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ILDFAWLPPEINSARIFSGAGSGPLHMAAAAWQGLAADLAASAASFNSVISSLASGPWSGPASVSMAAAA APYVGWLDAAAGQAAAAASQARVAATAFETALSATVHPAAVTANRTSLVSLITTNFLGQNTPAIAATEFD YVEMWAQDVGAMVGYDAGATSVAAALTPFSIPPLDLAGLAAGINAQVAGVATAMTAAISPAAEGAIAGLP GVVAGVQSAAAAVPLDSVMSVAQIGMYPASMLMGPLMQLGSSANTAGLAGAQAAGLAAADMPKMVDAISP MKGLGGAGLGAGMAADLGKARLVGAMSVPPTWEGSIPKGLSTSAMAGLGAMPEVAGAGGAPMGMMPMPMG MGGAGAGMPGGMLGRGGASPHVVQSRPSVVPRIGVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3661 | - | - | 100% (387) | PPE family protein |
| M. marinum M | MMAR_3664 | - | 0.0 | 95.88% (388) | PPE family protein |
| M. marinum M | MMAR_4324 | - | e-137 | 65.83% (398) | PPE family protein, PPE49 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3148c | PPE49 | 1e-129 | 60.76% (395) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 1e-31 | 30.46% (417) | PPE protein |
| M. tuberculosis H37Rv | Rv2352c | PPE38 | 1e-164 | 73.15% (391) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-41 | 30.82% (425) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 5e-31 | 31.52% (368) | PPE family protein |
| M. avium 104 | MAV_2906 | - | 1e-63 | 39.90% (401) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-33 | 40.64% (219) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-37 | 30.99% (413) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3074 | - | 3e-62 | 41.12% (394) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-35 | 29.93% (401) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3661|M.marinum_M -------MILDFAWLPPEINSARIFSGAGSGPLHMAAAAWQGLAADLAAS
Rv2352c|M.tuberculosis_H37Rv -------MILDFSWLPPEINSARIYAGAGSGPLFMAAAAWEGLAADLRAS
Mb3148c|M.bovis_AF2122/97 -------MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAVDLWAS
MAV_2906|M.avium_104 ---------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAELYSF
MUL_3074|M.ulcerans_Agy99 -----MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAELRVT
MSMEG_0619|M.smegmatis_MC2_155 ------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAEYAAA
Mvan_0415|M.vanbaalenii_PYR-1 ------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAEYAAA
MAB_0809c|M.abscessus_ATCC_199 -----MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAHYSAT
TH_3113|M.thermoresistible__bu ------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDEYRAA
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
.** :: : *.*. .: ** * :.
MMAR_3661|M.marinum_M AASFNSVISSLASGPWSGPASVSMAAAAAPYVGWLDAAAGQAAAAASQAR
Rv2352c|M.tuberculosis_H37Rv ASSFDAVIAGLAAGPWSGPASVAMAGAAAPYVGWLSAAAGQAELSAGQAT
Mb3148c|M.bovis_AF2122/97 ASSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQAR
MAV_2906|M.avium_104 AAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVATQAR
MUL_3074|M.ulcerans_Agy99 VLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESAVQAA
MSMEG_0619|M.smegmatis_MC2_155 AAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAAVQHE
Mvan_0415|M.vanbaalenii_PYR-1 AAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAAAQHE
MAB_0809c|M.abscessus_ATCC_199 AQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARAVQHG
TH_3113|M.thermoresistible__bu AVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLE
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTATQLT
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQ-NWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
. : : : * .: * * : . . *
MMAR_3661|M.marinum_M VAATAFETALSATVHPAAVTANRTSLVSLITTNFLGQNTPAIAATEFDYV
Rv2352c|M.tuberculosis_H37Rv AAATAFEAALAATVHPAAVTANRVLLGALVATNILGQNTPAIAATEFDYV
Mb3148c|M.bovis_AF2122/97 AAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDYL
MAV_2906|M.avium_104 LAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAEAEYA
MUL_3074|M.ulcerans_Agy99 AAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPTIAAVEAQYC
MSMEG_0619|M.smegmatis_MC2_155 TAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNEADYV
Mvan_0415|M.vanbaalenii_PYR-1 AAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTEADYV
MAB_0809c|M.abscessus_ATCC_199 AAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATEADYV
TH_3113|M.thermoresistible__bu AAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNEADYA
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYT
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADYI
* : * : : *: * :*.:* * .* * :*
MMAR_3661|M.marinum_M EMWAQDVGAMVGYDAGATSVAAALTPFSIPPLDLAGLAAGINAQVAGVAT
Rv2352c|M.tuberculosis_H37Rv EMWAQDVGAMVGYHAGAAAVAETLTPFSVPPLDLAGLASQAGAQLTGMAT
Mb3148c|M.bovis_AF2122/97 EMWAQDVAAMVGYHAGAKSVAATLAPFSLPPVSLAGLAAQVGTQVAGMAT
MAV_2906|M.avium_104 EMWAQDAAAMYAY-AAASAAAAELTPFTEPPRTTE--SSAAARQSAAVAQ
MUL_3074|M.ulcerans_Agy99 EMWAQDAMAMYGY-AGSSAAATRLSEFLAPQHNTN--PAGLLAQQSTLAQ
MSMEG_0619|M.smegmatis_MC2_155 RMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASASVQQ
Mvan_0415|M.vanbaalenii_PYR-1 RMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAADVTA
MAB_0809c|M.abscessus_ATCC_199 RMWVQAATTMATYQTASEVALASAPPSTPPPSILHD------------HD
TH_3113|M.thermoresistible__bu RMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAITGAH
MLBr_01182|M.leprae_Br4923 EMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEEVVEE
Mflv_0768|M.gilvum_PYR-GCK RMWNQAAAVMTAYETETVLNTTFEP--VAPPKPIAVPPGSEAAFAGAMSG
.** * . .* * : .
