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MDFGVLPPEINSGRMYAGPGSGPMLAAAAAWDGLATELQSTAADYGSVISVLTGVWSGQSSGTMAAAAAP YVAWMSATAALAREAAAQASAAAAAYEAAFAATVPPPVVAANRAELAVLAATNIFGQNTGAIAAAEARYA EMWAQDAAAMYGYAGSSSVATQVTPFAAPPPTTNAAGLATQGVAVAQAVGASAGNARSLVSEVLEFLATA GTNYNKTVASLMNAVTGVPYASSVYNSMLGLGFAESKMVLPANDTVISTIFGMVQFQKFFNPVTPFNPDL IPKSALGAGLGLRSAISSGLGSTAPAISAGASQAGSVGGMSVPPSWAAATPAIRTVAAVFSSTGLQAVPA AAISEGSLLSQMALASVAGGALGGAAARATGGFLGGGRVTAVKKSLKDSDSPDKLRRVVAHMMEKPESVQ HWHTDEDGLDDLLAELKKKPGIHAVHMAGGNKAEIAPTISESG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1802 | PPE30 | - | 100% (463) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1809 | PPE33 | e-118 | 50.53% (471) | PPE family protein |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | 6e-89 | 49.63% (407) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1830 | PPE30 | 0.0 | 100.00% (463) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-33 | 32.45% (379) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-48 | 35.48% (420) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2254c | - | 4e-30 | 36.97% (211) | PPE family protein |
| M. marinum M | MMAR_2685 | - | 1e-120 | 52.64% (473) | PPE family protein, PPE30 |
| M. avium 104 | MAV_2905 | - | 1e-118 | 49.68% (473) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 2e-33 | 29.50% (400) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-36 | 32.70% (367) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3071 | - | 1e-116 | 51.37% (473) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-38 | 31.14% (411) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1802|M.tuberculosis_H37Rv -------------MDFGVLPPEINSGRMYAGPGSGPMLAAAAAWDGLATE
Mb1830|M.bovis_AF2122/97 -------------MDFGVLPPEINSGRMYAGPGSGPMLAAAAAWDGLATE
MMAR_2685|M.marinum_M -------------MFYAAFPPEINSGRMYTGPGSGPLLAAAAAWDAVAAE
MUL_3071|M.ulcerans_Agy99 -------------MFYAAFPPEINSGRVYTGPGSEPLLAAAAAWDAVAAE
MAV_2905|M.avium_104 -------------MNFALQPPEITSAQLYTGPGAGPMLTAAAAWDALAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_2254c|M.abscessus_ATCC_199 ----------MSAPIWMAFPPEVHSALLGAGPGPGPLLAAAAQWHALSYE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
MSMEG_0064|M.smegmatis_MC2_155 --------------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVL
.** : : *.*. .: *. * ::
Rv1802|M.tuberculosis_H37Rv LQSTAADYGSVISVLT-GVWSGQSSGTMAAAAAPYVAWMSATAALAREAA
Mb1830|M.bovis_AF2122/97 LQSTAADYGSVISVLT-GVWSGQSSGTMAAAAAPYVAWMSATAALAREAA
MMAR_2685|M.marinum_M LQSTAAAFSSVIASLTSGPWIGPSSLAMAAAVAPYVTWMGATAAQAAQAA
MUL_3071|M.ulcerans_Agy99 LQSTAAAFSSVIASLTSGPWIGPSSLAMAAAVAPYVTWMGATATQAAQAA
MAV_2905|M.avium_104 LQSAASSYAAVVNGLADEAWAGPSAAAMAAAAAPYVAWLSATSAQARTAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_2254c|M.abscessus_ATCC_199 YSMAATELTQLLGVTAAGVWQGSSATQYVASHTPYLAWLTQQSATSAANA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
MSMEG_0064|M.smegmatis_MC2_155 LETQAAELAAALTNLT-SVWTGAASERAVAATMPMITWLQTTAAQAQKRA
* : : * .: . * *: :: . .
