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MDFGFLPPEVNSARMYAGPGSGSLLAAAGSWDSLAAELSITAAVYESVLAGLTGLYWHGPASRAMAAGAA PYVGWLHTTAERAQQTATQARAAAAAYELAHAMTVPPAAVAANRTQLAALVATNFFGQNTAAIAATEAQY AEYWAQDAAAMYAYSASSAAAAQFSPFASPRRTTDPGGVTAQQAAVAAAETGSTGTDSGTQVIPPTAGAS EIPLDFRILDTILGAQTTFRSIFTTEGIPAGIIQADKNLGILPNLATIPAALPRTPALSASPTGLGRIDA VLARAARIGPMSVPAGWTAATGNPVAAAPVTGWSEPSAADARPGVTAPGLPGIPGATLRRAALVVPRYGV RITVMARPPAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4015 | - | - | 100% (362) | PPE family protein |
| M. avium 104 | MAV_4014 | - | 3e-93 | 51.15% (393) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 7e-75 | 43.20% (419) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3159 | PPE50 | 1e-100 | 53.93% (382) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-31 | 30.75% (374) | PPE protein |
| M. tuberculosis H37Rv | Rv3136 | PPE51 | 1e-98 | 52.86% (384) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-38 | 33.25% (418) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 4e-33 | 31.48% (378) | PPE family protein |
| M. marinum M | MMAR_0191 | - | 1e-99 | 53.00% (383) | PPE family protein, PPE51_2 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-36 | 37.05% (386) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 3e-34 | 41.41% (198) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2428 | - | 8e-96 | 50.79% (382) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-35 | 33.42% (386) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3136|M.tuberculosis_H37Rv -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
MUL_2428|M.ulcerans_Agy99 -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE
MMAR_0191|M.marinum_M -------------MDFAMLPPEVNSGLMYTGPGAGSLLAAANSWDELAIE
Mb3159|M.bovis_AF2122/97 -------------MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAE
MAV_4015|M.avium_104 -------------MDFGFLPPEVNSARMYAGPGSGSLLAAAGSWDSLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
: .** :* : ***...:*.*. * *. .
Rv3136|M.tuberculosis_H37Rv LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
MUL_2428|M.ulcerans_Agy99 LGTTAETCGSILTGLTDLSWRGPASESMAASAAPCVGWLYRTAEQTQQAA
MMAR_0191|M.marinum_M LGTTAQTYESVLSGLTSMYWAGPASESMAAKAAPYVWWLHSTAEQTQQTA
Mb3159|M.bovis_AF2122/97 LASAAENYGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQTA
MAV_4015|M.avium_104 LSITAAVYESVLAGLTGLYWHGPASRAMAAGAAPYVGWLHTTAERAQQTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
:* : : : * :: :* ** : *
Rv3136|M.tuberculosis_H37Rv IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
MUL_2428|M.ulcerans_Agy99 IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE
MMAR_0191|M.marinum_M TQCRAAAMAFEQAYAMTVPPPVILANRMQLMSLVATNFFGQNTAAIAALE
Mb3159|M.bovis_AF2122/97 TQARAAAAAFEQAHAMTVPPALVTANRAELKALIASNLLGQNTAAIAAIE
MAV_4015|M.avium_104 TQARAAAAAYELAHAMTVPPAAVAANRTQLAALVATNFFGQNTAAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
: .** *: * : . : *: *: :*::* *: .* *
Rv3136|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPAGLTAQAAAV
MUL_2428|M.ulcerans_Agy99 AQYAEMWAQDAAAMYGYATTSAAAG-MLTPFSSPNQATSPAGLAAQSTAV
MMAR_0191|M.marinum_M AQYAEMWEQDAAAMYGYATSAAMAA-QLVPFSSPQQTTNPAGLSAQSAAV
Mb3159|M.bovis_AF2122/97 AQYAEMWAQDAAAMYGYATTSAAAR-QLTPFSSPQQTTNPAGLAAQNAAV
MAV_4015|M.avium_104 AQYAEYWAQDAAAMYAYSASSAAAA-QFSPFASPRRTTDPGGVTAQQAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAAL-AATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAAL-AATPTATPAPFVLAPGVGEAGRAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAV-AAAPVSAPAPFLLKPGVGEAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAV-MSAPASSPAPLLLAPGVSEAADAM
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVAL-ASAPPSTPPPSILHD--HDHGHDD
*:*.. * * *::* * : * . :.*
Rv3136|M.tuberculosis_H37Rv SQA--------TDPLSLLIETVTQALQALT--------------------
MUL_2428|M.ulcerans_Agy99 TQANATAA--ATDPITQLVSSLTQSLGAIQA-------------------
MMAR_0191|M.marinum_M NQADATAA--AANPLSDLIALVQKGLAALAGA------------------
Mb3159|M.bovis_AF2122/97 TQAATNSAGNTPTALSQLSSFLSQAVEAPTG-------------------
MAV_4015|M.avium_104 AAAETG---------STGTDSGTQVIPPTAG-------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQ--------------
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDP
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDP
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDP
MAB_0809c|M.abscessus_ATCC_199 HDHEHGHDDDHGHGDLDPTDP-EWWVHVAGEMVEHFELLLNNLLTDPAAL
Rv3136|M.tuberculosis_H37Rv ---IPSFIPEDFTFLDAIFAGYATVGVTQDVESFVAGTIGAESNLGLLNV
MUL_2428|M.ulcerans_Agy99 ---IPSILPDDFTILDGVFSAYATVGVTQDIESFCAGVIGAENNLGLIGS
MMAR_0191|M.marinum_M ---FPNLLPDDFSILDGIFAGYATVGVSQDCESIIAGIIGAESNLGMLGA
