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ILDFSWLPPEINSARIYAGAGSGPLFMAAAAWEGLAADLRASASSFDAVIAGLAAGPWSGPASVAMAGAA APYVGWLSAAAGQAELSAGQATAAATAFEAALAATVHPAAVTANRVLLGALVATNILGQNTPAIAATEFD YVEMWAQDVGAMVGYHAGAAAVAETLTPFSVPPLDLAGLASQAGAQLTGMATSVSAALSPIAEGAVEGVP AVVAAAQSVAAGLPVDAALQVGQAAAYPASMLIGPMMQLAQMGTTANTAGLAGAEAAGLAAADVPTFAGD IASGTGLGGAGGLGAGMSAELGKARLVGAMSVPPTWEGSVPARMASSAMAGLGAMPAEVPAAGGPMGMMP MPMGMGGAGAGMPAGMMGRGGANPHVVQARPSVVPRVGIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2352c | PPE38 | - | 100% (391) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3125c | PPE49 | e-132 | 61.96% (397) | PPE family protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 2e-72 | 44.39% (401) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3148c | PPE49 | 1e-131 | 61.71% (397) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 5e-32 | 30.77% (416) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-44 | 32.03% (434) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 2e-30 | 30.50% (400) | PPE family protein |
| M. marinum M | MMAR_3661 | - | 1e-164 | 73.15% (391) | PPE family protein |
| M. avium 104 | MAV_2906 | - | 5e-66 | 40.40% (396) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 1e-37 | 32.86% (423) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 2e-38 | 31.70% (429) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3074 | - | 5e-64 | 42.05% (390) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 7e-33 | 30.15% (408) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2352c|M.tuberculosis_H37Rv -------MILDFSWLPPEINSARIYAGAGSGPLFMAAAAWEGLAADLRAS
MMAR_3661|M.marinum_M -------MILDFAWLPPEINSARIFSGAGSGPLHMAAAAWQGLAADLAAS
Mb3148c|M.bovis_AF2122/97 -------MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAVDLWAS
MAV_2906|M.avium_104 ---------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAELYSF
MUL_3074|M.ulcerans_Agy99 -----MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAELRVT
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MAB_0809c|M.abscessus_ATCC_199 -----MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAHYSAT
: .** :: : *.*. *: **: * :.
Rv2352c|M.tuberculosis_H37Rv ASSFDAVIAGLAAGPWSGPASVAMAGAAAPYVGWLSAAAGQAELSAGQAT
MMAR_3661|M.marinum_M AASFNSVISSLASGPWSGPASVSMAAAAAPYVGWLDAAAGQAAAAASQAR
Mb3148c|M.bovis_AF2122/97 ASSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQAR
MAV_2906|M.avium_104 AAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVATQAR
MUL_3074|M.ulcerans_Agy99 VLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESAVQAA
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQ-NWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLSQ-MWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALTNLTS-VWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
TH_4447|M.thermoresistible__bu ADELAGSLAALAG-AWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MAB_0809c|M.abscessus_ATCC_199 AQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARAVQHG
. . : : * :: * * : .: : *
Rv2352c|M.tuberculosis_H37Rv AAATAFEAALAATVHPAAVTANRVLLGALVATNILGQNTPAIAATEFDY-
MMAR_3661|M.marinum_M VAATAFETALSATVHPAAVTANRTSLVSLITTNFLGQNTPAIAATEFDY-
Mb3148c|M.bovis_AF2122/97 AAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDY-
MAV_2906|M.avium_104 LAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAEAEY-
MUL_3074|M.ulcerans_Agy99 AAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPTIAAVEAQY-
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEY-
MAB_0809c|M.abscessus_ATCC_199 AAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATEADY-
* :: * : : *: * :*.:* * .* * :*
Rv2352c|M.tuberculosis_H37Rv VEMWAQDVGAMVGYHAGAAA-----VAETLTP------------------
MMAR_3661|M.marinum_M VEMWAQDVGAMVGYDAGATS-----VAAALTP------------------
Mb3148c|M.bovis_AF2122/97 LEMWAQDVAAMVGYHAGAKS-----VAATLAP------------------
MAV_2906|M.avium_104 AEMWAQDAAAMYAY-AAASA-----AAAELTP------------------
MUL_3074|M.ulcerans_Agy99 CEMWAQDAMAMYGY-AGSSA-----AATRLSE------------------
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNTTFEPVAPPKP------------------
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILNSTFEPVAPPKP------------------
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNLLFEPIMPMKP------------------
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMNILFEPIMPMKP------------------
MLBr_01182|M.leprae_Br4923 TEMWIQDAAAMTSYQASVLE-----AVGATKA------------------
MAB_0809c|M.abscessus_ATCC_199 VRMWVQAATTMATYQTASEVALASAPPSTPPPSILHDHDHGHDDHDHEHG
.** * . .* * :
Rv2352c|M.tuberculosis_H37Rv ------------------------------------FSVPPLDLAGLASQ
MMAR_3661|M.marinum_M ------------------------------------FSIPPLDLAGLAAG
Mb3148c|M.bovis_AF2122/97 ------------------------------------FSLPPVSLAGLAAQ
MAV_2906|M.avium_104 ------------------------------------FTEPPRTTE--SSA
MUL_3074|M.ulcerans_Agy99 ------------------------------------FLAPQHNTN--PAG
Mflv_0768|M.gilvum_PYR-GCK ------------------------------------IAVPPGSEAAFAGA
Mvan_0077|M.vanbaalenii_PYR-1 ------------------------------------ITVFGSTQAAMATA
MSMEG_0064|M.smegmatis_MC2_155 ------------------------------------IVLPGVGETTAAAA
TH_4447|M.thermoresistible__bu ------------------------------------IVIPGVGEAAVAGA
MLBr_01182|M.leprae_Br4923 ------------------------------------FTAPPLGVNEVGLA
MAB_0809c|M.abscessus_ATCC_199 HDDDHGHGDLDPTDPEWWVHVAGEMVEHFELLLNNLLTDPAALLTNLPMV
:
Rv2352c|M.tuberculosis_H37Rv AGAQLTGMATSVSAALSPIAEGAVEGVPAVVAAAQSVAAGLPVDAALQVG
MMAR_3661|M.marinum_M INAQVAGVATAMTAAISPAAEGAIAGLPGVVAGVQSAAAAVPLDSVMSVA
Mb3148c|M.bovis_AF2122/97 VGTQVAGMATTASAAVTPVVEGAMASVPTVMSGMQSLVSQLP----LQHA
MAV_2906|M.avium_104 AARQSAAVAQSAASDLPAQLSTLIDVTPTMLQGLATTPSAAAATP--AAS
MUL_3074|M.ulcerans_Agy99 LLAQQSTLAQ------------LMSAVPNVLQGLASSNTSASAPSGLLST
Mflv_0768|M.gilvum_PYR-GCK MSGAVPGAGEAVMRNAIISKVSSTAKLDTANQIAGRAEGTLRGVVDRAGS
Mvan_0077|M.vanbaalenii_PYR-1 IGSAAPGIASAAARNATFTKVSVVGKLDEVNQKAGHAEGLLQQAADSGRS
MSMEG_0064|M.smegmatis_MC2_155 LAQTAPRVAEGVMRNAVIEGVSAIATIESVGLAAGHAAAQANFAEQRGQG
TH_4447|M.thermoresistible__bu LGKAAAMAPAAAARDLVFAKVSAQATVESAALQAGRAVAQGNMAAQRAEG
MLBr_01182|M.leprae_Br4923 QEVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVD
MAB_0809c|M.abscessus_ATCC_199 LADVAFHAAQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSP
Rv2352c|M.tuberculosis_H37Rv QAA--------------AYPASMLIGPMMQLAQMGTTANTAGLAGAEAAG
MMAR_3661|M.marinum_M QIG--------------MYPASMLMGPLMQLG---SSANTAGLAGAQAAG
Mb3148c|M.bovis_AF2122/97 SML--------------FLPVRILTSPITTLAS--MARESATRLGPPAGG
MAV_2906|M.avium_104 IIE--------------AIYP-ITAALRPFFAAVTGAYSPIG--AIILPG
MUL_3074|M.ulcerans_Agy99 LLS--------------GNGQSWLATLWSEFGPNANIWNTIASTGFLLPS
Mflv_0768|M.gilvum_PYR-GCK HAEKSQG-----------LEQAPQQGMQMGMQMASQLGSTLGQMPQQMMQ
Mvan_0077|M.vanbaalenii_PYR-1 QAEQGQL-----------LQQAPQQGMQMGMQMASQLGSTLGQLPQQMMQ
MSMEG_0064|M.smegmatis_MC2_155 AAQKGEN---AGQEAGRESGKNMQQGMQMVMQMGSQA----AQAPAQLAS
TH_4447|M.thermoresistible__bu TVQKTENL--AHQSATRSEPQQLQQGVQMGMQMGSQLGSTLAQLPQQAGQ
MLBr_01182|M.leprae_Br4923 VATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSL
MAB_0809c|M.abscessus_ATCC_199 EILAVEPG------SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPT
Rv2352c|M.tuberculosis_H37Rv ---LAAADVPTFAG-DIASGTGLG--GAGGLGAGMS--------------
MMAR_3661|M.marinum_M ---LAAADMPKMVD-AISPMKGLG--GAG-LGAGMA--------------
Mb3148c|M.bovis_AF2122/97 ---LAAANTPNPSGAAIPAFKPLG--GRE-LGAGMS--------------
MAV_2906|M.avium_104 GWWLLSLQALGLAQNAPGVAELLG--GGKAIAGGLSPLAPLRGGYVSAVT
MUL_3074|M.ulcerans_Agy99 NMVTPFLGMLDTAAVADAAEDALRTTGSGALGGALS--APLG-----SVG
Mflv_0768|M.gilvum_PYR-GCK GVTQPFQQLTQPLQQMSSLFGGM--MNGDK-GAQIG--------MVGATP
Mvan_0077|M.vanbaalenii_PYR-1 GVTQPFQQLTQPLQQMSSLFGQMGGLGGDR-GAQIG--------MLGATP
MSMEG_0064|M.smegmatis_MC2_155 MFQSGVQTMTQPLQQATQMVSQFASMGGSERAMQVG--------LMGASP
TH_4447|M.thermoresistible__bu MISQPMQQLTAPLQQVSSVFGQMGGMGSGD-SAQIG--------LIGASP
MLBr_01182|M.leprae_Br4923 VNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRG----------LLGS
MAB_0809c|M.abscessus_ATCC_199 ASGTAPAPPSPPPVGDPGFSFPYAVGGGPRLGTGLALAAQVR----RGTS
. . .
