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MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAVDLWASASSFESVLAALTTGPWTGPASMSMAAA ASPYVGWLSTVASQAQLAAIQARAAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEF DYLEMWAQDVAAMVGYHAGAKSVAATLAPFSLPPVSLAGLAAQVGTQVAGMATTASAAVTPVVEGAMASV PTVMSGMQSLVSQLPLQHASMLFLPVRILTSPITTLASMARESATRLGPPAGGLAAANTPNPSGAAIPAF KPLGGRELGAGMSAGLGQAQLVGSMSVPPTWQGSIPISMASSAMSGLGVPPNPVALTQAAGAAGGGMPMM LMPMSISGAGAGMPGGLMDRDGAGWHVTQARLTVIPRTGVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3148c | PPE49 | - | 100% (391) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 4e-68 | 42.23% (412) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1817 | PPE26 | 5e-66 | 41.65% (389) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0768 | - | 2e-30 | 30.38% (418) | PPE protein |
| M. tuberculosis H37Rv | Rv3125c | PPE49 | 0.0 | 99.74% (391) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-44 | 34.32% (405) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 3e-29 | 40.24% (169) | PPE family protein |
| M. marinum M | MMAR_4324 | - | 1e-129 | 61.17% (394) | PPE family protein, PPE49 |
| M. avium 104 | MAV_2928 | - | 2e-64 | 40.67% (418) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 4e-34 | 31.95% (410) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 1e-34 | 30.50% (423) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3074 | - | 4e-64 | 42.19% (384) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 7e-32 | 31.54% (409) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
Mb3148c|M.bovis_AF2122/97 -------MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAVDLWAS
Rv3125c|M.tuberculosis_H37Rv -------MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAADLWAS
MMAR_4324|M.marinum_M -------MMLDFAWLPPEINSTRIFSGAGSGPLFAAASAWEGLAQDLYAS
MAV_2928|M.avium_104 --------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAELGIA
MUL_3074|M.ulcerans_Agy99 -----MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAELRVT
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MAB_0809c|M.abscessus_ATCC_199 -----MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAHYSAT
: .** :: : *.*. *:: **: * ..
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQ-NWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLSQ-MWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALTNLTS-VWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
TH_4447|M.thermoresistible__bu ADELAGSLAALAG-AWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
Mb3148c|M.bovis_AF2122/97 ASSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQAR
Rv3125c|M.tuberculosis_H37Rv ASSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQAR
MMAR_4324|M.marinum_M ASSFDSVVSGLSSGSWSGPASVSMAAAAAPYVGWLSAAAGQAESAANQAR
MAV_2928|M.avium_104 ASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETASQGR
MUL_3074|M.ulcerans_Agy99 VLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESAVQAA
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MAB_0809c|M.abscessus_ATCC_199 AQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARAVQHG
. . : : * :: * *: : .:. : *
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
Mb3148c|M.bovis_AF2122/97 AAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDY-
Rv3125c|M.tuberculosis_H37Rv AAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDY-
