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VLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAADLWASASSFESVLAALTTGPWTGPASMSMAAAA SPYVGWLSTVASQAQLAAIQARAAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFD YLEMWAQDVAAMVGYHAGAKSVAATLAPFSLPPVSLAGLAAQVGTQVAGMATTASAAVTPVVEGAMASVP TVMSGMQSLVSQLPLQHASMLFLPVRILTSPITTLASMARESATRLGPPAGGLAAANTPNPSGAAIPAFK PLGGRELGAGMSAGLGQAQLVGSMSVPPTWQGSIPISMASSAMSGLGVPPNPVALTQAAGAAGGGMPMML MPMSISGAGAGMPGGLMDRDGAGWHVTQARLTVIPRTGVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3125c | PPE49 | - | 100% (391) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv2352c | PPE38 | e-132 | 61.96% (397) | PPE family protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 3e-68 | 42.23% (412) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3148c | PPE49 | 0.0 | 99.74% (391) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 6e-30 | 30.38% (418) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-44 | 34.32% (405) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 9e-30 | 40.83% (169) | PPE family protein |
| M. marinum M | MMAR_4324 | - | 1e-129 | 61.17% (394) | PPE family protein, PPE49 |
| M. avium 104 | MAV_2928 | - | 7e-65 | 40.91% (418) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 1e-33 | 31.71% (410) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 3e-34 | 30.50% (423) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3074 | - | 1e-64 | 42.45% (384) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-31 | 41.84% (196) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3125c|M.tuberculosis_H37Rv -------MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAADLWAS
Mb3148c|M.bovis_AF2122/97 -------MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAVDLWAS
MMAR_4324|M.marinum_M -------MMLDFAWLPPEINSTRIFSGAGSGPLFAAASAWEGLAQDLYAS
MAV_2928|M.avium_104 --------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAELGIA
MUL_3074|M.ulcerans_Agy99 -----MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAELRVT
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
MAB_0809c|M.abscessus_ATCC_199 -----MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAHYSAT
Mvan_0415|M.vanbaalenii_PYR-1 ------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAEYAAA
: .** :: : *.*. .:: **: * ..
Rv3125c|M.tuberculosis_H37Rv ASSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQAR
Mb3148c|M.bovis_AF2122/97 ASSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQAR
MMAR_4324|M.marinum_M ASSFDSVVSGLSSGSWSGPASVSMAAAAAPYVGWLSAAAGQAESAANQAR
MAV_2928|M.avium_104 ASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETASQGR
MUL_3074|M.ulcerans_Agy99 VLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESAVQAA
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALTNLTS-VWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
TH_4447|M.thermoresistible__bu ADELAGSLAALAG-AWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQ-NWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
MAB_0809c|M.abscessus_ATCC_199 AQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARAVQHG
Mvan_0415|M.vanbaalenii_PYR-1 AAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAAAQHE
. . : : * :: * *: : . : *
Rv3125c|M.tuberculosis_H37Rv AAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDY-
Mb3148c|M.bovis_AF2122/97 AAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDY-
MMAR_4324|M.marinum_M TAATAFEAALSATVHPAAVTANRMSLVSLVATNILGQNTPAIAANEFDY-
MAV_2928|M.avium_104 AAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATEAQY-
MUL_3074|M.ulcerans_Agy99 AAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPTIAAVEAQY-
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEY-
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
MAB_0809c|M.abscessus_ATCC_199 AAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATEADY-
Mvan_0415|M.vanbaalenii_PYR-1 AAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTEADY-
. * :: * : : *: * :*.:* * .* * :*
Rv3125c|M.tuberculosis_H37Rv LEMWAQDVAAMVGYHAGAKSVAATLAPFSLPP--VSLAG-----------
Mb3148c|M.bovis_AF2122/97 LEMWAQDVAAMVGYHAGAKSVAATLAPFSLPP--VSLAG-----------
MMAR_4324|M.marinum_M LEMWAQDVAAMVGYHGGASSVAAALVPFSLPP--VDLAG-----------
MAV_2928|M.avium_104 MEMWAQDAAAMYGYAA-ASQTASTLSPFAAPPNTTAPEG-----------
