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DFGILPPEVTSALIHAGPGAWSWIEAAGVWQQLSMELEQSASSYTAELAALSTTWQGPSALAMTRALEPY VDWLRITAQQCQEIATSVQTATAAFELTHWTVVHPSLVAANRARLAMLLATNFFGINYPAIAETEAEYHA MWVNNSAAMYRYAATSATAVRLPRFTEPPQVANPSGVSTQAAMVPATNAADSGTQTGVAGTLQAASTAFF DPNTGWFKYWSTWGNQFLAASGFPINLIGVLAQLQTASGFQSLGADVAGGLAEGTAALSAAEVRLVSAVG AAGSSLAPRAALGVGISLGNLTMPPATVGMLGSQAPVQLASAASPLATGAGQPPMLPMTPMRPGGNGTRR RNGRDYDDIEYGAELPGTVMQRPPSAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4273 | - | - | 100% (378) | PPE family protein |
| M. avium 104 | MAV_4274 | - | e-100 | 51.85% (378) | PPE family protein |
| M. avium 104 | MAV_4015 | - | 5e-50 | 35.71% (392) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1731c | PPE22 | 2e-53 | 35.47% (406) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 9e-23 | 36.32% (201) | PPE protein |
| M. tuberculosis H37Rv | Rv1705c | PPE22 | 2e-53 | 35.47% (406) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 7e-34 | 29.25% (424) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-25 | 27.35% (362) | PPE family protein |
| M. marinum M | MMAR_1235 | - | 1e-100 | 52.09% (382) | PPE family protein, PPE14 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-26 | 34.47% (206) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-25 | 36.36% (198) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3087 | - | 3e-51 | 32.94% (422) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-24 | 30.75% (335) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4273|M.avium_104 -------------MDFGILPPEVTSALIHAGPGAWSWIEAAGVWQQLSME
MMAR_1235|M.marinum_M -------------MDFIAMPPEMTSALIHSGPGPESLIEAADAWQRLGAD
Mb1731c|M.bovis_AF2122/97 -------------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAE
Rv1705c|M.tuberculosis_H37Rv -------------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAE
MUL_3087|M.ulcerans_Agy99 -------------MDYGMLPPEVTSALMYAGPGSSSMVAAASAWNALAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
: .** * : ***. . . *. .* *. :
MAV_4273|M.avium_104 LEQSASSYTAELAALSTT-WQGPSALAMTRALEPYVDWLRITAQQCQEIA
MMAR_1235|M.marinum_M LEESVRAHDPVLSALTDV-WRGPSSAAMVGAISPYLTWLRATAQQCQQLA
Mb1731c|M.bovis_AF2122/97 LSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAA
Rv1705c|M.tuberculosis_H37Rv LSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAA
MUL_3087|M.ulcerans_Agy99 LNSTAQGYLTVITQLSSEEWMGPASATMAQAVEPFMTWMSVTAGQAEHAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
:. : : : * :: *: *: : *
MAV_4273|M.avium_104 TSVQTATAAFELTHWTVVHPSLVAANRARLAMLLATNFFGINYPAIAETE
MMAR_1235|M.marinum_M ASAQVAAAAFSSTLATVVHPSEVRANRIALAQLLATNRLGRNLAAIAETE
Mb1731c|M.bovis_AF2122/97 SQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATE
Rv1705c|M.tuberculosis_H37Rv SQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATE
MUL_3087|M.ulcerans_Agy99 TQAQSAAAAFETAFAAVVPPPLIATNLAELTQALQTNMFGLNNGVIAQLE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
*: *: : : * : * :* * ** *
MAV_4273|M.avium_104 AEYHAMWVNNSAAMYRYAATSATAVRLPRFTEPPQVANPSGVSTQAAMVP
MMAR_1235|M.marinum_M AQYEGMWVNNSAAMYRYEAASVQAVALPQFSSPLSTPDLTGSATRANVAA
Mb1731c|M.bovis_AF2122/97 AQYAEMWAQDAMAMYGYAGSSATATKVTPFAPPPNTTSPSAAATQLSAVA
Rv1705c|M.tuberculosis_H37Rv AQYAEMWAQDAMAMYGYAGSSATATKVTPFAPPPNTTSPSAAATQLSAVA
MUL_3087|M.ulcerans_Agy99 AQYAEMWAQDASAMYNYAASSALATKIESFTEAPTIASPAASTTQGAAVS
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
*:* ** : : * * . : .
