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LAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAHYSATAQELRAILAATHASAWHGPSAETYVA AHTPYLEWLNQGALESNARAVQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHDHDHGHDDHDHEHGHDDDHGHGDLDPTDPEW WVHVAGEMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIGQFAPALIQPALALAIANLGWA AGFAGLAGIQPSPEILAVEPGSVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSPPP VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRGIE YMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDPEHG RQD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0809c | - | - | 100% (494) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_2254c | - | 7e-86 | 41.04% (519) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 1e-82 | 41.49% (511) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0288 | PPE3 | 1e-106 | 44.82% (531) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-89 | 41.56% (527) | PPE protein |
| M. tuberculosis H37Rv | Rv0280 | PPE3 | 1e-106 | 44.82% (531) | PPE family protein |
| M. leprae Br4923 | MLBr_00539 | PPE | 7e-76 | 38.15% (540) | PPE-family protein |
| M. marinum M | MMAR_0538 | - | 1e-110 | 45.32% (523) | PPE family protein, PPE3 |
| M. avium 104 | MAV_4349 | - | 1e-112 | 46.58% (526) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-82 | 39.96% (518) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-62 | 63.69% (179) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 1e-108 | 45.11% (521) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-93 | 43.74% (519) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0288|M.bovis_AF2122/97 ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
Rv0280|M.tuberculosis_H37Rv ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
MMAR_0538|M.marinum_M ----------MVAPVWFASPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MLBr_00539|M.leprae_Br4923 -----------MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAE
MAV_4349|M.avium_104 ----MTTVPAMTAPIWMASPPEVHSALLSSGPGPASVFAAAAAWSALGAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
*:: ****:*::*. *.* ..:: .. *.:.
Mb0288|M.bovis_AF2122/97 YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
Rv0280|M.tuberculosis_H37Rv YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
MMAR_0538|M.marinum_M YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MLBr_00539|M.leprae_Br4923 YRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDVA
MAV_4349|M.avium_104 YASAAEELSGLLASAQAGAWQGPSAASYVAAHGPYLAWLTRASAHSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
* .* *: .:* .: ..*.* : :*.: *:* ** : : *
Mb0288|M.bovis_AF2122/97 ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
Rv0280|M.tuberculosis_H37Rv ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
MMAR_0538|M.marinum_M AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MLBr_00539|M.leprae_Br4923 TQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNE
MAV_4349|M.avium_104 AQHETAGTAYTAALAAMPTLPELAANHAVHGALVATNFFGINTIPIAVNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
:: ... **::*: .*** **: *:. :..*:.***:*:***** .*
Mb0288|M.bovis_AF2122/97 ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAA-----EAADD
Rv0280|M.tuberculosis_H37Rv ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAA-----EAADD
MMAR_0538|M.marinum_M ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAA-----PAAA-
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAA-----PAAA-
MLBr_00539|M.leprae_Br4923 EEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDVEKD
MAV_4349|M.avium_104 ADYARMWVQAAGTMATYQAVSTAAVAAVPQPDPAPSILRS-TAAHDHDDH
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD--------HD
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLP----------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAP----------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKP----------
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAP----------
:*.:** :** :*:**.: : *: :.* . *.* :*