MMAR_4324|M.marinum_M TAATAFEAALSATVHPAAVTANRMSLVSLVATNILGQNTPAIAANEFDY-
MAV_2928|M.avium_104 AAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATEAQY-
MUL_3074|M.ulcerans_Agy99 AAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPTIAAVEAQY-
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEY-
MAB_0809c|M.abscessus_ATCC_199 AAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATEADY-
. * :: * : : *: * :*.:* * .* * :*
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGSE----------
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILNSTFEPVAPPKPITVFGSTQ----------
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPGVGE----------
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMNILFEPIMPMKPIVIPGVGE----------
Mb3148c|M.bovis_AF2122/97 LEMWAQDVAAMVGYHAGAKSVAATLAPFSLPP--VSLAGL----------
Rv3125c|M.tuberculosis_H37Rv LEMWAQDVAAMVGYHAGAKSVAATLAPFSLPP--VSLAGL----------
MMAR_4324|M.marinum_M LEMWAQDVAAMVGYHGGASSVAAALVPFSLPP--VDLAGL----------
MAV_2928|M.avium_104 MEMWAQDAAAMYGYAA-ASQTASTLSPFAAPPNTTAPEGE----------
MUL_3074|M.ulcerans_Agy99 CEMWAQDAMAMYGYAG-SSAAATRLSEFLAPQHNTNPAGL----------
MLBr_01182|M.leprae_Br4923 TEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGL----------
MAB_0809c|M.abscessus_ATCC_199 VRMWVQAATTMATYQTASEVALASAPPSTPPPSILHDHDHGHDDHDHEHG
.** * . .* *
Mflv_0768|M.gilvum_PYR-GCK ------------------AAFAGAMSGAVPGAGEAVMRNAIISKVSSTAK
Mvan_0077|M.vanbaalenii_PYR-1 ------------------AAMATAIGSAAPGIASAAARNATFTKVSVVGK
MSMEG_0064|M.smegmatis_MC2_155 ------------------TTAAAALAQTAPRVAEGVMRNAVIEGVSAIAT
TH_4447|M.thermoresistible__bu ------------------AAVAGALGKAAAMAPAAAARDLVFAKVSAQAT
Mb3148c|M.bovis_AF2122/97 ------------------AAQVGTQVAGMATTASA-------------AV
Rv3125c|M.tuberculosis_H37Rv ------------------AAQVGTQVAGMATTASA-------------AV
MMAR_4324|M.marinum_M ------------------ASQIGTQAFGMVTSASS-------------AL
MAV_2928|M.avium_104 ------------------SDQAAAVSQAMAQPAGSTAQTAANTSS-QLAT
MUL_3074|M.ulcerans_Agy99 ------------------LAQQSTLAQLMS------------------AV
MLBr_01182|M.leprae_Br4923 ------------------AQEVVEEVVEEVVEEVVEAEQAIS----QAAL
MAB_0809c|M.abscessus_ATCC_199 HDDDHGHGDLDPTDPEWWVHVAGEMVEHFELLLNNLLTDPAALLTNLPMV
Mflv_0768|M.gilvum_PYR-GCK LDTANQIAGRAEGTLRGVVDRAGSHAEKSQG-------------------
Mvan_0077|M.vanbaalenii_PYR-1 LDEVNQKAGHAEGLLQQAADSGRSQAEQGQL-------------------
MSMEG_0064|M.smegmatis_MC2_155 IESVGLAAGHAAAQANFAEQRGQGAAQKGEN-----------AGQEAGRE
TH_4447|M.thermoresistible__bu VESAALQAGRAVAQGNMAAQRAEGTVQKTENL----------AHQSATRS
Mb3148c|M.bovis_AF2122/97 TPVVEG--------AMASVPTVMSGMQSLVS-------------------
Rv3125c|M.tuberculosis_H37Rv TPVVEG--------AMASVPTVMSGMQSLVS-------------------
MMAR_4324|M.marinum_M ATPVQS--------VMAAVPTALTTLQS----------------------
MAV_2928|M.avium_104 PQALSAGTSQAATQASSSSASQTGPFTWLTS-------------------
MUL_3074|M.ulcerans_Agy99 PNVLQG--------LASSNTSASAPSGLLST-------------------
MLBr_01182|M.leprae_Br4923 DQAVNEG--MEATVVPQVDQQVNVDVATPQT-------------------
MAB_0809c|M.abscessus_ATCC_199 LADVAFHAAQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSP
Mflv_0768|M.gilvum_PYR-GCK LEQAPQQGMQMGMQMASQLGSTLGQMPQQMMQGVTQPFQQLTQPLQQMSS
Mvan_0077|M.vanbaalenii_PYR-1 LQQAPQQGMQMGMQMASQLGSTLGQLPQQMMQGVTQPFQQLTQPLQQMSS
MSMEG_0064|M.smegmatis_MC2_155 SGKNMQQGMQMVMQMGSQA----AQAPAQLASMFQSGVQTMTQPLQQATQ