Rv1802|M.tuberculosis_H37Rv AQASAAAAAYEAAFAATVPPPVVAANRAELAVLAATNIFGQNTGAIAAAE
Mb1830|M.bovis_AF2122/97 AQASAAAAAYEAAFAATVPPPVVAANRAELAVLAATNIFGQNTGAIAAAE
MMAR_2685|M.marinum_M TQATAAATAYETAFAAHVPPVEIAANRAQLAMLVATNLFGQNTAAIAAAE
MUL_3071|M.ulcerans_Agy99 TQATAAATAYETAFAAHVPPVEIAANRAQLAMLVATNLFGQNTAAIAAAE
MAV_2905|M.avium_104 EQATAAASAFESAFAAVVPPAEIATNRARLAMLSASNVFGQNSAAIAAAE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_2254c|M.abscessus_ATCC_199 ALHETSAAAYTTALAAMPTLPELATNHTVHGILVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
MSMEG_0064|M.smegmatis_MC2_155 LQASAQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNE
. * :. *:: . : *: * :*.:* *: .** *
Rv1802|M.tuberculosis_H37Rv ARY-AEMWAQDAAAMYGYAGSSSVATQVTPFAAPPPTTNAAGLATQGVAV
Mb1830|M.bovis_AF2122/97 ARY-AEMWAQDAAAMYGYAGSSSVATQVTPFAAPPPTTNAAGLATQGVAV
MMAR_2685|M.marinum_M SQY-AEMWAQDATAMDGYASSSAAASEVTPFAEPPQVVNAAGLASQAAVV
MUL_3071|M.ulcerans_Agy99 SQY-AEMWAQDATAMDGYASSSAAASEVTPVAEPRQVVNAAGLASQAAVV
MAV_2905|M.avium_104 AEY-GQMWAQDAAAMFGYASASAAATRLAPFTEPPKTTNDAGIAAQAAAL
Mflv_0325|M.gilvum_PYR-GCK ADY-VRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADY-VRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAA
MAB_2254c|M.abscessus_ATCC_199 ADY-VRMWVQAATTMGVYQGVSSTAVAAAAPTTTSPLIMPPGS-ELSRMA
TH_3113|M.thermoresistible__bu ADY-ARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAA
MLBr_01182|M.leprae_Br4923 AEY-TEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLG------------
MSMEG_0064|M.smegmatis_MC2_155 MDYFVRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPG---------
* .** * * :* * .
Rv1802|M.tuberculosis_H37Rv AQAVG--ASAGN--------------------------------------
Mb1830|M.bovis_AF2122/97 AQAVG--ASAGN--------------------------------------
MMAR_2685|M.marinum_M GQAAA--ASPAATVQD----------------------------------
MUL_3071|M.ulcerans_Agy99 GQAAA--ASPAATVQD----------------------------------
MAV_2905|M.avium_104 GEATGRGAGTAAADAT----------------------------------
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRL-----------YGEVLRFL
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRA-----------YGELLRFL
MAB_2254c|M.abscessus_ATCC_199 ADMSGFAAQAQATESGSALDSSNSVIDQL---------------------
TH_3113|M.thermoresistible__bu ITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTL
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 --------------------------------------------------
Rv1802|M.tuberculosis_H37Rv ----------ARSLVSEVLEFLATAGTNYNKTVASLMNAVTGVPYASSVY
Mb1830|M.bovis_AF2122/97 ----------ARSLVSEVLEFLATAGTNYNKTVASLMNAVTGVPYASSVY
