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DYGMLPPEVTSALMYAGPGSSSMVAAASAWNALAAELNSTAQGYLTVITQLSSEEWMGPASATMAQAVEP FMTWMSVTAGQAEHAATQAQSAAAAFETAFAAVVPPPLIATNLAELTQALQTNMFGLNNGVIAQLEAQYA EMWAQDASAMYNYAASSALATKIESFTEAPTIASPAASTTQGAAVSAAQATSAASTQSTVQSFLSQITSQ LGQLASPSGTQSFVSQLGASNPILTEIWFLLTGQTVLPNNLGTFMQGYSNYASFFYNTEGLPYFSVGMGN FGVQMAKTLGLITQPAAAAAAALPKVPGLGGALGAIGSAGSQVAAGLGSGAHVGHLAVPASWPGASVAEA VRPTVQAVSEPITSPEAANVIGGMPVGATGAGRGVGSGPRYGFKPTVMARPLPAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3087 | - | - | 100% (406) | PPE family protein |
| M. ulcerans Agy99 | MUL_1701 | - | 3e-95 | 47.83% (414) | PPE family protein |
| M. ulcerans Agy99 | MUL_5078 | - | 1e-83 | 42.34% (411) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1817 | PPE26 | 1e-111 | 54.94% (415) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-24 | 31.94% (216) | PPE protein |
| M. tuberculosis H37Rv | Rv1789 | PPE26 | 1e-111 | 54.94% (415) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-43 | 30.99% (426) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 7e-28 | 27.65% (405) | PPE family protein |
| M. marinum M | MMAR_2671 | - | 0.0 | 99.26% (406) | PPE family protein, PPE26 |
| M. avium 104 | MAV_2924 | - | 1e-110 | 53.03% (413) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 7e-29 | 29.58% (409) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 8e-31 | 28.81% (413) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-28 | 28.86% (395) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3087|M.ulcerans_Agy99 -------------MDYGMLPPEVTSALMYAGPGSSSMVAAASAWNALAAE
MMAR_2671|M.marinum_M -----------MAMDYGMLPPEVTSALMYAGPGSSSMVAAASAWNALAAE
Mb1817|M.bovis_AF2122/97 -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
Rv1789|M.tuberculosis_H37Rv -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
MAV_2924|M.avium_104 -------------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.** * : ***...: :*. :* *: *
MUL_3087|M.ulcerans_Agy99 LNSTAQGYLTVITQLSSEEWMGPASATMAQAVEPFMTWMSVTAGQAEHAA
MMAR_2671|M.marinum_M LNSTAQGYLTVITQLSSEEWMGPASATMAQAVEPYMTWMSVTAGQAEHAA
Mb1817|M.bovis_AF2122/97 LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
Rv1789|M.tuberculosis_H37Rv LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
MAV_2924|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
::* : : : * .: *: *: :. . ..
MUL_3087|M.ulcerans_Agy99 TQAQSAAAAFETAFAAVVPPPLIATNLAELTQALQTNMFGLNNGVIAQLE
MMAR_2671|M.marinum_M TQAQSAAAAFETAFAAVVPPPLIATNRAELTQALQTNMFGLNNGVIAQLE
Mb1817|M.bovis_AF2122/97 TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
Rv1789|M.tuberculosis_H37Rv TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
MAV_2924|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* ** *. *:: . : * :*.:* *. ** *
MUL_3087|M.ulcerans_Agy99 AQYAEMWAQDASAMYNYAASSALATKIES-FTEAPTIASPAASTTQGAAV
MMAR_2671|M.marinum_M AQYAEMWAQDASAMYNYAASSALATKIES-FTEAPTIANPAASTTQGAAV
Mb1817|M.bovis_AF2122/97 AQYGEMWAQDSAAMYAYAGSSASASAVTP-FSTPPQIANPTAQGTQAAAV
Rv1789|M.tuberculosis_H37Rv AQYGEMWAQDSAAMYAYAGSSASASAVTP-FSTPPQIANPTAQGTQAAAV
MAV_2924|M.avium_104 AQYGEYWAQDAAAMYSYAGQSASASKVTP-FQKAPQVTNPSGQAAQSAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATK-AFTAPPLGVNEVGLAQEVVE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:* . * * ::.* * . : .* : : .