MUL_3074|M.ulcerans_Agy99 CEMWAQDAMAMYGYAG-SSAAATRLSEFLAPQHNTNPAG-----------
MLBr_01182|M.leprae_Br4923 TEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVG-----------
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPG-------------
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMNILFEPIMPMKPIVIPG-------------
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPP-------------
MAB_0809c|M.abscessus_ATCC_199 VRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD------------H
Mvan_0415|M.vanbaalenii_PYR-1 VRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAADVT
.** * . .* *
Rv3125c|M.tuberculosis_H37Rv ------------------------------------LAAQVGTQVAGMAT
Mb3148c|M.bovis_AF2122/97 ------------------------------------LAAQVGTQVAGMAT
MMAR_4324|M.marinum_M ------------------------------------LASQIGTQAFGMVT
MAV_2928|M.avium_104 ------------------------------------ESDQAAAVSQAMAQ
MUL_3074|M.ulcerans_Agy99 ------------------------------------LLAQQSTLAQLMS-
MLBr_01182|M.leprae_Br4923 ------------------------------------LAQEVVEEVVEEVV
MSMEG_0064|M.smegmatis_MC2_155 ------------------------------------VGETTAAAALAQTA
TH_4447|M.thermoresistible__bu ------------------------------------VGEAAVAGALGKAA
Mflv_0768|M.gilvum_PYR-GCK ------------------------------------GSEAAFAGAMSGAV
MAB_0809c|M.abscessus_ATCC_199 DHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAGEMVEHF
Mvan_0415|M.vanbaalenii_PYR-1 AFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPLGNT
Rv3125c|M.tuberculosis_H37Rv TASA------------AVTPVVEG--------AMASVPTVMSGMQSLVSQ
Mb3148c|M.bovis_AF2122/97 TASA------------AVTPVVEG--------AMASVPTVMSGMQSLVSQ
MMAR_4324|M.marinum_M SASS------------ALATPVQS--------VMAAVPTALTTLQS----
MAV_2928|M.avium_104 PAGSTAQTAANTSSQLATPQALSAGTSQAATQASSSSASQTGPFTWLTSA
MUL_3074|M.ulcerans_Agy99 ----------------AVPNVLQG--------LASSNTSASAPSGLLSTL
MLBr_01182|M.leprae_Br4923 EEVVEAEQAIS---QAALDQAVNEG--MEATVVPQVDQQVNVDVATPQTA
MSMEG_0064|M.smegmatis_MC2_155 PRVAEGVMRNAVIEGVSAIATIESVGLAAGHAAAQANFAEQRGQGAAQKG
TH_4447|M.thermoresistible__bu AMAPAAAARDLVFAKVSAQATVESAALQAGRAVAQGNMAAQRAEGTVQKT
Mflv_0768|M.gilvum_PYR-GCK PGAGEAVMRNAIISKVSSTAKLDTANQIAGRAEGTLRGVVDRAGSHAEKS
MAB_0809c|M.abscessus_ATCC_199 ELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIGQFAPALIQPALAL
Mvan_0415|M.vanbaalenii_PYR-1 IKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVAT
:
Rv3125c|M.tuberculosis_H37Rv LPLQHASMLFLPVRILT--SPITTLASMARESATR--LGPPAGGLAAANT
Mb3148c|M.bovis_AF2122/97 LPLQHASMLFLPVRILT--SPITTLASMARESATR--LGPPAGGLAAANT
MMAR_4324|M.marinum_M LPLQDASMLMYPFSMAM--SPLMNLMSSSLRGSTAGVAGATAAGIPAS-A
MAV_2928|M.avium_104 LQNLQQSGLPTPTNNYLGLSPTFYTVMLKQTSGLGYFSNGITAFWSQLAQ
MUL_3074|M.ulcerans_Agy99 LSGNGQSWLATLWSEFG---PNANIWNTIASTGFLLPSNMVTPFLGMLDT
MLBr_01182|M.leprae_Br4923 VPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSA
MSMEG_0064|M.smegmatis_MC2_155 EN-AGQEAGRESGKNMQQGMQMVMQMGSQA----AQAPAQLASMFQSGVQ
TH_4447|M.thermoresistible__bu ENLAHQSATRSEPQQLQQGVQMGMQMGSQLGSTLAQLPQQAGQMISQPMQ
Mflv_0768|M.gilvum_PYR-GCK QG---------LEQAPQQGMQMGMQMASQLGSTLGQMPQQMMQGVTQPFQ
MAB_0809c|M.abscessus_ATCC_199 AIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMAASAGTALAPSPPA
Mvan_0415|M.vanbaalenii_PYR-1 TLAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQ-----PSPAI
Rv3125c|M.tuberculosis_H37Rv PNPSGAAIPAFKPLGGRELGAGMSAG-LGQAQLVG-SMSVPPTWQGSIPI
Mb3148c|M.bovis_AF2122/97 PNPSGAAIPAFKPLGGRELGAGMSAG-LGQAQLVG-SMSVPPTWQGSIPI
MMAR_4324|M.marinum_M AKLVDAPVSGVKAMGGAGLGSSISAG-LGKARMVG-AVSVPPTWEGSMPT
MAV_2928|M.avium_104 QLVSGPGGSTAGAGGAWYPTPQFASLGLGNLGSVGGASHVSAISAGAGRA
MUL_3074|M.ulcerans_Agy99 AAVADAAEDALRTTGSGALGGALSAP----LGSVGGQAGLAAAGN-AAIV
MLBr_01182|M.leprae_Br4923 MKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSS-GGHVTAQLGRAASI
MSMEG_0064|M.smegmatis_MC2_155 TMTQPLQQATQMVSQFASMGGSERAMQVGLMGASPFSNHPMLGGSGPSTG
TH_4447|M.thermoresistible__bu QLTAPLQQVSSVFGQMGGMGSGD-SAQIGLIGASPFSNHPLAGGSGPATG
Mflv_0768|M.gilvum_PYR-GCK QLTQPLQQMSSLFG---GMMNGDKGAQIGMVGATPFSNHPAIGGTGPATG
MAB_0809c|M.abscessus_ATCC_199 SAAAPAAPASAPAPT---ASGTAPAPPSPPPVGDPGFSFPYAVGGGPRLG
Mvan_0415|M.vanbaalenii_PYR-1 AVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGR---D
.
