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DFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAELSVAAVGYERVITTLQTEEWLGPASTLMVEAVAP YVAWMRATAIQAEQAASQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATEAQYA EMWAQDAMAMYGYAGSSATATKVTPFAPPPNTTSPSAAATQLSAVAKAAGTSAGAAQSAIAELIAHLPNT LLGLTSPLSSALTAAATPGWLEWFINWYLPISQLFYNTVGLPYFAIGIGNSLITSWRALGWIGPEAAEAA AAAPAAVGAAVGGTGPVSAGLGNAATIGKLSLPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAGAAGNL LGGMPLAGSGTGTGGAGPRYGFRVTVMSRPPFAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1705c | PPE22 | - | 100% (385) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1789 | PPE26 | e-124 | 61.04% (403) | PPE family protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 4e-97 | 50.99% (406) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1731c | PPE22 | 0.0 | 99.74% (385) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-29 | 31.13% (363) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-50 | 34.12% (422) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 8e-31 | 29.04% (396) | PPE family protein |
| M. marinum M | MMAR_2516 | - | 1e-149 | 67.68% (393) | PPE family protein |
| M. avium 104 | MAV_2924 | - | 1e-100 | 50.86% (409) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-34 | 30.70% (417) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-33 | 31.47% (394) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1701 | - | 1e-149 | 67.43% (393) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 9e-35 | 31.16% (414) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
Rv1705c|M.tuberculosis_H37Rv -------------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAE
Mb1731c|M.bovis_AF2122/97 -------------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAE
MMAR_2516|M.marinum_M -------------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASE
MUL_1701|M.ulcerans_Agy99 -------------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASE
MAV_2924|M.avium_104 -------------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
* .** :* : ***. .: :*. * *: :
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
Rv1705c|M.tuberculosis_H37Rv LSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAA
Mb1731c|M.bovis_AF2122/97 LSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAA
MMAR_2516|M.marinum_M LSFTADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAEQAA
MUL_1701|M.ulcerans_Agy99 LSFTADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAERAA
MAV_2924|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
:* : : * .: ** *: : . .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
Rv1705c|M.tuberculosis_H37Rv SQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATE
Mb1731c|M.bovis_AF2122/97 SQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATE
MMAR_2516|M.marinum_M KQAEAAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLE
MUL_1701|M.ulcerans_Agy99 KQAEAAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLE
MAV_2924|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
.:. *. :*:: . : *: * *. * : ** *
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEMSRMSA
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
Rv1705c|M.tuberculosis_H37Rv AQYAEMWAQDAMAMYGYAGSSATAT-KVTPFAPPPNTTSPS--AAATQLS
Mb1731c|M.bovis_AF2122/97 AQYAEMWAQDAMAMYGYAGSSATAT-KVTPFAPPPNTTSPS--AAATQLS
MMAR_2516|M.marinum_M AQDAEMWAQDARAMYTYAGSSASAT-KITAFTPPPETANPA--ASALQSN
MUL_1701|M.ulcerans_Agy99 AQYAEMWAQDARAMYTYAGSSASAT-KITAFTPPPETANPA--ASALQSN
MAV_2924|M.avium_104 AQYGEYWAQDAAAMYSYAGQSASAS-KVTPFQKAPQVTNPS--GQAAQSA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
*: . * * * :* * . * .*
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_2230c|M.abscessus_ATCC_199 DMSGMAAQAQAAESGMALDDSESFFDKLMR----------QIQEFFSDPL
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG----FADALPDGLL
Rv1705c|M.tuberculosis_H37Rv AVAKAAGTSAG---------------------------------AAQSAI
Mb1731c|M.bovis_AF2122/97 AVAKAAGTSAG---------------------------------AAQSAI
MMAR_2516|M.marinum_M ATSTAAATAAG---------------------------------AAQSTL
MUL_1701|M.ulcerans_Agy99 ATSTAAATAAG---------------------------------AAQSTL
MAV_2924|M.avium_104 AVSTATANSTSTNTTKALQS---------------------LAQPASSST
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAA---------------------LDQAVNEGM
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_2230c|M.abscessus_ATCC_199 GTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPL
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP----------AYLFPVLV
Rv1705c|M.tuberculosis_H37Rv AELIAHLPNTLLGLTSPLSS---ALTAAATPG------------------
Mb1731c|M.bovis_AF2122/97 AELIAHLPNTLLGLTSPLSS---ALTAAATPG------------------
MMAR_2516|M.marinum_M AGVISQLPNALTSLTSPIAS---ALTSAASPAT-----------------
MUL_1701|M.ulcerans_Agy99 AGVISQLPNALTSLTSPIAS---ALTSAASPAT-----------------
MAV_2924|M.avium_104 TATKAATTAASTTSTDPLSEIWFLLTGQTSLPT-----------------
MLBr_01182|M.leprae_Br4923 EATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQ-----------------
.
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_2230c|M.abscessus_ATCC_199 WLPLLLVG---------LAQLVNPVPV-EADAPADEPAPQQARVERSSPQ
TH_3113|M.thermoresistible__bu YLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLA
Rv1705c|M.tuberculosis_H37Rv ---------------WLEWFINWYLPIS---QLFYNTVGLPYFAIGIGNS
Mb1731c|M.bovis_AF2122/97 ---------------WLEWFINWYLPIS---QLFYNTVGLPYFAIGIGNS
MMAR_2516|M.marinum_M ---------------WIDWLVNWYLPIS---QLFYNTVGLPYFAIGIGSS
MUL_1701|M.ulcerans_Agy99 ---------------WIDWLVNWYLPIS---QLFYNTVGLPYFAIGIGSS
MAV_2924|M.avium_104 ---------------NLGTLVNGYSPFA---GLFYNTEGLPYFSTGMANT
MLBr_01182|M.leprae_Br4923 ---------------LWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNG
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAGR
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGR
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVANR
MAB_2230c|M.abscessus_ATCC_199 QQPFAMGGMPGGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQED
TH_3113|M.thermoresistible__bu GLAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPAPTG---SAAPTTGT
Rv1705c|M.tuberculosis_H37Rv LITSWRALG-WIGPEAAEAAA------AAPAAVGAAVGGTGPVSAGLGNA
Mb1731c|M.bovis_AF2122/97 LITSWRALG-WIGPEAAEAAA------AAPAAVGAAVGGTGPVSAGLGNA
MMAR_2516|M.marinum_M LITSERALG-LIGPEAEAAAAGAGAAEAAAGAAPAALGGAGPIGAGLGNA
MUL_1701|M.ulcerans_Agy99 LITSERALG-LIGPEAEAAAAGAGAAEAAAGAAPAALGGAGPIGAGLGNA
MAV_2924|M.avium_104 FTQIAKSVG-AIGGAAPAAAKALPGLGGLGGMLGGGAAAAHPVAA-LGGA
MLBr_01182|M.leprae_Br4923 MGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRA
. . . .
Mflv_0325|M.gilvum_PYR-GCK DPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKG
Mvan_0415|M.vanbaalenii_PYR-1 DPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAG
MSMEG_0619|M.smegmatis_MC2_155 DPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEE
MAB_2230c|M.abscessus_ATCC_199 PPAARFGPTLNEGSGAKAPAAGISAAAA-AAASARSRARRKRGARIKDPA
TH_3113|M.thermoresistible__bu APGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPG-VARRSAGA
Rv1705c|M.tuberculosis_H37Rv ATIG-KLSLPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAG-AAGNLLG
Mb1731c|M.bovis_AF2122/97 ATIG-KLSVPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAG-AAGNLLG
MMAR_2516|M.marinum_M SALG-KLSVPPSWAGSGLDVPPSV-SAGGPLASDIVNPPEAS-APGSLLG
MUL_1701|M.ulcerans_Agy99 SALG-KLSVPPSWPGSGLDVPPSV-SAGGPLASDIVNPPEAS-APGSLLG
MAV_2924|M.avium_104 GSIGGKLSVPVAWSG--APATPALGHAIP--VSSISAAPEAAGGPGNLLG
MLBr_01182|M.leprae_Br4923 ASIG-SLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPM
. .
Mflv_0325|M.gilvum_PYR-GCK RGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--EQ
Mvan_0415|M.vanbaalenii_PYR-1 RAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--AQ
MSMEG_0619|M.smegmatis_MC2_155 RGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--VT
MAB_2230c|M.abscessus_ATCC_199 PQFMDMNSPVDP-DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTS
TH_3113|M.thermoresistible__bu RRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPAS-MS
Rv1705c|M.tuberculosis_H37Rv G-MPLAG-SGTGTGGAGPRYGFRVTVMSRPPFAG----------------
Mb1731c|M.bovis_AF2122/97 G-MPLAG-SGTGTGGAGPRYGFRVTVMSRPPFAG----------------
MMAR_2516|M.marinum_M G-MPLAGGPGGAAAGAGPRYGFRVTVMARPPFAG----------------
MUL_1701|M.ulcerans_Agy99 G-MPLAGGPGGAAAGAGPRYGFRVTVMARPPFAG----------------
MAV_2924|M.avium_104 G-MPLAGAGAGGHGAAGPKYGFRPTVMARPPFAG----------------
MLBr_01182|M.leprae_Br4923 APMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG----------------
.
Mflv_0325|M.gilvum_PYR-GCK AGGLTT-LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK
Mvan_0415|M.vanbaalenii_PYR-1 AGGLTT-LPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS
MSMEG_0619|M.smegmatis_MC2_155 AAGLTT-LTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPR
MAB_2230c|M.abscessus_ATCC_199 AAGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPG
TH_3113|M.thermoresistible__bu AATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPA
Rv1705c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1731c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2516|M.marinum_M --------------------------------------------------
MUL_1701|M.ulcerans_Agy99 --------------------------------------------------
MAV_2924|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK P-----
Mvan_0415|M.vanbaalenii_PYR-1 Q-----
MSMEG_0619|M.smegmatis_MC2_155 R-----
MAB_2230c|M.abscessus_ATCC_199 ERGAST
TH_3113|M.thermoresistible__bu EPN---
Rv1705c|M.tuberculosis_H37Rv ------
Mb1731c|M.bovis_AF2122/97 ------
MMAR_2516|M.marinum_M ------
MUL_1701|M.ulcerans_Agy99 ------
MAV_2924|M.avium_104 ------
MLBr_01182|M.leprae_Br4923 ------