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DFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAELYSFAAAYTSTIAGLTVGSWLGPAATSMSAAAAP FIAWATTTAGQAEQVATQARLAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAEAEYA EMWAQDAAAMYAYAAASAAAAELTPFTEPPRTTESSAAARQSAAVAQSAASDLPAQLSTLIDVTPTMLQG LATTPSAAAATPAASIIEAIYPITAALRPFFAAVTGAYSPIGAIILPGGWWLLSLQALGLAQNAPGVAEL LGGGKAIAGGLSPLAPLRGGYVSAVTPDAGGVAGSMGRSTLVGSLSVPPGWTTAAPVLRTVASVLPAASS ATAAAMPASGGAVFGEMAAASLAGRALAGAGVRTVGNGTTGAATAAAADGAATTATIIVVPAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2906 | - | - | 100% (414) | PPE family protein |
| M. avium 104 | MAV_2910 | - | e-117 | 58.12% (425) | PPE family protein |
| M. avium 104 | MAV_3356 | - | e-102 | 50.95% (422) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1837 | PPE32 | 1e-137 | 62.05% (419) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-35 | 32.32% (427) | PPE protein |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | 1e-137 | 62.05% (419) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-42 | 33.10% (426) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 7e-34 | 30.12% (415) | PPE family protein |
| M. marinum M | MMAR_2684 | - | 1e-111 | 55.01% (429) | PPE family protein, PPE32 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-35 | 30.73% (423) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 6e-36 | 32.40% (429) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 1e-110 | 54.78% (429) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-38 | 33.18% (428) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2684|M.marinum_M ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
Mb1837|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
Rv1808|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
MAV_2906|M.avium_104 -------------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0047|M.abscessus_ATCC_1997 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSTQ
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
* .** :* : *.*...: :*. * *. :
MMAR_2684|M.marinum_M LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
Mb1837|M.bovis_AF2122/97 LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
Rv1808|M.tuberculosis_H37Rv LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
MAV_2906|M.avium_104 LYSFAAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0047|M.abscessus_ATCC_1997 YATAATELTELLGSTVAGSWQGPSAMQYAASHAPYLAWLTQQSAMSATNA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
: * : : * .: *: * . . .
MMAR_2684|M.marinum_M TQAKLAAGAYETAFAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
Mb1837|M.bovis_AF2122/97 AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
Rv1808|M.tuberculosis_H37Rv AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
MAV_2906|M.avium_104 TQARLAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0047|M.abscessus_ATCC_1997 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
. :* .: :* : . : *: *: :*::* *: .** *
MMAR_2684|M.marinum_M AQYLEMWAQDAAAMYAYAGTAAAAS-ALTPFTEPPQ-----------TTN
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAAS-ALTPFTEPPQ-----------TTN
Mb1837|M.bovis_AF2122/97 AHYAEMWAQDAAAMYGYAGSSATAS-QLAPFSEPPQ-----------TTN
Rv1808|M.tuberculosis_H37Rv AHYAEMWAQDAAAMYGYAGSSATAS-QLAPFSEPPQ-----------TTN
MAV_2906|M.avium_104 AEYAEMWAQDAAAMYAYAAASAAAA-ELTPFTEPPR-----------TTE
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0047|M.abscessus_ATCC_1997 ADYIRMWIQAATTMGVYQGVSSAALAATTPTQPSPMIMAPG-GEMSRMSA
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*.* .** * *::* * . * .*
MMAR_2684|M.marinum_M PVAGAAQSAAVAQASSTAASSDVVSQLA----------------------
MUL_3072|M.ulcerans_Agy99 PVAGAAQSAAVAQASSTAASSDVVSQLA----------------------
Mb1837|M.bovis_AF2122/97 PSATAAQSAVVAQAAGAAASSDITAQLS----------------------
Rv1808|M.tuberculosis_H37Rv PSATAAQSAVVAQAAGAAASSDITAQLS----------------------
MAV_2906|M.avium_104 SSAAARQSAAVAQS----AASDLPAQLS----------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEG----------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0047|M.abscessus_ATCC_1997 DMMSMAAQPQAAESGSALDSSNNIMDQL--------------MRFMTNPL
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG-------FADALPD
. *: . :
MMAR_2684|M.marinum_M -----GLITSVPNALQTLATTSAAPTAASILPEVSLPPWLATNLANWNTI
MUL_3072|M.ulcerans_Agy99 -----GLITSVPNALQTLATTSAAPTAASILPEVSLPPWLATNLANWNTI
Mb1837|M.bovis_AF2122/97 -----QLISLLPSTLQSLATTATATSAS---------AGWDTVLQSITTI
Rv1808|M.tuberculosis_H37Rv -----QLISLLPSTLQSLATTATATSAS---------AGWDTVLQSITTI
MAV_2906|M.avium_104 -----TLIDVTPTMLQGLATTPSAAAAT---PAASIIEAIYPITAALRPF
MLBr_01182|M.leprae_Br4923 -----MEATVVPQVDQQVNVDVATPQTAVP---DSSSAAAPQLWGGFAQH
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_0047|M.abscessus_ATCC_1997 GTLQDMIEDFMRNPVAAFFAWFPLLFFIAYEAFFIPFGFTFWGVLLSAPA
TH_3113|M.thermoresistible__bu GLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGV
.
MMAR_2684|M.marinum_M MATLTGPFSLQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYS----PKAI
MUL_3072|M.ulcerans_Agy99 MATLTGPFSLQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYS----PKAI
Mb1837|M.bovis_AF2122/97 LANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLG----PKAA
Rv1808|M.tuberculosis_H37Rv LANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLG----PKAA
MAV_2906|M.avium_104 FAAVTGAYSPIGAIILPGGWWLLSLQALGLAQNAPGVAELLGG---GKAI
MLBr_01182|M.leprae_Br4923 LSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAP----TT---TKAA
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_0047|M.abscessus_ATCC_1997 WLPIVLGLALSALVPPAG-----IEEPGQEDEPGREPTRIE---RRSPQQ
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
MMAR_2684|M.marinum_M TGTLAPLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQAA
MUL_3072|M.ulcerans_Agy99 TGTLAPLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQAA
Mb1837|M.bovis_AF2122/97 AGALSPLAPLR--GGYIADITPLGGGATGGIARAIYVGSLSVPQGWAEAA
Rv1808|M.tuberculosis_H37Rv AGALSPLAPLR--GGYIGDITPLGGGATGGIARAIYVGSLSVPQGWAEAA
MAV_2906|M.avium_104 AGGLSPLAPLR--GGYVSAVTPDAGGVAGSMGRSTLVGSLSVPPGWTTAA
MLBr_01182|M.leprae_Br4923 ESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTAS
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAG-SPPAPGAPAAAAATFVPYVVAGRD
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATG-TAPAPGAPAAATASFVPYAVAGRD
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAP-AGTTVAAPAPAAATFVPYAVANRD
MAB_0047|M.abscessus_ATCC_1997 DLQLAHVPSGSPTPGGSTTTTVTSGGSAPPAPAPATATPAYMVYAVQEDP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAG--GPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSP
. . . .
MMAR_2684|M.marinum_M PAMRLVSSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFGSS
MUL_3072|M.ulcerans_Agy99 PAMRLVSSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFGSS
Mb1837|M.bovis_AF2122/97 PVMRAVASVLPG-TGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRSG
Rv1808|M.tuberculosis_H37Rv PVMRAVASVLPG-TGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRSG
MAV_2906|M.avium_104 PVLRTVASVLPAASSATAAAMPASGGAVFGEMAAASLAGRALAGAGVRTV
MLBr_01182|M.leprae_Br4923 QPVTAATRALSP-----------ARVAVATESESAPLLGGGLPMAPMVPG
Mflv_0325|M.gilvum_PYR-GCK PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGR
Mvan_0415|M.vanbaalenii_PYR-1 PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGR
MSMEG_0619|M.smegmatis_MC2_155 PGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEER
MAB_0047|M.abscessus_ATCC_1997 PAARFGPTLNEGSGAKAPAAGISAAA---AAAASARSRARRKRAARIKDP
TH_3113|M.thermoresistible__bu PPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEP
.
MMAR_2684|M.marinum_M SGGAVANSLGGVVAEADPAAATIIVIPALDE-------------------
MUL_3072|M.ulcerans_Agy99 SGGAVANSLGGVVAEADPAAATIIVIPALDE-------------------
Mb1837|M.bovis_AF2122/97 AG--AARVAGGSVTEDVASTTTIIVIPAD---------------------
Rv1808|M.tuberculosis_H37Rv AG--AARVAGGSVTEDVASTTTIIVIPAD---------------------
MAV_2906|M.avium_104 GNG-TTGAATAAAADGAATTATIIVVPAD---------------------
MLBr_01182|M.leprae_Br4923 GGSGTGGVNTALRLQPRAFVMPRNPAAG----------------------
Mflv_0325|M.gilvum_PYR-GCK G--YADAYADYEELPDDGP-PEQPAPRVTASTRGAGPMGFAGTVSRGD--
Mvan_0415|M.vanbaalenii_PYR-1 A--YADAYADYEPEPDDEP-PVRQEPRIAATERGAGPMGFAGTVSRDA--
MSMEG_0619|M.smegmatis_MC2_155 G--YADAYMDYEE-PDEDP-APQPEPRVRASERGSDAMGFTGTVTRHD--
MAB_0047|M.abscessus_ATCC_1997 A--PQFMDMNSSVAPDFSESAARQTTGVGASARGAGRLGFAGTAPAAAGT
TH_3113|M.thermoresistible__bu AGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAPSAAGI
.
MMAR_2684|M.marinum_M --------------------------------------------------
MUL_3072|M.ulcerans_Agy99 --------------------------------------------------
Mb1837|M.bovis_AF2122/97 --------------------------------------------------
Rv1808|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2906|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK EQAGGLT---TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHD
Mvan_0415|M.vanbaalenii_PYR-1 AQAGGLT---TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHD
MSMEG_0619|M.smegmatis_MC2_155 VTAAGLT---TLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPE
MAB_0047|M.abscessus_ATCC_1997 TAAAGLVERDSGTAEALDGARTVPMLPTSWGTDSEHGP-------DRPAE
TH_3113|M.thermoresistible__bu RVLGGAG----RISRTRGSVPHAEITPGDPTEPSSPTDR-----AHRPAE
MMAR_2684|M.marinum_M -----
MUL_3072|M.ulcerans_Agy99 -----
Mb1837|M.bovis_AF2122/97 -----
Rv1808|M.tuberculosis_H37Rv -----
MAV_2906|M.avium_104 -----
MLBr_01182|M.leprae_Br4923 -----
Mflv_0325|M.gilvum_PYR-GCK GKEKP
Mvan_0415|M.vanbaalenii_PYR-1 GKDSQ
MSMEG_0619|M.smegmatis_MC2_155 GGPRR
MAB_0047|M.abscessus_ATCC_1997 GGSST
TH_3113|M.thermoresistible__bu PN---