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAVRE-PSTPGSGI
MMAR_0761|M.marinum_M -AGANSGSTAGAGLRSPAAGYSGLYNSANSDAGARSVATREAPANAGAGI
MUL_1395|M.ulcerans_Agy99 -AGANSGSTAGAGLRSPAVGYSGLYNSANSDAGARSVATREAPANAGAGI
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 -VAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRN
MSMEG_0619|M.smegmatis_MC2_155 TLTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu ---------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_4783|M.abscessus_ATCC_1997 TLDGDAEN--RTIPMLPGTWDVTDDDR------------------
Mb0450c|M.bovis_AF2122/97 PKSNFYPSPDRESAYASPRIGQPVGSE------------------
Rv0442c|M.tuberculosis_H37Rv PKSNFYPSPDRESAYASPRIGQPVGSE------------------
MMAR_0761|M.marinum_M PRSSFYP--NRETADSEADIQLPLRTE------------------
MUL_1395|M.ulcerans_Agy99 PRSSFYP--NRETADSEADIQLPLRTE------------------
MAV_4704|M.avium_104 ---------------------------------------------
MLBr_01182|M.leprae_Br4923 PAAG-----------------------------------------