MMAR_3661|M.marinum_M AMTAAISPAAEGAIAGLPGVVAGVQSAAAAVPLDSVMSVAQIG-------
Rv2352c|M.tuberculosis_H37Rv SVSAALSPIAEGAVEGVPAVVAAAQSVAAGLPVDAALQVGQAA-------
Mb3148c|M.bovis_AF2122/97 TASAAVTPVVEGAMASVPTVMSGMQSLVSQLP----LQHASML-------
MAV_2906|M.avium_104 SAASDLPAQLSTLIDVTPTMLQGLATTPSAAAATP--AASIIE-------
MUL_3074|M.ulcerans_Agy99 ------------LMSAVPNVLQGLASSNTSASAPSGLLSTLLS-------
MSMEG_0619|M.smegmatis_MC2_155 MSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK-------
Mvan_0415|M.vanbaalenii_PYR-1 FAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR-------
MAB_0809c|M.abscessus_ATCC_199 HGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG-------
TH_3113|M.thermoresistible__bu VTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLLAPLL
MLBr_01182|M.leprae_Br4923 VVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATP------
Mflv_0768|M.gilvum_PYR-GCK AVPGAGEAVMRNAIISKVSSTAKLDTANQIAGRAEGTLRGVVDR------
MMAR_3661|M.marinum_M --------------MYPASMLMGPLMQLG---SSANTAGLAGAQAAG---
Rv2352c|M.tuberculosis_H37Rv --------------AYPASMLIGPMMQLAQMGTTANTAGLAGAEAAG---
Mb3148c|M.bovis_AF2122/97 --------------FLPVRILTSPITTLAS--MARESATRLGPPAGG---
MAV_2906|M.avium_104 --------------AIYP-ITAALRPFFAAVTGAYSPIG--AIILPGGWW
MUL_3074|M.ulcerans_Agy99 --------------GNGQSWLATLWSEFGPNANIWNTIASTGFLLPSNMV
MSMEG_0619|M.smegmatis_MC2_155 -------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWP
Mvan_0415|M.vanbaalenii_PYR-1 -------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWV
MAB_0809c|M.abscessus_ATCC_199 -------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIG
TH_3113|M.thermoresistible__bu PGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAVSGML
MLBr_01182|M.leprae_Br4923 -----QTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLS
Mflv_0768|M.gilvum_PYR-GCK ------------AGSHAEKSQGLEQAPQQGMQMGMQMASQLGSTLGQMPQ
MMAR_3661|M.marinum_M LAAADMPKMVD-AISPMKGLG--GAG-LGAGMA-----------------
Rv2352c|M.tuberculosis_H37Rv LAAADVPTFAG-DIASGTGLG--GAGGLGAGMS-----------------
Mb3148c|M.bovis_AF2122/97 LAAANTPNPSGAAIPAFKPLG--GRE-LGAGMS-----------------
MAV_2906|M.avium_104 LLSLQALGLAQNAPGVAELLG--GGKAIAGGLSPLAPLRGGYVSAVTPDA
MUL_3074|M.ulcerans_Agy99 TPFLGMLDTAAVADAAEDALRTTGSGALGGALS--APLG-----SVGGQA
MSMEG_0619|M.smegmatis_MC2_155 TWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAA
Mvan_0415|M.vanbaalenii_PYR-1 GASILYPSLLLLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAAS
MAB_0809c|M.abscessus_ATCC_199 QFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMA
TH_3113|M.thermoresistible__bu AQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGGASAA
MLBr_01182|M.leprae_Br4923 LVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLG------SSSG
Mflv_0768|M.gilvum_PYR-GCK QMMQGVTQPFQQLTQPLQQMSSLFGGMMNGDKGAQIGMVGATPFSNHPAI
MMAR_3661|M.marinum_M ----ADLGKARLVGAMSVPPTWEGSIPKG-LSTSAMAGLGAMP-------
Rv2352c|M.tuberculosis_H37Rv ----AELGKARLVGAMSVPPTWEGSVPAR-MASSAMAGLGAMP-------
Mb3148c|M.bovis_AF2122/97 ----AGLGQAQLVGSMSVPPTWQGSIPIS-MASSAMSGLGVPPNP--VAL
MAV_2906|M.avium_104 GGVAGSMGRSTLVGSLSVPPGWTTAAPVLRTVASVLPAASSAT-------
MUL_3074|M.ulcerans_Agy99 G--LAAAGNAAIVGKLSVPPSWTGAAPLASPLGSALGGTPMVA-------
MSMEG_0619|M.smegmatis_MC2_155 P----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATF
Mvan_0415|M.vanbaalenii_PYR-1 SPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASF
MAB_0809c|M.abscessus_ATCC_199 ASAG-TALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PPVGDPGFS
TH_3113|M.thermoresistible__bu P---VPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSP-PPAGHSVPP
MLBr_01182|M.leprae_Br4923 GHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVAT-----
Mflv_0768|M.gilvum_PYR-GCK GG-TGPATGSGLVRAASLPG--AGGSAPQTPLMSNLVGSGLQPTS-----
. . .
MMAR_3661|M.marinum_M -EVAGAGGAPMGMMPMPMGMGGAGAGMPGGMLGRGGASPHVVQSRPSVVP
Rv2352c|M.tuberculosis_H37Rv -AEVPAAGGPMGMMPMPMGMGGAGAGMPAGMMGRGGANPHVVQARPSVVP
Mb3148c|M.bovis_AF2122/97 TQAAGAAGGGMPMMLMPMSISGAGAGMPGGLMDRDGAGWHVTQARLTVIP
MAV_2906|M.avium_104 -AAAMPASG--GAVFGEMAAASLAGRALAGAGVRTVGNGTTGAATAAAAD
MUL_3074|M.ulcerans_Agy99 -PPPTAAAGMPGMPFGNMAGQPFG-RALPQYGFR-----PTFVARPPAAG
MSMEG_0619|M.smegmatis_MC2_155 VPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRR
Mvan_0415|M.vanbaalenii_PYR-1 VPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRR
MAB_0809c|M.abscessus_ATCC_199 FPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARR
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
MLBr_01182|M.leprae_Br4923 -ESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-
Mflv_0768|M.gilvum_PYR-GCK -PVAVGAGAGPGAGVGLAPVGTGGGMGAGGPMGMFGQRGKSGGNKPGLNA
MMAR_3661|M.marinum_M RIGVG---------------------------------------------
Rv2352c|M.tuberculosis_H37Rv RVGIG---------------------------------------------
Mb3148c|M.bovis_AF2122/97 RTGVG---------------------------------------------
MAV_2906|M.avium_104 GAATTATIIVVPAD------------------------------------
MUL_3074|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 RKKGAQIEERGYADAYMDYE-EPDEDPAPQPEPRVRASERGSDAMGFTGT
Mvan_0415|M.vanbaalenii_PYR-1 RRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGT
MAB_0809c|M.abscessus_ATCC_199 RRDKGKQQGRG--IEYMDMN---ATARCEEPAPDTTASHRGAGTMGFAGT
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHGH-RHEHQQPASMSAATAPSAAGIRVLGGAGR
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK PAPLDHDLGEDEDEEW----------------------------------
MMAR_3661|M.marinum_M --------------------------------------------------
Rv2352c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3148c|M.bovis_AF2122/97 --------------------------------------------------
MAV_2906|M.avium_104 --------------------------------------------------
MUL_3074|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 VTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGP
Mvan_0415|M.vanbaalenii_PYR-1 VSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPDERHNHHDGKD
MAB_0809c|M.abscessus_ATCC_199 VIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD---------
TH_3113|M.thermoresistible__bu ISRTRGSVPHAEITP------GDPTEPSSPTDRAHRPAEPN---------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3661|M.marinum_M --
Rv2352c|M.tuberculosis_H37Rv --
Mb3148c|M.bovis_AF2122/97 --
MAV_2906|M.avium_104 --
MUL_3074|M.ulcerans_Agy99 --
MSMEG_0619|M.smegmatis_MC2_155 RR
Mvan_0415|M.vanbaalenii_PYR-1 SQ
MAB_0809c|M.abscessus_ATCC_199 --
TH_3113|M.thermoresistible__bu --
MLBr_01182|M.leprae_Br4923 --
Mflv_0768|M.gilvum_PYR-GCK --