Mb0288|M.bovis_AF2122/97 DHDHDHDHG-GEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIPFEDYT
Rv0280|M.tuberculosis_H37Rv DHDHDHDHG-GEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIPFEDYT
MMAR_0538|M.marinum_M -HDHDHDHG-GDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPYDDYV
MUL_1202|M.ulcerans_Agy99 -HDHDHDHG-GDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPYDDYV
MLBr_00539|M.leprae_Br4923 SRHDGHSHG-GHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYV
MAV_4349|M.avium_104 EHGDDHDHDHGFDSPLNQFVAQILRLFG---IDWDPVEGTLNGLPYEAYT
MAB_0809c|M.abscessus_ATCC_199 HGHDDHDHEHGHDD--------------------DHGHGDLD--------
Mflv_0325|M.gilvum_PYR-GCK ----GVGEAGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLR
Mvan_0415|M.vanbaalenii_PYR-1 ----GVGEAGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLR
MSMEG_0619|M.smegmatis_MC2_155 ----GVGEAGSASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVP
TH_3569|M.thermoresistible__bu ----GVSEAADAMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLD
. .. . . :
Mb0288|M.bovis_AF2122/97 DAAQPIWWVVRAIEFSKDFETFVQELFVNPVEAFQFYFELLLFDYPTHIV
Rv0280|M.tuberculosis_H37Rv DAAQPIWWVVRAIEFSKDFETFVQELFVNPVEAFQFYFELLLFDYPTHIV
MMAR_0538|M.marinum_M NAAQPIWWLVRALEFGQDFQTFIKELFTNPIGAIEFMVELVLFDWPTHIA
MUL_1202|M.ulcerans_Agy99 NAAQPIWWLVRALEFGQDFQTFIKELFTNPIGAIEFMVELVLFDWPTHIA
MLBr_00539|M.leprae_Br4923 YPGQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTHIV
MAV_4349|M.avium_104 SPADPLWWVVRALELFSDFQQFGALLQENPAAAFQFITELVLLDWPTHLA
MAB_0809c|M.abscessus_ATCC_199 -PTDPEWWVHVAGEMVEHFELLLNNLLTDP-AALLTNLPMVLADVAFHAA
Mflv_0325|M.gilvum_PYR-GCK FLFEPIFNFLR--DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVS
Mvan_0415|M.vanbaalenii_PYR-1 FLFEPIFDFLR--DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVS
MSMEG_0619|M.smegmatis_MC2_155 GGQ-AILDFLK--DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFF
TH_3569|M.thermoresistible__bu QLFGPIVDFLR--DPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFT
. . : . : : :* *: ::
Mb0288|M.bovis_AF2122/97 QIVEALSQS-PQLLAVALGSVISNLGAVTGFAGLS-GLAGMQPAAIPAL-
Rv0280|M.tuberculosis_H37Rv QIVEALSQS-PQLLAVALGSVISNLGAVTGFAGLS-GLAGMQPAAIPAL-
MMAR_0538|M.marinum_M QIIQALAQS-PQLLAVALGGVVANLGAISGLAGLS-GLAGLHSAALPA--
MUL_1202|M.ulcerans_Agy99 QIIQALAQS-PQLLAVALGGVVANLGAISGLAGLS-GLAGLHSAALPA--
MLBr_00539|M.leprae_Br4923 QLGTWLAEY-PQLLLVALGGTIANLGAVTGLAGLSSGLSAGPSAAIPTVV
MAV_4349|M.avium_104 QLASWLPTQ-PQLLLVPALVAAAPFGALAGFAGVAGQPPLPAPVAEPAT-
MAB_0809c|M.abscessus_ATCC_199 QLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG-
Mflv_0325|M.gilvum_PYR-GCK WVGASILYP-SLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEP-
Mvan_0415|M.vanbaalenii_PYR-1 WVGASILYP-SLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEP-
MSMEG_0619|M.smegmatis_MC2_155 NLVGWPTWG-MIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDE-
TH_3569|M.thermoresistible__bu NLVGWPTWA-MILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEA-
: : . .
Mb0288|M.bovis_AF2122/97 ---APVAAAPPTLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASATPA
Rv0280|M.tuberculosis_H37Rv ---APVAAAPSTLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASATPA
MMAR_0538|M.marinum_M ---AIAPIAPPMPPGVALAPTVATSVAAPTPPSAPPSA--TSTVANAAPP
MUL_1202|M.ulcerans_Agy99 ---AIAPIAPPMPPGVALAPTVAASVAAPTPPSAPPSA--ASTVANAAPP
MLBr_00539|M.leprae_Br4923 PESAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASA---ASAAAAAPA
MAV_4349|M.avium_104 ----PSAAAPTGLPATAGATPIAASAAASVPAPTPAPT--AATVSSPAPP
MAB_0809c|M.abscessus_ATCC_199 ---SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAP--TASGTAPAPP
Mflv_0325|M.gilvum_PYR-GCK ---APAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTV----SAGSPPAP
Mvan_0415|M.vanbaalenii_PYR-1 ---AASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTV----ATGTAPAP
MSMEG_0619|M.smegmatis_MC2_155 ---APQEVAAAPRTDQPLAVGISPAGVPGSAATAAAPA----PAPAGTTV
TH_3569|M.thermoresistible__bu ---APEEDVAAP-------------------VRAEPQN----PLPLTXXX
. . .