MAV_4273|M.avium_104 ATNAADSGTQTGVAGTLQAASTAFFDPNTGWFK-----------------
MMAR_1235|M.marinum_M AAAAPVAAASP--LDVLQSLTS--IDPNSGWFG-----------------
Mb1731c|M.bovis_AF2122/97 KAAGTSAGAAQSAIAELIAHLPNTLLGLTSP-----LSSALTAA------
Rv1705c|M.tuberculosis_H37Rv KAAGTSAGAAQSAIAELIAHLPNTLLGLTSP-----LSSALTAA------
MUL_3087|M.ulcerans_Agy99 AAQATSAASTQSTVQSFLSQITSQLGQLASPSGTQSFVSQLGASNPILTE
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATP-Q
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLK---
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLR---
MAB_4783|M.abscessus_ATCC_1997 -------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLIT---
MAV_4273|M.avium_104 -------------YWSTWGNQFLAASGFPINLIGVLAQLQTASGFQSLGA
MMAR_1235|M.marinum_M -------------LANTYANQFVS-SGFPVNLLSYLAQNTSAQALTSVAP
Mb1731c|M.bovis_AF2122/97 ---------ATPGWLEWFINWYLPIS---QLFYNTVGLPYFAIGIGNSLI
Rv1705c|M.tuberculosis_H37Rv ---------ATPGWLEWFINWYLPIS---QLFYNTVGLPYFAIGIGNSLI
MUL_3087|M.ulcerans_Agy99 IWFLLTGQTVLPNNLGTFMQGYSNYA---SFFYNTEGLPYFSVGMGNFGV
MLBr_01182|M.leprae_Br4923 TAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMG
Mflv_0325|M.gilvum_PYR-GCK ---------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGA
Mvan_0415|M.vanbaalenii_PYR-1 ---------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGA
MSMEG_0619|M.smegmatis_MC2_155 ---------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVG
TH_3569|M.thermoresistible__bu ---------DPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVG
MAB_4783|M.abscessus_ATCC_1997 ---------DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMG
MAV_4273|M.avium_104 DVAGGLAEGTAALSAAEVRLVSAVGAAGSSLAPR--------AALGVGIS
MMAR_1235|M.marinum_M DIAEGLSEGESALGESAATLSSAVEGVGAAAAPT--------AALGVGMP
Mb1731c|M.bovis_AF2122/97 TSWRALGWIGPEAAEAAAAAP--AAVGAAVGGTG-----PVSAGLGNAAT
Rv1705c|M.tuberculosis_H37Rv TSWRALGWIGPEAAEAAAAAP--AAVGAAVGGTG-----PVSAGLGNAAT
MUL_3087|M.ulcerans_Agy99 QMAKTLGLITQPAAAAAAALPKVPGLGGALGAIGSA-GSQVAAGLGSGAH
MLBr_01182|M.leprae_Br4923 SAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAAS
Mflv_0325|M.gilvum_PYR-GCK SILYPSLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSA
Mvan_0415|M.vanbaalenii_PYR-1 SILYPSLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPA
MSMEG_0619|M.smegmatis_MC2_155 WPTWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVA
TH_3569|M.thermoresistible__bu WPTWAMILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDV
MAB_4783|M.abscessus_ATCC_1997 TPIYAAIMGPAAGISIPLAITLASLSQMPEAPPV---------DAPAETV
MAV_4273|M.avium_104 LGNLTMPPATVGML------GSQAPVQLASAASPLATGAGQPPMLP----
MMAR_1235|M.marinum_M IGNLTAPPAAAGLLP-----AAQTPVQLASVASPLGTAESGFPMLPP---
Mb1731c|M.bovis_AF2122/97 IGKLSVPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAGAAGNLLGG---
Rv1705c|M.tuberculosis_H37Rv IGKLSLPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAGAAGNLLGG---
MUL_3087|M.ulcerans_Agy99 VGHLAVPASWPGAS------VAEAVRPTVQAVSEPITSPEAANVIGG---
MLBr_01182|M.leprae_Br4923 IGSLRVPQTWTTASQP----VTAATRALSPARVAVATESESAPLLGGGLP
Mflv_0325|M.gilvum_PYR-GCK PSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPG---APAAAAATF
Mvan_0415|M.vanbaalenii_PYR-1 PTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPG---APAAATASF
MSMEG_0619|M.smegmatis_MC2_155 AAPRTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVA---APAPAAATF
TH_3569|M.thermoresistible__bu AAP-------------------VRAEPQNPLPLTXXX-------------
MAB_4783|M.abscessus_ATCC_1997 PARIDQPHAVAMGGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEG
MAV_4273|M.avium_104 ---MTPMRPGGNGTRRRNGRDYDDIEYGAELPGTVMQRPPSAG-------
MMAR_1235|M.marinum_M --LMPPPISAGSGWRKRKQQKYEDLEYGLELKGTFMPRPPSAG-------
Mb1731c|M.bovis_AF2122/97 ---MPLAGSGTGTG-GAGPR--------YGFRVTVMSRPPFAG-------
Rv1705c|M.tuberculosis_H37Rv ---MPLAGSGTGTG-GAGPR--------YGFRVTVMSRPPFAG-------
MUL_3087|M.ulcerans_Agy99 ---MPVGATGAGRGVGSGPR--------YGFKPTVMARPLPAG-------
MLBr_01182|M.leprae_Br4923 MAPMVPGGGSGTGGVNTALR--------LQPRAFVMPRNPAAG-------
Mflv_0325|M.gilvum_PYR-GCK VPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRR
Mvan_0415|M.vanbaalenii_PYR-1 VPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRR
MSMEG_0619|M.smegmatis_MC2_155 VPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 LGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRR
MAV_4273|M.avium_104 --------------------------------------------------
MMAR_1235|M.marinum_M --------------------------------------------------
Mb1731c|M.bovis_AF2122/97 --------------------------------------------------
Rv1705c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3087|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK RQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTV
Mvan_0415|M.vanbaalenii_PYR-1 RQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTV
MSMEG_0619|M.smegmatis_MC2_155 KKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTV
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 RRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVH
MAV_4273|M.avium_104 --------------------------------------------------
MMAR_1235|M.marinum_M --------------------------------------------------
Mb1731c|M.bovis_AF2122/97 --------------------------------------------------
Rv1705c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3087|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK SRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDG
Mvan_0415|M.vanbaalenii_PYR-1 SRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNH
MSMEG_0619|M.smegmatis_MC2_155 TRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDD
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 TATTAVEATGLSTLDGDAEN--RTIPMLPGTWDVTDDDR-----------
MAV_4273|M.avium_104 -------
MMAR_1235|M.marinum_M -------
Mb1731c|M.bovis_AF2122/97 -------
Rv1705c|M.tuberculosis_H37Rv -------
MUL_3087|M.ulcerans_Agy99 -------
MLBr_01182|M.leprae_Br4923 -------
Mflv_0325|M.gilvum_PYR-GCK HDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 HDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 PEGGPRR
TH_3569|M.thermoresistible__bu -------
MAB_4783|M.abscessus_ATCC_1997 -------