MUL_3087|M.ulcerans_Agy99 SAAQATSAASTQSTVQSFLSQITSQLGQLASPSGTQSFVSQLG-ASNPIL
MMAR_2671|M.marinum_M SAAQATSAASTQSTVQSFLSQITSQLGQLASPSGTQSFVSQLG-ASNPIL
Mb1817|M.bovis_AF2122/97 ATAAGTAQST--------LTEMITGL-----PNALQSLTSPLLQSSNGPL
Rv1789|M.tuberculosis_H37Rv ATAAGTAQST--------LTEMITGL-----PNALQSLTSPLLQSSNGPL
MAV_2924|M.avium_104 STATANSTSTNTTKALQSLAQPASSS-----TTATKAATTAASTTSTDPL
MLBr_01182|M.leprae_Br4923 EVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQ
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPDPNDPIEMLLKNS-QHFLGMYRALKGLITDPV
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAP----LFPPGFADALPDGLL
MUL_3087|M.ulcerans_Agy99 TEIWFLLTGQT-VLPNNLGTFMQGYSNYASFFY-----------------
MMAR_2671|M.marinum_M TEIWFLLTGQT-VLPNNLGTFMQGYSNYASFFY-----------------
Mb1817|M.bovis_AF2122/97 SWLWQILFGTP-NFPTSISALLTDLQPYASFFY-----------------
Rv1789|M.tuberculosis_H37Rv SWLWQILFGTP-NFPTSISALLTDLQPYASFFY-----------------
MAV_2924|M.avium_104 SEIWFLLTGQT-SLPTNLGTLVNGYSPFAGLFY-----------------
MLBr_01182|M.leprae_Br4923 TAVPDSSSAAAPQLWGGFAQHLSPINDTLSMIN-----------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMGTPIYAAI
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGV
:
MUL_3087|M.ulcerans_Agy99 ------------------------------NTEGLPYFSVGMGNFGVQMA
MMAR_2671|M.marinum_M ------------------------------NTEGLPYFSVGMGNFGVQMA
Mb1817|M.bovis_AF2122/97 ------------------------------NTEGLPYFSIGMGNNFIQAA
Rv1789|M.tuberculosis_H37Rv ------------------------------NTEGLPYFSIGMGNNFIQSA
MAV_2924|M.avium_104 ------------------------------NTEGLPYFSTGMANTFTQIA
MLBr_01182|M.leprae_Br4923 ------------------------------NHAGMANAGLSLVNGMGSAM
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_4783|M.abscessus_ATCC_1997 MGPAAGISIPLAITLAS---LSQMPEAPPVDAPAETVPARIDQPHAVAMG
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
MUL_3087|M.ulcerans_Agy99 KTLGLITQPAAAAAAALP-KVPGLGGALGAIGSAGSQVAAG----LGSGA
MMAR_2671|M.marinum_M KTLGLITQPAAAAAAALP-KVPGLGGALGAIGSAGSQVAAG----LGSGA
Mb1817|M.bovis_AF2122/97 KTLGLIGSAAPAAVAAAGDAAKGLPGLGGMLG--GGPVAAG----LGNAA
Rv1789|M.tuberculosis_H37Rv KTLGLIGSAAPAAVAAAGDAAKGLPGLGGMLG--GGPVAAG----LGNAA
MAV_2924|M.avium_104 KSVGAIGGAAPAAAKAL----PGLGGLGGMLG--GGAAAAHPVAALGGAG
MLBr_01182|M.leprae_Br4923 KSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQ----LGRAA
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDP
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDP
MAB_4783|M.abscessus_ATCC_1997 GAPAPTASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEGLGYAVRGDGP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPP
. .
MUL_3087|M.ulcerans_Agy99 HVG-HLAVPASWPG-ASVAEAVRPTVQAVSEPITSPEAA----NVIGG--
MMAR_2671|M.marinum_M HVG-HLAVPASWPG-ASVAEAVRPTVQAVSEPITSPEAA----NVIGG--
Mb1817|M.bovis_AF2122/97 SVG-KLSVPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAA--PGSLLGG--
Rv1789|M.tuberculosis_H37Rv SVG-KLSVPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAA--PGSLLGG--
MAV_2924|M.avium_104 SIGGKLSVPVAWSG-APATPALGHA-IPVSSISAAPEAAGGPGNLLGG--
MLBr_01182|M.leprae_Br4923 SIG-SLRVPQTWTTASQPVTAATRALSPARVAVATESES---APLLGGGL
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKG--
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAG--
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEE--
MAB_4783|M.abscessus_ATCC_1997 GFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDD--
TH_3113|M.thermoresistible__bu AGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEP--
: :
MUL_3087|M.ulcerans_Agy99 ----MPVGATGAGRGVGSGPRYGFKPTVMARPLPAG--------------
MMAR_2671|M.marinum_M ----MPVGATGAGRGVGSGPRYGFKPTVMARPLPAG--------------
Mb1817|M.bovis_AF2122/97 ----LPLAGAGGAG---AGPRYGFRPTVMARPPFAG--------------
Rv1789|M.tuberculosis_H37Rv ----LPLAGAGGAG---AGPRYGFRPTVMARPPFAG--------------
MAV_2924|M.avium_104 ----MPLAGAGAGGHGAAGPKYGFRPTVMARPPFAG--------------
MLBr_01182|M.leprae_Br4923 PMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG--------------
Mflv_0325|M.gilvum_PYR-GCK --RGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DE
Mvan_0415|M.vanbaalenii_PYR-1 --RAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AA
MSMEG_0619|M.smegmatis_MC2_155 --RGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DV
MAB_4783|M.abscessus_ATCC_1997 --RGYRHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAV
TH_3113|M.thermoresistible__bu --AGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAP---
MUL_3087|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2671|M.marinum_M --------------------------------------------------
Mb1817|M.bovis_AF2122/97 --------------------------------------------------
Rv1789|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2924|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK QAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK
Mvan_0415|M.vanbaalenii_PYR-1 QAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS
MSMEG_0619|M.smegmatis_MC2_155 TAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPR
MAB_4783|M.abscessus_ATCC_1997 EATGLSTLDGDAEN--RTIPMLPGTWDVTDDDR-----------------
TH_3113|M.thermoresistible__bu SAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN--
MUL_3087|M.ulcerans_Agy99 -
MMAR_2671|M.marinum_M -
Mb1817|M.bovis_AF2122/97 -
Rv1789|M.tuberculosis_H37Rv -
MAV_2924|M.avium_104 -
MLBr_01182|M.leprae_Br4923 -
Mflv_0325|M.gilvum_PYR-GCK P
Mvan_0415|M.vanbaalenii_PYR-1 Q
MSMEG_0619|M.smegmatis_MC2_155 R
MAB_4783|M.abscessus_ATCC_1997 -
TH_3113|M.thermoresistible__bu -