MMAR_2685|M.marinum_M --------LLATGPISWLLQLGADLSTGYTAAVTALLNGLFG-PSGATTY
MUL_3071|M.ulcerans_Agy99 --------LLATGPISWLLQLGADLSTGYTAAVTALLNGLFG-PSGATTY
MAV_2905|M.avium_104 --------APPSGIISQLLEALGNASRGYMDFWDQVLNTLTGSPLAGTTW
Mflv_0325|M.gilvum_PYR-GCK FEPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSW
Mvan_0415|M.vanbaalenii_PYR-1 FEPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSW
MAB_2254c|M.abscessus_ATCC_199 ----LNFFR---DPLGTLRQIIEDFIRNPGAALATWLPFLLVLASMTYVL
TH_3113|M.thermoresistible__bu LAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVA
MLBr_01182|M.leprae_Br4923 -----------VNEVGLAQEVVEEVVEEVVEEVVEAEQAISQAALDQAVN
MSMEG_0064|M.smegmatis_MC2_155 --------------VGETTAAAALAQTAPRVAEGVMRNAVIEGVSAIATI
:. :
Rv1802|M.tuberculosis_H37Rv NS--MLGLGFAESKMVLPANDTVISTIFGMVQFQKFFNPVTPFNPDLIPK
Mb1830|M.bovis_AF2122/97 NS--MLGLGFAESKMVLPANDTVISTIFGMVQFQKFFNPVTPFNPDLIPK
MMAR_2685|M.marinum_M LT--LYNAIKTPLNFTTGFNDIGLLINFPASQFLKFA-PHPGLGP--LPK
MUL_3071|M.ulcerans_Agy99 LT--LYNAIKTPLNFTTGFNDIGLLINFPASQLLKFA-PHPGLGP--LPK
MAV_2905|M.avium_104 QN--TFGILADIGRFSTVANDSMSPINLAMTEFKMFY--KLPVEGLDIPK
Mflv_0325|M.gilvum_PYR-GCK VG---ASILYPSLFLLPLLATTLAIVAGVGQHLLSLLNTPPAEEAAEEPA
Mvan_0415|M.vanbaalenii_PYR-1 VG---ASILYPSLLLLPLVATTLAIVLGVGAYLLENLPAPAEDAPAEEPA
MAB_2254c|M.abscessus_ATCC_199 F----AQVFW--LFWAALLSAPLWLPLLILAAWQYLQPPAVDAAPADEIR
TH_3113|M.thermoresistible__bu VSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADG
MLBr_01182|M.leprae_Br4923 EG------------MEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLW
MSMEG_0064|M.smegmatis_MC2_155 ES--------------------VGLAAGHAAAQANFAEQRGQGAAQKGEN
Rv1802|M.tuberculosis_H37Rv SALGAGLGLRSAISSGLGSTAPAISAGASQAGS---VGGMSVPPSWAAAT
Mb1830|M.bovis_AF2122/97 SALGAGLGLRSAISSGLGSTAPAISAGASQAGS---VGGMSVPPSWAAAT
MMAR_2685|M.marinum_M DALGGGLGLAPHWNQGTLFSAIQPEAMTPHWGRGTLVGKLTVPPSWAAAT
MUL_3071|M.ulcerans_Agy99 DALGGGLGLAPHWNQGTLFSAIQPEAMTPHWGRGTLVGKLTVPPSWAAAT
MAV_2905|M.avium_104 SALGAGLGLR---SAGAGLTG-AVSVGVGEANT---VGRLSVPPTWASAT
Mflv_0325|M.gilvum_PYR-GCK PAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVS---AGSPPAPG-APA
Mvan_0415|M.vanbaalenii_PYR-1 ASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVA---TGTAPAPG-APA
MAB_2254c|M.abscessus_ATCC_199 PELGSTVNGQREHIEPLPAIALAPTATPVPTASAS---APSAPAPAPAPT
TH_3113|M.thermoresistible__bu GASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVP
MLBr_01182|M.leprae_Br4923 GGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAE
MSMEG_0064|M.smegmatis_MC2_155 AGQEAGRESGKNMQQGMQMVMQMGSQAAQAPAQLASMFQSGVQTMTQPLQ
. .
Rv1802|M.tuberculosis_H37Rv PAIRTVAAVFSSTGL------QAVPAAAISEGSLLSQMALASVAGGALGG
Mb1830|M.bovis_AF2122/97 PAIRTVAAVFSSTGL------QAVPAAAISEGSLLSQMALASVAGGALGG
MMAR_2685|M.marinum_M PTIRTVAAALSAAGP------EAVPAAALGEGGLLSSMAVAGMLGSAFGA
MUL_3071|M.ulcerans_Agy99 PTIRTVAAALSAAGP------EAVPAAALGEGGLLSSMAVAGMLGSAFGA
MAV_2905|M.avium_104 PAIRLASGLAPATAA------AAAPAAGIPAG-LLGQMALGSVTGGALGA
Mflv_0325|M.gilvum_PYR-GCK AAAATFVPYVVAGRD---PYEGFSPTVRDSTGAKAPAGTIPAAASGIAAS
Mvan_0415|M.vanbaalenii_PYR-1 AATASFVPYAVAGRD---PGTGFSPTVRDSTSAKAPASGIPAAASGVAAS
MAB_2254c|M.abscessus_ATCC_199 AAGAGFAPYLVGAIPDEPPAIQFGPTLNEGNKAQAPASGISAAAA-AAAS
TH_3113|M.thermoresistible__bu PAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAA
MLBr_01182|M.leprae_Br4923 SAFKAMGSAVQSTGR---------GLLGSSSGGHVTAQLGRAASIGSLRV
MSMEG_0064|M.smegmatis_MC2_155 QATQMVSQFASMGGS------ERAMQVGLMGASPFSNHPMLGGSGPSTGA
:
Rv1802|M.tuberculosis_H37Rv AAARATGGFLGGGRVTAVKKSLKDSDSPDKLRRVVAHMMEKPES-VQHWH
Mb1830|M.bovis_AF2122/97 AAARATGGFLGGGRVTAVKKSLKDSDSPDKLRRVVAHMMEKPES-VQHWH
MMAR_2685|M.marinum_M GAPDAYKRAGVRSRLTPLKD-LKDATSPEKLKRLVAQISEKPES-VQHHT
MUL_3071|M.ulcerans_Agy99 GAPDAYKRAGVRSRLTPLKD-LKDATSPEKLKRLVAQISEKPES-VQHHT
MAV_2905|M.avium_104 VAPHVGS--GRGVRVRAAKP-----AEPVKLDDVIAKLQRQPEA-VQHWN
Mflv_0325|M.gilvum_PYR-GCK AAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVT-ASTRG
Mvan_0415|M.vanbaalenii_PYR-1 AAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIA-ATERG
MAB_2254c|M.abscessus_ATCC_199 ARSRARRKRGARVKDPAPQYMDMNVTVDADYGE-PPGSAQRQST-ASARG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDG--------LHGHRHEHQQPASMSAATA-PSAAG
MLBr_01182|M.leprae_Br4923 PQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPM-VPGGG
MSMEG_0064|M.smegmatis_MC2_155 GLVRAMSLPGAGGTAPRTPLLSNLLGISGEMKAAPAGAGSAAAGGLAPVG
Rv1802|M.tuberculosis_H37Rv TDEDGLDDLLAELKKKPGIHAVHMAGGNKA---------EIAPTISESG-
Mb1830|M.bovis_AF2122/97 TDEDGLDDLLAELKKKPGIHAVHMAGGNKA---------EIAPTISESG-
MMAR_2685|M.marinum_M VDQEGLDSLLEQLAKKPGIHAVHLSKGDKA---------KVVPTDAQPG-
MUL_3071|M.ulcerans_Agy99 VDQEGLDSLLEQLAKKPGIHAVHLSKGDKA---------KVVPTDAQPG-
MAV_2905|M.avium_104 VDKAGLDDLLDRLSKKPGIHAVHVSSGGKP---------TVTLPDAGPAG
Mflv_0325|M.gilvum_PYR-GCK AGPMGFAGTVSRGDEQAGGLTTLAGDSFGGGPRE-----PMLPGTWDPDA
Mvan_0415|M.vanbaalenii_PYR-1 AGPMGFAGTVSRDAAQAGGLTTLPGDPFGGGPKA-----PMLPGTWDPDT
MAB_2254c|M.abscessus_ATCC_199 AGHLGLAGTSPKTTATAAGLVARGSAGSDTDVPETARIVPMIPTTWSTDS
TH_3113|M.thermoresistible__bu IRVLGGAGRISRTRGSVPHAEITPGDPTE----------PSSPTDRAHRP
MLBr_01182|M.leprae_Br4923 SGTGGVN-TALRLQPRAFVMPRNPAAG-----------------------
MSMEG_0064|M.smegmatis_MC2_155 AGAGGGAGAPVAHAGQNSKSGGKKDGLVAP---------TPLTYDLSEDE
*
Rv1802|M.tuberculosis_H37Rv ---------------------
Mb1830|M.bovis_AF2122/97 ---------------------
MMAR_2685|M.marinum_M ---------------------
MUL_3071|M.ulcerans_Agy99 ---------------------
MAV_2905|M.avium_104 SA-------------------
Mflv_0325|M.gilvum_PYR-GCK TDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 EPD------ERHNHHDGKDSQ
MAB_2254c|M.abscessus_ATCC_199 DEAID----------------
TH_3113|M.thermoresistible__bu AEPN-----------------
MLBr_01182|M.leprae_Br4923 ---------------------
MSMEG_0064|M.smegmatis_MC2_155 DDEW-----------------