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FYAAFPPEINSGRMYTGPGSGPMLAAAVAWNGLAAELQSTAASYSSVISGLISGSWVGPSALAMAAAAGP YVTWVNSTAAQATQAADQATAAAGAYEIAFAAHVPPPVIATNRSQLAALVASNLVGQNTAAIAATEAQYA EMWVQDAIAMDTYASASAAASQVTPFSEPPQIVDASGLANQAAAAGQAASTSAGAAAQAILANNPISALL QLGADLANGYTATATQLLNTLFGPSGAETYLTLFGAVDEVSSNLAVLNDEGLLVNLPISQALKYGNKPVE FGVLPKDALGGGLGLAPNFGKGTLFGAIRPDDVAAHFGRGTLVGKLSVPPSWAVATPDIRAVAAALSAAG PHAVSAAALGQGSLLSSMSMAGMAGAAFGAGAPSAVAGAAVKGGRNTLEDLKDRHSPEKLKRLVAQISEK PDSVQHHSVDQEGLDSLLGQLSKKPGVHAVHLSKGKKPKIVPSDAQLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1460 | - | - | 100% (469) | PPE family protein |
| M. marinum M | MMAR_2685 | - | 0.0 | 71.22% (469) | PPE family protein, PPE30 |
| M. marinum M | MMAR_1461 | - | 1e-77 | 44.67% (394) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1830 | PPE30 | 1e-117 | 49.79% (474) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-36 | 39.53% (215) | PPE protein |
| M. tuberculosis H37Rv | Rv1809 | PPE33 | 1e-117 | 50.10% (477) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 8e-45 | 33.00% (400) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 7e-33 | 43.20% (169) | PPE family protein |
| M. avium 104 | MAV_2909 | - | 1e-147 | 60.34% (474) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-35 | 30.02% (423) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 9e-36 | 36.48% (233) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3071 | - | 0.0 | 70.15% (469) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-38 | 40.77% (233) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1460|M.marinum_M -------------MFYAAFPPEINSGRMYTGPGSGPMLAAAVAWNGLAAE
MUL_3071|M.ulcerans_Agy99 -------------MFYAAFPPEINSGRVYTGPGSEPLLAAAAAWDAVAAE
MAV_2909|M.avium_104 -------------MFYGAFPPEFNSGRMYSGPGAGSFVAAATAWQNLAAE
Mb1830|M.bovis_AF2122/97 -------------MDFGVLPPEINSGRMYAGPGSGPMLAAAAAWDGLATE
Rv1809|M.tuberculosis_H37Rv -------------MDFGLQPPEITSGEMYLGPGAGPMLAAAVAWDGLAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: .** * : ***. .:::*. * :. .
MMAR_1460|M.marinum_M LQSTAASYSSVISGLISGSWVGPSALAMAAAAGPYVTWVNSTAAQATQAA
MUL_3071|M.ulcerans_Agy99 LQSTAAAFSSVIASLTSGPWIGPSSLAMAAAVAPYVTWMGATATQAAQAA
MAV_2909|M.avium_104 LQSAAASYSSVLSGLTAGPWVGPSSLAMASAAAPYVAWMQQTAAQAAETA
Mb1830|M.bovis_AF2122/97 LQSTAADYGSVIS-VLTGVWSGQSSGTMAAAAAPYVAWMSATAALAREAA
Rv1809|M.tuberculosis_H37Rv LQSMAASYASIVEGMASESWLGPSSAGMAAAAAPYVTWMSGTSAQAKAAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
: * : : : : * *: . ** *: : . *
MMAR_1460|M.marinum_M DQATAAAGAYEIAFAAHVPPPVIATNRSQLAALVASNLVGQNTAAIAATE
MUL_3071|M.ulcerans_Agy99 TQATAAATAYETAFAAHVPPVEIAANRAQLAMLVATNLFGQNTAAIAAAE
MAV_2909|M.avium_104 AQATAAATAYETAFAAHVPPAVIAENRALLAQLVATNIFGQNTAAIAANE
Mb1830|M.bovis_AF2122/97 AQASAAAAAYEAAFAATVPPPVVAANRAELAVLAATNIFGQNTGAIAAAE
Rv1809|M.tuberculosis_H37Rv DQARAAVVAYETAFAAVVPPPQIAANRSQLISLVATNIFGQNTAAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: .*. ** *:: . : *:: * :*:.* *: .* *
MMAR_1460|M.marinum_M AQYAEMWVQDAIAMDTYASASAAAS-QVTPFSEPPQIVDASGLANQAAAA
MUL_3071|M.ulcerans_Agy99 SQYAEMWAQDATAMDGYASSSAAAS-EVTPVAEPRQVVNAAGLASQAAVV
MAV_2909|M.avium_104 AQYGEFWAQDATAMDTYFAASATAANKLTEFGPAPKTTNEAAQPMQAAAV
Mb1830|M.bovis_AF2122/97 ARYAEMWAQDAAAMYGYAGSSSVAT-QVTPFAAPPPTTNAAGLATQGVAV
Rv1809|M.tuberculosis_H37Rv AEYGEMWAQDTMAMFGYASSSATAS-RLTPFTAPPQTTNPSGLAGQAAAT
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAAL-AATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAAL-AATPTATPAPFVLAPGVGEAGRAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAV-AAAPVSAPAPFLLKPGVGEAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAV-MSAPASSPAPLLLAPGVSEAADAM
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVAL-ASAPPSTPPPSILHD---------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
: * .:* * : :* * * .