TH_4447|M.thermoresistible__bu EPQQLQQGVQMGMQMGSQLGSTLAQLPQQAGQMISQPMQQLTAPLQQVSS
Mb3148c|M.bovis_AF2122/97 ---QLPLQHASMLFLPVRILT--SPITTLASMARESATR--LGPPAGGLA
Rv3125c|M.tuberculosis_H37Rv ---QLPLQHASMLFLPVRILT--SPITTLASMARESATR--LGPPAGGLA
MMAR_4324|M.marinum_M ----LPLQDASMLMYPFSMAM--SPLMNLMSSSLRGSTAGVAGATAAGIP
MAV_2928|M.avium_104 ---ALQNLQQSGLPTPTNNYLGLSPTFYTVMLKQTSGLGYFSNGITAFWS
MUL_3074|M.ulcerans_Agy99 ---LLSGNGQSWLATLWSEFG---PNANIWNTIASTGFLLPSNMVTPFLG
MLBr_01182|M.leprae_Br4923 ---AVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNG
MAB_0809c|M.abscessus_ATCC_199 EILAVEPGSVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAP
Mflv_0768|M.gilvum_PYR-GCK LFGGM--MNGDK-GAQIGMVGATPFSNHPAIGGTGPATGSGLVRAASLPG
Mvan_0077|M.vanbaalenii_PYR-1 LFGQMGGLGGDR-GAQIGMLGATPFSNHPAIGGSGAATGAGLVRAASLPG
MSMEG_0064|M.smegmatis_MC2_155 MVSQFASMGGSERAMQVGLMGASPFSNHPMLGGSGPSTGAGLVRAMSLPG
TH_4447|M.thermoresistible__bu VFGQMGGMGSGD-SAQIGLIGASPFSNHPLAGGSGPATGAGLVRAASLPG
Mb3148c|M.bovis_AF2122/97 AANTPNPSGAAI--PAFKPLGGRELGAGMSAG-LGQAQLVG-SMSVPPTW
Rv3125c|M.tuberculosis_H37Rv AANTPNPSGAAI--PAFKPLGGRELGAGMSAG-LGQAQLVG-SMSVPPTW
MMAR_4324|M.marinum_M AS-AAKLVDAPV--SGVKAMGGAGLGSSISAG-LGKARMVG-AVSVPPTW
MAV_2928|M.avium_104 QLAQQLVSGPGG--STAGAGGAWYPTPQFASLGLGNLGSVGGASHVSAIS
MUL_3074|M.ulcerans_Agy99 MLDTAAVADAAE--DALRTTGSGALGGALSAP----LGSVGGQAGLAAAG
MLBr_01182|M.leprae_Br4923 MGSAMKSLAPTT--TKAAESAFKAMGSAVQSTGRGLLGSSS-GGHVTAQL
MAB_0809c|M.abscessus_ATCC_199 APPSPPPVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQ
. . .
Mflv_0768|M.gilvum_PYR-GCK AGGSAPQTPLMSNLVGSGLQPT-SPVAVGAGAGPGAGVGLAPVGTGGGMG
Mvan_0077|M.vanbaalenii_PYR-1 AGGTAARTPLMSNLVGSGLQPTVSAVAVGAGAGAGAGAGLAPVGAGSGMG
MSMEG_0064|M.smegmatis_MC2_155 AGGTAPRTPLLSNLLG-ISG-EMKAAPAGAGSA-AAG-GLAPVGAGAGGG
TH_4447|M.thermoresistible__bu LGGTSPTTSLISNLLG-HQNPTAAPAPTGAVAG-GAGTGPAPIG---GGG
Mb3148c|M.bovis_AF2122/97 QGSIPISMASSAMSGLGVPPNPVALTQAAGAAGGGMPMMLMPMSI-SGAG
Rv3125c|M.tuberculosis_H37Rv QGSIPISMASSAMSGLGVPPNPVALTQAAGAAGGGMPMMLMPMSI-SGAG
MMAR_4324|M.marinum_M EGSMPTRMASSAMSGLGAAGVANEAEMAAAGRPAGMPMMPMPMGAGAGAG
MAV_2928|M.avium_104 AGAGRAGALSVPQQWATLTSAVSPAVSEEGSAVQAAAGG-APGGAANGLL
MUL_3074|M.ulcerans_Agy99 N-AAIVGKLSVPPSWTGAAPLASPLGSALGGTPMVAP---PPTAAAG--M
MLBr_01182|M.leprae_Br4923 GRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGL
MAB_0809c|M.abscessus_ATCC_199 AAAAETAAARQARRRRDKGKQQGRGIEYMDMNATARCEEPAPDTTASHRG
. . .
Mflv_0768|M.gilvum_PYR-GCK AGGP--MGMFGQRGKSGGNKPGLNAPAPLDHDLGEDEDEEW---------
Mvan_0077|M.vanbaalenii_PYR-1 GGGP--MGMLGQRGKSGGNKPGLNAPAPLEHDLSEDDDDDW---------
MSMEG_0064|M.smegmatis_MC2_155 AGAP--VAHAGQNSKSGGKKDGLVAPTPLTYDLSEDEDDEW---------
TH_4447|M.thermoresistible__bu MGAP--MAAMGQNQKSGGSKSGLKAPAPLVQDLSEDEGDDW---------
Mb3148c|M.bovis_AF2122/97 AGMP--GGLMDRDGAG-WHVT---QARLTVIPRTGVG-------------
Rv3125c|M.tuberculosis_H37Rv AGMP--GGLMDRDGAG-WHVT---QARLTVIPRTGVG-------------
MMAR_4324|M.marinum_M GGMP--GGMLGRGGAS-PNPI---QSRPSVVPRTGIG-------------
MAV_2928|M.avium_104 RGMP--VGALGRRGAA-AGYVNKYGFRYSVLTRPPSAG------------
MUL_3074|M.ulcerans_Agy99 PGMP--FGNMAGQPFG-RALP-QYGFRPTFVARPPAAG------------
MLBr_01182|M.leprae_Br4923 PMAP--MVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG------------
MAB_0809c|M.abscessus_ATCC_199 AGTMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD