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MPNFWALPPEINSTRIYLGPGSGPILAAAQGWNALASELEKTKVGLQSALDTLLESYRGQSSQALIQQTL PYVQWLTTTAEHAHKTAIQLTAAANAYEQARAAMVPPAMVRANRVQTTVLKAINWFGQFSTRIADKEADY EQMWFQDALVMENYWEAVQEAIQSTSHFEDPPEMADDYDEAWMLNTVFDYHNENAKEEVIHLVPDVNKER GPIELVTKVDKEGTIRLVYDGEPTFSYKEHPKF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2108 | PPE36 | - | 100% (243) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1802 | PPE30 | 8e-37 | 47.65% (170) | PPE family protein |
| M. tuberculosis H37Rv | Rv1705c | PPE22 | 7e-36 | 43.55% (186) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2132 | PPE36 | 1e-142 | 100.00% (243) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 3e-23 | 37.25% (153) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-44 | 48.50% (200) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 5e-25 | 35.75% (179) | PPE family protein |
| M. marinum M | MMAR_1460 | - | 1e-36 | 47.67% (172) | PPE family protein |
| M. avium 104 | MAV_4015 | - | 4e-35 | 48.00% (175) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 9e-24 | 40.00% (150) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-24 | 38.69% (168) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2428 | - | 3e-34 | 39.27% (219) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 2e-24 | 36.21% (174) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2108|M.tuberculosis_H37Rv --------MPNFWALPPEINSTRIYLGPGSGPILAAAQGWNALASELEKT
Mb2132|M.bovis_AF2122/97 --------MPNFWALPPEINSTRIYLGPGSGPILAAAQGWNALASELEKT
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MAV_4015|M.avium_104 ---------MDFGFLPPEVNSARMYAGPGSGSLLAAAGSWDSLAAELSIT
MUL_2428|M.ulcerans_Agy99 ---------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAELGTT
MMAR_1460|M.marinum_M ---------MFYAAFPPEINSGRMYTGPGSGPMLAAAVAWNGLAAELQST
MAB_0809c|M.abscessus_ATCC_199 -----MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAHYSAT
TH_3113|M.thermoresistible__bu ------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDEYRAA
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
.** :: : *.*. .: ** * :.
Rv2108|M.tuberculosis_H37Rv KVGLQSALDTLLES-YRGQSSQALIQQTLPYVQWLTTTAEHAHKTAIQLT
Mb2132|M.bovis_AF2122/97 KVGLQSALDTLLES-YRGQSSQALIQQTLPYVQWLTTTAEHAHKTAIQLT
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MAV_4015|M.avium_104 AAVYESVLAGLTGLYWHGPASRAMAAGAAPYVGWLHTTAERAQQTATQAR
MUL_2428|M.ulcerans_Agy99 AETCGSILTGLTDLSWRGPASESMAASAAPCVGWLYRTAEQTQQAAIQAR
MMAR_1460|M.marinum_M AASYSSVISGLISGSWVGPSALAMAAAAGPYVTWVNSTAAQATQAADQAT
MAB_0809c|M.abscessus_ATCC_199 AQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARAVQHG
TH_3113|M.thermoresistible__bu AVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLE
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQN-WQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLSQM-WQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALTNLTSV-WTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
: : : * .: * *: : : . *
Rv2108|M.tuberculosis_H37Rv AAANAYEQARAAMVPPAMVRANRVQTTVLKAINWFGQFSTRIADKEADY-
Mb2132|M.bovis_AF2122/97 AAANAYEQARAAMVPPAMVRANRVQTTVLKAINWFGQFSTRIADKEADY-
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEY-
MAV_4015|M.avium_104 AAAAAYELAHAMTVPPAAVAANRTQLAALVATNFFGQNTAAIAATEAQY-
MUL_2428|M.ulcerans_Agy99 TAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANEAQY-
MMAR_1460|M.marinum_M AAAGAYEIAFAAHVPPPVIATNRSQLAALVASNLVGQNTAAIAATEAQY-
MAB_0809c|M.abscessus_ATCC_199 AAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATEADY-
TH_3113|M.thermoresistible__bu AAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNEADY-
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
. * : * : : *: * * .* * .* :*
Rv2108|M.tuberculosis_H37Rv EQMWFQDALVMENYWEAVQEAIQSTSHFEDPPEMADDYDEAWMLNTVFDY
Mb2132|M.bovis_AF2122/97 EQMWFQDALVMENYWEAVQEAIQSTSHFEDPPEMADDYDEAWMLNTVFDY
MLBr_01182|M.leprae_Br4923 TEMWIQDAAAMTSYQASVLEAVGATKAFTAPP---LGVNEVGLAQEVVEE
MAV_4015|M.avium_104 AEYWAQDAAAMYAYSASSAAAAQFS-PFASPRRTTDPGGVTAQQAAVAAA
MUL_2428|M.ulcerans_Agy99 AEMWAQDAAAMYGYATTSAAAGMLT-PFSSPNQATSPAGLAAQSTAVTQA
MMAR_1460|M.marinum_M AEMWVQDAIAMDTYASASAAASQVT-PFSEPPQIVDASGLANQAAAAGQA
MAB_0809c|M.abscessus_ATCC_199 VRMWVQAATTMATYQTASEVALASAPPSTPPPSILHDHDHGHDDHDHEHG
TH_3113|M.thermoresistible__bu ARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTG----ESATAA
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGSEAAFAGAMSGA
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILNSTFEPVAPPKPITVFGSTQAAMATAIGSA
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPGVGETTAAAALAQT
. * * * .* *
Rv2108|M.tuberculosis_H37Rv HNENAKEEVIHLVPDVNK--------ERGPIELVT---------------
Mb2132|M.bovis_AF2122/97 HNENAKEEVIHLVPDVNK--------ERGPIELVT---------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVP---------------
MAV_4015|M.avium_104 ETGSTGTDSGTQVIPPTAG----------ASEIPL---------------
MUL_2428|M.ulcerans_Agy99 NATAAATDPITQLVSSLTQSLGAI--QAIPSILPD---------------
MMAR_1460|M.marinum_M ASTSAGAAAQAILANNPISALLQLGADLANGYTAT---------------
MAB_0809c|M.abscessus_ATCC_199 HDDDHGHGDLDPTDPEWWVHVAGEMVEHFELLLNN---------------
TH_3113|M.thermoresistible__bu ITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTL
Mflv_0768|M.gilvum_PYR-GCK VPGAGEAVMRNAIISKVSSTAKLDTANQIAGRAEG---------------
Mvan_0077|M.vanbaalenii_PYR-1 APGIASAAARNATFTKVSVVGKLDEVNQKAGHAEG---------------
MSMEG_0064|M.smegmatis_MC2_155 APRVAEGVMRNAVIEGVSAIATIESVGLAAGHAAA---------------
Rv2108|M.tuberculosis_H37Rv ------------------------KVDKEG--------------------
Mb2132|M.bovis_AF2122/97 ------------------------KVDKEG--------------------
MLBr_01182|M.leprae_Br4923 ------------------------QVDQQVNVDVATPQTAVPDSSSAAAP
MAV_4015|M.avium_104 ------------------------DFRILDTILG--------AQTTFRSI
MUL_2428|M.ulcerans_Agy99 ------------------------DFTILDGVFS--------AYATVGVT
MMAR_1460|M.marinum_M ------------------------ATQLLNTLFGPS------GAETYLTL
MAB_0809c|M.abscessus_ATCC_199 ------------------------LLTDPAALLTNLPMVLADVAFHAAQL
TH_3113|M.thermoresistible__bu LAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVA
Mflv_0768|M.gilvum_PYR-GCK ------------------------TLRGVVDRAG--------SHAEKSQG
Mvan_0077|M.vanbaalenii_PYR-1 ------------------------LLQQAADSGR--------SQAEQGQL
MSMEG_0064|M.smegmatis_MC2_155 ------------------------QANFAEQRGQ--------GAAQKGEN
Rv2108|M.tuberculosis_H37Rv ---------------TIRLVYDGE---------------------PTFSY
Mb2132|M.bovis_AF2122/97 ---------------TIRLVYDGE---------------------PTFSY
MLBr_01182|M.leprae_Br4923 QLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTK
MAV_4015|M.avium_104 FTTEGIPAGIIQADKNLGILPNLATIPAALP----------------RTP
MUL_2428|M.ulcerans_Agy99 QDIESFCAGVIGAENNLGLIGSSENPAEVTPSDF-----GLGSLISSTAP
MMAR_1460|M.marinum_M FGAVDEVSSNLAVLNDEGLLVNLPISQALKYGN---------KPVEFGVL
MAB_0809c|M.abscessus_ATCC_199 ASTIGQFAPALIQPALALAIANLG-WAAGFAGLAGIQPSPEILAVEPGSV
TH_3113|M.thermoresistible__bu VSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVP---A
Mflv_0768|M.gilvum_PYR-GCK LEQAPQ----QGMQMGMQMASQLGSTLGQMPQQMMQGVTQPFQQLTQPLQ
Mvan_0077|M.vanbaalenii_PYR-1 LQQAPQ----QGMQMGMQMASQLGSTLGQLPQQMMQGVTQPFQQLTQPLQ
MSMEG_0064|M.smegmatis_MC2_155 AGQEAGRESGKNMQQGMQMVMQMGSQAAQAPAQLASMFQSGVQTMTQPLQ
Rv2108|M.tuberculosis_H37Rv KEHPKF--------------------------------------------
Mb2132|M.bovis_AF2122/97 KEHPKF--------------------------------------------
MLBr_01182|M.leprae_Br4923 AAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTT
MAV_4015|M.avium_104 ALSASPTGLG-----------------RIDAVLARAARIGPMSVPAGWTA
MUL_2428|M.ulcerans_Agy99 ASAASGGGLGS----------------AVAASVGRSGSIGQLSVPPSWSA
MMAR_1460|M.marinum_M PKDALGGGLGLAPNFGKGTLFGAIRPDDVAAHFGRGTLVGKLSVPPSWAV
MAB_0809c|M.abscessus_ATCC_199 EDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSPPPVGD
TH_3113|M.thermoresistible__bu ADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGH
Mflv_0768|M.gilvum_PYR-GCK QMSSLFGGM--MNGDK-GAQIGMVGATPFSNHPAIGGTGPATGSGLVRAA
Mvan_0077|M.vanbaalenii_PYR-1 QMSSLFGQMGGLGGDR-GAQIGMLGATPFSNHPAIGGSGAATGAGLVRAA
MSMEG_0064|M.smegmatis_MC2_155 QATQMVSQFASMGGSERAMQVGLMGASPFSNHPMLGGSGPSTGAGLVRAM
Rv2108|M.tuberculosis_H37Rv --------------------------------------------------
Mb2132|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 ASQPVTAATRALSPAR---------------VAVATESESAPLLGGGLPM
MAV_4015|M.avium_104 AT---GNPVAAAPVTG--------------WSEPSAADARPGVTAPGLPG
MUL_2428|M.ulcerans_Agy99 PS---ARMVSALSPSG--------------LTTIPGTEEAAAAGSPGFPG
MMAR_1460|M.marinum_M ATPDIRAVAAALSAAGPHAVSAAALGQGSLLSSMSMAGMAGAAFGAGAPS
MAB_0809c|M.abscessus_ATCC_199 -----PGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAE
TH_3113|M.thermoresistible__bu SVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAA
Mflv_0768|M.gilvum_PYR-GCK SLPGAGGSAPQTPLMSNLVGSGLQPT-SPVAVGAGAGPGAGVGLAPVGTG
Mvan_0077|M.vanbaalenii_PYR-1 SLPGAGGTAARTPLMSNLVGSGLQPTVSAVAVGAGAGAGAGAGLAPVGAG
MSMEG_0064|M.smegmatis_MC2_155 SLPGAGGTAPRTPLLSNLLG----ISGEMKAAPAGAGSAAAGGLAPVGAG
Rv2108|M.tuberculosis_H37Rv --------------------------------------------------
Mb2132|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 APMVPGGGSGTGG-------------------------------------
MAV_4015|M.avium_104 IPGATLRR---------------------AALVVPR--------------
MUL_2428|M.ulcerans_Agy99 MVAPPATR---------------------ASGVLPR--------------
MMAR_1460|M.marinum_M AVAGAAVKGGRNTLEDLKDRHSPEKLKRLVAQISEKPDSVQHHSVDQEGL
MAB_0809c|M.abscessus_ATCC_199 TAAARQARR--RRDKGKQQGRGIEYMDMNATARCEEPAPDTTASHRGAGT
TH_3113|M.thermoresistible__bu AAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAPSAAGIR---V
Mflv_0768|M.gilvum_PYR-GCK GGMGAGGPMGMFGQRGK---------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 SGMGGGGPMGMLGQRGK---------------------------------
MSMEG_0064|M.smegmatis_MC2_155 AGGGAGAPVAHAGQNSK---------------------------------
Rv2108|M.tuberculosis_H37Rv -----------------------------------------------
Mb2132|M.bovis_AF2122/97 -----------------------------------------------
MLBr_01182|M.leprae_Br4923 -------------VNTALRLQPRAFVMPRNPAAG-------------
MAV_4015|M.avium_104 -------------YGVRITVMARP---PAAG----------------
MUL_2428|M.ulcerans_Agy99 -------------YGVRLTVMAHP---PAAG----------------
MMAR_1460|M.marinum_M DSLLGQLSKKPGVHAVHLSKGKKPKIVPSDAQLG-------------
MAB_0809c|M.abscessus_ATCC_199 MGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD
TH_3113|M.thermoresistible__bu LGGAGRISRTRGSVPHAEITPGDP------TEPSSPTDRAHRPAEPN
Mflv_0768|M.gilvum_PYR-GCK -------------SGGNKPGLNAPAPLDHDLGEDEDEEW--------
Mvan_0077|M.vanbaalenii_PYR-1 -------------SGGNKPGLNAPAPLEHDLSEDDDDDW--------
MSMEG_0064|M.smegmatis_MC2_155 -------------SGGKKDGLVAPTPLTYDLSEDEDDEW--------