MMAR_1460|M.marinum_M GQAASTSAGA----AAQAILANN----PISALLQLGADLANGYTATATQL
MUL_3071|M.ulcerans_Agy99 GQAAAASPAA----TVQDLLATG----PISWLLQLGADLSTGYTAAVTAL
MAV_2909|M.avium_104 SSAASTPAAN----VAQTAASAASTTLPYSGPFSGPANLAYLYQTFMTNL
Mb1830|M.bovis_AF2122/97 AQAVGASAGN-----ARS---------LVSEVLEFLATAGTNYNKTVASL
Rv1809|M.tuberculosis_H37Rv GQATALASGTNAVTTALSSAAAQFPFDIIPTLLQGLATLSTQYTQLMGQL
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQP----MAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNF
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQA----QAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDF
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQA----TAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDF
TH_3569|M.thermoresistible__bu ATTQQIGSQA----TAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDF
MAB_0809c|M.abscessus_ATCC_199 ---HDHGHDD----HDHEHGHDDDHG---------HGDLDPTDPEWWVHV
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
MMAR_1460|M.marinum_M LNTLFG-PSGAETYLTLFGAVDEVSSNLAVLNDEGLLVNLPISQALKYGN
MUL_3071|M.ulcerans_Agy99 LNGLFG-PSGATTYLTLYNAIKTPLNFTTGFNDIGLLINFPASQLLKFAP
MAV_2909|M.avium_104 FNTVPG---GASFYTSMYNAVKVPLGLTTQFNGVGLLVNFPLSQWLKFAP
Mb1830|M.bovis_AF2122/97 MNAVTGVPYASSVYNSMLGLGFAESKMVLPANDTVISTIFGMVQFQKFFN
Rv1809|M.tuberculosis_H37Rv INAIFG-PTGATTYQNVFVTAANVTKFSTWANDAMSAPNLGMTEFKVFWQ
Mflv_0325|M.gilvum_PYR-GCK LRDPIG-NTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPS
Mvan_0415|M.vanbaalenii_PYR-1 LRDPLG-NTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPS
MSMEG_0619|M.smegmatis_MC2_155 LKDPLG-NLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGM
TH_3569|M.thermoresistible__bu LRDPIG-NLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAM
MAB_0809c|M.abscessus_ATCC_199 AGEMVE-HFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIGQFAP
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGS
.
MMAR_1460|M.marinum_M KPV--EFGVLPKDA----LGGGLGLAPNFGKGTLFGAIRPDDVAAHFGRG
MUL_3071|M.ulcerans_Agy99 HP---GLGPLPKDA----LGGGLGLAPHWNQGTLFSAIQPEAMTPHWGRG
MAV_2909|M.avium_104 -PI--GYGALPKDA----LGAGLG-ALGFGRGTLYSAISP--VAGMGNAG
Mb1830|M.bovis_AF2122/97 PVTPFNPDLIPKSA----LGAGLGLRSAISSGLGS---TAPAISAGASQA
Rv1809|M.tuberculosis_H37Rv PPP---APEIPKSS----LGAGLGLRSGLSAGL------AHAASAGLGQA
Mflv_0325|M.gilvum_PYR-GCK LFLLPLLATTLAIV----AGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPS
Mvan_0415|M.vanbaalenii_PYR-1 LLLLPLVATTLAIV----LGVGAYLLENLPAP-AEDAPAEEPAASSPAPT
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAAL----GITGLVLLIDHVLNNPVDVPAEDEAPQEVAAA
TH_3569|M.thermoresistible__bu ILASPVLIPLAITL----GVAGLVMIADQAQP-----PAEEAAPEEDVAA
MAB_0809c|M.abscessus_ATCC_199 ALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMAASAG
MLBr_01182|M.leprae_Br4923 AMKSLAPTTTKAAES---AFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRA
. .
MMAR_1460|M.marinum_M TLVGKLSVPPSWAVATPDIRAVAAALSAAGPHAVSAAALGQGSLLSSMSM
MUL_3071|M.ulcerans_Agy99 TLVGKLTVPPSWAAATPTIRTVAAALSAAGPEAVPAAALGEGGLLSSMAV
MAV_2909|M.avium_104 TLVGKLSIPPSWATATPSIRTVAAALSAAGAEAVPAAALGEGSLFSSMGL
Mb1830|M.bovis_AF2122/97 GSVGGMSVPPSWAAATPAIRTVAAVFSSTGLQAVPAAAISEGSLLSQMAL
Rv1809|M.tuberculosis_H37Rv NLVGDLSVPPSWASATPAVRLVANTLPATSLAAAPATQIP-ANLLGQMAL
Mflv_0325|M.gilvum_PYR-GCK RPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVV
Mvan_0415|M.vanbaalenii_PYR-1 RADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAV
MSMEG_0619|M.smegmatis_MC2_155 PRTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAV
TH_3569|M.thermoresistible__bu P-------------------VRAEPQNPLPLTXXX---------------
MAB_0809c|M.abscessus_ATCC_199 TALAPSPPASAAAPAAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVG
MLBr_01182|M.leprae_Br4923 ASIGSLRVPQTWTTASQPVTAATRALSPARVAVATE------------SE
. .
MMAR_1460|M.marinum_M AG-MAGAAFGAGAPSAVAGAAVKGGRNTLED-LKDRHSPEKLKRLVAQIS
MUL_3071|M.ulcerans_Agy99 AG-MLGSAFGAGAPDAYKRAGVRSRLTPLKD-LKDATSPEKLKRLVAQIS
MAV_2909|M.avium_104 AG-MLGSAVGSGGPTMVR-GGVRNRMTAIKD-LKDKQSPEQLKRLVAQIS
Mb1830|M.bovis_AF2122/97 AS-VAGGALGGAAARATGGFLGGGRVTAVKKSLKDSDSPDKLRRVVAHMM
Rv1809|M.tuberculosis_H37Rv GS-MTGGALGAAAP----AIYTGSGARARANGGTPSAEPVKLEAVIAQLQ
Mflv_0325|M.gilvum_PYR-GCK AGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEE
Mvan_0415|M.vanbaalenii_PYR-1 AGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDE
MSMEG_0619|M.smegmatis_MC2_155 ANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQ
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 GGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGK
MLBr_01182|M.leprae_Br4923 SAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-----
MMAR_1460|M.marinum_M EKPDSVQHHSVDQEGLDSLLGQLSKKPGVHAVHLSKGKK---PKIVPSDA
MUL_3071|M.ulcerans_Agy99 EKPESVQHHTVDQEGLDSLLEQLAKKPGIHAVHLSKGDK---AKVVPTDA
MAV_2909|M.avium_104 EQPESVQHHNVDQENLDTLLEQLAKKPGIHAVHLKKGDK---SKVLPADA
Mb1830|M.bovis_AF2122/97 EKPESVQHWHTDEDGLDDLLAELKKKPGIHAVHMAGGNK---AEIAPTIS
Rv1809|M.tuberculosis_H37Rv KQPDAVRHWNVDKADLDGLLDRLSKQPGIHAVHVSNGDK---PKVALPDT
Mflv_0325|M.gilvum_PYR-GCK IKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDE
Mvan_0415|M.vanbaalenii_PYR-1 IAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAA
MSMEG_0619|M.smegmatis_MC2_155 IEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDV
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 QQGRG-----IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGA
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MMAR_1460|M.marinum_M QLG-----------------------------------------------
MUL_3071|M.ulcerans_Agy99 QPG-----------------------------------------------
MAV_2909|M.avium_104 QLG-----------------------------------------------
Mb1830|M.bovis_AF2122/97 ESG-----------------------------------------------
Rv1809|M.tuberculosis_H37Rv QLGSH---------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK QAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKE
Mvan_0415|M.vanbaalenii_PYR-1 QAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKD
MSMEG_0619|M.smegmatis_MC2_155 TAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGP
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 TASGLAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD---------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MMAR_1460|M.marinum_M --
MUL_3071|M.ulcerans_Agy99 --
MAV_2909|M.avium_104 --
Mb1830|M.bovis_AF2122/97 --
Rv1809|M.tuberculosis_H37Rv --
Mflv_0325|M.gilvum_PYR-GCK KP
Mvan_0415|M.vanbaalenii_PYR-1 SQ
MSMEG_0619|M.smegmatis_MC2_155 RR
TH_3569|M.thermoresistible__bu --
MAB_0809c|M.abscessus_ATCC_199 --
MLBr_01182|M.leprae_Br4923 --