Rv2352c|M.tuberculosis_H37Rv -------AELGKARLVGAMSVP--PTWEGSVPAR-MASSAMAGLGAMP--
MMAR_3661|M.marinum_M -------ADLGKARLVGAMSVP--PTWEGSIPKG-LSTSAMAGLGAMP--
Mb3148c|M.bovis_AF2122/97 -------AGLGQAQLVGSMSVP--PTWQGSIPIS-MASSAMSGLGVPPNP
MAV_2906|M.avium_104 PDAGGVAGSMGRSTLVGSLSVP--PGWTTAAPVLRTVASVLPAASSAT--
MUL_3074|M.ulcerans_Agy99 GQAG--LAAAGNAAIVGKLSVP--PSWTGAAPLASPLGSALGGTPMVA--
Mflv_0768|M.gilvum_PYR-GCK FSNHPAIGGTGPATGSGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPT-S
Mvan_0077|M.vanbaalenii_PYR-1 FSNHPAIGGSGAATGAGLVRAASLPGAGGTAARTPLMSNLVGSGLQPTVS
MSMEG_0064|M.smegmatis_MC2_155 FSNHPMLGGSGPSTGAGLVRAMSLPGAGGTAPRTPLLSNLLG-ISG-EMK
TH_4447|M.thermoresistible__bu FSNHPLAGGSGPATGAGLVRAASLPGLGGTSPTTSLISNLLG-HQNPTAA
MLBr_01182|M.leprae_Br4923 SSGGHVTAQLGRAASIGSLRVP--QTWTTASQPVTAATRALSPARVAVAT
MAB_0809c|M.abscessus_ATCC_199 AAARSSAREQAAAAETAAARQARRRRDKGKQQGRGIEYMDMNATARCEEP
. : . :
Rv2352c|M.tuberculosis_H37Rv ----AEVPAAGGPMGMMPMPMGMGGAGAGMPAGMMGRGGANPHVVQARPS
MMAR_3661|M.marinum_M ----EVAGAGGAPMGMMPMPMGMGGAGAGMPGGMLGRGGASPHVVQSRPS
Mb3148c|M.bovis_AF2122/97 VALTQAAGAAGGGMPMMLMPMSISGAGAGMPGGLMDRDGAGWHVTQARLT
MAV_2906|M.avium_104 ----AAAMPASG--GAVFGEMAAASLAGRALAGAGVRTVGNGTTGAATAA
MUL_3074|M.ulcerans_Agy99 ----PPPTAAAGMPGMPFGNMAGQPFG-RALPQYGFR-----PTFVARPP
Mflv_0768|M.gilvum_PYR-GCK PVAVGAGAGPGAGVGLAPVGTGGGMGAGGPMGMFGQRGKSGGNKPGLNAP
Mvan_0077|M.vanbaalenii_PYR-1 AVAVGAGAGAGAGAGLAPVGAGSGMGGGGPMGMLGQRGKSGGNKPGLNAP
MSMEG_0064|M.smegmatis_MC2_155 AAPAGAGSA-AAG-GLAPVGAGAGGGAGAPVAHAGQNSKSGGKKDGLVAP
TH_4447|M.thermoresistible__bu PAPTGAVAG-GAGTGPAPIG---GGGMGAPMAAMGQNQKSGGSKSGLKAP
MLBr_01182|M.leprae_Br4923 ----ESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPA
MAB_0809c|M.abscessus_ATCC_199 APDTTASHRGAGTMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPN
Rv2352c|M.tuberculosis_H37Rv VVPRVGIG---------
MMAR_3661|M.marinum_M VVPRIGVG---------
Mb3148c|M.bovis_AF2122/97 VIPRTGVG---------
MAV_2906|M.avium_104 AADGAATTATIIVVPAD
MUL_3074|M.ulcerans_Agy99 AAG--------------
Mflv_0768|M.gilvum_PYR-GCK APLDHDLGEDEDEEW--
Mvan_0077|M.vanbaalenii_PYR-1 APLEHDLSEDDDDDW--
MSMEG_0064|M.smegmatis_MC2_155 TPLTYDLSEDEDDEW--
TH_4447|M.thermoresistible__bu APLVQDLSEDEGDDW--
MLBr_01182|M.leprae_Br4923 AG---------------
MAB_0809c|M.abscessus_ATCC_199 TWDPEHGRQD-------
.