Mb3159|M.bovis_AF2122/97 ---WPNILPDDFTILDGILAAYATVGVTQDIESICAGIIGAENNLGLLGA
MAV_4015|M.avium_104 ----ASEIPLDFRILDTILGAQTTFRSIFTTEGIPAGIIQADKNLGILPN
MLBr_01182|M.leprae_Br4923 ---VDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINN
Mflv_0325|M.gilvum_PYR-GCK IGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLP
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLP
MSMEG_0619|M.smegmatis_MC2_155 LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASP
TH_3569|M.thermoresistible__bu IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASP
MAB_0809c|M.abscessus_ATCC_199 LTNLPMVLADVAFHAAQLASTIGQFAPALIQPALALAIANLGWAAGFAGL
: . :
Rv3136|M.tuberculosis_H37Rv GDENPAEVTPGDFGIGELVSATSPGGGVSASGAGGAA-------------
MUL_2428|M.ulcerans_Agy99 -SENPAEVTPSDFGLGSLISSTAPAS--AASGGG----------------
MMAR_0191|M.marinum_M ASENPAELAPGDIGIGSVLSSAPSVGG-AVSGPG----------------
Mb3159|M.bovis_AF2122/97 ASENPAELAPGAFGIDAALSSAEKGA--AASMHD----------------
MAV_4015|M.avium_104 LATIPAALPR-----TPALSASPTGLG-----------------------
MLBr_01182|M.leprae_Br4923 HAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLG
Mflv_0325|M.gilvum_PYR-GCK LLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPA
Mvan_0415|M.vanbaalenii_PYR-1 LVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAI
MSMEG_0619|M.smegmatis_MC2_155 FLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAV
TH_3569|M.thermoresistible__bu VLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--------
MAB_0809c|M.abscessus_ATCC_199 AGIQPSPEILAVEPGSVEDAPMA-ASAGTALAPSPPASAAAP--------
Rv3136|M.tuberculosis_H37Rv -SVGNTVLASVGRANSIGQLSVPPSWAAPSTRPVSALSPAGLTTLPG-TD
MUL_2428|M.ulcerans_Agy99 --LGSAVAASVGRSGSIGQLSVPPSWSAPSARMVSALSPSGLTTIPGTEE
MMAR_0191|M.marinum_M -----AVLVSVGRAGSIGQLSVPASWAAPATRQVAALSSAGLTTIPG-TE
Mb3159|M.bovis_AF2122/97 -----AVLASAGRAGSIGPMSVPPSWATPSSTPVSALSGAGLTTLDG-TD
MAV_4015|M.avium_104 -----RIDAVLARAARIGPMSVPAGWTAATGNPVAAAPVTGWSEPSAADA
MLBr_01182|M.leprae_Br4923 SSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATE
Mflv_0325|M.gilvum_PYR-GCK TMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGF
Mvan_0415|M.vanbaalenii_PYR-1 AVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGF
MSMEG_0619|M.smegmatis_MC2_155 GISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGF
TH_3569|M.thermoresistible__bu -----------VRAEPQNPLPLTXXX------------------------
MAB_0809c|M.abscessus_ATCC_199 -----AAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGGPRLGTGL
.
Rv3136|M.tuberculosis_H37Rv VAEHGMPG-----VPG-VPVAAGR-ASGVLPRYGVRLTVMAHPPAAG---
MUL_2428|M.ulcerans_Agy99 AAAAGSPG-----FPGMVAPPATR-ASGVLPRYGVRLTVMAHPPAAG---
MMAR_0191|M.marinum_M EAAHGIPG-----MPGMPVGSSSR-ASSVVPRYGVRLTVMAHPPAAG---
Mb3159|M.bovis_AF2122/97 VAEHGTPG-----LPGVPAGTDKR-ASGVIPRYGVRLTVMSRPPAAG---
MAV_4015|M.avium_104 RPGVTAPG-----LPGIPGATLRR-AALVVPRYGVRITVMARPPAAG---
MLBr_01182|M.leprae_Br4923 SESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG---
Mflv_0325|M.gilvum_PYR-GCK SPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADA
Mvan_0415|M.vanbaalenii_PYR-1 SPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADA
MSMEG_0619|M.smegmatis_MC2_155 TPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 ALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRG----
Rv3136|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2428|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0191|M.marinum_M --------------------------------------------------
Mb3159|M.bovis_AF2122/97 --------------------------------------------------
MAV_4015|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK YADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLTTLA
Mvan_0415|M.vanbaalenii_PYR-1 YADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLTTLP
MSMEG_0619|M.smegmatis_MC2_155 YMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTTLT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 -IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASGLAMLS
Rv3136|M.tuberculosis_H37Rv -------------------------------------------
MUL_2428|M.ulcerans_Agy99 -------------------------------------------
MMAR_0191|M.marinum_M -------------------------------------------
Mb3159|M.bovis_AF2122/97 -------------------------------------------
MAV_4015|M.avium_104 -------------------------------------------
MLBr_01182|M.leprae_Br4923 -------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK -GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 -GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 -GDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 RDDDLFEGVRAPMVPNTWDPEHGRQD-----------------