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VFSDFATLPPEVISTQIHVGPGAVPLLAAAAAWDGLAAELHGTAASYASVISELVGESWQGSSSESMAAA AAPYVAWLSATAGLAEQTAAQARAAAAAYESAVAATVPPAVVAANRSLLATLLQTNILGQNDAAIAATED EYGQMWAQDVAAMFSYAAASESAGELTPFEQAPATTNDAGPATQAAAAAAAESTSLSSWLKQLEAYITSL TGQYTQFWQNLIGGATGSTEIAPFWETLYSSISQVGTQATWTNVVNATIGLGVSQWKNFFIYAPWSAAMA KSSLGAGLASPGHIASGIAAKPVSAVLGNAPTVGELSVPAGWATAAPAIRLASTALPATSLAAAAATDFS GVVNEATLGSLAGGALGSPAARVVSTTGIPTRAITGERRQGPVKLDRIIAQLQQMPEQVQHWNVDEAGLD DLVARLRTTPGVHAVHVTDGEQVAVGSPASKLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3355 | - | - | 100% (454) | PPE family protein |
| M. avium 104 | MAV_2905 | - | e-109 | 49.02% (459) | PPE family protein |
| M. avium 104 | MAV_2909 | - | 5e-84 | 42.62% (474) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1830 | PPE30 | 4e-97 | 45.42% (469) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-30 | 30.39% (385) | PPE protein |
| M. tuberculosis H37Rv | Rv1809 | PPE33 | 1e-110 | 48.08% (468) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-42 | 31.59% (421) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 3e-28 | 25.85% (410) | PPE family protein |
| M. marinum M | MMAR_1460 | - | 5e-86 | 40.47% (472) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-33 | 30.68% (414) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 5e-34 | 32.91% (392) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3071 | - | 9e-84 | 40.73% (464) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 9e-35 | 29.95% (394) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3355|M.avium_104 ----------MVFSDFATLPPEVISTQIHVGPGAVPLLAAAAAWDGLAAE
Rv1809|M.tuberculosis_H37Rv -------------MDFGLQPPEITSGEMYLGPGAGPMLAAAVAWDGLAAE
MMAR_1460|M.marinum_M -------------MFYAAFPPEINSGRMYTGPGSGPMLAAAVAWNGLAAE
MUL_3071|M.ulcerans_Agy99 -------------MFYAAFPPEINSGRVYTGPGSEPLLAAAAAWDAVAAE
Mb1830|M.bovis_AF2122/97 -------------MDFGVLPPEINSGRMYAGPGSGPMLAAAAAWDGLATE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** * : ***. .: :*. :* :: *
MAV_3355|M.avium_104 LHGTAASYASVISELVGESWQGSSSESMAAAAAPYVAWLSATAGLAEQTA
Rv1809|M.tuberculosis_H37Rv LQSMAASYASIVEGMASESWLGPSSAGMAAAAAPYVTWMSGTSAQAKAAA
MMAR_1460|M.marinum_M LQSTAASYSSVISGLISGSWVGPSALAMAAAAGPYVTWVNSTAAQATQAA
MUL_3071|M.ulcerans_Agy99 LQSTAAAFSSVIASLTSGPWIGPSSLAMAAAVAPYVTWMGATATQAAQAA
Mb1830|M.bovis_AF2122/97 LQSTAADYGSVIS-VLTGVWSGQSSGTMAAAAAPYVAWMSATAALAREAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
. * : : : * .: ** *: : . ..
MAV_3355|M.avium_104 AQARAAAAAYESAVAATVPPAVVAANRSLLATLLQTNILGQNDAAIAATE
Rv1809|M.tuberculosis_H37Rv DQARAAVVAYETAFAAVVPPPQIAANRSQLISLVATNIFGQNTAAIAATE
MMAR_1460|M.marinum_M DQATAAAGAYEIAFAAHVPPPVIATNRSQLAALVASNLVGQNTAAIAATE
MUL_3071|M.ulcerans_Agy99 TQATAAATAYETAFAAHVPPVEIAANRAQLAMLVATNLFGQNTAAIAAAE
Mb1830|M.bovis_AF2122/97 AQASAAAAAYEAAFAATVPPPVVAANRAELAVLAATNIFGQNTGAIAAAE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
* .*. *: *.: . : *:: * :*:.* * .** *
MAV_3355|M.avium_104 DEYGQMWAQDVAAMFSYAAASESAGELTPFEQAPATTNDAGPATQAAAA-
Rv1809|M.tuberculosis_H37Rv AEYGEMWAQDTMAMFGYASSSATASRLTPFTAPPQTTNPSGLAGQAAATG
MMAR_1460|M.marinum_M AQYAEMWVQDAIAMDTYASASAAASQVTPFSEPPQIVDASGLANQAAAAG
MUL_3071|M.ulcerans_Agy99 SQYAEMWAQDATAMDGYASSSAAASEVTPVAEPRQVVNAAGLASQAAVVG
Mb1830|M.bovis_AF2122/97 ARYAEMWAQDAAAMYGYAGSSSVATQVTPFAAPPPTTNAAGLATQGVAVA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLG-------------
* .** * . .* * . : : .
MAV_3355|M.avium_104 --------AAAESTSLSSW-------------------------------
Rv1809|M.tuberculosis_H37Rv QATALASGTNAVTTALSSA-------------------------------
MMAR_1460|M.marinum_M --------QAASTSAGAAA-------------------------------
MUL_3071|M.ulcerans_Agy99 --------QAAAASPAATV-------------------------------
Mb1830|M.bovis_AF2122/97 --------QAVGASAGN---------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFD-VSNIIADIIRLYG----------EVLRFLF
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALD-LSNIIADLIRAYG----------ELLRFLF
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLD-LSSIISDLLNQYL----------QGVPGG-
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPD-PNDPIEMLLKNS-----------QHFLGMY
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAV_3355|M.avium_104 ---------LKQLEAYIT--------SLTGQYTQFWQNLIGGATGSTEIA
Rv1809|M.tuberculosis_H37Rv ---------AAQFPFDIIPTLLQGLATLSTQYTQLMGQLINAIFGPTG-A
MMAR_1460|M.marinum_M ---------QAILANNPISALLQLGADLANGYTATATQLLNTLFG-PSGA
MUL_3071|M.ulcerans_Agy99 ---------QDLLATGPISWLLQLGADLSTGYTAAVTALLNGLFG-PSGA
Mb1830|M.bovis_AF2122/97 -------------ARSLVSEVLEFLATAGTNYNKTVASLMNAVTGVPYAS
Mflv_0325|M.gilvum_PYR-GCK EPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 EPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 QAILDFLK---DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_4783|M.abscessus_ATCC_1997 RALKGLIT---DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 --------------VNEVGLAQEVVEEVVEEVVEEVVEAEQAISQAALDQ
MAV_3355|M.avium_104 PFWETLYSSISQVGTQATWTNVVNATIGLGVSQWKNFFIY--APWSAAMA
Rv1809|M.tuberculosis_H37Rv TTYQNVFVTAANVTKFSTWANDAMSAPNLGMTEFKVFWQ---PPPAPEIP
MMAR_1460|M.marinum_M ETYLTLFGAVDEVSSNLAVLNDEGLLVNLPISQALKYG--NKPVEFGVLP
MUL_3071|M.ulcerans_Agy99 TTYLTLYNAIKTPLNFTTGFNDIGLLINFPASQLLKFA--PHP-GLGPLP
Mb1830|M.bovis_AF2122/97 SVYNSMLGLGFAESKMVLPANDTVISTIFGMVQFQKFFNPVTPFNPDLIP
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT--LAIVAGVGQ---HLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT--LAIVLGVGA---YLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGITGLVLLIDH---VLNNPVDVPAEDEA
MAB_4783|M.abscessus_ATCC_1997 -TFAVMGTPIYAAIMGPAAGISIPLAITLAS------LSQMPEAPPVDAP
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MLBr_01182|M.leprae_Br4923 AVNEGMEATVVPQVDQQVNVDVATPQTAVPDSS-------------SAAA
MAV_3355|M.avium_104 KSSLGAGLASPGHIASG-----IAAKPVSAVLGNAPTVGELSVP-----A
Rv1809|M.tuberculosis_H37Rv KSSLGAGLGLRSGLSAG-----LAHA-ASAGLGQANLVGDLSVP-----P
MMAR_1460|M.marinum_M KDALGGGLGLAPNFGKGTLFGAIRPDDVAAHFGRGTLVGKLSVP-----P
MUL_3071|M.ulcerans_Agy99 KDALGGGLGLAPHWNQGTLFSAIQPEAMTPHWGRGTLVGKLTVP-----P
Mb1830|M.bovis_AF2122/97 KSALGAGLGLRSAISSG--LGSTAP-AISAGASQAGSVGGMSVP-----P
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSP-----P
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTA-----P
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAG-----T
MAB_4783|M.abscessus_ATCC_1997 AETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPGSA-----P
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
MLBr_01182|M.leprae_Br4923 PQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKS-----L
.
MAV_3355|M.avium_104 GWATAAPAIRLASTALPATSLAAAAATDFSG--VVNEATLGSLAGGALGS
Rv1809|M.tuberculosis_H37Rv SWASATPAVRLVANTLPATSLAAAPATQIPAN-LLGQMALGSMTGGALGA
MMAR_1460|M.marinum_M SWAVATPDIRAVAAALSAAGPHAVSAAALGQGSLLSSMSMAGMAGAAFGA
MUL_3071|M.ulcerans_Agy99 SWAAATPTIRTVAAALSAAGPEAVPAAALGEGGLLSSMAVAGMLGSAFGA
Mb1830|M.bovis_AF2122/97 SWAAATPAIRTVAAVFSSTGLQAVPAAAISEGSLLSQMALASVAGGALGG
Mflv_0325|M.gilvum_PYR-GCK APGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGI
Mvan_0415|M.vanbaalenii_PYR-1 APGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGV
MSMEG_0619|M.smegmatis_MC2_155 TVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGV
MAB_4783|M.abscessus_ATCC_1997 AP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQ-PAPGVARRSAGARRAASIVEPAGSAAAAA
MLBr_01182|M.leprae_Br4923 APTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRV
. . .:
MAV_3355|M.avium_104 PAARVVSTTGIPTRAITGER----RQGPVKLDRIIAQLQQMPEQVQHWNV
Rv1809|M.tuberculosis_H37Rv AAPAIYTGSGARARANGGTP----SAEPVKLEAVIAQLQKQPDAVRHWNV
MMAR_1460|M.marinum_M GAPSAVAGAAVKGGRNTLED-LKDRHSPEKLKRLVAQISEKPDSVQHHSV
MUL_3071|M.ulcerans_Agy99 GAPDAYKRAGVRSRLTPLKD-LKDATSPEKLKRLVAQISEKPESVQHHTV
Mb1830|M.bovis_AF2122/97 AAARATGGFLGGGRVTAVKKSLKDSDSPDKLRRVVAHMMEKPESVQHWHT
Mflv_0325|M.gilvum_PYR-GCK AASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTAST
Mvan_0415|M.vanbaalenii_PYR-1 AASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATE
MSMEG_0619|M.smegmatis_MC2_155 AASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASE
MAB_4783|M.abscessus_ATCC_1997 LACNPATGKSRRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTAVASG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-----------AATAPSA
MLBr_01182|M.leprae_Br4923 PQTWTTASQPVTAATRALSP---ARVAVATESESAPLLGGGLPMAPMVPG
MAV_3355|M.avium_104 DEAGLDDLVARLRTT--PGVHAVHVTDGEQVAVGSPASKLG---------
Rv1809|M.tuberculosis_H37Rv DKADLDGLLDRLSKQ--PGIHAVHVSNGDKPKVALPDTQLGSH-------
MMAR_1460|M.marinum_M DQEGLDSLLGQLSKK--PGVHAVHLSKGKKPKIVPSDAQLG---------
MUL_3071|M.ulcerans_Agy99 DQEGLDSLLEQLAKK--PGIHAVHLSKGDKAKVVPTDAQPG---------
Mb1830|M.bovis_AF2122/97 DEDGLDDLLAELKKK--PGIHAVHMAGGNKAEIAPTISESG---------
Mflv_0325|M.gilvum_PYR-GCK RGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATD
Mvan_0415|M.vanbaalenii_PYR-1 RGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEP
MSMEG_0619|M.smegmatis_MC2_155 RGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENP
MAB_4783|M.abscessus_ATCC_1997 TGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDVTDDD
TH_3113|M.thermoresistible__bu AGIRVLGGAGRISRT-RGSVPHAEITPGDPTE--PSSPTDRAHRPAEPN-
MLBr_01182|M.leprae_Br4923 GGSGTGGVNTALRLQPRAFVMPRNPAAG----------------------
. *
MAV_3355|M.avium_104 -------------------
Rv1809|M.tuberculosis_H37Rv -------------------
MMAR_1460|M.marinum_M -------------------
MUL_3071|M.ulcerans_Agy99 -------------------
Mb1830|M.bovis_AF2122/97 -------------------
Mflv_0325|M.gilvum_PYR-GCK DRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 D------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 AP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 R------------------
TH_3113|M.thermoresistible__bu -------------------
MLBr_01182|M.leprae_Br4923 -------------------