For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDFAMLPPEVNSGLMYTGPGAGSLLAAANSWDELAIELGTTAQTYESVLSGLTSMYWAGPASESMAAKAA PYVWWLHSTAEQTQQTATQCRAAAMAFEQAYAMTVPPPVILANRMQLMSLVATNFFGQNTAAIAALEAQY AEMWEQDAAAMYGYATSAAMAAQLVPFSSPQQTTNPAGLSAQSAAVNQADATAAAANPLSDLIALVQKGL AALAGAFPNLLPDDFSILDGIFAGYATVGVSQDCESIIAGIIGAESNLGMLGAASENPAELAPGDIGIGS VLSSAPSVGGAVSGPGAVLVSVGRAGSIGQLSVPASWAAPATRQVAALSSAGLTTIPGTEEAAHGIPGMP GMPVGSSSRASSVVPRYGVRLTVMAHPPAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0191 | - | - | 100% (381) | PPE family protein, PPE51_2 |
| M. marinum M | MMAR_1513 | - | e-145 | 68.23% (384) | PPE family protein, PPE51 |
| M. marinum M | MMAR_1514 | - | e-134 | 64.68% (385) | PPE family protein, PPE51_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3160 | PPE51 | 1e-147 | 68.12% (389) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 9e-29 | 37.44% (195) | PPE protein |
| M. tuberculosis H37Rv | Rv3136 | PPE51 | 1e-147 | 68.12% (389) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-43 | 33.41% (419) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-28 | 40.85% (164) | PPE family protein |
| M. avium 104 | MAV_4015 | - | 1e-100 | 53.00% (383) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 6e-32 | 31.91% (376) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-31 | 30.98% (397) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2428 | - | 1e-144 | 67.97% (384) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-28 | 28.88% (412) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3160|M.bovis_AF2122/97 -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
Rv3136|M.tuberculosis_H37Rv -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
MUL_2428|M.ulcerans_Agy99 -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE
MMAR_0191|M.marinum_M -------------MDFAMLPPEVNSGLMYTGPGAGSLLAAANSWDELAIE
MAV_4015|M.avium_104 -------------MDFGFLPPEVNSARMYAGPGSGSLLAAAGSWDSLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.**.:* : ***...: :*. * *. .
Mb3160|M.bovis_AF2122/97 LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
Rv3136|M.tuberculosis_H37Rv LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
MUL_2428|M.ulcerans_Agy99 LGTTAETCGSILTGLTDLSWRGPASESMAASAAPCVGWLYRTAEQTQQAA
MMAR_0191|M.marinum_M LGTTAQTYESVLSGLTSMYWAGPASESMAAKAAPYVWWLHSTAEQTQQTA
MAV_4015|M.avium_104 LSITAAVYESVLAGLTGLYWHGPASRAMAAGAAPYVGWLHTTAERAQQTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : : * .: . * ** : .
Mb3160|M.bovis_AF2122/97 IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
Rv3136|M.tuberculosis_H37Rv IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
MUL_2428|M.ulcerans_Agy99 IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE
MMAR_0191|M.marinum_M TQCRAAAMAFEQAYAMTVPPPVILANRMQLMSLVATNFFGQNTAAIAALE
MAV_4015|M.avium_104 TQARAAAAAYELAHAMTVPPAAVAANRTQLAALVATNFFGQNTAAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* .** *. * : . : *: *: :*::* *: .* *
Mb3160|M.bovis_AF2122/97 AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPAGLTAQAAAV
Rv3136|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPAGLTAQAAAV
MUL_2428|M.ulcerans_Agy99 AQYAEMWAQDAAAMYGYATTSAAAG-MLTPFSSPNQATSPAGLAAQSTAV
MMAR_0191|M.marinum_M AQYAEMWEQDAAAMYGYATSAAMAA-QLVPFSSPQQTTNPAGLSAQSAAV
MAV_4015|M.avium_104 AQYAEYWAQDAAAMYAYSASSAAAA-QFSPFASPRRTTDPGGVTAQQAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:*.. * * *::* * : * ..
Mb3160|M.bovis_AF2122/97 SQA------TDPLSLLIETVTQALQ-------------------------
Rv3136|M.tuberculosis_H37Rv SQA------TDPLSLLIETVTQALQ-------------------------
MUL_2428|M.ulcerans_Agy99 TQANATAAATDPITQLVSSLTQSLG-------------------------
MMAR_0191|M.marinum_M NQADATAAAANPLSDLIALVQKGLA-------------------------
MAV_4015|M.avium_104 AAA-------ETGSTGTDSGTQVIP-------------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNE-----------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Mb3160|M.bovis_AF2122/97 -----------ALT--IPSFIPEDFTFLDAIFAGYATVGVTQDVESFVAG
Rv3136|M.tuberculosis_H37Rv -----------ALT--IPSFIPEDFTFLDAIFAGYATVGVTQDVESFVAG
MUL_2428|M.ulcerans_Agy99 -----------AIQA-IPSILPDDFTILDGVFSAYATVGVTQDIESFCAG
MMAR_0191|M.marinum_M -----------ALAGAFPNLLPDDFSILDGIFAGYATVGVSQDCESIIAG
MAV_4015|M.avium_104 -----------PTAG--ASEIPLDFRILDTILGAQTTFRSIFTTEGIPAG
MLBr_01182|M.leprae_Br4923 -------GMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQH
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
: . .
Mb3160|M.bovis_AF2122/97 TIGAESNLGLLNVGDENPAEVTPGDFGIGELVSATSPGGGVSASGAGGAA
Rv3136|M.tuberculosis_H37Rv TIGAESNLGLLNVGDENPAEVTPGDFGIGELVSATSPGGGVSASGAGGAA
MUL_2428|M.ulcerans_Agy99 VIGAENNLGLIGS-SENPAEVTPSDFGLGSLISSTAPAS--AASGGG---
MMAR_0191|M.marinum_M IIGAESNLGMLGAASENPAELAPGDIGIGSVLSSAPSVGG-AVSGPG---
MAV_4015|M.avium_104 IIQADKNLGILPNLATIPAALPR-----TPALSAS-------PTGLG---
MLBr_01182|M.leprae_Br4923 LSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAM
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
.
Mb3160|M.bovis_AF2122/97 --------------SVGNTVLASVGRANSIGQLSVPPSWAAPSTRPVSAL
Rv3136|M.tuberculosis_H37Rv --------------SVGNTVLASVGRANSIGQLSVPPSWAAPSTRPVSAL
MUL_2428|M.ulcerans_Agy99 ---------------LGSAVAASVGRSGSIGQLSVPPSWSAPSARMVSAL
MMAR_0191|M.marinum_M ------------------AVLVSVGRAGSIGQLSVPASWAAPATRQVAAL
MAV_4015|M.avium_104 ------------------RIDAVLARAARIGPMSVPAGWTAATGNPVAAA
MLBr_01182|M.leprae_Br4923 GSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAAT
Mflv_0325|M.gilvum_PYR-GCK A-------EEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGS
Mvan_0415|M.vanbaalenii_PYR-1 A-------EEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGT
MSMEG_0619|M.smegmatis_MC2_155 P-------QEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPA
MAB_0809c|M.abscessus_ATCC_199 S-------VEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPA
TH_3113|M.thermoresistible__bu A-------SAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPP
. * . . .
Mb3160|M.bovis_AF2122/97 SPAGLTTLPG-TDVAEHGMPG--VPG-VPVAAGRASG----VLPRYGVRL
Rv3136|M.tuberculosis_H37Rv SPAGLTTLPG-TDVAEHGMPG--VPG-VPVAAGRASG----VLPRYGVRL
MUL_2428|M.ulcerans_Agy99 SPSGLTTIPGTEEAAAAGSPG--FPGMVAPPATRASG----VLPRYGVRL
MMAR_0191|M.marinum_M SSAGLTTIPG-TEEAAHGIPG--MPGMPVGSSSRASS----VVPRYGVRL
MAV_4015|M.avium_104 PVTGWSEPSAADARPGVTAPG--LPGIPGATLRRAAL----VVPRYGVRI
MLBr_01182|M.leprae_Br4923 RALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRA
Mflv_0325|M.gilvum_PYR-GCK PPAPGAPAAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAA
Mvan_0415|M.vanbaalenii_PYR-1 APAPGAPAAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAA
MSMEG_0619|M.smegmatis_MC2_155 GTTVAAPAPAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAA
MAB_0809c|M.abscessus_ATCC_199 PPSP-PPVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQ
TH_3113|M.thermoresistible__bu AGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAG
.
Mb3160|M.bovis_AF2122/97 TVMAHPPAAG----------------------------------------
Rv3136|M.tuberculosis_H37Rv TVMAHPPAAG----------------------------------------
MUL_2428|M.ulcerans_Agy99 TVMAHPPAAG----------------------------------------
MMAR_0191|M.marinum_M TVMAHPPAAG----------------------------------------
MAV_4015|M.avium_104 TVMARPPAAG----------------------------------------
MLBr_01182|M.leprae_Br4923 FVMPRNPAAG----------------------------------------
Mflv_0325|M.gilvum_PYR-GCK SGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVT
Mvan_0415|M.vanbaalenii_PYR-1 SGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIA
MSMEG_0619|M.smegmatis_MC2_155 SGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVR
MAB_0809c|M.abscessus_ATCC_199 AAAAETAAARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTT
TH_3113|M.thermoresistible__bu SAAAAAAARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATA
. *
Mb3160|M.bovis_AF2122/97 --------------------------------------------------
Rv3136|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2428|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0191|M.marinum_M --------------------------------------------------
MAV_4015|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK ASTRGAGPMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPD
Mvan_0415|M.vanbaalenii_PYR-1 ATERGAGPMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPD
MSMEG_0619|M.smegmatis_MC2_155 ASERGSDAMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGD
MAB_0809c|M.abscessus_ATCC_199 ASHRGAGTMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP-
TH_3113|M.thermoresistible__bu PSAAGIRVLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN
Mb3160|M.bovis_AF2122/97 ----------------------
Rv3136|M.tuberculosis_H37Rv ----------------------
MUL_2428|M.ulcerans_Agy99 ----------------------
MMAR_0191|M.marinum_M ----------------------
MAV_4015|M.avium_104 ----------------------
MLBr_01182|M.leprae_Br4923 ----------------------
Mflv_0325|M.gilvum_PYR-GCK ATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ENPAP------SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 -----------EHGRQD-----
TH_3113|M.thermoresistible__bu ----------------------