Mb0288|M.bovis_AF2122/97 PPPAPGAAGFGYPYAIAP-PGIGFGSGMSAS--ASAQRKAPQPDSAAAAA
Rv0280|M.tuberculosis_H37Rv PPPAPGAAGFGYPYAIAP-PGIGFGSGMSAS--ASAQRKAPQPDSAAAAA
MMAR_0538|M.marinum_M PPPAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARRKAPEPD-SAALA
MUL_1202|M.ulcerans_Agy99 PPPAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARRKAPEPD-SAALA
MLBr_00539|M.leprae_Br4923 PP-GTGFGGFSPYLVDGRGPGVGFGSGRQSAY-ANKVSESVSDSAVAEAA
MAV_4349|M.avium_104 APPAPGAAPFAPPYAVPP-PGVGFGSKARASVDTRAKSKSPQPD-SNAVG
MAB_0809c|M.abscessus_ATCC_199 SPPPVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAA
Mflv_0325|M.gilvum_PYR-GCK GAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAA
Mvan_0415|M.vanbaalenii_PYR-1 GAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAA
MSMEG_0619|M.smegmatis_MC2_155 AAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAA
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mb0288|M.bovis_AF2122/97 AAAAVRDQARARRRR-RVTRRGYGDEFMDMNIDVDPDWGPPPGEDPVTST
Rv0280|M.tuberculosis_H37Rv AAAAVRDQARARRRR-RVTRRGYGDEFMDMNIDVDPDWGPPPGEDPVTST
MMAR_0538|M.marinum_M AAAAAREEARRRRRK-RKTERGYGEEFMDV--EVDPDWGGPRDDEP----
MUL_1202|M.ulcerans_Agy99 AAAAVREEARRRRRK-RKTERGYGEEFMDV--EVDPDWGGPLDDEP----
MLBr_00539|M.leprae_Br4923 AQASAREQARAWRRRSAAKERGYREEVITMNTGFDAAIPSPVDQTG---S
MAV_4349|M.avium_104 AGSAVREAAHARRRQ---RSRRRGEEFMDMNVGVDPDWDEPA-------T
MAB_0809c|M.abscessus_ATCC_199 AETAAARQARRRRDK--GKQQGRGIEYMDMNATARCEEPAPD-------T
Mflv_0325|M.gilvum_PYR-GCK SAAERRKRRRRQKEE--IKGRGYADAYADYEELPDDGPPEQPAPR----V
Mvan_0415|M.vanbaalenii_PYR-1 SAAERRKRRRRQKDE--IAGRAYADAYADYEPEPDDEPPVRQEPR----I
MSMEG_0619|M.smegmatis_MC2_155 SLASRRKRRRKKGAQ--IEERGYADAYMDYEE-PDEDPAPQPEPR----V
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mb0288|M.bovis_AF2122/97 VASDRGAGHLGFAGTARREAVADAAGMTTLAG-DDFGDGPTTPMVPGSWD
Rv0280|M.tuberculosis_H37Rv VASDRGAGHLGFAGTARREAVADAAGMTTLAG-DDFGDGPTTPMVPGSWD
MMAR_0538|M.marinum_M VASTQGAGRLGFAGTVHSESAATAAGLTTLVA-DEFGGGPKMPMLPGTWD
MUL_1202|M.ulcerans_Agy99 VASTQGAGRLGFAGTVHSESAATAAGLTTLVA-DEFGGGPKMPMLPGTWD
MLBr_00539|M.leprae_Br4923 RVSDCGAGSFGFAGTVSKEAVVEVAGLTTLAG-DDFGGGPTMPMVPGTWA
MAV_4349|M.avium_104 TASPRGAGNLGFAGTAPRETVA-AAGMTQLAG-DEFGGGAGMPLLPGSWA
MAB_0809c|M.abscessus_ATCC_199 TASHRGAGTMGFAGTVIKTGAT-ASGLAMLSRDDDLFEGVRAPMVPNTWD
Mflv_0325|M.gilvum_PYR-GCK TASTRGAGPMGFAGTVSRGDEQ-AGGLTTLAG-DSFGGGPREPMLPGTWD
Mvan_0415|M.vanbaalenii_PYR-1 AATERGAGPMGFAGTVSRDAAQ-AGGLTTLPG-DPFGGGPKAPMLPGTWD
MSMEG_0619|M.smegmatis_MC2_155 RASERGSDAMGFTGTVTRHDVT-AAGLTTLTG-DTFDDRPVTPMLPGTWD
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mb0288|M.bovis_AF2122/97 PDRDAPGSAEPGDRG---------
Rv0280|M.tuberculosis_H37Rv PDRDAPGSAEPGDRG---------
MMAR_0538|M.marinum_M TDSDAPSD----------------
MUL_1202|M.ulcerans_Agy99 TDSDAPSD----------------
MLBr_00539|M.leprae_Br4923 PARESSDEGR--------------
MAV_4349|M.avium_104 PP-DPRDSGV--------------
MAB_0809c|M.abscessus_ATCC_199 PEHGRQD-----------------
Mflv_0325|M.gilvum_PYR-GCK PDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 PDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 GDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ------------------------