Rv3125c|M.tuberculosis_H37Rv SMASSAMSGLGVP---PNPVALTQAAGAAGGGMPMMLMPMSI-SGAGAGM
Mb3148c|M.bovis_AF2122/97 SMASSAMSGLGVP---PNPVALTQAAGAAGGGMPMMLMPMSI-SGAGAGM
MMAR_4324|M.marinum_M RMASSAMSGLGAA---GVANEAEMAAAGRPAGMPMMPMPMGAGAGAGGGM
MAV_2928|M.avium_104 GALSVPQQWATLT---SAVSPAVSEEGSAVQAAAGG-APGGAANGLLRGM
MUL_3074|M.ulcerans_Agy99 GKLSVPPSWTGAA---PLASPLGSALGGTPMVAP---PPTAAAG--MPGM
MLBr_01182|M.leprae_Br4923 GSLRVPQTWTTAS---QPVTAATRALSPARVAVATESESAPLLGGGLPMA
MSMEG_0064|M.smegmatis_MC2_155 AGLVRAMSLPGAGGTAPRTPLLSNLLGISG-EMKAAPAGAGSA-AAG-GL
TH_4447|M.thermoresistible__bu AGLVRAASLPGLGGTSPTTSLISNLLGHQNPTAAPAPTGAVAG-GAGTGP
Mflv_0768|M.gilvum_PYR-GCK SGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPTSPVAVGAGAGPGAGVGL
MAB_0809c|M.abscessus_ATCC_199 TGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRGI
Mvan_0415|M.vanbaalenii_PYR-1 PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGR
. .
Rv3125c|M.tuberculosis_H37Rv PGGLM-------------------------DRDGAG-WHVT---QARLTV
Mb3148c|M.bovis_AF2122/97 PGGLM-------------------------DRDGAG-WHVT---QARLTV
MMAR_4324|M.marinum_M PGGML-------------------------GRGGAS-PNPI---QSRPSV
MAV_2928|M.avium_104 PVGAL-------------------------GRRGAA-AGYVNKYGFRYSV
MUL_3074|M.ulcerans_Agy99 PFGNM-------------------------AGQPFG-RALP-QYGFRPTF
MLBr_01182|M.leprae_Br4923 PMVPG-------------------------GGSGTGGVNTALRLQPRAFV
MSMEG_0064|M.smegmatis_MC2_155 APVGA--------------------GAGGGAGAPVAHAGQNSKSGGKKDG
TH_4447|M.thermoresistible__bu APIG-----------------------GGGMGAPMAAMGQNQKSGGSKSG
Mflv_0768|M.gilvum_PYR-GCK APVGT--------------------GGGMGAGGPMGMFGQRGKSGGNKPG
MAB_0809c|M.abscessus_ATCC_199 EYMDMNATAR---CEEP----APDTTASHRGAGTMGFAGTVIKTGATASG
Mvan_0415|M.vanbaalenii_PYR-1 AYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGG
.
Rv3125c|M.tuberculosis_H37Rv IPRTGVG-----------------------------------
Mb3148c|M.bovis_AF2122/97 IPRTGVG-----------------------------------
MMAR_4324|M.marinum_M VPRTGIG-----------------------------------
MAV_2928|M.avium_104 LTRPPSAG----------------------------------
MUL_3074|M.ulcerans_Agy99 VARPPAAG----------------------------------
MLBr_01182|M.leprae_Br4923 MPRNPAAG----------------------------------
MSMEG_0064|M.smegmatis_MC2_155 LVAPTPLTYDLSEDED----DEW-------------------
TH_4447|M.thermoresistible__bu LKAPAPLVQDLSEDEG----DDW-------------------
Mflv_0768|M.gilvum_PYR-GCK LNAPAPLDHDLGEDED----EEW-------------------
MAB_0809c|M.abscessus_ATCC_199 LAMLSRDDDLFEGVRAPMVPNTWDP------EHGRQD-----
Mvan_0415|M.vanbaalenii_PYR-1 LTTLP-GDPFGGGPKAPMLPGTWDPDTEPDERHNHHDGKDSQ
: